JayalakshmiUdayasankarMD

PubMed

• 4 citations
  Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide.
  Jayalakshmi Udayasankar, Sakeneh Zraika, Kathryn Aston-Mourney, Shoba L. Subramanian, Barbara Brooks-Worrell, Gerald J. Taborsky, Rebecca L. Hull> ;Transplantation Proceedings. 2013 Mar 1
• 31 citations
  Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide
  Kathryn Aston-Mourney, Sakeneh Zraika, Jayalakshmi Udayasankar, Shoba L. Subramanian, Pattie S. Green, Steven E. Kahn, Rebecca L. Hull> ;The Journal of Biological Chemistry. 2013 Feb 1
• 61 citations
  cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets
  Savitha Subramanian, Rebecca L. Hull, Sakeneh Zraika, Kathryn Aston-Mourney, Jayalakshmi Udayasankar, Steven E. Kahn> ;Diabetologia. 2012 Jan 1
• 228 citations
  β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
  Catherine A. Jurgens, Mirna N. Toukatly, Corinne L. Fligner, Jayalakshmi Udayasankar, Shoba L. Subramanian, Sakeneh Zraika, Kathryn Aston-Mourney, Darcy B. Carr, Per W...> ;The American Journal of Pathology. 2011 Jun 1
• 45 citations
  Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.
  Kathryn Aston-Mourney, Rebecca L. Hull, Sakeneh Zraika, Jayalakshmi Udayasankar, Savitha Subramanian, Steven E. Kahn> ;Diabetologia. 2011 Apr 12
• 32 citations
  Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.
  Sakeneh Zraika, Kathryn Aston-Mourney, Peter Marek, Rebecca L. Hull, Pattie S. Green, Jayalakshmi Udayasankar, Shoba L. Subramanian, Daniel P. Raleigh, Steven E. Kahn> ;The Journal of Biological Chemistry. 2010 Jun 11
• 52 citations
  Body Mass Index Is Associated with Increased Creatinine Clearance by a Mechanism Independent of Body Fat Distribution
  Fernando Gerchman, Jenny Tong, Kristina M. Utzschneider, Sakeneh Zraika, Jayalakshmi Udayasankar, Marguerite J. McNeely, Darcy B. Carr, Donna L. Leonetti, Bessie A. Yo...> ;The Journal of Clinical Endocrinology and Metabolism. 2009 Jul 7
• 48 citations
  Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
  Rebecca L. Hull, Sakeneh Zraika, Jayalakshmi Udayasankar, Kathryn Aston-Mourney, Shoba L. Subramanian, Steven E. Kahn> ;Diabetologia. 2009 Apr 8
• 174 citations
  Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis
  Sakeneh Zraika, Rebecca L. Hull, Jayalakshmi Udayasankar, Kathryn Aston-Mourney, Shoba L. Subramanian, Robert Kisilevsky, Walter A. Szarek, Steven E. Kahn> ;Diabetologia. 2009 Jan 16
• 104 citations
  The Dipeptidyl Peptidase-4 Inhibitor Vildagliptin Improves β-Cell Function and Insulin Sensitivity in Subjects With Impaired Fasting Glucose
  Kristina M. Utzschneider, Jenny Tong, Brenda Montgomery, Jayalakshmi Udayasankar, Fernando Gerchman, Santica M. Marcovina, Catherine Watson, Monica Ligueros-Saylan, Ja...> ;Diabetes Care. 2008 Jan 1
• 86 citations
  Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies.
  Kristina M. Utzschneider, R. L. Prigeon, Jenny Tong, Fernando Gerchman, Daniel B. Carr, Sakeneh Zraika, Jayalakshmi Udayasankar, Brenda Montgomery, Andrea Mari, Steven...> ;Diabetologia. 2007 Oct 11
• 43 citations
  Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.
  Rebecca L. Hull, Sakeneh Zraika, Jayalakshmi Udayasankar, Robert Kisilevsky, Walter A. Szarek, Thomas N. Wight, Steven E. Kahn> ;American Journal of Physiology. Cell Physiology. 2007 Sep 5
• 10 citations
  Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans.
  Fernando Gerchman, Jenny Tong, Kristina M. Utzschneider, Rebecca L. Hull, Sakeneh Zraika, Jayalakshmi Udayasankar, Marguerite J. McNeely, Dennis L. Andress, Donna L. L...> ;Diabetes Research and Clinical Practice. 2007 Aug 1
• 33 citations
  Glucose- and time-dependence of islet amyloid formation in vitro.
  Sakeneh Zraika, Rebecca L. Hull, Jayalakshmi Udayasankar, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Steven E. Kahn> ;Biochemical and Biophysical Research Communications. 2007 Mar 2
• 33 citations
  Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.
  Sakeneh Zraika, Rebecca L. Hull, Jayalakshmi Udayasankar, Anne Clark, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Steven E. Kahn> ;Diabetes. 2007 Feb 1
• 50 citations
  Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Fa...
  Renate E. van Genugten, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Sakeneh Zraika, Jayalakshmi Udayasankar, Edward J. Boyko, Wilfred Y. Fujimoto, Steven ...> ;Diabetes. 2006 Dec 1
• 58 citations
  Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets
  Jayalakshmi Udayasankar, Keiichi Kodama, Rebecca L. Hull, Sakeneh Zraika, Kathryn Aston-Mourney, Shoba L. Subramanian, Jenny Tong, Mirjam V. Faulenbach, Josep Vidal, S...> ;Diabetologia. 2009 Jan 1
• Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects.
  Tong, J., Utzschneider, K. M., Carr, D. B., Zraika, S., Udayasankar, J., Gerchman, F., Knopp, R. H., Kahn, S. E.> ;Diabetologia. 2007 Feb
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