Jeffrey Ryan Gehlhausen MD PhD

Summary

• Jeff Gehlhausen, MD, PhD, is an Assistant Professor of Dermatology and Pathology at Yale School of Medicine, Director of the Yale Autoimmune Skin Disease Clinic, and a physician-scientist focused on autoimmune and inflammatory skin disease. His research program integrates single-cell genomics, spatial transcriptomics, computational biology, and mechanistic immunology to define how tissue-intrinsic inflammatory circuits drive diseases such as cutaneous lupus erythematosus and dermatomyositis. A major focus of his laboratory is understanding how retroelements and other endogenous nucleic acid species activate innate immune sensing pathways and type I interferon programs within skin-resident cells, with the goal of identifying mechanisms that explain disease activity, treatment response, and therapeutic resistance. Clinically, Dr. Gehlhausen leads a specialized autoimmune dermatology clinic and practices dermatopathology with an emphasis on inflammatory and autoimmune dermatoses, bridging patient care, morphologic diagnosis, and molecular profiling of diseased tissue. His work is directed toward developing more precise biomarkers and therapeutic strategies for patients with autoimmune skin disease.