JasonA.WertheimMDPhD

General Surgery • Chicago, IL

Transplantation

Assistant Professor in Surgery-Organ Transplantation, Northwestern University Medical School

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Office
676 N Saint Clair St
Chicago, IL 60611
Phone+1 312-695-8900

Fax+1 312-695-9194
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Education & Training

Massachusetts General HospitalResidency, Surgery, 2004 - 2009
Perelman School of Medicine at the University of PennsylvaniaClass of 2004

Certifications & Licensure

IL State Medical License 2011 - 2026
AZ State Medical License 2020 - 2026
CA State Medical License 2009 - 2024
American Board of Surgery Surgery

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Publications & Presentations

PubMed

A class of peptides designed to replicate and enhance the Receptor for Hyaluronic Acid Mediated Motility binding domain.
Kyle M Koss, Terrance J Sereda, Vlad K Kumirov, Jason A Wertheim> ;Acta Biomaterialia. 2023 Sep 1
2 citations
Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase.
Katherine E Hekman, Kyle M Koss, David Z Ivancic, Congcong He, Jason A Wertheim> ;Stem Cells Translational Medicine. 2022 Nov 18
Bioengineered 3D electrospun nanofibrous scaffold with human liver cells to study alcoholic liver disease in vitro.
Prativa Das, Michael D. DiVito, Jason A. Wertheim, Lay Poh Tan> ;Integrative Biology. 2021 Jul 8
65 citations
A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids.
Jan Wysocki, Minghao Ye, Luise Hassler, Ashwani Kumar Gupta, Yuguo Wang, Vlad Nicoleascu, Glenn Randall, Jason A. Wertheim, Daniel Batlle> ;Journal of the American Society of Nephrology. 2021 Feb 1
2 citations
An efficient method to generate kidney organoids at the air-liquid interface.
Ashwani Kumar Gupta, David Ivancic, Bilal A. Naved, Jason A Wertheim, Leif Oxburgh> ;Journal of Biological Methods. 2021 Jan 1
Taking the Next Step: a Neural Coaptation Orthotopic Hind Limb Transplant Model to Maximize Functional Recovery in Rat.
Feibo Zheng, Andy Tully, Kyle Koss, Xiaomin Zhang, Longhui Qiu, Jiao Jing Wang, Bilal A. Naved, David Ivancic, James M. Mathew, Jason A. Wertheim, Zheng Jenny Zhang> ;Journal of Visualized Experiments. 2020 Aug 30
17 citations
Collagen-I and fibronectin modified three-dimensional electrospun PLGA scaffolds for long-term in vitro maintenance of functional hepatocytes.
Prativa Das, Michael D. DiVito, Jason A. Wertheim, Lay Poh Tan> ;Materials Science & Engineering. C, Materials for Biological Applications. 2020 Jun 1
18 citations
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids
Ashwani Kumar Gupta, Prasenjit Sarkar, Jason A. Wertheim, Xinchao Pan, Thomas L. Carroll, Leif Oxburgh> ;Communications Biology. 2020 May 11
29 citations
Structure-Dependent Biodistribution of Liposomal Spherical Nucleic Acids.
Jennifer R. Ferrer, Andrew J. Sinegra, David Ivancic, Xin Yi Yeap, Longhui Qiu, Jiao Jing Wang, Zheng Jenny Zhang, Jason A. Wertheim, Chad A. Mirkin> ;ACS Nano. 2020 Jan 17
15 citations
Dual Toll-Like Receptor Targeting Liposomal Spherical Nucleic Acids.
Jennifer R. Ferrer, Jason A. Wertheim, Chad A. Mirkin> ;Bioconjugate Chemistry. 2019 Mar 4
33 citations
Poly(ethylene glycol)-crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior.
Jimmy Su, Simon C. Satchell, Jason A. Wertheim, Ramille N. Shah> ;Biomaterials. 2019 May 1
22 citations
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21.
Konrad T Sawicki, Hsiang-Chun Chang, Jason S. Shapiro, Marina Bayeva, Adam De Jesus, Brian N. Finck, Jason A. Wertheim, Perry J. Blackshear, Hossein Ardehali> ;JCI Insight. 2018 Jul 12
2 citations
Correction to: Dual-Purpose Bioreactors to Monitor Noninvasive Physical and Biochemical Markers of Kidney and Liver Scaffold Recellularization, by Uzarski JS, Bijonows...
Joseph S. Uzarski, Brent M. Bijonowski, Bo Wang, Heather H. Ward, Angela Wandinger-Ness, William M. Miller, Jason A. Wertheim> ;Tissue Engineering. Part C, Methods. 2018 Jul 1
57 citations
Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro.
Jessica H. Brown, Prativa Das, Michael D. DiVito, David Ivancic, Lay Poh Tan, Jason A. Wertheim> ;Acta Biomaterialia. 2018 Feb 15
33 citations
Kidney decellularized extracellular matrix hydrogels: Rheological characterization and human glomerular endothelial cell response to encapsulation
Jimmy Su, Simon C. Satchell, Ramille N. Shah, Jason A. Wertheim> ;Journal of Biomedical Materials Research. Part A. 2018 Sep 1
21 citations
Residual sodium dodecyl sulfate in decellularized muscle matrices leads to fibroblast activation in vitro and foreign body response in vivo.
Emily E. Friedrich, Steven T. Lanier, Solmaz Niknam-Bienia, Gabriel A. Arenas, Divya Rajendran, Jason A. Wertheim, Robert D. Galiano> ;Journal of Tissue Engineering and Regenerative Medicine. 2018 Mar 1
35 citations
Vascular scaffolds with enhanced antioxidant activity inhibit graft calcification.
Bin Jiang, Rachel Suen, Jiao Jing Wang, Zheng Zhang, Jason A. Wertheim, Guillermo A. Ameer> ;Biomaterials. 2017 Nov 1
46 citations
Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds.
Joseph S. Uzarski, Michael D. DiVito, Jason A. Wertheim, William M. Miller> ;Biomaterials. 2017 Jun 1
267 citations
The promise of organ and tissue preservation to transform medicine
Sebastian Giwa, Jedediah K. Lewis, Luis M. Alvarez, Robert Langer, Alvin E. Roth, George M. Church, James F. Markmann, David H. Sachs, Anil Chandraker, Jason A. Werthe...> ;Nature Biotechnology. 2017 Jun 1
42 citations
Re)Building a Kidney
Leif Oxburgh, Thomas L. Carroll, Ondine Cleaver, Daniel R. Gossett, Deborah K. Hoshizaki, Jeffrey A. Hubbell, Benjamin D. Humphreys, Sanjay Jain, Jan Jensen, David L. ...> ;Journal of the American Society of Nephrology. 2017 May 1
40 citations
Targeting Heparin to Collagen within Extracellular Matrix Significantly Reduces Thrombogenicity and Improves Endothelialization of Decellularized Tissues
Bin Jiang, Rachel Suen, Jason A. Wertheim, Guillermo A. Ameer> ;Biomacromolecules. 2016 Nov 29
2 citations
Novel technology for liver regeneration and replacement.
Jason A. Wertheim> ;Liver Transplantation. 2016 Nov 1
82 citations
Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments.
Bo Wang, Adam E. Jakus, Pedro M. Baptista, Shay Soker, Alejandro Soto-Gutierrez, Michael Abecassis, Ramille N. Shah, Jason A. Wertheim> ;Stem Cells Translational Medicine. 2016 Jul 15
Tissue Engineering: Mechanocompatible Polymer-Extracellular-Matrix Composites for Vascular Tissue Engineering (Adv. Healthcare Mater. 13/2016)
Bin Jiang, Rachel Suen, Jiao Jing Wang, Zheng Jenny Zhang, Jason A. Wertheim, Guillermo A. Ameer> ;Advanced Healthcare Materials. 2016 Jul 1
14 citations
Mechanocompatible Polymer-Extracellular-Matrix Composites for Vascular Tissue Engineering.
Bin Jiang, Rachel Suen, Jiao Jing Wang, Zheng Zhang, Jason A. Wertheim, Guillermo A. Ameer> ;Advanced Healthcare Materials. 2016 Jul 1
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Press Mentions

Bioengineered Organs & Kidney Diseases with Susan Quaggin, MDJuly 25th, 2019
Grow Your Own Kidney? Chicago Researchers Are Getting CloserFebruary 13th, 2019
Q&A with Susan Quaggin, MD, Director of Feinberg’s New $5.8 Million Kidney CenterDecember 3rd, 2018
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