JeffreyLouisCurtisMDATSF, FERS

Asthma & COPD, Critical Care Medicine, Pleural Disease

Professor of Internal Medicine, University of Michigan Health System; Pulmonary & Critical Care Medicine Section, VA Ann Arbor Healthcare System

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Office
Ann Arbor VA Healthsystem (506/111G)
2215 Fuller Road
Ann Arbor, MI 48105
Phone+1 734-845-3457

Fax+1 734-845-3257
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Education & Training

University of California (San Francisco)Fellowship, Pulmonary Disease and Critical Care Medicine, 1983 - 1986
National Institutes of Health Clinical CenterFellowship, Clinical and Laboratory Immunology, 1981 - 1983
Johns Hopkins University/Bayview Medical CenterChief Residency, Internal Medicine, 1980 - 1981
Johns Hopkins University/Bayview Medical CenterResidency, Internal Medicine, 1977 - 1980
Georgetown University School of MedicineClass of 1977

Certifications & Licensure

MI State Medical License 1990 - 2027
MD State Medical License 1979 - 1990
CA State Medical License 1983 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Lifetime Scientific Achievement Award AII Assembly, ATS, 2019
John B. Barnwell Award Department of Veteran Affairs, 2019
Elected Fellow American Thoracic Society, 2018
Editorial Board, American Journal of Respiratory & Critical Care Medicine American Thoracic Society
Elected Fellow European Respiratory Society, 2014
Chair, Allergy, Immunology & Inflammation Assembly American Thoracic Society
Member, Board of Directors American Thoracic Society
Chair, Respiration Study Section, Merit Review Board Department of Veterans Affairs
Chair, Research Career Development Award Committee (CADE 1) Department of Veterans Affairs
Member, review panel, Barnwell & Middleton Awards Department of Veterans Affairs
Member, Data Safety Monitoring Board, Specialized Centers of Clinical Research NHBLI
Ad hoc reviewer The Wellcome Trust, United Kingdom
Member, BLRD/CSRD Non-Clinician Eligibility Review Board Department of Veterans Affairs
Member, Scientific Advisory Committee American Thoracic Society
Career Investigator Award American Lung Association of Michigan
Elected Fellow American College of Chest Physicians
Elected Fellow American College of Physicians
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Clinical Trials

Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function Start of enrollment: 2005 Sep 01
Completed
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD Start of enrollment: 2005 Sep 01
Completed
Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations Start of enrollment: 2005 Sep 01
Completed
T Lymphocyte Cells in Individuals Experiencing an Acute Exacerbation of Chronic Obstructive Pulmonary Disease Start of enrollment: 2005 Sep 01
Completed
Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease Start of enrollment: 2005 Sep 01
Completed
Benefits of Lightweight Ambulatory Oxygen Systems for Individuals With Chronic Obstructive Pulmonary Disease Start of enrollment: 2005 Mar 01
Terminated
Not Applicable
Effect of Macrolide Antibiotics on Airway Inflammation in People With Chronic Obstructive Pulmonary Disease (COPD) Start of enrollment: 2007 Aug 01
Completed
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) Start of enrollment: 2007 Nov 01
Active, not recruiting
Long-term Oxygen Treatment Trial Start of enrollment: 2009 Jan 01
Completed
Phase 3
Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM) Start of enrollment: 2010 Feb 01
Completed
Study of COPD Subgroups and Biomarkers Start of enrollment: 2010 Nov 01
Active, not recruiting
Lung HIV Microbiome Project (Michigan Site) Start of enrollment: 2009 Oct 01
Completed
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis Start of enrollment: 2015 Oct 01
Completed
Not Applicable
VA CoronavirUs Research and Efficacy Studies-1 Start of enrollment: 2020 Nov 16
Terminated
Phase 3
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Publications & Presentations

PubMed

14 citations
Disseminated Curvularia infection. Additional therapeutic and clinical considerations with evidence of medical cure.
Pierce Nf, Millan Jc, Bender Bs, Jeffrey L. Curtis> ;Archives of Pathology & Laboratory Medicine. 1986 Oct 1
Analysis of immune status of hemodialyzed adults: association with prior transfusions.
Bender BS, Curtis JL, Nagel JE, Chrest FJ, Kraus ES, Briefel GR, Adler WH> ;Kidney Int. 1984 Oct
Primary in vitro plaque-forming cell response to DAGG-Ficoll: LPS-induced enhancement mediated by interleukin-1.
Curtis JL, Nordin AA> ;Immunology. 1984 Aug
Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction.
Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS> ;Chest. 1986 Sep
Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man.
Jacques C, Richmond G, Tierney L, Curtis JL, McKerrow J, Warnock ML> ;Hum Pathol. 1992 Feb
The sensitivity of high-resolution CT in detecting idiopathic pulmonary fibrosis proved by open lung biopsy. A prospective study.
Orens JB, Kazerooni EA, Martinez FJ, Curtis JL, Gross BH, Flint A, Lynch JP 3rd> ;Chest. 1995 Jul
Lung volume reduction surgery alters management of pulmonary nodules in patients with severe COPD.
Ojo TC, Martinez F, Paine R 3rd, Christensen PJ, Curtis JL, Weg JG, Kazerooni EA, Whyte R> ;Chest. 1997 Dec
Preoperative echocardiographic evaluation of patients referred for lung volume reduction surgery.
Bach DS, Curtis JL, Christensen PJ, Iannettoni MD, Whyte RI, Kazerooni EA, Armstrong W, Martinez FJ> ;Chest. 1998 Oct
Weight gain after lung volume reduction surgery is not correlated with improvement in pulmonary mechanics.
Christensen PJ, Paine R 3rd, Curtis JL, Kazerooni EA, Iannettoni MD, Martinez FJ> ;Chest. 1999 Dec
Lymphocyte-endothelial cell adhesive interactions in lung immunity: lessons from the murine response to particulate antigen.
Curtis JL, Wolber FM, Sonstein J, Craig RA, Polak T, Knibbs RN, Todt J, Seitzman GD, Stoolman LM> ;Immunopharmacology. 2000 Jul 25
76 citations
Short-term and long-term outcomes after bilateral lung volume reduction surgery: Prediction by quantitative CT
Kevin R. Flaherty, Ella A. Kazerooni, Jeffrey L. Curtis, Mark D. Iannettoni, Leslie A. Lange, M. Anthony Schork, Fernando J. Martinez> ;Chest. 2001 May 1
The Effect of Chronic Altitude Exposure on COPD Outcomes in the SPIROMICS Cohort.
Rajat Suri, Daniela Markovic, Han Woo, Mehrdad Arjomandi, R Graham Barr, Russell P Bowler, Gerard Criner, Jeffrey L Curtis, Mark T Dransfield, M Bradley Drummond, Spyr...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Mar 20
1 citations
Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations.
Regan, E., Lowe, M., Make, B., Curtis, J., Chen, Q., Crooks, J., Wilson, C., Oates, G., Gregg, R., Baldomero, A., Bhatt, S., Diaz, A., Benos, P., O'Brien, J., Young, K...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Jan 1
Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers.
Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L Curtis, Jennifer M Wang, Rubén San José Estépar, Ivan O Rosas, Jared R Mayers, Brian D Hobbs, Craig P Hers...> ;Respiratory Research. 2023 Nov 4
Use of the Spirometric "Fixed-Ratio" Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study.
Bhatt, S. P., Regan, E., Lowe, M., Make, B., Curtis, J., Chen, Q., Cho, M., Crooks, J., Lowe, K., Wilson, C., O'Brien, J., Oates, G., Baldomero, A., Kinney, G., Young,...> ;Journal of General Internal Medicine. 2023 Oct 1
1 citations
Longitudinal Follow-Up of Participants With Tobacco Exposure and Preserved Spirometry.
William McKleroy, Tracie Shing, Wayne H Anderson, Mehrdad Arjomandi, Hira Anees Awan, Igor Barjaktarevic, R Graham Barr, Eugene R Bleecker, John Boscardin, Russell P B...> ;JAMA. 2023 Aug 1
3 citations
Changes in Lung Volumes with Spirometric Disease Progression in COPD.
Bhatt, S. P., Mehrdad Arjomandi, Siyang Zeng, Jianhong Chen, Surya P Bhatt, Fereidoun Abtin, Igor Barjaktarevic, R Graham Barr, Eugene R Bleecker, Russell G Buhr, Gera...> ;Chronic Obstructive Pulmonary Diseases. 2023 Jul 26
Understanding COPD Etiology, Pathophysiology, and Definition.
Jeffrey L Curtis> ;Respiratory Care. 2023 Jul 1
1 citations
Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.
Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K O'Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L Curtis, MeiLan K Han, Jerry A Krishnan, Emily S W...> ;Plos Genetics. 2023 Jun 1
2 citations
Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations.
Min Hyung Ryu, Jeong H Yun, Jarrett D Morrow, Aabida Saferali, Peter Castaldi, Robert Chase, Meryl Stav, Zhonghui Xu, Igor Barjaktarevic, MeiLan Han, Wassim Labaki, Yv...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Aug 1
A blood and bronchoalveolar lavage protein signature of rapid FEVdecline in smoking-associated COPD.
Katarina M DiLillo, Katy C Norman, Christine M Freeman, Stephanie A Christenson, Neil E Alexis, Wayne H Anderson, Igor Z Barjaktarevic, R Graham Barr, Alejandro P Come...> ;Scientific Reports. 2023 May 22
Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.
Manuel Izquierdo, Chad R Marion, Frank Genese, John D Newell, Wanda K O'Neal, Xingnan Li, Gregory A Hawkins, Igor Barjaktarevic, R Graham Barr, Stephanie Christenson, ...> ;Chronic Obstructive Pulmonary Diseases. 2023 Jul 26
Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease.
Moll, M., Bhatt, S. P., Tran, T., Kinney, G., Comellas, A., Hoth, K., Baldomero, A., Mamary, A., Curtis, J., Hanania, N., Casaburi, R., Young, K., Kim, V., Make, B., W...> ;Respiratory Medicine. 2023 Mar 1
1 citations
Machine learning for screening of at-risk, mild and moderate COPD patients at risk of FEVdecline: results from COPDGene and SPIROMICS.
Jennifer M Wang, Wassim W Labaki, Susan Murray, Fernando J Martinez, Jeffrey L Curtis, Eric A Hoffman, Sundaresh Ram, Alexander J Bell, Craig J Galban, MeiLan K Han, C...> ;Frontiers in Physiology. 2023 Jan 1
1 citations
Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS.
Vickram Tejwani, Han Woo, Chen Liu, Anna K Tillery, Amanda J Gassett, Richard E Kanner, Eric A Hoffman, Fernando J Martinez, Prescott G Woodruff, R Graham Barr, Ashraf...> ;Respiratory Research. 2022 Nov 14
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Grant Support

Merit Review Award "Modulation of steroid immunosuppression by alveolar efferocytosis"Department of Veterans Affairs (Clinical Studies Research & Development)2015–Present
“Understanding the Lung Microbiome in HIV-Infected & HIV-Uninfected Individuals”National Heart, Lung & Blood Institute (NHLBI)2009–Present
Apoptotic T Cell Clearance From Murine LungsNational Heart, Lung, And Blood Institute2001–2010
Innate And Adaptive Immunity In COPD ExacerbationsNational Heart, Lung, And Blood Institute2005–2009
T Cell Adhesion Molecules In Murine Lupus PneumonitisNational Heart, Lung, And Blood Institute1999–2002
Pulmonary Lymphocyte Apoptosis And Cell Cycle ArrestNational Heart, Lung, And Blood Institute1996–2000