Jane Hoyt Buckner MD

PubMed

• Rheumatoid arthritis - the role of T cells in this complex systemic autoimmune disease.
  Christina S Savvides, Eddie A James, Jane H Buckner
  Current Opinion in Immunology. 2025-04-09
• Reduced function of the adaptor SH2B3 promotes T1D via altered cytokine-regulated, T cell intrinsic immune tolerance.
  Taylor K Watson, Aaron B I Rosen, Travis Drow, Jacob A Medjo, Matthew A MacQuivey
  Diabetes. 2025-03-06
• A coding single nucleotide polymorphism in the interleukin-6 receptor enhances IL-6 signalling in CD4 T cells and predicts treatment response to tocilizumab in giant c...
  Robert Zorc, Christopher Redmond, McKella Sylvester, Mary Maclean, Luciana Yamamoto de Almeida
  Annals of the Rheumatic Diseases. 2025-02-24

Journal Articles

• Autoantibodies Against Neurologic Antigens in Nonneurologic Autoimmunity  
  Jane H Buckner, David A Hafler, Richard J Nowak, The Journal of Immunology
• Citrullinated Aggrecan Epitopes as Targets of Auto‐Reactive CD4+ T Cells in Patients with Rheumatoid Arthritis  
  Jeffrey Carlin, Jane H Buckner, Eddie A James, Mariana J Kaplan, Arthritis & Rheumatology
• Research Paper A Novel and Rapid Method to Quantify Treg Mediated Suppression of CD4 T Cells  
  Jane H. Buckner, Carmen Mikacenic, ScienceDirect
• Angiomatous variant of so-called mesothelioma of the atrioventricular node.  
  Hoyt JC, Hutchins GM, Arch Pathol Lab Med. 1986; 110:851-52
• Effects of anti-inflammatory and immunosuppressive drugs on pregnancy and fertility.  
  Roubenoff R, Hoyt J, Petri M, Hochberg M, Hellman D, Sem Arthritis Rheum. 1988; 18:88-110
• Variceal transformation of the subendocardial microvasculature in regions of chronic myocardial ischemia.  
  Hoyt JC, Hutchins GM, Am Heart J. 1989; 117:830-36
• Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen specific CD4+ cells with similar TCR avidity.  
  Holzer U, Kwok WW, Nepom GT, Buckner JH, J Immunol. 2003; 170:1218-23
• Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.  
  Walker MR, Kasprowicz D, Gersuk B, Benard A, Van Landeghen M, Buckner J, Ziegler S, J Clin. Invest. 2003; 112:1437-43
• De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.  
  Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH, Proc Natl Acad Sci U.S.A. 2005; 102:4103-08
• High molecular weight hyaluronan promotes the activation and suppressive effects of CD4+CD25+ T-regs.  
  Bollyky PL, Lord JD, Masewicz SA, Evanko SP, Rosenberg C, Buckner JH, Wight TN, Nepom GT, J Immunol. 2007 Jul 15;179(2):744-7
• Assessment of suppressive capacity by human regulatory T cells using a reproducible, bi-directional CFSE-based in vitro assay.  
  Schneider A, Buckner JH, Methods Mol Biol. 2011;707:233-41. PMID: 21287339
• Polychondritis reference.  
  Buckner JH, Medscape Online Reference
• Multifunctional T cell reactivity to native and glycosylated type-II collagen in rheumatoid arthritis.  
  Snir O, Backlund J, Bostrom J, Andersson I, Kihlberg J, Buckner J, Klareskog L, Holmdahl R, Arthritis Rheum. 2012 Mar 5. doi: 10.1002/art.34459. NIHMS360527
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Books/Book Chapters

• Immunologic Aspects of Rheumatic Disease: Cambridge Reviews in Clinical Immunology. 
  Chapter: The role of MHC antigens in autoimmunity 
  Buckner J and Nepom GTEditors: J.S.H. Gaston.Cambridge University Press
• HLA 2004: Immunobiology of the Human MHC. 
  Chapter: MHC peptide tetramers: analysis of adaptive immune responses 
  Nepom GT, Buckner J, Holzer U, Reichstetter S, Danke N and Kwok WWEditors: Hansen JA and Dupont B.Volume I & II, IHWG Press, Seattle
• Arthritis and Allied Conditions. 
  Chapter: Structure, function, and genetics of the human leukocyte antigen complex in rheumatic disease 
  Buckner JH, Nepom GTEditors: W.J. Koopman and L. W. Moreland.Lippincott Williams and WilkinsEdition 15,

Abstracts/Posters

• Multiple alterations in IL-2R signaling contribute to decreased response to IL-2 in CD4+ T cells of T1D subjects as revealed by genotype/phenotype analysis.
  Long SA, Cerosaletti K, Shilling H, Zhang S, Zhang Z-Y, Pihoker C, Greenbaum C, Buckner J, Tolerance and Autoimmunity Keystone Symposium, Taos, NM
• Rapamycin Promotes Induction of CD4+FoxP3+ T cells that Proliferate in Response to Common Gamma Chain Cytokines.
  Long SA, Van Landeghen M., Buckner, JH, Oral presentation, Federation of Clinical Immunology Societies (FOCIS) conference, San Diego, CA
• Genetic Variation in PTPN22 Corresponds to Altered Signaling in B Lymphocytes.
  Arechiga AF, Buckner JH, American Association of Immunologists meeting, Miami, FL
• IL-2 Enhances FOXP3 Expression in Treg of Healthy but Not Diabetic Subjects.
  Long SA, Schneider A, Bollyky P, Greenbaum C and Buckner JH, Immune tolerance Keystone Conference, Keystone, CO
• IL-2 Treatment Enhances Expression of FOXP3 in Lupus but not Diabetic Subjects.
  Long SA, Shilling H, Stevens A, Pihoker C, Greenbaum C, and Buckner JH, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
• Effector T cells of T1D Subjects are Resistant to Suppression by adaptive Tregs.
  Schneider A, Greenbaum C, Pihoker C, and Buckner J, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
• The PTPN22 1858C/T Functional Polymorphism is Associated with Relapsing Polychondritis.
  Shilling HG, Wei S, Onengut-Gumuscu S, Leighty WW, Concannon P, and Buckner JH, Federation of Clinical Immunology Societies (FOCIS) conference, Boston, MA
• Diminished IL-2 Responsiveness and FOXP3 Expression in T1D Subjects Revealed by a Disease-Associated Variant of PTPN2.
  Long SA, Bollyky P, Cerosaletti K, Shilling H, Pihoker C, Sanda S, Greenbaum C and Buckner JH, 96th annual meeting of The American Association of Immunologists (AAI) conference, Seattle, WA
• Persistence of FOXP3 Expression is Impaired in RR-MS Tregs.
  Schneider A, Kita M, Long SA, Buckner J, 96th annual meeting of The American Association of Immunologists (AAI) conference, Seattle, WA
• The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling.
  Habib T, Arechiga AF, Funk A, He Y, Zhang X, Zhang Z-Y, Buckner JH, 96th annual meeting of The American Association of Immunologists (AAI) conference, Seattle, WA
• Induction of Autoantigen-Specific CD4+CD25+ Regulatory T Cells in Vitro.
  Walker MR, Carson BD, Ziegler SF, Nepom GT, and Buckner JH, Federation of Clinical Immunology Societies Annual Meeting, San Francisco, CA
• Blunted BCR Signaling, a Source of Lost Tolerance in Autoimmunity.
  Habib T, Funk A, Rieck M, Brahmandam A, Greenbaum C, Sanda S, Rawlings D, Buckner J, Tolerance and Autoimmunity Keystone Symposium, Taos, NM
• The PTPN22 allelic variant 1858T is associated with multiple alterations in TCR signaling and function.
  Habib T, Funk A, Rieck M, Buckner JH, Tolerance and Autoimmunity Keystone Symposium, Taos, NM
• FOXP3 persistence and common -chain cytokine signaling are impaired in RR-MS Tregs.
  Schneider A, Long SA, Kita M, Buckner J, Tolerance and Autoimmunity Keystone Symposium, Taos, NM
• Association of non-coding SNPs in the autoimmune susceptibility gene PTPN2 with diminished PTPN2 expression.
  Cerosaletti K, Long SA, Ho JC, Wan JY, Buckner JH, Oral presentation FOCIS, Boston, MA
• A T1D-associated variant of PTPN2 correlates with decreased IL-2/IL-15 responsiveness, reduced FOXP3 expression and impaired CD8 T cell differentiation.
  SA Long, K Cerosaletti, H Shilling, P Bollyky, D Rawlings, S Sanda, JH Buckner, FOCIS Poster presentation, Boston, MA
• PTPN22 Modulates B Cell Tolerance in Human Autoimmunity.
  T Habib, A Funk, M Rieck, A Brahmandam, X Dai, AK Panigrahi, ET Luning Prak, A Meyer-Bahlburg, S Sanda, C Greenbaum, DJ Rawlings, and JH Buckner, Keystone Symposium, Whistler, British Columbia, Canada
• Genotype-phenotype analyses reveal disease mechanisms that underlie human autoimmunity.
  J Buckner, 50th Midwinter Conference of Immunologists, Asilomar, Pacific Grove, CA
• The challenge of developing antigen specific Treg therapy in T1D.
  J Buckner, SA Long, S Gupta, A Schneider, P Samuels, Twelfth International Conference on the Immunology of Diabetes, IDS Victoria 2012, Vancouver, BC
• T Cells Specific to the Type II Collagen (261-273) Peptides Are Present in a Patient with Relapsing Polychondritis.
  Buckner JH, Kwok WW, Van Landeghen M, Tsaknaridis L, Arthritis and Rheum 2001 44:S9 #438
• Antibody repertoire expressed by adult pre-B cells.
  Buckner JH, Kantor KB, Herzenberg LA, Merrill CE, Hillson JL, J Immunol 1993 150:259A
• Human adult CD5-positive B cells express a unique repertoire that differs from both conventional B cells and fetal B cells.
  Buckner JH, Kantor KB, Herzenberg LA, Merrill CE, Hillson JL, Arthritis and Rheum 1994 37:S322
• pH plays a critical role in HLA DQ allele-specific binding.
  Buckner JH, Nepom B, Nepom GT, Kwok WW, Arthritis and Rheum 1995 38:S254
• Evaluation of the immune response to collagen in patients with relapsing polychondritis.
  Buckner JH, Arthritis and Rheum 1997 40:S268 #1423
• Matrilin-1 as an autoantigen in relapsing polychondritis.
  Buckner JH, Kleeman-Fischer D, Wu J, Arthritis and Rheum 1999 42:S109 #229
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Lectures

• Genotype-phenotype analysis reveals common disease mechanisms in autoimmunity. 
  University of California, San Francisco, and Genentech, San Francisco, CA
• Update on Arthritis Research: Striving for a Cure Together. 
  The Arthritis Foundation, Pacific Northwest Chapter, Shoreline, WA
• T Cell Immunoregulation. 
  University of Oxford, 14th EASD Oxford Workshop, Oxford, United Kingdom
• Multiple mechanisms contribute to impaired immune regulation in individuals with T1D. 
  Juvenile Diabetes Research Foundation Center meeting, Harvard University, Boston, MA
• Mechanisms of Altered Lymphocyte Function in Type I Diabetes. 
• Mechanisms of impaired regulation in T1D. 
  4th International Conference on Autoimmunity: Mechanisms & Novel Treatments, Crete, Greece
• Signals Underlying Receptor Editing. 
  Tolerance and Autoimmunity Keystone Symposium,Taos, NM
• The impact of impaired antigen receptor signaling in T1D and debate: Impaired regulatory T cells or resistant effector T cells? 
  2010 Levine Symposium, Las Vegas, NV
• Mechanisms of impaired tolerance in type 1 diabetes. 
  97th annual meeting of The American Association of Immunologists, Baltimore, MD
• Genotype-phenotype Analysis Reveals Common Disease Mechanisms in Autoimmunity. 
  FOCIS 2010 (Federation of Clinical Immunological Societies), Boston, MA
• Functional Analysis of the PTPN22 Autoimmunity Gene. 
  American Diabetes Association 70th Annual Scientific Sessions, Orlando, FL
• It’s a Family Affair. 
  Pat’s Fund, Redmond, WA
• Mechanisms of Lost Tolerance in Type 1 Diabetes: Genotype-phenotype Analysis reveals Common Disease Pathways. 
  University of Kentucky, Lexington
• Genotype-phenotype analysis reveals common disease mechanisms in autoimmunity. 
  Amgen, Seattle, WA
• Novel Mechanisms of Impaired T-cell Regulation in Autoimmunity. 
  Benaroya Research Institute Symposium, Seattle, WA
• Genotype-phenotype analyses reveal disease mechanisms that underlie human autoimmunity. 
  50th Midwinter Conference of Immunologists, Asilomar, Pacific Grove, CA
• Genotype-phenotype analyses reveal disease mechanisms that underlie human autoimmunity. 
  University of Massachusetts Medical School, Department of Pathology, Worcester, MA
• T cell regulation and autoimmune pathogenesis: Th17, T regs and more. 
  2011 Annual Scientific Meeting of the American College of Rheumatology, Chicago, IL
• Defective T cell Regulation in T1D. 
  International Symposium of the 2011 Annual Meeting of Japanese Society for Immunology, Chiba, Japan
• Exploiting the genetics of type 1 diabetes to identify disease mechanisms. 
  University of Washington Poll Scholar Symposium, Seattle, WA
• Genotype- phenotype studies in human autoimmunity. 
  Pfizer, Inc. San Francisco, CA
• Novel mechanisms of impaired T cell regulation in T1D. 
  Deeley Research Centre, Victoria, British Columbia, Canada
• The challenge of developing antigen specific Treg therapy in T1D. 
  Twelfth International Conference on the Immunology of Diabetes, Victoria, British Columbia, Canada
• Immunopathology of T1D. 
  Keystone Symposium, Whistler, BC, Canada
• Missing Pieces. 
  Pat’s Fund Dinner: Keynote Speaker, Seattle
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Other

• Polychondritis. 
  Compton N, Buckner JH, Harp KI, Raugi GJ, eMedicine online book
  http://emedicine.medscape.com/article/331475-overview