
Jayakar Vasudev Nayak MD PhD
Rhinology & Paranasal Sinus Disease
Physician
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801 Welch RoadStanford, CA 94305
Phone+1 650-723-5281
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Summary
- Jayakar V. Nayak, MD, PhD is a surgeon-scientist based in Stanford, CA, who specializes in Otolaryngology with a subspecialty in Rhinology/Endoscopic Sinus & Skull Base Surgery.
He completed his PhD in Immunology in 2001 and MD in 2003 (dual degree) at the University of Pittsburgh School of Medicine, followed by residency training in Otolaryngology - Head and Neck Surgery at the University of Pittsburgh Medical Center from 2003-2008. He completed advanced fellowship training in Rhinologand sinus y at the University of Pennsylvania in 2009 and joined the faculty in the Stanford Department of Otolaryngology - Head and Neck Surgery in January 2010.
Clinically, he treats the gamut of medical and surgical nasal and sinus disorders including nasal obstruction, acute and chronic rhinosinusitis, nasal polyposis, nosebleeds, fungal sinusitis, septal perforations, empty nose syndrome, and nasal tumors and cancers. When necessary, he performs a wide range of nasal and sinus surgeries in both the office and operating room to assist in the care of his complex patients.
From the research front, I am interested in using basic science and translational approaches to better understand i) upper airway basal cell regeneration and capacity for stem cell therapy for cystic fibrosis chronic rhinosinusitis (CF-CRS); ii) innate and acquired upper airway immunity due to acute/chronic infection from SARS-CoV-2 and other respiratory viruses to aid in novel vaccine development; iii) immune system : nasal epithelium cellular and molecular dynamic interactions in the upper airway; iv) upper airway physiology in both health and during chronic inflammation and settings of tissue loss such as empty nose syndrome (ENS). I ultimately hope to create rational, easily implemeted, cell-based and cell-free biologic and regenerative therapies for patients suffering from airway diseases.
Education & Training
University of PennsylvaniaCertification, Rhinology/Endoscopic Sinus & Skull Base Surgery, 2008 - 2009
UPMC Medical Education (Pittsburgh)Residency, Otolaryngology - Head and Neck Surgery, 2004 - 2008
UPMC Medical Education (Pittsburgh)Residency, Surgery, 2003 - 2004
University of Pittsburgh School of MedicineClass of 2003
Certifications & Licensure
CA State Medical License 2009 - 2027
PA State Medical License 2003 - 2014
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2012-2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012-2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
Clinical Trials
- A User Study of SYNUS Pain Relief Made by Tivic Health Systems Start of enrollment: 2018 Feb 02
Publications & Presentations
PubMed
- Does Debridement of Intracranial Disease in Acute Invasive Fungal Sinusitis Improve Survival?Alice E Huang, Christine K Lee, Jayakar V Nayak, Peter H Hwang, Zara M Patel
Journal of Neurological Surgery. Part B, Skull Base. 2026-10-01 - Outcomes of Biologic Switching in Chronic Rhinosinusitis With Nasal Polyps.Beverly J Fu, Itzel Jimenez, Michael T Chang, Zara M Patel, Jayakar V Nayak
American Journal of Rhinology & Allergy. 2026-08-14 - Patency of the Cavernous Sinus After Medial Wall Resection: An Observational Study.Axel E Renteria, Maxime Fieux, Bruna Castro, Lirit Levi, Li-Ting Hung
Journal of Neurological Surgery. Part B, Skull Base. 2026-08-01
Press Mentions
Research in Brief: Why Some Sinus Polyps Keep Returning and How to Tackle ThemSeptember 29th, 2025
Breath: James Nestor’s Book on How We Breathe May Inspire CliniciansMarch 14th, 2025
Bedtime Routine: Brush Teeth, Wash Face, Tape MouthOctober 18th, 2021
Grant Support
- Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwaySTANFORD UNIVERSITY2021–2026
- Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwaySTANFORD UNIVERSITY2021–2026
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