JayRKostmanMD

Infectious Disease • Philadelphia, PA

HIV/AIDS Medicine

Medical Director, John Bell Health Center, Philadelphia FIGHT Community Health Centers

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Office
1207 Chestnut St
Fl 3
Philadelphia, PA 19107
Phone+1 215-662-8229

Fax+1 215-243-3272
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Education & Training

Temple University HospitalFellowship, Infectious Disease, 1988 - 1991
Temple University HospitalResidency, Internal Medicine, 1984 - 1988
Yale School of MedicineClass of 1984

Certifications & Licensure

PA State Medical License 1986 - 2024
NJ State Medical License 1991 - 1995
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Philadelphia Magazine Castle Connolly, 2005-2014
Super Doctor SuperDoctors.com

Clinical Trials

A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks
Completed
Not Applicable
A Study of the Long-Term Outcomes of HIV-Positive Patients Start of enrollment: 1999 Mar 01
Completed
Antiviral Activity of Peg-IFN-Alpha-2A in Chronic HIV-1 Infection Start of enrollment: 2008 Jan 01
Completed
Phase 2
Pilot Peg-Interferon-a2b in Decreasing Viral DNA in HIV Start of enrollment: 2013 Aug 07
Completed
Phase 2
Reducing Proviral HIV DNA With Interferon-a Start of enrollment: 2015 Feb 11
Unknown status
Phase 2
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Publications & Presentations

PubMed

3 citations
Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons.
Pablo Tebas, Kenn Lynn, Livio Azzoni, Giorgio Cocchella, Emmanouil Papasavvas, Matthew Fair, Brijesh Karanam, Paridhima Sharma, Jacqueline D Reeves, Christos J Petropo...> ;AIDS. 2023 Jul 1
9 citations
The Hepatitis C Care Cascade During the Direct-Acting Antiviral Era in a United States Commercially Insured Population.
Nicole D Ferrante, Craig W Newcomb, Kimberly A Forde, Charles E Leonard, Jessie Torgersen, Benjamin P Linas, Sarah E Rowan, David L Wyles, Jay Kostman, Stacey B Troosk...> ;Open Forum Infectious Diseases. 2022 Sep 1
27 citations
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV.
Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Joh...> ;Nature Communications. 2021 Jun 29
Comparable HIV suppression by pegylated-IFN-α2a or pegylated-IFN-α2b during a 4-week analytical treatment interruption.
Emmanouil Papasavvas, Livio Azzoni, Brian N Ross, Matthew Fair, Bonnie J Howell, Daria J. Hazuda, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Luis J. Montaner> ;AIDS. 2021 May 27
26 citations
Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.
H. Nina Kim, Craig Newcomb, Dena M. Carbonari, Jason Roy, Jessie Torgersen, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg,...> ;Hepatology. 2021 Sep 1
13 citations
Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption
Leila B. Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron R. Goldman, Hsin-Yao Tang, Clovis S. Palmer, Alan L. Landay, Jonathan Z. Li, Karam Mounzer, Jay R. Kostman, Q...> ;Mbio. 2021 Feb 23
Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During S...
Emmanouil Papasavvas, Livio Azzoni, Brian N Ross, Matthew Fair, Zhe Yuan, Kwasi Gyampoh, Agnieszka Mackiewicz, Amanda C Sciorillo, Amelie Pagliuzza, Steven M Lada, Guo...> ;Clinical Infectious Diseases. 2021 Feb 1
6 citations
Safety, Immune, and Antiviral Effects of Pegylated Interferon Alpha 2b Administration in Antiretroviral Therapy-Suppressed Individuals: Results of Pilot Clinical Trial
Emmanouil Papasavvas, Livio Azzoni, Amélie Pagliuzza, Mohamed Abdel-Mohsen, Brian N Ross, Matthew Fair, Bonnie J Howell, Daria J. Hazuda, Nicolas Chomont, Qingsheng Li...> ;AIDS Research and Human Retroviruses. 2021 Jan 29
17 citations
We Must Do Better: Addressing HCV Treatment Barriers in Persons Who Inject Drugs in the United States.
Stacey Trooskin, Gregory J. Dore, Jay R. Kostman> ;The Journal of Infectious Diseases. 2020 Nov 27
79 citations
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Mohamed Abdel-Mohsen, Douglas D. Richman, Robert F. Siliciano, Michel C. Nussenzweig, Bonnie J. Howell, Javier Martinez-Picado, Nicolas Chomont, Katharine J. Bar, Xu G...> ;Nature Medicine. 2020 Sep 7
8 citations
Interferon-α alters host glycosylation machinery during treated HIV infection
Leila B. Giron, Florent Colomb, Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Matthew Fair, Alitzel Anzurez, Mohammad Damra, Karam Mounzer, Jay R. Kostman, Pablo T...> ;Ebiomedicine. 2020 Sep 1
2 citations
Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals.
Leila B. Giron, Livio Azzoni, Xiangfan Yin, Kenneth Lynn, Brian N Ross, Matthew Fair, Mohammad Damra, Amanda C Sciorillo, Qin Liu, Jeffrey M. Jacobson, Karam Mounzer, ...> ;AIDS. 2020 Aug 1
4 citations
Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy.
Emmanouil Papasavvas, Livio Azzoni, Brian N Ross, Matthew Fair, Zhe Yuan, Kwasi Gyampoh, Agnieszka Mackiewicz, Amanda C Sciorillo, Amelie Paggliuzza, Steven M. Lada, G...> ;Clinical Infectious Diseases. 2020 Jun 18
17 citations
Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Leila B. Giron, Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Alitzel Anzurez, Mohammad Damra, Karam Mounzer, Jay R. Kostman, Ian Sanne, Cynthia Firnhaber, Hiroaki...> ;AIDS. 2020 Apr 1
14 citations
Determinants of Liver Complications Among HIV/Hepatitis B Virus-Coinfected Patients.
Vincent Lo Re, Craig Newcomb, Dena M. Carbonari, Jason Roy, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg, Angel M. Mayor,...> ;Journal of Acquired Immune Deficiency Syndromes. 2019 Sep 1
14 citations
NK Response Correlates with HIV Decrease in Pegylated IFN-α2a-Treated Antiretroviral Therapy-Suppressed Subjects.
Emmanouil Papasavvas, Livio Azzoni, Andrew V. Kossenkov, Noor Dawany, Knashawn H. Morales, Matthew Fair, Brian N Ross, Kenneth Lynn, Agnieszka Mackiewicz, Karam Mounze...> ;Journal of Immunology. 2019 Aug 1
Listen to Your Heart.
Jay R. Kostman> ;JAMA. 2019 May 14
5 citations
Comparison of the prevalence, severity, and risk factors for hepatic steatosis in HIV-infected and uninfected people
Jessie Torgersen, Kaku So-Armah, Matthew S. Freiberg, Matthew Bidwell Goetz, Matthew J. Budoff, Joseph K. Lim, Tamar H. Taddei, Adeel A. Butt, Maria C. Rodriguez-Barra...> ;BMC Gastroenterology. 2019 Apr 15
8 citations
Analytical antiretroviral therapy interruption does not irreversibly change preinterruption levels of cellular HIV.
Emmanouil Papasavvas, Steven M. Lada, Jocelin Joseph, Xiangfan Yin, Qin Liu, Livio Azzoni, Karam Mounzer, Jay R. Kostman, Douglas D. Richman, Luis J. Montaner> ;AIDS. 2018 Aug 24
Analytical ART interruption does not irreversibly change pre-interruption levels of cellular HIV.
Papasavvas, E., Lada, S. M., Joseph, J., Yin, X., Liu, Q., Azzoni, L., Mounzer, K., Kostman, J. R., Richman, D., Montaner, L. J.> ;AIDS (London, England). 2018 Jun 13
60 citations
Absolute Insurer Denial of Direct-Acting Antiviral Therapy for Hepatitis C: A National Specialty Pharmacy Cohort Study.
Charitha Gowda, Stephen Lott, Matthew Grigorian, Dena M. Carbonari, M. Elle Saine, Stacey Trooskin, Jason Roy, Jay R. Kostman, Paul Urick, Vincent Lo Re> ;Open Forum Infectious Diseases. 2018 Jun 1
85 citations
CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.
Mohamed Abdel-Mohsen, Leticia Kuri-Cervantes, Judith Grau-Expósito, Adam M. Spivak, Racheal A. Nell, Costin Tomescu, Surya Vadrevu, Leila B. Giron, Carla Serra-Peinado...> ;Science Translational Medicine. 2018 Apr 18
8 citations
Risk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status.
Dana Byrne, Janet P. Tate, Kimberly A. Forde, Joseph K. Lim, Matthew Bidwell Goetz, David Rimland, Maria C. Rodriguez-Barradas, Adeel A. Butt, Cynthia L. Gibert, Sheld...> ;Clinical Infectious Diseases. 2017 Oct 16
7 citations
Risk of liver decompensation with cumulative use of mitochondrial toxic nucleoside analogues in HIV/hepatitis C virus coinfection
Vincent Lo Re rd, Bret Zeldow, Michael J. Kallan, Janet P. Tate, Dena M. Carbonari, Sean Hennessy, Jay R. Kostman, Joseph K. Lim, Matthew Bidwell Goetz, Robert E. Gros...> ;Pharmacoepidemiology and Drug Safety. 2017 Jul 19
8 citations
HCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy-treated HIV/HCV-co-infected subjects.
Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Qin Liu, Jocelin Joseph, Agnieszka Mackiewicz, Brian N Ross, Kenneth Lynn, Jeffrey M. Jacobson, Karam Mounzer, Jay R....> ;Journal of Viral Hepatitis. 2017 May 11
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