JavierEOesterheldMD

Pediatric Hematology & Oncology • Charlotte, NC

Jeff Gordon Children’s Foundation Endowed Chair Cancer and Blood Disorders @ Levine Children’s Specialty Medical Director, Pediatric Hematology/Oncology/BMT and Palliative Care; Levine Children's Hospital

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Office
1001 Blythe Blvd
Charlotte, NC 28203
Phone+1 704-381-9900

Fax+1 704-381-9901
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Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 2004 - 2007
Rutgers New Jersey Medical SchoolResidency, Pediatrics, 2001 - 2004
Universidad Central del Caribe School of MedicineClass of 2001

Certifications & Licensure

NC State Medical License 2007 - 2024
ND State Medical License 2011 - 2012
NY State Medical License 2004 - 2007
NJ State Medical License 2002 - 2006
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Physician Practice Connections Recognition Program National Committee for Quality Assurance, 2011-2014

Clinical Trials

Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma Start of enrollment: 2008 Jan 14
Completed
Phase 2
T-cell Depleted Alternative Donor Transplantation Start of enrollment: 2009 Aug 01
Terminated
Phase 2
Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Start of enrollment: 2010 Jun 01
Terminated
Phase 1, Phase 2
Donor Lymphocyte Infusion After Alternative Donor Transplantation Start of enrollment: 2009 Aug 01
Terminated
Phase 1, Phase 2
A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Start of enrollment: 2011 Mar 01
Completed
Phase 1
AC220 for Children With Relapsed/Refractory ALL or AML Start of enrollment: 2011 Sep 01
Completed
Phase 1
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Start of enrollment: 2011 Dec 01
Terminated
Phase 1, Phase 2
Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma Start of enrollment: 2011 Dec 01
Terminated
Phase 1, Phase 2
Randomized Efficacy Study of TPI 287 to Treat Primary Refractory or Early Relapsed Neuroblastoma Start of enrollment: 2011 Dec 01
Terminated
Phase 1, Phase 2
Preventative Trial of DFMO in Patients With High Risk Neuroblastoma in Remission Start of enrollment: 2012 Jun 01
Active, not recruiting
Phase 2
Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer Start of enrollment: 2013 Feb 01
Active, not recruiting
Not Applicable
Molecular-Guided Therapy for Childhood Cancer Start of enrollment: 2014 Jul 08
Completed
Not Applicable
Pediatric Precision Laboratory Advanced Neuroblastoma Therapy Start of enrollment: 2015 Sep 01
Recruiting
Phase 2
Trial of Tolcapone With Oxaliplatin for Neuroblastoma Start of enrollment: 2015 Dec 01
Terminated
Phase 1
A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma Start of enrollment: 2016 Mar 01
Completed
Phase 1, Phase 2
Neuroblastoma Maintenance Therapy Trial Start of enrollment: 2016 Feb 01
Recruiting
Phase 2
Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma Start of enrollment: 2016 Oct 25
Active, not recruiting
Phase 2
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy Start of enrollment: 2021 Sep 20
Recruiting
Phase 1
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Publications & Presentations

PubMed

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial.
Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B Nagulapally, Karl Dykema, Valerie I Brown, Michael...> ;Genome Medicine. 2024 Feb 12
Guidelines for outpatient administration of naxitamab: Experience from Atrium Health Levine Children's Hospital.
Trovillion, E., Michael, M., Jordan, C., Brown, L., Phillips, K., Saulnier-Sholler, G., Oesterheld, J.> ;Cancer Medicine. 2024 Feb 1
2 citations
Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons.
Javier Oesterheld, William Ferguson, Jacqueline M Kraveka, Genevieve Bergendahl, Thomas Clinch, Elizabeth Lorenzi, Don Berry, Randal K Wada, Michael S Isakoff, Don E E...> ;Journal of Clinical Oncology. 2024 Jan 1
3 citations
A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma.
Jacqueline M Kraveka, Elizabeth C Lewis, Genevieve Bergendahl, William Ferguson, Javier Oesterheld, Elizabeth Kim, Abhinav B Nagulapally, Karl J Dykema, Valerie I Brow...> ;Cancer Reports. 2022 Nov 1
11 citations
ALK rearrangements in infantile fibrosarcoma-like spindle cell tumors of soft tissue and kidney.
Serena Y. Tan, Alyaa Al-Ibraheemi, William A Arhens, Javier Oesterheld, Julie C. Fanburg-Smith, Yajuan J. Liu, Sheri L. Spunt, Erin R. Rudzinski, Cheryl M. Coffin, Jes...> ;Histopathology. 2021 Nov 29
8 citations
Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion
Sara A. Byron, William P.D. Hendricks, Abhinav Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie I. Brown, Don E Eslin, Deanna Mitchell, Albert Corneliu...> ;Cancer Research. 2021 Oct 5
6 citations
A dose substitution of anthracycline intensity with dose-dense rituximab in children and adolescents with good-risk mature B-cell lymphoma.
S. Goldman, Matthew J. Barth, Bruce Shiramizu, Qiuhu Shi, Jessica Hochberg, Liana Klejmont, Lauren Harrison, Jackie Basso, Yaya Chu, Humayun Islam, Perry Gerard, Melis...> ;Leukemia. 2021 May 3
13 citations
Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.
Javier Oesterheld, Damon R. Reed, Bhuvana A. Setty, Michael S. Isakoff, Patrick A. Thompson, Hong Yin, Masanori Hayashi, David M. Loeb, Tiffany Smith, Rikesh J Makanji...> ;Pediatric Blood & Cancer. 2020 Jul 1
22 citations
Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
Michael J. Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon Kelley, Cara A Rabik, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Deepa Bhojwani, Sima ...> ;Clinical Cancer Research. 2020 Jan 22
31 citations
A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma
Elizabeth C. Lewis, Jacqueline M. Kraveka, William S. Ferguson, Don Eslin, Valerie I. Brown, Genevieve Bergendahl, William Roberts, Randal K. Wada, Javier Oesterheld, ...> ;International Journal of Cancer. 2020 Dec 1
58 citations
Maintenance DFMO Increases Survival in High Risk Neuroblastoma
Giselle Saulnier Sholler, William S. Ferguson, Genevieve Bergendahl, Jeffrey P. Bond, Kathleen A. Neville, Don Eslin, Valerie I. Brown, William Roberts, Randal K. Wada...> ;Scientific Reports. 2018 Sep 27
80 citations
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J. Wilkes, Robyn M. Dennis, Kenneth Heym, Theodore W. Laetsch, Melissa Widener, Susan R. Rheingold, Ja...> ;Leukemia. 2018 Mar 15
12 citations
Combination of clofarabine, cyclophosphamide, and etoposide for relapsed or refractory childhood and adolescent acute myeloid leukemia.
Yoav H. Messinger, Jessica Boklan, John M. Goldberg, Steven G. DuBois, Javier Oesterheld, Oussama Abla, Alissa Martin, Joanna Weinstein, Nobuko Hijiya> ;Pediatric Hematology and Oncology. 2017 Oct 17
5 citations
A case of advanced infantile myofibromatosis harboring a novel MYH10-RET fusion.
Margaret Rosenzweig, Siraj M. Ali, Victor W. Wong, Alexa B. Schrock, Theodore W. Laetsch, William Ahrens, Andreas M. Heilmann, Samantha Morley, Yakov Chudnovsky, Rache...> ;Pediatric Blood & Cancer. 2017 Jul 1
50 citations
A Phase I Study of Quizartinib Combined With Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
Todd M. Cooper, Jeannette Cassar, Elena Eckroth, Jemily Malvar, Richard Sposto, Paul S. Gaynon, Bill H. Chang, Lia Gore, Keith J. August, Jessica A. Pollard, Steven G....> ;Clinical Cancer Research. 2016 Aug 15
12 citations
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors
Don W. Coulter, Christine M. Walko, Jai N. Patel, Billie M. Moats-Staats, Andrew W. McFadden, Scott V. Smith, Wasiuddin A. Khan, Arlene S. Bridges, Allison M. Deal, Ja...> ;Anti-Cancer Drugs. 2013 Apr 1
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Journal Articles

Pediatric ALK+ anaplastic large cell lymphoma with t(3:8)(q26.2;q24) translocation and c-myc rearrangement terminating in a leukemic phase.
Sara Monaco, Lawrence Tsao, Vundavalli VS Murty, Subhadra V Nandula, Virginia Donovan, Javier E Oesterheld, Govind Bhagat, and Bachir Alobeid, American Journal of Hematology, 9/5/2006

Other

Investigation of mean platelet volume as a predictor of acute versus chronic immune thrombocytopenic purpura in children: An exploratory analysis
Jessica Keim-Malpass, Jenifer L. Lavigne, Jennifer Pope, Javier Oesterheld, Clinical Nursing Studies Vol. 3, No.3
2015
More Clinical Research Sites Needed for Pediatric Oncology
Javier E Oesterheld, Oncology Times
8/26/2010
Myeloablative chemotherapy with autologous stem cell rescue for Ewing sarcoma
Gilman AL, Oesterheld J, Bone Marrow Transplant 42 (11)
2008

Press Mentions

Shop TalkOctober 5th, 2020
Integrated Teamwork Ensures That Pediatric Cancer Patients Receive Medication, Despite National Drug ShortageJanuary 24th, 2020
Through My Eyes: Behind the Scenes with Charlotte Pediatric Oncologist, Dr. OsterheldSeptember 17th, 2019
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