JayaramanChandrasekharMD

PubMed

• 9 citations
  1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
  Qin Guo, Jayaraman Chandrasekhar, David C. Ihle, David J. Wustrow, Bertrand L. Chenard, James E. Krause, Hutchison Alan J, Dawn Alderman, Charles S. Cheng, Daniel N. C...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Sep 15
• 13 citations
  Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
  Charles A. Blum, Xiaozhang Zheng, Harry Brielmann, Kevin J. Hodgetts, Rajagopal Bakthavatchalam, Jayaraman Chandrasekhar, James E. Krause, Daniel N. Cortright, David J...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Aug 15
• 6 citations
  2-Arylpyrimidines: Novel CRF-1 receptor antagonists
  Yoon Taeyoung, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, James E. Krause, Hutchison Alan J, Raymond F. Horvath, Ping Ge, John H. Kehne, Diane Hoffman,...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Aug 15
• 30 citations
  Strategies and tactics for optimizing the Hit-to-Lead process and beyond--a computational chemistry perspective.
  Charles J. Manly, Jayaraman Chandrasekhar, Joseph W. Ochterski, Jack Hammer, Benjamin B. Warfield> ;Drug Discovery Today. 2008 Feb 1
• 10 citations
  The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists
  Yoon Taeyoung, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, Jayaraman Chandrasekhar, Raymond F. Horvath, Ping Ge, Mark T. Kershaw, James E. Krause, John ...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Feb 1
• 21 citations
  From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
  Xiaozhang Zheng, Kevin J. Hodgetts, Harry Brielmann, Hutchison Alan J, Frank Burkamp, A. Brian Jones, Peter Blurton, Robert Clarkson, Jayaraman Chandrasekhar, Rajagopa...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Oct 1
• 16 citations
  Controlling chemistry with cations: photochemistry within zeolites.
  Vaidhyanathan Ramamurthy, J. Shailaja, Lakshmi S. Kaanumalle, Raghavan B. Sunoj, Jayaraman Chandrasekhar> ;Chemical Communications. 2003 Jul 23
• 48 citations
  Contributions of conformational compression and preferential transition state stabilization to the rate enhancement by chorismate mutase.
  Cristiano Ruch Werneck Guimarães, Matthew P. Repasky, Jayaraman Chandrasekhar, Julian Tirado-Rives, William L. Jorgensen> ;Journal of the American Chemical Society. 2003 May 10
• 35 citations
  Investigation of solvent effects for the Claisen rearrangement of chorismate to prephenate: mechanistic interpretation via near attack conformations.
  Matthew P. Repasky, Cristiano Ruch Werneck Guimarães, Jayaraman Chandrasekhar, Julian Tirado-Rives, William L. Jorgensen> ;Journal of the American Chemical Society. 2003 May 8
• 7 citations
  Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antag...
  He Zhao, Xiaoyan Zhang, Kevin J. Hodgetts, Andrew Thurkauf, Jack Hammer, Jayaraman Chandrasekhar, Andrzej Kieltyka, Robbin Brodbeck, Stanislaw Rachwal, Renee Primus, C...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Feb 1
• 12 citations
  Light-induced geometric isomerization of 1,2-diphenylcyclopropanes included within Y zeolites: Role of Cation-guest binding
  Lakshmi S. Kaanumalle, J. Sivaguru, Raghavan B. Sunoj, P. H. Lakshminarasimhan, Jayaraman Chandrasekhar, Vaidhyanathan Ramamurthy> ;The Journal of Organic Chemistry. 2002 Dec 13
• 177 citations
  PDDG/PM3 and PDDG/MNDO: improved semiempirical methods.
  Matthew P. Repasky, Jayaraman Chandrasekhar, William L. Jorgensen> ;Journal of Computational Chemistry. 2002 Dec 1
• 5 citations
  Structural Effects on the Formation of Proton and Alkali Metal Ion Adducts of Apolar, Neutral Peptides: Electrospray Ionization Mass Spectrometry and Ab Initio Theoret...
  R. Sudha, Manoranjan Panda, Jayaraman Chandrasekhar, Padmanabhan Balaram> ;Chemistry. 2002 Nov 4
• 13 citations
  Improved semiempirical heats of formation through the use of bond and group equivalents.
  Matthew P. Repasky, Jayaraman Chandrasekhar, William L. Jorgensen> ;Journal of Computational Chemistry. 2002 Mar 1
• 3 citations
  Modeling of ion permeation in calcium and sodium channel selectivity filters.
  P.S. Raj Ganesh, Baron Chanda, S.K. Gupta, Mathew K. Mathew, Jayaraman Chandrasekhar> ;Proteins. 2000 Mar 1
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