JaySSkylerMD

Endocrinology • Miami, FL

Diabetes, Lipid Metabolism

Professor of Medicine, University Miami School of Medicine

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Office
1450 Nw 10th Ave
Miami, FL 33136
Phone+1 305-243-3636

Fax+1 305-243-6575
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Education & Training

Duke University HospitalResidency, Internal Medicine, 1970 - 1973
Duke University HospitalInternship, Transitional Year, 1969 - 1970
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1969

Certifications & Licensure

FL State Medical License 1976 - 2025
NC State Medical License 1972 - 1999
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Whos Who in Medicine and Healthcare Marquis Whos Who
Super Doctor SuperDoctors.com

Clinical Trials

The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1) Start of enrollment: 1994 Feb 01
Completed
Phase 3
TrialNet Pathway to Prevention of T1D Start of enrollment: 2004 Feb 01
Recruiting
New Onset of Type 1 Diabetes Mycophenolate Mofetil-Daclizumab Clinical Trial Start of enrollment: 2004 May 01
Completed
Phase 2
Improving Metabolic Assessments in Type 1 Diabetes Mellitus Clinical Trials Start of enrollment: 2004 Nov 01
Completed
Not Applicable
T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus Start of enrollment: 2005 Sep 01
Completed
Nutritional Intervention to Prevent Diabetes Start of enrollment: 2006 Jun 01
Completed
Not Applicable
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus Start of enrollment: 2007 Feb 01
Completed
Phase 3
Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes Mellitus Start of enrollment: 2008 Feb 01
Completed
Phase 2
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects Start of enrollment: 2009 Feb 01
Completed
Phase 2
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes Start of enrollment: 2010 Sep 01
Terminated
Phase 2, Phase 3
Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk" Start of enrollment: 2010 Aug 01
Completed
Phase 2
CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1 Start of enrollment: 2013 Mar 01
Completed
Phase 2
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Publications & Presentations

PubMed

HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prev...
Lue Ping Zhao, George K Papadopoulos, Alberto Pugliese, Hemang M Parikh, William W Kwok, Terry P Lybrand, George P Bondinas, Antonis K Moustakas, Ruihan Wang, Chul-Woo...> ;Diabetes Care. 2024 Mar 18
Evidence for C-peptide as a Validated Surrogate to Predict Clinical Benefits in Trials of Disease-Modifying Therapies for Type 1 Diabetes.
Latres, E., Greenbaum, C., Oyaski, M., Dayan, C., Colhoun, H., Lachin, J., Rickels, M., Ahmed, S., Marinac, M., Skyler, J., Dutta, S., Herold, K.> ;Diabetes. 2024 Feb 13
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes.
Vikas S Sridhar, Christine P Limonte, Per-Henrik Groop, Hiddo J L Heerspink, Richard E Pratley, Peter Rossing, Jay S Skyler, David Z I Cherney> ;Diabetologia. 2024 Jan 1
4 citations
Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ON...
Hiddo J L Heerspink, Andreas L Birkenfeld, David Z I Cherney, Helen M Colhoun, Linong Ji, Chantal Mathieu, Per-Henrik Groop, Richard E Pratley, Sylvia E Rosas, Peter R...> ;Diabetes Research and Clinical Practice. 2023 Oct 1
1 citations
Importance of residual insulin secretion in type 1 diabetes.
Jay S Skyler> ;The Lancet. Diabetes & Endocrinology. 2023 Jul 1
4 citations
Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies.
Jay M Sosenko, David Cuthbertson, Emily K Sims, Heba M Ismail, Brandon M Nathan, Laura M Jacobsen, Mark A Atkinson, Carmella Evans-Molina, Kevan C Herold, Jay S Skyler...> ;Diabetes Care. 2023 May 1
11 citations
Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.
William E Russell, Brian N Bundy, Mark S Anderson, Laura A Cooney, Stephen E Gitelman, Robin S Goland, Peter A Gottlieb, Carla J Greenbaum, Michael J Haller, Jeffrey P...> ;Diabetes Care. 2023 May 1
3 citations
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes.
Ele Ferrannini, Andrea Mari, Gabriela S F Monaco, Jay S Skyler, Carmella Evans-Molina> ;Diabetologia. 2023 Mar 1
1 citations
Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.
Emily K Sims, David Cuthbertson, Jamie L Felton, Heba M Ismail, Brandon M Nathan, Laura M Jacobsen, Emily Paprocki, Alberto Pugliese, Jerry Palmer, Mark Atkinson, Carm...> ;Diabetes Care. 2022 Dec 1
1 citations
The Transition From a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk.
Heba M Ismail, David Cuthbertson, Stephen E Gitelman, Jay S Skyler, Andrea K Steck, Henry Rodriguez, Mark Atkinson, Brandon M Nathan, Maria J Redondo, Kevan C Herold, ...> ;Diabetes Care. 2022 Oct 1
1 citations
Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1.
Lue Ping Zhao, Jay Skyler, George K Papadopoulos, Alberto Pugliese, James Antonio Najera, George P Bondinas, Antonis K Moustakas, Ruihan Wang, Chul-Woo Pyo, Wyatt C Ne...> ;Diabetes Care. 2022 Jul 7
43 citations
Correction to: The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of...
Richard I G Holt, J Hans DeVries, Amy Hess-Fischl, Irl B Hirsch, M Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S Skyle...> ;Diabetologia. 2022 Jan 1
7 citations
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current St...
Brandon M. Nathan, Maria J. Redondo, Heba M. Ismail, Laura M. Jacobsen, Emily K. Sims, Jerry P. Palmer, Jay S. Skyler, Laura E. Bocchino, Susan Geyer, Jay M. Sosenko> ;Diabetes Care. 2021 Dec 1
113 citations
COVID-19 and metabolic disease: mechanisms and clinical management.
Charlotte Steenblock, Peter Schwarz, Barbara Ludwig, Andreas Linkermann, Paul Zimmet, Konstantin Y. Kulebyakin, Vsevolod A. Tkachuk, Alexander G. Markov, Hendrik Lehne...> ;The Lancet. Diabetes & Endocrinology. 2021 Oct 4
139 citations
The Management of Type 1 Diabetes in Adults. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).
Richard I. G. Holt, J. Hans DeVries, Amy Hess-Fischl, Irl B. Hirsch, M. Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S....> ;Diabetes Care. 2021 Sep 27
649 citations
The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).
Richard I G Holt, J Hans DeVries, Amy Hess-Fischl, Irl B Hirsch, M Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S Skyle...> ;Diabetologia. 2021 Dec 1
14 citations
Dual-hormone artificial pancreas for management of type 1 diabetes: Recent progress and future directions
Marco Infante, David A. Baidal, Michael R. Rickels, Andrea Fabbri, Jay S. Skyler, Rodolfo Alejandro, Camillo Ricordi> ;Artificial Organs. 2021 Jul 15
2 citations
New insights into halting type 1 diabetes.
Jay S. Skyler> ;The Lancet. Diabetes & Endocrinology. 2021 Jun 29
1 citations
Weekly Insulin Becoming a Reality.
Jay S. Skyler> ;Diabetes Care. 2021 Jun 21
56 citations
Novel therapies with precision mechanisms for type 2 diabetes mellitus
Leigh Perreault, Jay S. Skyler, Julio Rosenstock> ;Nature Reviews. Endocrinology. 2021 May 4
26 citations
Consequences of the COVID-19 pandemic for patients with metabolic diseases.
Stefan R Bornstein, Francesco Rubino, Barbara Ludwig, Hannes Rietzsch, Peter Schwarz, Roman N. Rodionov, Kamlesh Khunti, David L. Hopkins, Andreas L. Birkenfeld, Bernh...> ;Nature Metabolism. 2021 Feb 25
7 citations
Index60 as an additional diagnostic criterion for type 1 diabetes
Maria J. Redondo, Brandon M. Nathan, Laura M. Jacobsen, Emily K. Sims, Laura E. Bocchino, Alberto Pugliese, Desmond A. Schatz, Mark A. Atkinson, Jay S. Skyler, Jerry P...> ;Diabetologia. 2021 Jan 26
1 citations
Corona Pandemic: Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society
Johnny Ludvigsson, Matthias von Herrath, Roberto Mallone, Karsten Buschard, Corrado M. Cilio, Maria E. Craig, Jorma Ilonen, David Leslie, Julie E. M. McGeoch, Darius A...> ;Frontiers in Public Health. 2020 Sep 30
8 citations
The Pathological Evolution of Glucose Response Curves During the Progression to Type 1 Diabetes in the TrialNet Pathway to Prevention Study.
Heba M. Ismail, Mario A Cleves, Ping Xu, Ingrid Libman, Dorothy J. Becker, Jennifer B. Marks, Jay S. Skyler, Jerry P. Palmer, Jay M. Sosenko> ;Diabetes Care. 2020 Sep 4
18 citations
Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1) and ...
Jay M. Sosenko, Jay S. Skyler, Kevan C. Herold, Desmond A. Schatz, Michael J. Haller, Alberto Pugliese, Mario A Cleves, Susan Geyer, Lisa E. Rafkin, Della Matheson, Je...> ;Diabetes. 2020 May 21
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Press Mentions

How a Pioneering Diabetes Drug Offers Hope for Preventing Autoimmune DisordersFebruary 15th, 2023
The Diabetes Research Institute Appoints World-Renowned Diabetes Expert, Matthias Von Herrath, M.D., to Scientific DirectorJanuary 26th, 2023
Researchers to Report First Results from Highly Anticipated Type 1 Diabetes Intervention TrialMay 26th, 2022
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Grant Support

Type 1 Diabetes Trialnet: Support FacilitiesNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Type 1 Diabetes TrialnetNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2004
Diabetes Prevention Trial-Iddm (Dpt-1)National Institute Of Diabetes And Digestive And Kidney Diseases1994–2000
Insulin Sensitivity, Blood Pressure, And Glucose ToleranceNational Heart, Lung, And Blood Institute1991–1995
Diabetes Prevention TrialNational Institute Of Diabetes And Digestive And Kidney Diseases1994
Prevention Of Type I Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases1993
Diabetes Mellitus: Pathogenesis And Immune InterventionNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1987
Diabetes Mellitus: Pathogenesis And Immune InterventionNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985

Hospital Affiliations

University of Miami HospitalMiami, Florida
UMHC-Sylvester Comprehensive Cancer CenterMiami, Florida