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Jayakar Nayak, MD, Otolaryngology (ENT), Stanford, CA

Jayakar Vasudev Nayak MD PhD

Rhinology & Paranasal Sinus Disease


Physician

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  • 801 Welch RoadStanford, CA 94305

  • Phone+1 650-723-5281

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Summary

  • Jayakar V. Nayak, MD, PhD is a surgeon-scientist based in Stanford, CA, who specializes in Otolaryngology with a subspecialty in Rhinology/Endoscopic Sinus & Skull Base Surgery.

    He completed his PhD in Immunology in 2001 and MD in 2003 (dual degree) at the University of Pittsburgh School of Medicine, followed by residency training in Otolaryngology - Head and Neck Surgery at the University of Pittsburgh Medical Center from 2003-2008. He completed advanced fellowship training in Rhinologand sinus y at the University of Pennsylvania in 2009 and joined the faculty in the Stanford Department of Otolaryngology - Head and Neck Surgery in January 2010.

    Clinically, he treats the gamut of medical and surgical nasal and sinus disorders including nasal obstruction, acute and chronic rhinosinusitis, nasal polyposis, nosebleeds, fungal sinusitis, septal perforations, empty nose syndrome, and nasal tumors and cancers. When necessary, he performs a wide range of nasal and sinus surgeries in both the office and operating room to assist in the care of his complex patients.

    From the research front, I am interested in using basic science and translational approaches to better understand i) upper airway basal cell regeneration and capacity for stem cell therapy for cystic fibrosis chronic rhinosinusitis (CF-CRS); ii) innate and acquired upper airway immunity due to acute/chronic infection from SARS-CoV-2 and other respiratory viruses to aid in novel vaccine development; iii) immune system : nasal epithelium cellular and molecular dynamic interactions in the upper airway; iv) upper airway physiology in both health and during chronic inflammation and settings of tissue loss such as empty nose syndrome (ENS). I ultimately hope to create rational, easily implemeted, cell-based and cell-free biologic and regenerative therapies for patients suffering from airway diseases.

Education & Training

  • University of Pennsylvania
    University of PennsylvaniaCertification, Rhinology/Endoscopic Sinus & Skull Base Surgery, 2008 - 2009
  • UPMC Medical Education (Pittsburgh)
    UPMC Medical Education (Pittsburgh)Residency, Otolaryngology - Head and Neck Surgery, 2004 - 2008
  • UPMC Medical Education (Pittsburgh)
    UPMC Medical Education (Pittsburgh)Residency, Surgery, 2003 - 2004
  • University of Pittsburgh School of Medicine
    University of Pittsburgh School of MedicineClass of 2003

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 2009 - 2027
  • PA State Medical License
    PA State Medical License 2003 - 2014
  • Otolaryngology
    American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2012-2014, 2016-2017
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012-2014, 2016-2017
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013

Clinical Trials

Publications & Presentations

PubMed

Press Mentions

  • Research in Brief: Why Some Sinus Polyps Keep Returning and How to Tackle Them
    Research in Brief: Why Some Sinus Polyps Keep Returning and How to Tackle ThemSeptember 29th, 2025
  • Breath: James Nestor’s Book on How We Breathe May Inspire Clinicians
    Breath: James Nestor’s Book on How We Breathe May Inspire CliniciansMarch 14th, 2025
  • Bedtime Routine: Brush Teeth, Wash Face, Tape Mouth
    Bedtime Routine: Brush Teeth, Wash Face, Tape MouthOctober 18th, 2021

Grant Support

  • Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwaySTANFORD UNIVERSITY2021–2026
  • Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwaySTANFORD UNIVERSITY2021–2026

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