JeffreyRandallHoltMD

PubMed

• 3 citations
  Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.
  Carl Nist-Lund, Bifeng Pan, Amy L. Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B. Polley, Gwenaëlle S. G. Géléoc, J...> ;Nature Communications. 2019 Feb 8
• 184 citations
  TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.
  Bifeng Pan, Nurunisa Akyuz, Xiao-Ping Liu, Yukako Asai, Carl Nist-Lund, Kiyoto Kurima, Bruce Derfler, Bence György, Walrati Limapichat, Sanket Walujkar, Lahiru N. Wima...> ;Neuron. 2018 Aug 22
• 17 citations
  Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.
  Hiroshi Nakanishi, Kiyoto Kurima, Bifeng Pan, Philine Wangemann, Tracy S. Fitzgerald, Gwenaëlle S. G. Géléoc, Jeffrey R. Holt, Andrew J. Griffith> ;Scientific Reports. 2018 Aug 14
• 23 citations
  Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1
  Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, G...> ;Scientific Reports. 2018 Aug 14
• 324 citations
  Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
  Xue Gao, Yong Tao, Veronica Lamas, Mingqian Huang, Wei-Hsi Yeh, Bifeng Pan, Yujuan Hu, Johnny Hao Hu, David B. Thompson, Yilai Shu, Yamin Li, Hongyang Wang, Shiming Ya...> ;Nature. 2018 Jan 11
• 35 citations
  Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells
  David P. Corey, Jeffrey R. Holt> ;The Journal of Neuroscience. 2016 Oct 26
• 65 citations
  Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
  Xiao-Ping Liu, Karl R. Koehler, Andrew M. Mikosz, Eri Hashino, Jeffrey R. Holt> ;Nature Communications. 2016 May 24
• 3 citations
  Plug-N-Play: Mechanotransduction Goes Modular
  Nurunisa Akyuz, Jeffrey R. Holt> ;Neuron. 2016 Mar 16
• 165 citations
  Sound Strategies for Hearing Restoration
  Gwenaëlle S. G. Géléoc, Jeffrey R. Holt> ;Science. 2014 May 9
• 47 citations
  Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice
  Junhuang Zou, Tihua Zheng, Chongyu Ren, Charles Askew, Xiao Ping Liu, Bifeng Pan, Jeffrey R. Holt, Yong Wang, Jun Yang> ;Human Molecular Genetics. 2014 May 1
• 25 citations
  TMC function in hair cell transduction.
  Jeffrey R. Holt, Bifeng Pan, Mounir A. Koussa, Yukako Asai> ;Hearing Research. 2014 May 1
• 28 citations
  Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.
  Geoffrey C. Horwitz, Jessica R. Risner-Janiczek, Jeffrey R. Holt> ;The Journal of General Physiology. 2014 Apr 1
• 30 citations
  Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear
  Ye-Hyun Kim, Jeffrey R. Holt> ;The Journal of General Physiology. 2013 Sep 1
• 283 citations
  TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.
  Bifeng Pan, Gwenaëlle S. G. Géléoc, Yukako Asai, Geoffrey C. Horwitz, Kiyoto Kurima, Kotaro Ishikawa, Yoshiyuki Kawashima, Andrew J. Griffith, Jeffrey R. Holt> ;Neuron. 2013 Aug 7
• 7 citations
  Gene Therapy for Deaf Mice Goes Viral
  Jeffrey R. Holt, Luk H. Vandenberghe> ;Molecular Therapy. 2012 Oct 1
• 42 citations
  The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene
  Ruishuang Geng, Sami Melki, Daniel H.-C. Chen, Guilian Tian, David N. Furness, Tomoko Oshima-Takago, Jakob Neef, Tobias Moser, Charles Askew, Geoff Horwitz, Jeffrey R....> ;The Journal of Neuroscience. 2012 Jul 11
• 10 citations
  The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear
  Michaela E. Levin, Jeffrey R. Holt> ;Journal of Neurophysiology. 2012 Jul 1
• 281 citations
  Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes
  Yoshiyuki Kawashima, Gwenaëlle S. G. Géléoc, Kiyoto Kurima, Valentina Labay, Andrea Lelli, Yukako Asai, Tomoko Makishima, Doris K. Wu, Charles C. Della Santina, Jeffre...> ;The Journal of Clinical Investigation. 2011 Dec 1
• 39 citations
  HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function
  Geoffrey C. Horwitz, Jessica R. Risner-Janiczek, Sherri M. Jones, Jeffrey R. Holt> ;The Journal of Neuroscience. 2011 Nov 16
• 27 citations
  Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells
  Katherine A. Steigelman, Andrea Lelli, Xudong Wu, Jiangang Gao, Susan Lin, Klaus Piontek, Claas Wodarczyk, Alessandra Boletta, Hyunho Kim, Feng Qian, Gregory G. Germin...> ;The Journal of Neuroscience. 2011 Aug 24
• 72 citations
  Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human
  Nikoletta Charizopoulou, Andrea Lelli, Margit Schraders, Kausik Ray, Michael S. Hildebrand, Arabandi Ramesh, C. R. Srikumari Srisailapathy, Jaap Oostrik, Ronald J.C. A...> ;Nature Communications. 2011 Feb 15
• 43 citations
  Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.
  Andrea Lelli, Piotr Kazmierczak, Yoshiyuki Kawashima, Ulrich Müller, Jeffrey R. Holt> ;The Journal of Neuroscience. 2010 Aug 25
• 31 citations
  A Quantitative Analysis of the Spatiotemporal Pattern of Transient Receptor Potential Gene Expression in the Developing Mouse Cochlea
  Yukako Asai, Jeffrey R. Holt, Gwenaëlle S. G. Géléoc> ;Journal of the Association for Research in Otolaryngology. 2010 Mar 1
• 23 citations
  HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.
  Geoffrey C. Horwitz, Andrea Lelli, Gwenaëlle S. G. Géléoc, Jeffrey R. Holt> ;Plos One. 2010 Jan 7
• 23 citations
  Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells
  Huawei Li, Hong Liu, C. Eduardo Corrales, Jessica R. Risner, Jeff Forrester, Jeffrey R. Holt, Stefan Heller, Albert S.B. Edge> ;BMC Neuroscience. 2009 Sep 24
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