JayRThiagarajahMDPhD

PubMed

• Holding Back the Tide: Interferon-gamma to the Rescue.
  Jay R Thiagarajah> ;Gastroenterology. 2024 Feb 8
• Intermittent Feasting: Dampening Our Gut Immune Spirits.
  Jay R Thiagarajah> ;Gastroenterology. 2024 Jan 1
• Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease.
  Meri Kalashyan, Krishnan Raghunathan, Haley Oller, Marie-Theres Bayer, Lissette Jimenez, Joseph T Roland, Elena Kolobova, Susan J Hagen, Jeffrey D Goldsmith, Mitchell ...> ;The Journal of Clinical Investigation. 2023 Oct 16
• 6 citations
  A Roadmap for the Human Gut Cell Atlas.
  Matthias Zilbauer, Kylie R James, Mandeep Kaur, Sebastian Pott, Zhixin Li, Albert Burger, Jay R Thiagarajah, Joseph Burclaff, Frode L Jahnsen, Francesca Perrone, Alexa...> ;Nature Reviews. Gastroenterology & Hepatology. 2023 Sep 1
• 10 citations
  Perspectives of Rare Disease Experts on Newborn Genome Sequencing.
  Nina B Gold, Sophia M Adelson, Nidhi Shah, Shardae Williams, Sarah L Bick, Emilie S Zoltick, Jessica I Gold, Alanna Strong, Rebecca Ganetzky, Amy E Roberts, Melissa Wa...> ;JAMA Network Open. 2023 May 1
• Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids.
  Meri Kalashyan, Krishnan Raghunathan, Haley Oller, Marie-Bayer Theres, Lissette Jimenez, Joseph T Roland, Elena Kolobova, Susan J Hagen, Jeffrey D Goldsmith, Mitchell ...> ;Biorxiv. 2023 Jan 29
• 29 citations
  Gasdermin D pore-forming activity is redox-sensitive.
  Pascal Devant, Elvira Boršić, Elsy M Ngwa, Haopeng Xiao, Edward T Chouchani, Jay R Thiagarajah, Iva Hafner-Bratkovič, Charles L Evavold, Jonathan C Kagan> ;Cell Reports. 2023 Jan 31
• The Immune Ghosts of Pandemics Past.
  Jay R Thiagarajah> ;Gastroenterology. 2023 Apr 1
• 11 citations
  The genetics of monogenic intestinal epithelial disorders.
  Stephen J Babcock, David Flores-Marin, Jay R Thiagarajah> ;Human Genetics. 2023 May 1
• 43 citations
  Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
  Daping Yang, Amanda Jacobson, Kimberly A Meerschaert, Joseph Joy Sifakis, Meng Wu, Xi Chen, Tiandi Yang, Youlian Zhou, Praju Vikas Anekal, Rachel A Rucker, Deepika Sha...> ;Cell. 2022 Oct 27
• Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene.
  Jay R Thiagarajah> ;Gastroenterology. 2022 Sep 1
• 13 citations
  The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development.
  Michael J Grey, Heidi De Luca, Doyle V Ward, Irini Am Kreulen, Katlynn Bugda Gwilt, Sage E Foley, Jay R Thiagarajah, Beth A McCormick, Jerrold R Turner, Wayne I Lencer> ;The Journal of Clinical Investigation. 2022 Sep 1
• 6 citations
  Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestin...
  Katelyn Dannheim, Jodie Ouahed, Michael Field, Scott Snapper, Bram P Raphael, Sarah C Glover, Phyllis R Bishop, Natalie Bhesania, Daniel Kamin, Jay Thiagarajah, Jeffre...> ;The American Journal of Surgical Pathology. 2022 Jun 1
• 2 citations
  Membrane Lipids in Epithelial Polarity: Sorting out the PIPs.
  Katlynn Bugda Gwilt, Jay R Thiagarajah> ;Frontiers in Cell and Developmental Biology. 2022 Jan 1
• 1 citations
  Minimally Invasive Image-Guided Gut Transport Function Measurement Probe.
  David O Otuya, Evangelia Gavgiotaki, Camella J Carlson, Serena Q Shi, Ariel J Lee, Alexander A Krall, Anita Chung, Catriona G Grant, Nitasha M Bhat, Peter Choy, Sarah ...> ;Frontiers in Physics. 2021 Sep 1
• 171 citations
  Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.
  Charles L. Evavold, Iva Hafner-Bratkovič, Pascal Devant, Jasmin M. D’Andrea, Elsy M. Ngwa, Elvira Boršić, John G. Doench, Martin W. LaFleur, Arlene H. Sharpe, Jay R. T...> ;Cell. 2021 Aug 19
• 34 citations
  Pycro-Manager: open-source software for customized and reproducible microscope control.
  Henry Pinkard, Nico Stuurman, Ivan Ivanov, Nicholas M. Anthony, Wei Ouyang, Bin Li, Bin Yang, Mark A. Tsuchida, Bryant B. Chhun, Grace Zhang, Ryan Mei, Michael W. Ande...> ;Nature Methods. 2021 Mar 5
• 9 citations
  Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis.
  Yanjia Jason Zhang, Lissette Jimenez, Svetlana Azova, Jessica Kremen, Yee-Ming Chan, Abdelrahman M. Elhusseiny, Hajirah N. Saeed, Jeff Goldsmith, Alyaa Al-Ibraheemi, A...> ;European Journal of Human Genetics. 2021 Feb 1
• 12 citations
  Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
  Denis Chang, Aaron T. Whiteley, Katlynn Bugda Gwilt, Wayne I. Lencer, John J. Mekalanos, Jay R. Thiagarajah> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 3
• 7 citations
  A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization
  Phi Luong, Qian Li, Pin-Fang Chen, Paul J. Wrighton, Denis Chang, Sean Dwyer, Marie-Theres Bayer, Scott B. Snapper, Steen H. Hansen, Jay R. Thiagarajah, Wolfram Goessl...> ;Molecular Biology of the Cell. 2020 Mar 19
• 9 citations
  NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency
  Razieh Khoshnevisan, Michael W. Anderson, Stephen Babcock, Sierra Anderson, David Illig, Benjamin Marquardt, Roya Sherkat, Katrin Schröder, Franziska Moll, Sebastian H...> ;Inflammatory Bowel Diseases. 2020 Jul 17
• 24 citations
  IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.
  Michael J. Grey, Eva Cloots, Mariska S. Simpson, Nicole LeDuc, Yevgeniy V. Serebrenik, Heidi De Luca, Delphine De Sutter, Phi Luong, Jay R. Thiagarajah, Adrienne W. Pa...> ;The Journal of Cell Biology. 2020 Feb 3
• 31 citations
  Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.
  Sasha Jardine, Sierra Anderson, Stephen Babcock, Gabriella Leung, Jie Pan, Neel Dhingani, Neil Warner, Conghui Guo, Iram Siddiqui, Daniel Kotlarz, James J. Dowling, Ro...> ;Gastroenterology. 2020 Mar 1
• 4 citations
  An Intravenous Fish Oil–Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease
  Lorenzo Anez-Bustillos, Duy T. Dao, Alexis K. Potemkin, Antonio R. Perez-Atayde, Bram P. Raphael, Alexandra N. Carey, Daniel Kamin, Jay R. Thiagarajah, McGreggor Crowl...> ;Hepatology. 2019 Mar 1
• 29 citations
  Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
  Tianying Duan, Onur Cil, Jay R. Thiagarajah, Alan S. Verkman> ;JCI Insight. 2019 Feb 21
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Journal Articles

• An Intravenous Fish Oil Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with MVID  
  Kathleen M Gura, Bram P Raphael, Jay Thiagarajah, Alexandra N Carey, Daniel S Kamin, Hepatology