JasonCirilKovacicMDPhD FRACP FAHA FACC FSCAI

PubMed

• Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease.
  Ignacio Fernando Hall, Franceska Kishta, Yang Xu, Andrew H Baker, Jason C Kovacic> ;Cardiovascular Research. 2024 Mar 14
• 2 citations
  Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.
  Chani J Hodonsky, Adam W Turner, Mohammad Daud Khan, Nelson B Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily F...> ;Cell Genomics. 2024 Jan 10
• 6 citations
  Molecular biomarkers for vascular cognitive impairment and dementia.
  Satoshi Hosoki, Gurpreet K Hansra, Tharusha Jayasena, Anne Poljak, Karen A Mather, Vibeke S Catts, Ruslan Rust, Abhay Sagare, Jason C Kovacic, Amy Brodtmann, Anders Wa...> ;Nature Reviews. Neurology. 2023 Dec 1
• 3 citations
  Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis.
  Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W Turner, Chani J Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L Lino Cardenas, Ko...> ;Cell Reports. 2023 Nov 28
• Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.
  Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C An, Priyanka L Patel, Robert N O'Brien, Brittany N Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, ...> ;Cell Reports. 2023 Nov 28
• 1 citations
  Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts.
  Shouyuan Jiang, Steven G Wise, Jason C Kovacic, Jelena Rnjak-Kovacina, Megan S Lord> ;Trends in Biotechnology. 2024 Mar 1
• 1 citations
  Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy.
  Rebecca L Harper, Fang Fang, Hong San, Alejandra Negro, Cynthia St Hilaire, Dan Yang, Guibin Chen, Zhen Yu, Natalia I Dmitrieva, Jan Lanzer, Jean-Michel Davaine, Robin...> ;FASEB Journal. 2023 Jul 1
• Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV.
  Won Jun Lee, Haoxiang Cheng, Bridget M Whitney, Robin M Nance, Sierra R Britton, Kristina Jordahl, Sara Lindstrom, Stephanie A Ruderman, Mari M Kitahata, Michael S Saa...> ;International Journal of Cardiology. 2023 Jul 15
• 3 citations
  Acute Myocarditis and Pericarditis After mRNA COVID-19 Vaccinations-A Single-Centre Retrospective Analysis.
  Marina Wassif, Phillip Lo, Paul Satouris, Lucinda Swan, Daniel Tardo, Jason C Kovacic, David Muller, Kavitha Muthiah, Eugene Kotlyar, Nicole K Bart> ;Heart, Lung & Circulation. 2023 Apr 1
• 3 citations
  Advanced Proteomics and Cluster Analysis for Identifying Novel Obstructive Sleep Apnea Subtypes before and after Continuous Positive Airway Pressure Therapy.
  Vaishnavi Kundel, Oren Cohen, Samira Khan, Manishkumar Patel, Seunghee Kim-Schulze, Jason Kovacic, Mayte Suárez-Fariñas, Neomi A Shah> ;Annals of the American Thoracic Society. 2023 Jul 1
• 15 citations
  Endothelial to Mesenchymal Transition in Health and Disease.
  Yang Xu, Jason C Kovacic> ;Annual Review of Physiology. 2023 Feb 10
• The Australian New Zealand Spontaneous Coronary Artery Dissection (ANZ-SCAD) Registry - A Multi-Centre Cohort Study: Protocol, Background and Significance.
  Sul Ki Kim, Edwina Wing-Lun, Jaya Chandrasekhar, Aniket Puri, Sonya Burgess, Thomas J Ford, Jason Kovacic, Robert M Graham, Peter J Psaltis, Sarah Zaman> ;Heart, Lung & Circulation. 2022 Dec 1
• 12 citations
  Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.
  Michal Mokry, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M Mekke, Marie A C Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C V...> ;Nature Cardiovascular Research. 2022 Dec 1
• 6 citations
  Athletic Activity for Patients With Hypertrophic Cardiomyopathy and Other Inherited Cardiovascular Diseases: JACC Focus Seminar 3/4.
  Christopher Semsarian, Belinda Gray, Kristina H Haugaa, Rachel Lampert, Sanjay Sharma, Jason C Kovacic> ;Journal of the American College of Cardiology. 2022 Sep 27
• 10 citations
  Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome: JACC Focus Seminar 2/4.
  Andre La Gerche, Erin J Howden, Mark J Haykowsky, Gregory D Lewis, Benjamin D Levine, Jason C Kovacic> ;Journal of the American College of Cardiology. 2022 Sep 20
• 23 citations
  Exercise for Primary and Secondary Prevention of Cardiovascular Disease: JACC Focus Seminar 1/4.
  Wesley J Tucker, Isabel Fegers-Wustrow, Martin Halle, Mark J Haykowsky, Eugene H Chung, Jason C Kovacic> ;Journal of the American College of Cardiology. 2022 Sep 13
• 11 citations
  The Athlete's Heart-Challenges and Controversies: JACC Focus Seminar 4/4.
  Andre La Gerche, Meagan M Wasfy, Maria J Brosnan, Guido Claessen, Diane Fatkin, Hein Heidbuchel, Aaron L Baggish, Jason C Kovacic> ;Journal of the American College of Cardiology. 2022 Oct 4
• 5 citations
  Author Correction: Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.
  Adam W Turner, Shengen Shawn Hu, Jose Verdezoto Mosquera, Wei Feng Ma, Chani J Hodonsky, Doris Wong, Gaëlle Auguste, Yipei Song, Katia Sol-Church, Emily Farber, Soumya...> ;Nature Genetics. 2022 Aug 1
• 3 citations
  Subclinical Atherosclerosis in Young, Socioeconomically Vulnerable Hispanic and Non-Hispanic Black Adults.
  Josep Iglesies-Grau, Rodrigo Fernandez-Jimenez, Raquel Diaz-Munoz, Risa Jaslow, Amaya de Cos-Gandoy, Gloria Santos-Beneit, Christopher A Hill, Alexandra Turco, Daniell...> ;Journal of the American College of Cardiology. 2022 Jul 19
• The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.
  Lijiang Ma, Nicole S Bryce, Adam W Turner, Antonio F Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina d'Escamard, Nirupama Chandel, Bhar...> ;Plos Genetics. 2022 Jun 1
• 36 citations
  Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.
  Ma, W., Adam W Turner, Shengen Shawn Hu, Jose Verdezoto Mosquera, Wei Feng Ma, Chani J Hodonsky, Doris Wong, Gaëlle Auguste, Yipei Song, Katia Sol-Church, Emily Farber...> ;Nature Genetics. 2022 Jun 1
• Author Correction: Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.
  Georges, A., Yang, M., Berrandou, T., Bakker, M., Dikilitas, O., Kiando, S., Ma, L., Satterfield, B., Sengupta, S., Yu, M., Deleuze, J., Dupré, D., Hunker, K., Kyryach...> ;Nature Communications. 2022 Apr 20
• 39 citations
  A mechanistic framework for cardiometabolic and coronary artery diseases.
  Simon Koplev, Marcus Seldin, Katyayani Sukhavasi, Raili Ermel, Shichao Pang, Lingyao Zeng, Sean Bankier, Antonio Di Narzo, Haoxiang Cheng, Vamsidhar Meda, Angela Ma, H...> ;Nature Cardiovascular Research. 2022 Jan 1
• 9 citations
  A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals
  Christoph Schaniel, Priyanka Dhanan, Bin Hu, Yuguang Xiong, Teeya Raghunandan, David M. Gonzalez, Rafael Dariolli, Sunita L. D’Souza, Arjun Singh Yadaw, Jens Hansen, G...> ;Stem Cell Reports. 2021 Nov 4
• 23 citations
  Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Communications. 2021 Oct 15
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Journal Articles

• Monocyte and Macrophage Dynamics in the Cardiovascular System  
  Jason Kovacic, MD, ScienceDirect
• JACC Focus Seminar: Macrophage in CVD Series JACC Focus Seminar Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CV...  
  Amanda C Doran, Jason C Kovacic, Edward A Fisher, Ira Tabas, ScienceDirect
• JACC Focus Seminar: Macrophage in CVD Series JACC Focus Seminar Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Ser...  
  Jason Kovacic, MD, ScienceDirect
• The Macrophage in Cardiac Homeostasis and Disease  
  Jason C Kovacic, Kory J Lavine, ScienceDirect
• Temporal Trends, Determinants, and Impact of High-Intensity Statin Prescriptions After Percutaneous Coronary Intervention  
  George Dangas, Serdar Farhan, Samin Sharma, Jason C Kovacic, Nitin Barman, Pedro Moreno, Joseph Sweeny, Birgit Vogel, Usman Baber, Roxana Mehran, ScienceDirect
• Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes after Intensive Statin Treatment: The YELLOW II study  
  Kini AS, Vengrenyuk Y, Shameer K, Maehara A, Purushothaman M, Yoshimura T, Matsumura M, Aquino M, Haider N, Johnson KW, Readhead B, Kidd BA, Feig JE, Krishnan P, Sween..., J Am Coll Cardiol, 1/1/2017
• Increased Lipid Length, Macrophage Infiltration, and Neovascularization in Coronary Atheroma from Patients with Chronic Kidney Disease  
  Pena J, Vengrenyuk Y, Kezbor S, Yoshimura T, Kovacic JC, Sharma SK, Baber U, Kini AS, Narula J, Moreno PR, JACC Imaging, 1/1/2017
• Impact Of Diabetes Mellitus On Ischemic Events In Men And Women After Percutaneous Coronary Intervention  
  Farhan S, Baber U, Aquino M, Vogel B, Chandrasekhar J, Faggioni M, Giustino G, Kautzky-Willer A, Sweeny J, Shah S, Vijay P, Barman N, Moreno P, Kovacic J, Dangas G, Ki..., Am J Cardiol, 1/1/2017
• Coronary Artery PET/MR Imaging: Feasibility, Limitations, and Solutions  
  Robson PM, Dweck MR, Trivieri MG, Abgral R, Karakatsanis NA, Contreras J, Gidwani U, Narula JP, Fuster V, Kovacic JC, Fayad ZA, JACC Imaging, 1/1/2017
• Hybrid MR/PET Imaging with FDG to Diagnose Active Cardiac Sarcoidosis  
  Dweck MR, Abgral R, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Palmisano A, Miller M, Lala A, Chang HL, Sanz J, Contreras J, Narula J, Fuster V, Padilla M, Fayad ..., JACC Imaging, 1/1/2017
• Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA)  
  Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad Z..., Am Heart J, 1/1/2017
• Basic Biology of Oxidative Stress and the Cardiovascular System  
  Sack MN, Fyhrquist FY, Saijonmaa OJ, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Impact of oxidative stress on the heart and vasculature  
  Munzel T, Camici GC, Maack C, Bonetti NR, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Oxidative stress and cardiovascular risk factors: obesity, diabetes, smoking and pollution  
  Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Prevalence, Correlates, and Impact of Coronary Calcification on Adverse Events Following PCI with Newer-Generation DES: Findings from a Large Multi-Ethnic Registry  
  Copeland-Halperin RS, Baber U, Aquino M, Rajamanickam A, Roy S, Hasan C, Barman N, Kovacic JC, Moreno P, Krishnan P, Sweeny JM, Mehran R, Dangas G, Kini AS, Sharma SK, Catheter Cardiovasc Interv, 1/1/2017
• Unraveling the complex genetics of coronary artery disease  
  Kovacic JC, J Am Coll Cardiol, 1/1/2017
• Family-Based Approaches to Cardiovascular Health Promotion  
  Vedanthan R, Bansilal S, Soto AV, Kovacic JC, Latina J, Jaslow R, Santana M, Gorga E, Kasarskis A, Hajjar R, Schadt EE, Bjorkegren JL, Fayad ZA, Fuster V, J Am Coll Cardiol, 1/1/2016
• Intraprocedural Transcatheter Aortic Valve Replacement (TAVR) Annulus Sizing Using Three-Dimensional Transesophageal Echocardiology And “The Turnaround Rule”  
  Wiley B, Kovacic JC, Basnet S, Makoto A, Kini A, Sharma S, Sengupta P, JACC Cardiovasc Imaging, 1/1/2016
• Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease  
  Talukdar HA, Asl HF, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skog..., Cell Systems, 1/1/2016
• Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis  
  Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, Kwak TH, Hajjar RJ, Park WJ, J Am Coll Cardiol, 1/1/2016
• Developmental origin and lineage plasticity of endogenous cardiac stem cells  
  Santini MP, Forte E, Harvey RP, Kovacic JC, Development, 1/1/2016
• Management of complete iliofemoral artery avulsion with a hybrid technique  
  Mosley GE, Beckerman W, Kovacic JC, Kini AS, Sharma SK, Tadros RO, J Vasc Surg Cases, 1/1/2016
• Endothelial-To-Mesenchymal Transition Is Common In Advanced Atherosclerotic Lesions And Is Associated With Plaque Instability  
  Evrard SM*, Lecce L*, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d’Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A..., Nat Commun, 1/1/2016
• Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases: The Stockholm-Tartu Atherosclerosis Reverse Network Engineering ...  
  Franzen O,* Ermel R,* Cohain A,* Akers NK, Di Narzo A, Talukdar HA, Asl HF, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Gianarelli C, Kovacic JC, Betsho..., Science, 1/1/2016
• PHACTR1 Is A Genetic Susceptibility Locus For Fibromuscular Dysplasia; Supporting Its Complex Genetic Pattern of Inheritance  
  Kiando SR, Tucker NR, Castro-Vega LJ, Katz A, D’Escamard V, Tréard C, Fraher D, Albuisson J, Kadian-Dodov D, Ye Z, Austin E, Yang ML, Hunker K, Barlassina C, Cusi D, G..., PLoS Genet, 1/1/2016
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Books/Book Chapters

• Interventional Cardiology: Principles and Practice 
  Chapter: Aortic Valvuloplasty and Large-Bore Percutaneous Arterial Access 
  Page 546 - 557Tomey M, Kini AS, Sharma SK, Kovacic JCEditors: George Dangas, Carlo Di-Mario, Nicholas Kipshidze.Wiley Blackwell Publishing, Oxford, United KingdomEdition 2nd,2017
• Interventional Cardiology: Principles and Practice 
  Chapter: Genetics and Pharmacogenetics in Interventional Cardiology 
  Page 459 - 468Johnston-Cox H, Bjorkegren JLM, Kovacic JCEditors: George Dangas, Carlo Di-Mario, Nicholas Kipshidze.Wiley Blackwell Publishing, Oxford, United KingdomEdition 2nd,2017
• Hurst’s the Heart 
  Chapter: Biology of the vessel wall 
  Page 144 - 160Johnston-Cox H, Fuster V, Kovacic JCEditors: Valentin Fuster, Robert Harrington, Jagat Narula, Zubin Eapen.The McGraw-Hill Companies Publishing, Columbus, OHEdition 14th,2017
• Cardiovascular Medicine - Reducing the Disease Burden 
  Chapter: The Pathogenesis of Atherothrombosis 
  Page 375 - 406Rocha VZ, Tomey M, Libby P, Fuster V, Kovacic JCEditors: Roberto Kalil and Valentin Fuster.Atheneu Publishing, Brazil2016
• Panvascular Medicine 
  Chapter: Atherothrombosis 
  Page 245 - 271Castellano JM, Kovacic JC and Fuster VEditors: Peter Lanzer.Springer-Verlag, Berlin & Heidelberg, Germany2015
• Atherosclerosis: The 21st Century Epidemic 
  Chapter: Cardiovascular Disease: From treatment to promoting health; a challenge for the next decade 
  Page 108 - 116Kovacic JC and Fuster VEditors: Conrado J. Estol and Marcelo Sanchez Sorondo.Pontificiae Academiae Scientiarvm, Vatican City2011
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Lectures

• Post Discharge Care: It's Not Over Yet What Do I Tell my Patient? 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
• Defining the cause of fibromuscular dysplasia; and redefining our understanding of spontaneous arterial dissection 
  1/1/2017
• Atherectomy for calcified lesions – Rotational Atherectomy 
  New Orleans, LA - 1/1/2017
• Mount Sinai DEFINE- FMD Study Update 
  Cleveland Clinic Foundation, Cleveland, OH - 1/1/2017
• Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Correlates with Instability 
  Sunday River, Newry, ME - 1/1/2017
• Defining the cause of the "rare" vascular disease fibromuscular dysplasia using systems genetics and leveraging CAD genetics datasets 
  Paris, France - 1/1/2017
• EndMT, CAD and FMD – intersecting vascular biology and disease states 
  Bethesda, MD - 1/1/2016
• LV support during PCI 
  Mount Sinai, New York, NY - 1/1/2016
• Indications for TAVR and the Role of Risk Assessment 
  Medellin, Colombia - 1/1/2016
• Minimally Invasive Devices for Cardiac Failure and LV support 
  Medellin, Colombia - 1/1/2016
• History of TAVR 
  New York, NY - 1/1/2016
• Low Coronary Height and TAVR 
  New York, NY - 1/1/2016
• Coronary Evaluation and Treatment Timing 
  New York, NY - 1/1/2016
• The High-Risk STEMI Patient. Elderly, CKD, Diabetics 
  New Orleans, LA - 1/1/2016
• The Integration of Genomics into Computerized Systems Biology: An Evolution in the Understanding of CV Disease by the Clinician 
  San Diego, CA - 1/1/2015
• Atherosclerosis and Vascular Disease: Inflammation, Genetics, and Cell Biology 
  Bethesda, MD - 1/1/2015
• ACS: Recent and Evolving Aspects, Definitions and Diagnostics, Acquired and Genetic Factors, Ischemic and Reperfusion Injury 
  New York, NY - 1/1/2015
• Leveraging Systems Genetics to Understand Fibromuscular Dysplasia and Coronary Artery Disease 
  Washington University School of Medicine, St. Louis, MO - 1/1/2015
• Tandem Heart: Is There Still a Role? 
  Washington, DC - 1/1/2014
• Endothelial to Mesenchymal Transition: From Cardiovascular Development to Disease 
  Glasgow, Scotland - 1/1/2014
• Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: time to DEFINE the cause! 
  Golden Jubilee National Hospital, Glasgow, Scotland - 1/1/2014
• The DEFINE FMD Study – defining the molecular and cellular basis of FMD using patient-derived fibroblasts 
  Cleveland, OH - 1/1/2014
• Left Main Intervention – Difficult Delivery 
  Las Vegas, NV - 1/1/2014
• Endothelial to Mesenchymal Transition and Beyond 
  New York, NY - 1/1/2014
• Becoming a successful researcher: How to secure funding and ramp-up your publications 
  Washington, DC - 1/1/2014
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