JeffreySHyamsMD

Pediatric Gastroenterology • Hartford, CT

Head, Div of Digestive Diseases, Hepatology and Nutrition Professor of Pediatrics

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Office
282 Washington St
Hartford, CT 06106
Phone(860) 545-9560
Fax(860) 545-9561
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Education & Training

Boston Children's HospitalFellowship, Gastroenterology, 1978 - 1980
Boston Children's HospitalResidency, Pediatrics, 1975 - 1978
Perelman School of Medicine at the University of PennsylvaniaClass of 1975

Certifications & Licensure

CT State Medical License 1980 - 2022
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Gastroenterology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Anti-TNF Therapy for Refractory Colitis in Hospitalized Children Start of enrollment: 2016 May 01Michael J Rosen, MD, MSCI
Predicting Response to Standardized Pediatric Colitis Therapy Start of enrollment: 2012 Jun 01Bookser, A.,Rutherford, A.,Griffiths, A.,Langseder, A.,Otley, A.,Patel, A.,Bancroft, B.,Skaggs, B.,Sudel, B.,MacIntyre, B.,Boyle, B.,Liriano, C.,Sauer, C.,Roach, C.,Bryant, C.,Womack-Ramirez, C.,Keljo, D....
Pediatric Alliance for International Neurogastrointestinal Functional Research Registry Start of enrollment: 2010 Apr 01Ballam, S.,Benninga, M.,Hyams, J.,Hyman, P.,Lorenzo, C.D.,Saps, M.,Sood, M.
Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry Start of enrollment: 2002 Jan 01Abadom, V.,Atkins, C.,Augustin, J.,Bachan, D.,Bancroft, B.,Boyer, K.,Carper, P.,Cochlin-Kacheiries, K.,Decker, A.,Dicaire, R.,Fernandez, M.,Frost, K.,Galloway, C.,Haskett, J.,Huffman, S.,Hyams, J.S.,Knigh...
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION) Phillip Minar, MD, MS

Publications & Presentations

PubMed

Electrocautery Incisional Therapy for an Atypical Esophageal Stricture in a Previously Healthy Patient.
Chelsea A Lepus, Michael Karasik, Douglas Moote, Jeffrey S. Hyams> ;Journal of Pediatric Gastroenterology and Nutrition. 2021 Feb 1
Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease.
Ye Xiong, Tomoyuki Mizuno, Ruben J Colman, Jeffrey S. Hyams, Joshua D. Noe, Brendan M. Boyle, Yi-Ting Tsai, Min Dong, Kimberly Jackson, N. C. Punt, Michael J. Rosen, L...> ;Clinical Pharmacology & Therapeutics. 2021 Jan 7
Colonic epithelial-derived Selenoprotein P is the source for antioxidant-mediated protection in colitis-associated cancer.
Sarah P. Short, Jennifer M. Pilat, Caitlyn W. Barrett, Vishruth K. Reddy, Yael Haberman, Jared Hendren, Benjamin J. Marsh, Cody E. Keating, Amy K. Motley, Kristina E. ...> ;Gastroenterology. 2021 Jan 1
Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn's disease.
Ryan C. Ungaro, Liangyuan Hu, Jiayi Ji, Shikha Nayar, Subra Kugathasan, Lee A. Denson, Jeffrey S. Hyams, Marla Dubinsky, Bruce E. Sands, Judy H. Cho> ;Alimentary Pharmacology & Therapeutics. 2020 Nov 1
Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease.
Ruben J. Colman, Yi-Ting Tsai, Kimberly Jackson, Brendan M. Boyle, Joshua D. Noe, Jeffrey S. Hyams, Geert R. D'Haens, Johan Van Limbergen, Michael J. Rosen, Lee A. Den...> ;Inflammatory Bowel Diseases. 2020 Sep 18
Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease.
Yael Haberman, Phillip Minar, Rebekah Karns, Phillip J. Dexheimer, Sudhir Ghandikota, Samuel Tegge, Daniel Shapiro, Brianne Shuler, Suresh Venkateswaran, Tzipi Braun, ...> ;Journal of Crohns & Colitis. 2020 Aug 8
Natural History of Very Early Onset Inflammatory Bowel Disease in North America: A Retrospective Cohort Study.
Basavaraj Kerur, Eric I. Benchimol, Karoline Fiedler, Marisa G. Stahl, Jeffrey S. Hyams, Michael C. Stephens, Ying Lu, Marian Pfefferkorn, Raza Alkhouri, Jennifer A. S...> ;Inflammatory Bowel Diseases. 2020 May 9
Cloning of ground-state intestinal stem cells from endoscopic biopsy samples.
Duleba, M., Yamamoto, Y., Neupane, R., Rao, W., Xie, J., Qi, Y., Liew, A., Niroula, S., Zhang, Y., Mahalingam, R., Wang, S., Goller, K., Ajani, J. A., Vincent, M., Ho,...> ;Nature protocols. 2020 Apr 3
Special considerations for biologic medications in pediatric ulcerative colitis
Logan Jerger, Jeffrey S. Hyams> ;Expert Opinion on Biological Therapy. 2020 Apr 1
Primary Cutaneous Follicle Center Lymphoma in a 16-Year-old boy With Crohn Disease Exposed to Infliximab and Methotrexate.
Sayej, W. N., Isakoff, M. S., DiGiuseppe, J. A., Moote, D., Balarezo, F., Finck, C., Hyams, J. S.> ;Journal of pediatric gastroenterology and nutrition. 2020 Jan 25
Development and Validation of the Mucosal Inflammation Noninvasive Index For Pediatric Crohn’s Disease
Martinus A. Cozijnsen, Assaf Ben Shoham, Ben Kang, Byung Ho Choe, Yon Ho Choe, Maria M.E. Jongsma, Richard K. Russell, Frank M. Ruemmele, Johanna C. Escher, Lissy de R...> ;Clinical Gastroenterology and Hepatology. 2020 Jan 1
Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary.
Dan Turner, Anne M. Griffiths, David C. Wilson, Diane R. Mould, Robert N. Baldassano, Richard K. Russell, Marla Dubinsky, Melvin B. Heyman, Lissy de Ridder, Jeffrey S....> ;Gut. 2020 Jan 1
Serologic, but Not Genetic, Markers Are Associated With Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease.
Sara K. Naramore, William E. Bennett, Guanglong Jiang, Subra Kugathasan, Lee A. Denson, Jeffrey S. Hyams, Steven J. Steiner> ;Journal of Pediatric Gastroenterology and Nutrition. 2019 Nov 1
Characterizing Clinical Features and Creating a Gene Expression Profile Associated With Pain Burden in Children With Inflammatory Bowel Disease.
Grossi, V., Hyams, J. S., Glidden, N. C., Knight, B. E., Young, E. E.> ;Inflammatory bowel diseases. 2019 Oct 19
Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis.
Rafal Tokarz, Jeffrey S. Hyams, David R. Mack, Brendan M. Boyle, Anne M. Griffiths, Neal S. Leleiko, Cary G. Sauer, Sapana Shah, James Markowitz, Susan S. Baker, Joel ...> ;Inflammatory Bowel Diseases. 2019 Sep 18
Health Care Cost for Children Newly Diagnosed With Inflammatory Bowel Disease.
Fondell, A. W., Mosha, M. H., Frank, C. R., Brangi, J. M., Hyams, J. S.> ;Inflammatory bowel diseases. 2019 Sep 11
Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.
Martin, J. C., Chang, C., Boschetti, G., Ungaro, R., Giri, M., Grout, J. A., Gettler, K., Chuang, L., Nayar, S., Greenstein, A. J., Dubinsky, M., Walker, L., Leader, A...> ;Cell. 2019 Sep 3
Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis.
Carmody, J. K., Plevinsky, J., Peugh, J. L., Denson, L. A., Hyams, J. S., Lobato, D., LeLeiko, N. S., Hommel, K. A.> ;Alimentary pharmacology & therapeutics. 2019 Aug 3
Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study.
Chenthan Krishnakumar, Cortney R. Ballengee, Chunyan Liu, Mi-Ok Kim, Susan S. Baker, Robert N. Baldassano, Stanley A. Cohen, Wallace Crandall, Lee A. Denson, Marla Dub...> ;Inflammatory Bowel Diseases. 2019 Jun 18
Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation
Hari K. Somineni, Suresh Venkateswaran, Varun Kilaru, Urko M. Marigorta, Angela Mo, David T. Okou, Richard Kellermayer, Kajari Mondal, Dawayland O. Cobb, Thomas D. Wal...> ;Gastroenterology. 2019 Jun 1
Challenges in IBD Research: Environmental Triggers.
Shuk-Mei Ho, James D. Lewis, Emeran A. Mayer, Scott E. Plevy, Emil Chuang, Stephen M. Rappaport, Kenneth Croitoru, Joshua R. Korzenik, Jeffrey P. Krischer, Jeffrey S. ...> ;Inflammatory Bowel Diseases. 2019 May 16
Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease.
Jing Wu, David M. Lubman, Subra Kugathasan, Lee A. Denson, Jeffrey S. Hyams, Marla Dubinsky, Anne M. Griffiths, Robert N. Baldassano, Joshua D. Noe, Shervin Rabizadeh,...> ;The American Journal of Gastroenterology. 2019 May 1
Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study.
Jeffrey S. Hyams, Sonia Davis Thomas, Nathan Gotman, Yael Haberman, Rebekah Karns, Melanie Schirmer, Angela Mo, David R. Mack, Brendan M. Boyle, Anne M. Griffiths, Nea...> ;The Lancet. 2019 Apr 27
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established...
Yael Haberman, Melanie Schirmer, Phillip Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel R. Rosh, James ...> ;Mucosal Immunology. 2019 Mar 1
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease.
Lee A. Denson, Ingrid Jurickova, Rebekah Karns, Kelly A. Shaw, David J. Cutler, David T. Okou, C. Alexander Valencia, Anne Dodd, Kajari Mondal, Bruce J. Aronow, Yael H...> ;Inflammatory Bowel Diseases. 2019 Feb 21
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