JeanLChanMD

PubMed

• 9 citations
  Crinecerfont Lowers Elevated Hormone Markers in Adults with 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
  Richard J. Auchus, Kyriakie Sarafoglou, Patricia Y. Fechner, Maria G. Vogiatzi, Erik A. Imel, Shanlee M Davis, Nagdeep Giri, Julia Sturgeon, Eiry Roberts, Jean L Chan,...> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Oct 15
• 56 citations
  Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo
  Catherine Frenette, Giuseppe Morelli, Mitchell L. Shiffman, R. Todd Frederick, Raymond A. Rubin, Michael B. Fallon, Jason T. Cheng, Matthew C. Cave, Saira Khaderi, Oma...> ;Clinical Gastroenterology and Hepatology. 2019 Mar 1
• 69 citations
  Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease.
  Mitchell L. Shiffman, Bradley Freilich, Raj Vuppalanchi, Kymberly D. Watt, Jean L. Chan, Al Spada, David T. Hagerty, Eugene R. Schiff> ;Alimentary Pharmacology & Therapeutics. 2019 Jan 1
• 30 citations
  Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
  Zhenyi Hu, H. Tanji, Shuangshuang Jiang, Shuting Zhang, Kyoin Koo, Jean Chan, Kentaro Sakaniwa, Umeharu Ohto, Albert Candia, Toshiyuki Shimizu, Hang Yin> ;Cell Chemical Biology. 2018 Oct 18
• 39 citations
  Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.
  Jean L. Chan, Joy Koda, Joseph S. Heilig, Elaine Cochran, Phillip Gorden, Elif A. Oral, Rebecca J. Brown> ;Clinical Endocrinology. 2016 Jul 1
• 74 citations
  The Clinical Approach to the Detection of Lipodystrophy – An AACE Consensus Statement
  Yehuda Handelsman, Elif A. Oral, Zachary T. Bloomgarden, Rebecca J. Brown, Jean L. Chan, Daniel Einhorn, Alan J. Garber, Abhimanyu Garg, W. Timothy Garvey, George Grun...> ;Endocrine Practice. 2013 Feb 22
• 97 citations
  Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy
  Jean L. Chan, Karen Lutz, Elaine Cochran, Wenying Huang, Yvette Peters, Christian Weyer, Phillip Gorden> ;Endocrine Practice. 2011 Nov 1
• 54 citations
  Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions
  Frank A.J.L. Scheer, Jean L. Chan, Jessica L. Fargnoli, John P. Chamberland, Kalliopi M. Arampatzi, Steven Shea, George L. Blackburn, Christos S. Mantzoros> ;Diabetologia. 2010 Aug 12
• 52 citations
  Rationale for Leptin-Replacement Therapy for Severe Lipodystrophy
  Elif A. Oral, Jean L. Chan> ;Endocrine Practice. 2010 Mar 1
• 52 citations
  Clinical classification and treatment of congenital and acquired lipodystrophy.
  Jean L. Chan, Elif A. Oral> ;Endocrine Practice. 2010 Mar 1
• 27 citations
  It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development.
  Jean L. Chan, Jonathan D. Roth, Christian Weyer> ;Journal of Investigative Medicine. 2009 Oct 1
• 115 citations
  Management of the Metabolic Syndrome and Type 2 Diabetes Through Lifestyle Modification
  Faidon Magkos, Mary Yannakoulia, Jean L. Chan, Christos S. Mantzoros> ;Annual Review of Nutrition. 2009 Jul 22
• 1 citations
  Effect of valsartan on left ventricular anatomy and systolic function and aortic elasticity.
  Lalita Khaodhiar, Aoife M. Brennan, Christina Lima, Jean L. Chan, Christos S. Mantzoros, Warren J. Manning, Peter G. Danias, Aristidis Veves> ;Metabolism. 2009 May 1
• 31 citations
  r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding pr...
  Aoife M. Brennan, Jennifer Lee, Sotirios Tsiodras, Jean L. Chan, John P. Doweiko, Sonia Nagy Chimienti, Sanjivini G. Wadhwa, Adolf W. Karchmer, Christos S. Mantzoros> ;European Journal of Endocrinology. 2008 Nov 24
• 6 citations
  Parathyroid carcinoma and neurofibromatosis
  Aram N. Demirjian, Joseph Grossman, Jean L. Chan, Sareh Parangi> ;Surgery. 2008 Nov 1
• 47 citations
  Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states
  Jean L. Chan, Catherine J. Williams, Patricia Raciti, Jennifer Blakeman, Theodore Kelesidis, Iosif Kelesidis, Michael L. Johnson, Michael O. Thorner, Christos S. Mantz...> ;The Journal of Clinical Endocrinology and Metabolism. 2008 Jul 1
• 14 citations
  Leptin Does Not Directly Regulate the Pancreatic Hormones Amylin and Pancreatic Polypeptide: Interventional studies in humans
  Janice J. Hwang, Jean L. Chan, Georgia Ntali, Dalia Malkova, Christos S. Mantzoros> ;Diabetes Care. 2008 May 1
• 38 citations
  Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states : regulation by gender and adiposity
  Jean L. Chan, Shekman L. Wong, Christos S. Mantzoros> ;Clinical Pharmacokinetics. 2008 Jan 1
• 29 citations
  Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay.
  Jean L. Chan, Shekman L. Wong, Christine Orlova, Patricia Raciti, Christos S. Mantzoros> ;The Journal of Clinical Endocrinology and Metabolism. 2007 Jun 1
• 51 citations
  Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans.
  Jean L. Chan, Joseph E. Mietus, Patricia Raciti, Ary L. Goldberger, Christos S. Mantzoros> ;Clinical Endocrinology. 2006 Oct 11
• 115 citations
  Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome i...
  Jennifer Lee, Jean L. Chan, Epaminondas Sourlas, Vassilios Raptopoulos, Christos S. Mantzoros> ;The Journal of Clinical Endocrinology and Metabolism. 2006 Jul 1
• 142 citations
  Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans
  Jean L. Chan, Giuseppe Matarese, Greeshma K. Shetty, Patricia Raciti, Iosif Kelesidis, Daniela Aufiero, Veronica De Rosa, Francesco Perna, Silvia Fontana, Christos S. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2006 May 30
• 85 citations
  Peptide YY Levels Are Elevated After Gastric Bypass Surgery
  Jean L. Chan, Edward C. Mun, Violeta Stoyneva, Christos S. Mantzoros, Allison B. Goldfine> ;Obesity. 2006 Feb 1
• 48 citations
  Peptide YY levels are decreased by fasting and elevated following caloric intake but are not regulated by leptin.
  Jean L. Chan, Violeta Stoyneva, Theodoros Kelesidis, Patricia Raciti, Christos S. Mantzoros> ;Diabetologia. 2006 Jan 1
• 27 citations
  Circulating Resistin Levels Are Not Associated with Fat Redistribution, Insulin Resistance, or Metabolic Profile in Patients with the Highly Active Antiretroviral Ther...
  Diana Barb, Sanjivini G. Wadhwa, Juergen Kratzsch, Alina Gavrila, Jean L. Chan, Catherine J. Williams, Adolf W. Karchmer, Christos S. Mantzoros> ;The Journal of Clinical Endocrinology and Metabolism. 2005 Sep 1
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