JaneHoytBucknerMD

PubMed

• 2 citations
  Down syndrome: insights into autoimmune mechanisms.
  Bernard Khor, Jane H Buckner> ;Nature Reviews. Rheumatology. 2023 Jul 1
• 7 citations
  Association of Antibodies to Prevotella copri in Anti-Cyclic Citrullinated Peptide-Positive Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With...
  Jennifer A Seifert, Elizabeth A Bemis, Kristina Ramsden, Cassidy Lowell, Kristen Polinski, Marie Feser, Chelsie Fleischer, M Kristen Demoruelle, Jane Buckner, Peter K ...> ;Arthritis & Rheumatology. 2023 Apr 1
• Deficiency in Human CD4T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms.
  Jing Song, Warren Anderson, Alex Hu, Kazushige Obata-Ninomiya, Steven F Ziegler, David J Rawlings, Jane H Buckner> ;Journal of Immunology. 2022 Oct 1
• 2 citations
  Th17 cells: from gut homeostasis to CNS pathogenesis.
  Jane H Buckner, Oliver J Harrison> ;Trends in Immunology. 2022 Mar 1
• 16 citations
  Fewer LAG-3T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes.
  Britta E Jones, Megan D Maerz, Henry T Bahnson, Ashwin Somasundaram, Cate Speake, Jane H Buckner, McCarthy, L., Lucas H McCarthy> ;Journal of Immunology. 2022 Feb 1
• 23 citations
  IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes
  Carla J. Greenbaum, Elisavet Serti, Katharina Lambert, Lia J Weiner, Sai Kanaparthi, Sandra Lord, Stephen E. Gitelman, Darrell M. Wilson, Jason L. Gaglia, Kurt J Griff...> ;JCI Insight. 2021 Nov 8
• 4 citations
  The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.
  Eric J. Allenspach, Nicholas J. Shubin, Karen Cerosaletti, Carmen Mikacenic, Jacquelyn A. Gorman, Matthew A MacQuivey, Aaron B I Rosen, Andrew E. Timms, Michelle N. Wr...> ;Journal of Immunology. 2021 Nov 5
• 13 citations
  HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind s...
  William F. C. Rigby, Jane H. Buckner, S. Louis Bridges, Marleen Nys, S. Gao, Martin Polinsky, Neelanjana Ray, Vivian P. Bykerk> ;Arthritis Research & Therapy. 2021 Sep 18
• 2 citations
  Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studi...
  Jan M. Hughes-Austin, Joachim H. Ix, Samuel R. Ward, Michael H. Weisman, James R. O'Dell, Ted R. Mikuls, Jane H. Buckner, Peter K. Gregersen, Richard M. Keating, M. Kr...> ;BMJ Open. 2021 Sep 14
• 30 citations
  Endomembrane targeting of human OAS1 p46 augments antiviral activity.
  Frank Soveg, Johannes Schwerk, Nandan S. Gokhale, Karen Cerosaletti, Julian R. Smith, Erola Pairo-Castineira, Alison M. Kell, Adriana Forero, Shivam A. Zaver, Katharin...> ;Elife. 2021 Aug 3
• 69 citations
  Immunotherapy: Building a bridge to a cure for type 1 diabetes
  Jeffrey A. Bluestone, Jane H. Buckner, Kevan C. Herold> ;Science. 2021 Jul 30
• 41 citations
  The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients.
  Sarah Pyfrom, Bam Paneru, James J. Knox, Michael P. Cancro, Sylvia Posso, Jane H. Buckner, Montserrat C. Anguera> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jun 15
• 100 citations
  Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
  Catherine C. Robertson, Inshaw Jrj., Suna Onengut-Gumuscu, Chen W-M., D F Santa Cruz, Huan Yang, Antony J. Cutler, Crouch Djm., Emily Farber, S L Bridges, Jeffrey C. E...> ;Nature Genetics. 2021 Jun 14
• 16 citations
  Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing.
  Adam K. Savage, Miriam V. Gutschow, Tony Chiang, Kathy Henderson, Richard Green, Monica Chaudhari, Elliott Swanson, Alexander T. Heubeck, Nina Kondza, Kelli C. Burley,...> ;Iscience. 2021 Apr 15
• Early Prognostic Indicators of Subsequent Hospitalization in Patients with Mild COVID-19
  Alyssa Ylescupidez, Aaron Rips, Henry T. Bahnson, Cate Speake, Punam Verma, Anne M. Hocking, Jane H. Buckner, Uma Malhotra> ;Journal of Clinical Medicine. 2021 Apr 8
• 18 citations
  Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clini...
  Elizabeth A. Bemis, M. Kristen Demoruelle, Jennifer Seifert, Kristen J. Polinski, Michael H. Weisman, Jane H. Buckner, Peter K. Gregersen, Ted R. Mikuls, James R. O'De...> ;Annals of the Rheumatic Diseases. 2021 Feb 1
• 22 citations
  The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity.
  Hamid Bolouri, Cate Speake, David A. G. Skibinski, S. Alice Long, Anne M. Hocking, Daniel J. Campbell, Jessica A. Hamerman, Uma Malhotra, Jane H. Buckner> ;The Journal of Clinical Investigation. 2021 Feb 1
• 19 citations
  Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis
  Jing Song, Anja Schwenzer, Alicia Wong, Sara Turcinov, Cliff Rims, Lorena Rodriguez Martinez, David Arribas-Layton, Christina Gerstner, Virginia S. Muir, Kim S. Midwoo...> ;JCI Insight. 2021 Mar 8
• 10 citations
  Association of lipid mediators and development of future incident inflammatory arthritis in an anti‐citrullinated protein antibody positive population
  Kristen J. Polinski, Elizabeth A. Bemis, Fan Yang, Tessa L. Crume, M. Kristen Demoruelle, Marie L. Feser, Jennifer Seifert, James R. O'Dell, Ted R. Mikuls, Michael H. ...> ;Arthritis & Rheumatology. 2021 Apr 23
• 2 citations
  Identifying the ‘Achilles heel’ of type 1 diabetes
  Manuela Battaglia, Jane H. Buckner, Megan K. Levings, Sarah J. Richardson, Florence Susan Wong, Timothy Tree> ;Clinical and Experimental Immunology. 2021 Feb 22
• 2 citations
  Sudden Cardiac Death due to Coronary Artery Vasculitis in a Patient with Relapsing Polychondritis.
  Heather Bukiri, Steven M. Ruhoy, Jane H. Buckner> ;Case Reports in Rheumatology. 2020 Nov 16
• 17 citations
  Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort.
  Kristen J. Polinski, Elizabeth A. Bemis, Marie L. Feser, Jennifer Seifert, M. Kristen Demoruelle, Christopher C. Striebich, Stacey Brake, James R. O'Dell, Ted R. Mikul...> ;Arthritis Care & Research. 2020 Dec 1
• 83 citations
  Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis.
  Carmelo Carmona-Rivera, Philip M. Carlucci, Rishi R. Goel, Eddie A. James, Stephen R. Brooks, Cliff Rims, Victoria Hoffmann, David A. Fox, Jane H. Buckner, Mariana J. ...> ;JCI Insight. 2020 Jul 9
• 63 citations
  Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.
  Honaker Yuchi Chiang, Nicholas Hubbard, Yufei Xiang, Logan Fisher, David Hagin, Karen Sommer, Yumei Song, Soo Jung Yang, Christina Lopez, Tori Tappen, Elizabeth M. Dam...> ;Science Translational Medicine. 2020 Jun 3
• 19 citations
  Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses
  Hannah Labinsky, Paul M. Panipinto, Kaytlyn A. Ly, Deric K. Khuat, Bhanupriya Madarampalli, Vineet Mahajan, Jonathan J. Clabeaux, Kevin M. MacDonald, Peter J. Verdin, ...> ;Arthritis & Rheumatology. 2020 Mar 12
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Journal Articles

• Autoantibodies Against Neurologic Antigens in Nonneurologic Autoimmunity  
  Jane H Buckner, David A Hafler, Richard J Nowak, The Journal of Immunology
• Citrullinated Aggrecan Epitopes as Targets of Auto‐Reactive CD4+ T Cells in Patients with Rheumatoid Arthritis  
  Jeffrey Carlin, Jane H Buckner, Eddie A James, Mariana J Kaplan, Arthritis & Rheumatology
• Research Paper A Novel and Rapid Method to Quantify Treg Mediated Suppression of CD4 T Cells  
  Jane H. Buckner, Carmen Mikacenic, ScienceDirect
• Angiomatous variant of so-called mesothelioma of the atrioventricular node.  
  Hoyt JC, Hutchins GM, Arch Pathol Lab Med. 1986; 110:851-52
• Effects of anti-inflammatory and immunosuppressive drugs on pregnancy and fertility.  
  Roubenoff R, Hoyt J, Petri M, Hochberg M, Hellman D, Sem Arthritis Rheum. 1988; 18:88-110
• Variceal transformation of the subendocardial microvasculature in regions of chronic myocardial ischemia.  
  Hoyt JC, Hutchins GM, Am Heart J. 1989; 117:830-36
• Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen specific CD4+ cells with similar TCR avidity.  
  Holzer U, Kwok WW, Nepom GT, Buckner JH, J Immunol. 2003; 170:1218-23
• Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.  
  Walker MR, Kasprowicz D, Gersuk B, Benard A, Van Landeghen M, Buckner J, Ziegler S, J Clin. Invest. 2003; 112:1437-43
• De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.  
  Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH, Proc Natl Acad Sci U.S.A. 2005; 102:4103-08
• High molecular weight hyaluronan promotes the activation and suppressive effects of CD4+CD25+ T-regs.  
  Bollyky PL, Lord JD, Masewicz SA, Evanko SP, Rosenberg C, Buckner JH, Wight TN, Nepom GT, J Immunol. 2007 Jul 15;179(2):744-7
• Assessment of suppressive capacity by human regulatory T cells using a reproducible, bi-directional CFSE-based in vitro assay.  
  Schneider A, Buckner JH, Methods Mol Biol. 2011;707:233-41. PMID: 21287339
• Polychondritis reference.  
  Buckner JH, Medscape Online Reference
• Multifunctional T cell reactivity to native and glycosylated type-II collagen in rheumatoid arthritis.  
  Snir O, Backlund J, Bostrom J, Andersson I, Kihlberg J, Buckner J, Klareskog L, Holmdahl R, Arthritis Rheum. 2012 Mar 5. doi: 10.1002/art.34459. NIHMS360527
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Books/Book Chapters

• Immunologic Aspects of Rheumatic Disease: Cambridge Reviews in Clinical Immunology. 
  Chapter: The role of MHC antigens in autoimmunity 
  Buckner J and Nepom GTEditors: J.S.H. Gaston.Cambridge University Press
• HLA 2004: Immunobiology of the Human MHC. 
  Chapter: MHC peptide tetramers: analysis of adaptive immune responses 
  Nepom GT, Buckner J, Holzer U, Reichstetter S, Danke N and Kwok WWEditors: Hansen JA and Dupont B.Volume I & II, IHWG Press, Seattle
• Arthritis and Allied Conditions. 
  Chapter: Structure, function, and genetics of the human leukocyte antigen complex in rheumatic disease 
  Buckner JH, Nepom GTEditors: W.J. Koopman and L. W. Moreland.Lippincott Williams and WilkinsEdition 15,

Abstracts/Posters

• The newly emerging B cell repertoire in the adult.
  Buckner JH, Kantor KB, Herzenberg LA, Merrill CE, Hillson JL, Arthritis and Rheum 1993 36:S200
• Antibody repertoire expressed by adult pre-B cells.
  Buckner JH, Kantor KB, Herzenberg LA, Merrill CE, Hillson JL, J Immunol 1993 150:259A
• Human adult CD5-positive B cells express a unique repertoire that differs from both conventional B cells and fetal B cells.
  Buckner JH, Kantor KB, Herzenberg LA, Merrill CE, Hillson JL, Arthritis and Rheum 1994 37:S322
• pH plays a critical role in HLA DQ allele-specific binding.
  Buckner JH, Nepom B, Nepom GT, Kwok WW, Arthritis and Rheum 1995 38:S254
• Evaluation of the immune response to collagen in patients with relapsing polychondritis.
  Buckner JH, Arthritis and Rheum 1997 40:S268 #1423
• Matrilin-1 as an autoantigen in relapsing polychondritis.
  Buckner JH, Kleeman-Fischer D, Wu J, Arthritis and Rheum 1999 42:S109 #229
• The immune response to cartilage proteins in patients with relapsing polychondritis.
  Bucker JH, Terato K, Reife RA, Wu J, Arthritis and Rheum 1999 42:S321 #1500
• Allele specific differences in binding affinity to clip influence peptide selection.
  Buckner JH, Blom I, Van Landeghen M, Nepom GT, The FASEB Journal April 2000 14(6):151.13
• IgG Subclass Distribution of Antibodies Against Type II Collagen in Patients with Relapsing Polychondritis and Rheumatoid Arthritis.
  Buckner JH, Tsaknaridis L, Reife R, Terato K, Arthritis and Rheum 2001 44:S9 #131
• T Cells Specific to the Type II Collagen (261-273) Peptides Are Present in a Patient with Relapsing Polychondritis.
  Buckner JH, Kwok WW, Van Landeghen M, Tsaknaridis L, Arthritis and Rheum 2001 44:S9 #438
• Effect of Transforming growth factor b1 (TGF-?1) on Human Antigen-specific Th1 and Th2 Memory cells.
  Holzer U, Van Landeghen M, Wang T, Buckner JH, Federation of Clinical Immunology Societies (FOCIS) meeting Paris
• DRB1*0401/*0404 Heterozygosity Enhances Activation of T cells.
  Buckner JH, Van Landeghen M, Rieck M, Gebe J, Nepom G, Arthritis and Rheumatism, 2003 Volume 48, number 9(supplement) S285
• Human CD4+CD25+ T regulatory cells can be induced upon activation of CD4+CD25- T cells in vitro.
  Walker M, Van Landeghen M, Gersuk V, Ziegler SF, Buckner JH, Arthritis Rheum, 2003 Volume 48, number 9 (supplement) S611
• Induction of Antigen-Specific CD4+CD25+ Regulatory T Cells from Human CD4+CD25- Cells.
  Walker M, Ziegler SF, Kasprowicz D, Nepom GT, Buckner JH, Federation of Clinical Immunology Societies Annual Meeting, Montreal, Quebec
• The Lifecycle Of In Vitro Generated CD4+CD25+FoxP3+ Human TR: Generation, Expansion, and Persistence.
  Walker MR, Carson BD, Ziegler SF, Buckner JH, Federation of Clinical Immunology Societies Annual Meeting, Boston MA
• Tissue Specific CD4+CD25+FoxP3+ Regulatory T cells: Generation, Isolation and Expansion.
  Walker MR, Carson BD, Ziegler SF, Nepom GT, Buckner JH, American College of Rheumatology Annual Meeting, San Diego, CA
• Generation of Autoantigen-Specific CD4+CD25+ Regulatory T cells From Human CD4+CD25- Cells.
  Walker MR, Carson BD, Ziegler SF, Nepom GT, and Buckner JH, Keystone Symposium: Regulatory T cells, Breckenridge, CO
• Induction of CD4+CD25+FoxP3+ Regulatory T Cells: Requirement for Gamma Chain Cytokines.
  Long SA, Walker M, Van Landeghen M and Buckner JH, Human Immunology Keystone Conference, Big Sky, MO
• Induction of Autoantigen-Specific CD4+CD25+ Regulatory T Cells in Vitro.
  Walker MR, Carson BD, Ziegler SF, Nepom GT, and Buckner JH, Federation of Clinical Immunology Societies Annual Meeting, San Francisco, CA
• Rapamycin Promotes Induction of CD4+FoxP3+ T cells that Proliferate in Response to Common Gamma Chain Cytokines.
  Long SA, Van Landeghen M., Buckner, JH, Oral presentation, Federation of Clinical Immunology Societies (FOCIS) conference, San Diego, CA
• Genetic Variation in PTPN22 Corresponds to Altered Signaling in B Lymphocytes.
  Arechiga AF, Buckner JH, American Association of Immunologists meeting, Miami, FL
• IL-2 Enhances FOXP3 Expression in Treg of Healthy but Not Diabetic Subjects.
  Long SA, Schneider A, Bollyky P, Greenbaum C and Buckner JH, Immune tolerance Keystone Conference, Keystone, CO
• IL-2 Treatment Enhances Expression of FOXP3 in Lupus but not Diabetic Subjects.
  Long SA, Shilling H, Stevens A, Pihoker C, Greenbaum C, and Buckner JH, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
• Effector T cells of T1D Subjects are Resistant to Suppression by adaptive Tregs.
  Schneider A, Greenbaum C, Pihoker C, and Buckner J, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
• The PTPN22 1858C/T Functional Polymorphism is Associated with Relapsing Polychondritis.
  Shilling HG, Wei S, Onengut-Gumuscu S, Leighty WW, Concannon P, and Buckner JH, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
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Lectures

• Relapsing Polychondritis. 
  Western Regional ACR Meeting, Seattle
• CD4 T cell responses to foreign and self antigens- Do the same rules apply? 
  University of North Dakota- Guest Lecture Dept. of Immunology
• HLA class II tetramers: tracking down autoimmune responses. 
  Autoimmune Biomarkers Symposium- Long Island, NY
• Generation of Regulatory T cells: Induction and isolation of antigen Specific TR. 
  FOCIS Meeting, Boston, MA
• Genes and Lupus. 
  Seattle Lupus Symposium
• Translational Research: Bed to Bedside. 
  Keynote Speaker at Arthritis: Arthritis Discoveries -Shoreline, Seattle
• HLA Class II Tetramers: a tool for tracking down and treating autoimmunity. 
  University of Michigan invited speaker: Rheumatology Grand Rounds
• State of the Art Speaker. 
  Western Chapter of the American Federation for Medical Research, Carmel, CA
• Cell therapy for type 1 diabetes? 
  Seattle Sweden Diabetes Awareness Day, Seattle
• The delicate balance of the immune system: solving the puzzle of autoimmunity. 
  Sunset Club Lecture Series Invited Speaker, Seattle
• Solving the puzzle of autoimmunity. 
  Pat’s Fund Breakfast: Keynote Speaker, Seattle
• Restoring Immune Regulation in Autoimmunity. 
  Virginia Mason Grand rounds, Virginia Mason Medical Center, Seattle
• Missing Pieces. 
  Pat’s Fund Dinner: Keynote Speaker, Seattle
• FOCIS Oral Presentation. 
  San Diego, CA
• Progress in Scleroderma; Translational Research at BRI. 
  The Evergreen Chapter of Scleroderma Foundation, Seattle
• Lupus Research Update. 
  Alliance for Lupus Research: Keynote Speaker, Seattle
• Progress in Autoimmunity Research. 
  Association of Women in Science, AWIS Seattle Chapter
• T Cell Regulation in Type 1 Diabetes. 
  University of Oslo, Norway
• The Basics of Autoimmune Disease. 
  Pat’s Fund, First Annual Seattle Autoimmunity Day
• Biomarkers to Predict Autoimmunity. 
  FOCIS (Federation of Clinical Immunological Societies), Boston, MA
• Regulatory T Cells and Type 1 Diabetes. 
  FOCIS Concurrent Thematic Symposium, Boston, MA
• Why do People get Auto-immune Disease? 
  Rheumatology Update for Primary Care Physicians, Virginia Mason Medical Center, Seattle
• Mechanisms of Altered Lymphocite Function in Type I Diabetes. 
  ASHI (American Society for Histocompatibility and Immunogenetics) 34th Annual Meeting, Toronto, Onta
• Genotype-phenotype Analysis Reveals Common Disease Mechanisms in Type 1 Diabetes. 
  University of Minnesota, Dept of Immunology, Minneapolis, MN
• Mechanisms of Lost Tolerance in Type 1 Diabetes: Genotype-phenotype Analysis reveals Common Disease Pathways. 
  University of Kentucky, Lexington
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Other

• Polychondritis. 
  Compton N, Buckner JH, Harp KI, Raugi GJ, eMedicine online book
  http://emedicine.medscape.com/article/331475-overview