JaneyLWiggsMDPhD

PubMed

• Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis.
  Yu Jing Liang, Yu Yao Wang, Shi Song Rong, Zhen Ji Chen, Shu Ying Chen, Jenson A Tham, Poemen P Chan, Jason C Yam, Chi Pui Pang, Clement C Tham, Li Jia Chen, Janey L W...> ;JAMA Ophthalmology. 2024 Mar 28
• 1 citations
  Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.
  Rishabh K Singh, Yan Zhao, Tobias Elze, Mae Gordon, Michael A Kass, Yuyang Luo, Louis R Pasquale, Todd Scheetz, Ayellet V Segrè, John Fingert, Janey L Wiggs, Nazlee Ze...> ;JAMA Ophthalmology. 2024 Apr 1
• Relationship between Oral Health and Glaucoma Traits in the United Kingdom.
  Jae H Kang, Siegfried K Wagner, Anthony P Khawaja, , Rachel H Lee, Janey L Wiggs, Louis R Pasquale> ;Journal of Glaucoma. 2024 Mar 5
• Machine Learning-Derived Baseline Visual Field Patterns Predict Future Glaucoma Onset in the Ocular Hypertension Treatment Study.
  Singh, R., Smith, S., Gordon, M., Kass, M., Scheetz, T., Segrè, A., Elze, T., Fingert, J., Wiggs, J., Zebardast, N.> ;Investigative Ophthalmology & Visual Science. 2024 Feb 1
• Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.
  Zekavat, S., Jorshery, S., Rauscher, F., Horn, K., Sekimitsu, S., Koyama, S., Nguyen, T., Costanzo, M., Jang, D., Burtt, N., Kühnapfel, A., Shweikh, Y., Ye, Y., Raghu,...> ;Science Translational Medicine. 2024 Jan 24
• Genetic Basis of Pigment Dispersion Syndrome and Pigmentary Glaucoma: An Update and Functional Insights.
  Rong, S., Yu, X., Wiggs, J.> ;Genes. 2024 Jan 23
• 4 citations
  A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.
  Verma, S., Gudiseva, H., Chavali, V., Salowe, R., Bradford, Y., Guare, L., Lucas, A., Collins, D., Vrathasha, V., Nair, R., Rathi, S., Zhao, B., He, J., Lee, R., Zeneb...> ;Cell. 2024 Jan 18
• Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma.
  Hamel, A., Yan, W., Rouhana, J., Monovarfeshani, A., Jiang, X., Mehta, P., Advani, J., Luo, Y., Liang, Q., Rajasundaram, S., Shrivastava, A., Duchinski, K., Mantena, S...> ;Nature Communications. 2024 Jan 9
• 1 citations
  TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study.
  Skanda Rajasundaram, Nazlee Zebardast, Puja Mehta, Anthony P Khawaja, Alasdair Warwick, Katherine Duchinski, Stephen Burgess, Dipender Gill, Ayellet V Segrè, Janey Wiggs> ;Journal of Translational Medicine. 2023 Nov 24
• WITHDRAWN: Genome-wide risk prediction of primary open-angle glaucoma across multiple ancestries.
  Puya Gharahkhani, Weixiong He, Xikun Han, Jue Sheng Ong, Miguel E Rentería, Janey L Wiggs, Anthony P Khawaja, Maciej Trzaskowski, David A Mackey, Jamie E Craig, Alex W...> ;Medrxiv. 2023 Nov 30
• 3 citations
  Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma.
  Wendy W Liu, Tyler G Kinzy, Jessica N Cooke Bailey, Zihe Xu, Pirro Hysi, Janey L Wiggs> ;Scientific Reports. 2023 Sep 23
• 3 citations
  Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants.
  Alan Kastner, Kelsey V Stuart, Giovanni Montesano, C Gustavo De Moraes, Jae H Kang, Janey L Wiggs, Louis R Pasquale, Pirro Hysi, Sharon Y L Chua, Praveen J Patel, Paul...> ;JAMA Ophthalmology. 2023 Oct 1
• 2 citations
  Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.
  Sayuri Sekimitsu, David Xiang, Sophie Lloyd Smith, Katie Curran, Tobias Elze, David S Friedman, Paul J Foster, Yuyang Luo, Louis R Pasquale, Tunde Peto, Ayellet V Segr...> ;JAMA Ophthalmology. 2023 Sep 1
• Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study.
  Rishabh K Singh, Yan Zhao, Tobias Elze, John Fingert, Mae Gordon, Michael A Kass, Yuyang Luo, Louis R Pasquale, Todd Scheetz, Ayellet V Segrè, Janey L Wiggs, Nazlee Ze...> ;Medrxiv. 2023 Aug 16
• Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1H NMR Spectroscopy Results From the UK Biobank.
  Louis R Pasquale, Anthony P Khawaja, Janey L Wiggs, Jihye Kim, Pirro Hysi, Tobias Elze, Jessica Lasky-Su, Jae H Kang, Oana Zeleznik> ;Investigative Ophthalmology & Visual Science. 2023 Aug 1
• 10 citations
  Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.
  Xikun Han, Puya Gharahkhani, Andrew R Hamel, Jue Sheng Ong, Miguel E Rentería, Puja Mehta, Xianjun Dong, Francesca Pasutto, Christopher Hammond, Terri L Young, Pirro H...> ;Nature Genetics. 2023 Jul 1
• 5 citations
  The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.
  Kian M Madjedi, Kelsey V Stuart, Sharon Y L Chua, Pradeep Y Ramulu, Alasdair Warwick, Robert N Luben, Zihan Sun, Mark A Chia, Hugues Aschard, Janey L Wiggs, Jae H Kang...> ;Ophthalmology. 2023 Oct 1
• 5 citations
  Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.
  Inas F Aboobakar, Edward Ryan A Collantes, Michael A Hauser, W Daniel Stamer, Janey L Wiggs> ;Human Molecular Genetics. 2023 Jul 20
• 6 citations
  Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.
  Oana A Zeleznik, Jae H Kang, Jessica Lasky-Su, A Heather Eliassen, Lisa Frueh, Clary B Clish, Bernard A Rosner, Tobias Elze, Pirro Hysi, Anthony Khawaja, Janey L Wiggs...> ;Nature Communications. 2023 May 19
• 1 citations
  Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes.
  Seyedeh Maryam Zekavat, Saman Doroodgar Jorshery, Yusrah Shweikh, Katrin Horn, Franziska G Rauscher, Sayuri Sekimitsu, Satoshi Kayoma, Yixuan Ye, Vineet Raghu, Hongyu ...> ;Medrxiv. 2023 May 17
• 3 citations
  Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disorders.
  Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, , Christopher J Hammond, Pirro G Hysi, Louis R Pasquale, Anthony P Khawaja, Alex W Hewi...> ;Ebiomedicine. 2023 Jun 1
• 10 citations
  Perspectives of Rare Disease Experts on Newborn Genome Sequencing.
  Nina B Gold, Sophia M Adelson, Nidhi Shah, Shardae Williams, Sarah L Bick, Emilie S Zoltick, Jessica I Gold, Alanna Strong, Rebecca Ganetzky, Amy E Roberts, Melissa Wa...> ;JAMA Network Open. 2023 May 1
• 3 citations
  Association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline.
  Sayuri Sekimitsu, Yusrah Shweikh, Sarah Shareef, Yan Zhao, Tobias Elze, Ayellet Segrè, Janey Wiggs, Nazlee Zebardast> ;The British Journal of Ophthalmology. 2024 Mar 20
• 3 citations
  Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes.
  Inas F Aboobakar, Tyler G Kinzy, Yan Zhao, Baojian Fan, Louis R Pasquale, Ayub Qassim, Antonia Kolovos, Joshua M Schmidt, Jamie E Craig, Jessica N Cooke Bailey, Janey ...> ;Ophthalmology. 2023 Jul 1
• 3 citations
  Genetic Associations Between Smoking- and Glaucoma-Related Traits.
  Jessica H Tran, Kelsey V Stuart, Victor de Vries, Joëlle E Vergroesen, Clara C Cousins, Pirro G Hysi, Ron Do, Ghislain Rocheleau, Jae H Kang, Janey L Wiggs, Stuart Mac...> ;Translational Vision Science & Technology. 2023 Feb 1
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Journal Articles

• Association of Long-Term Ambient Black Carbon Exposure and Oxidative Stress Allelic Variants with Intraocular Pressure in Older Men  
  Janey L Wiggs, Leon W Herndon, Pantel Vokonas, JAMA
• Genome-Wide Association Study of Primary Open-Angle Glaucoma in Continental and Admixed African Populations  
  Girish N Nadkarni, Michael A Hauser, Christopher A Girkin, Janey L Wiggs, R Rand Allingham, Jerome I Rotter, Robert N Weinreb, Human Genetics
• As a Central Corneal Thickness Locus  
  Janey L Wiggs, David S Friedman, Investigative Ophthalmology and Visual Science