JeffreyLKaineMD

Rheumatology • Venice, FL

Physician

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Office
411 Commercial Ct
Ste C
Venice, FL 34292
Phone+1 941-484-4409

Fax+1 941-485-3444
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Rheumatology, 1983 - 1984
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1979 - 1983
Yale School of MedicineClass of 1979

Certifications & Licensure

NC State Medical License 2020 - 2025
FL State Medical License 1986 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

Sarasota Magazine: Top Doctors Castle Connolly, 2004-2006, 2009-2014
CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2013
Top Doctors: Florida Castle Connolly, 2000
Fellow (FACR) American College of Rheumatology
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Clinical Trials

A Multi-center Study a Single IV Infusion of Allogeneic MPCs in Patients With Rheumatoid Arthritis and Incomplete Response to at Least One TNFα Inhibitor Start of enrollment: 2013 Jul 01
Completed
Phase 2
Phase IIB Dose Ranging Study in Subjects With Moderate to Severe Rheumatoid Arthritis Start of enrollment: 2012 Jun 01
Completed
Phase 2
A Study of LY3337641 in Rheumatoid Arthritis Start of enrollment: 2016 Aug 22
Terminated
Phase 2
A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Start of enrollment: 2016 May 02
Completed
Phase 3
A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Start of enrollment: 2016 Apr 12
Completed
Phase 3
A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Start of enrollment: 2016 Aug 02
Completed
Phase 3
A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Start of enrollment: 2017 May 09
Completed
Phase 3
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Publications & Presentations

PubMed

13 citations
Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials...
Vibeke Strand, Jeffrey L. Kaine, Rieke Alten, Gene V. Wallenstein, Annette Diehl, Harry Shi, Rebecca Germino, Christopher W. Murray> ;Arthritis Research & Therapy. 2020 Oct 15
52 citations
Understanding differences between men and women with axial spondyloarthritis.
Grace C. Wright, Jeffrey L. Kaine, Atul Deodhar> ;Seminars in Arthritis and Rheumatism. 2020 Aug 1
13 citations
Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis.
Jeffrey L. Kaine, John Tesser, Liza Takiya, Ryan DeMasi, Lisy Wang, M. Snyder, Koshika Soma, Haiyun Fan, Vara Bandi, Jürgen Wollenhaupt> ;Clinical Rheumatology. 2020 Feb 12
8 citations
Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 ...
Paul Bird, William G. Bensen, Bassel Elzorkany, Jeffrey L. Kaine, Bernadette Heizel Manapat-Reyes, k Virginia Pascual-Ramos, David Witcombe, Koshika Soma, Richard Zhan...> ;Journal of Clinical Rheumatology. 2019 Apr 1
29 citations
A pooled analysis of the safety of tofacitinib as monotherapy or in combination with background conventional synthetic disease-modifying antirheumatic drugs in a Phase...
Alan Kivitz, Stanley Cohen, Edward C. Keystone, Ronald F van Vollenhoven, Boulos Haraoui, Jeffrey L. Kaine, Haiyun Fan, Carol A. Connell, Eustratios Bananis, Liza Taki...> ;Seminars in Arthritis and Rheumatism. 2018 Jul 19
47 citations
Long-Term Safety of Subcutaneous Abatacept in Rheumatoid Arthritis: Integrated Analysis of Clinical Trial Data Representing More Than Four Years of Treatment
Rieke Alten, Jeffrey L. Kaine, Edward C. Keystone, Peter Nash, Ingrid Delaet, Mark C. Genovese> ;Arthritis & Rheumatology. 2014 Aug 1
84 citations
A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-...
David Martin, Melvin Churchill, Luis Felipe Flores-Suárez, Mario H. Cardiel, Daniel J. Wallace, Richard J. Martin, Kristine Phillips, Jeffrey L Kaine, Hua Dong, David ...> ;Arthritis Research & Therapy. 2013 Oct 25
61 citations
Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: results from...
Maria Greenwald, William Shergy, Jeffrey L. Kaine, Marianne T. Sweetser, Kye Gilder, Matthew D. Linnik> ;Arthritis and Rheumatism. 2011 Mar 1
56 citations
Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and...
Jeffrey L. Kaine, Geoffrey Gladstein, Ingrid Strusberg, Manuel Robles, Ingrid Louw, Sheila Gujrathi, Ramesh Pappu, Ingrid Delaet, Miranda Pans, Charles Ludivico> ;Annals of the Rheumatic Diseases. 2012 Jan 1
153 citations
Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I/II randomized, blinded, placebo-controlled, d...
Mark C. Genovese, Jeffrey L. Kaine, Mitchell B. Lowenstein, Jose Del Giudice, Andrew R. Baldassare, Joy Schechtman, Edward J. Fudman, Michael Kohen, Sheila Gujrathi, R...> ;Arthritis and Rheumatism. 2008 Sep 1
11 citations
Abatacept for the treatment of rheumatoid arthritis: A review.
Jeffrey L. Kaine> ;Current Therapeutic Research, Clinical and Experimental. 2007 Nov 1
195 citations
Immune responses following administration of influenza and pneumococcal vaccines to patients with rheumatoid arthritis receiving adalimumab.
Jeffrey L Kaine, Alan Kivitz, C. Birbara, Allison Y Luo> ;The Journal of Rheumatology. 2007 Feb 1
80 citations
Efficacy and safety of tacrolimus in patients with rheumatoid arthritis: a double-blind trial.
David E. Yocum, Daniel E. Furst, Jeffrey L. Kaine, Andrew R. Baldassare, Jon T Stevenson, Mary Ann Borton, Laurel J Mengle-Gaw, Benjamin D Schwartz, Wayne Wisemandle, ...> ;Arthritis and Rheumatism. 2003 Dec 1
47 citations
Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: a six-month, open-label study.
Joel M. Kremer, Joseph S Habros, Karen S. Kolba, Jeffrey L. Kaine, Mary Ann Borton, Laurel J Mengle-Gaw, Benjamin D Schwartz, Wayne Wisemandle, Qais A Mekki> ;Arthritis and Rheumatism. 2003 Oct 1
264 citations
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial
Joel M. Kremer, Mark C. Genovese, Grant W. Cannon, Jacques Caldwell, John J. Cush, Daniel E. Furst, Michael E. Luggen, E.C. Keystone, Michael H. Weisman, William M. Be...> ;Annals of Internal Medicine. 2002 Nov 5
85 citations
Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: A six-month, double-blind, randomized, dose-ranging study
Daniel E. Furst, Kenneth G. Saag, Roy M. Fleischmann, Yvonne Sherrer, Joel A. Block, Thomas J. Schnitzer, Joel Rutstein, Andrew R. Baldassare, Jeffrey L. Kaine, Leonar...> ;Arthritis and Rheumatism. 2002 Aug 1
205 citations
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate
Stanley Cohen, Grant W. Cannon, Michael Schiff, Arthur L. Weaver, Robert I. Fox, Nancy J. Olsen, Daniel E. Furst, John T. Sharp, Larry W. Moreland, Jacques Caldwell, J...> ;Arthritis and Rheumatism. 2001 Sep 1
13 citations
Treatment of elderly patients with nabumetone or diclofenac: gastrointestinal safety profile.
G. Morgan, Jeffrey Kaine, Ralph DeLapp, Robert H. Palmer> ;Journal of Clinical Gastroenterology. 2001 Apr 1
119 citations
The rapid assessment of disease activity in rheumatology (radar) questionnaire. Validity and sensitivity to change of a patient self-report measure of joint count and ...
John H. Mason, Jennifer J. Anderson, Robert F. Meenan, Kathleen M. Haralson, Donna Lewis-Stevens, Jeffrey L. Kaine> ;Arthritis and Rheumatism. 1992 Feb 1
61 citations
Idiotypic characteristics of immunoglobulins associated with systemic lupus erythematosus. Studies of antibodies deposited in glomeruli of humans.
Kenneth C. Kalunian, Niver Panosian-Sahakian, Fanny M. Ebling, Arthur H. Cohen, James S. Louie, Jeffrey L. Kaine, Bevra H. Hahn> ;Arthritis and Rheumatism. 1989 May 1
83 citations
Ro (SS-A) antibody and antigen in a patient with congenital complete heart block.
John B. Harley, Jeffrey L. Kaine, Owen F. Fox, Morris Reichlin, Barry L. Gruber> ;Arthritis and Rheumatism. 1985 Dec 1
2 citations
Detection of human autoantibodies specific for 5'-m7GMP and m7G(5')ppp(5')N.
Theodore W. Munns, M. Kathryn Liszewski, Sandra K. Freeman, Jeffrey L. Kaine> ;Biochemical and Biophysical Research Communications. 1985 Apr 30
8 citations
The kinetics of specific glucocorticoid binding in rat thymus cytosol: evidence for the existence of multiple binding states.
Jeffrey L. Kaine, Carl J. Nielsen> ;Molecular Pharmacology. 1975 Sep 1
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group.
Strand, V., Cohen, S., Schiff, M., Weaver, A., Fleischmann, R., Cannon, G., Fox, R., Moreland, L., Olsen, N., Furst, D., Caldwell, J., Kaine, J., Sharp, J., Hurley, F....> ;Arch Intern Med. 1999 Nov 22
Refractory massive pleural effusion in systemic lupus erythematosus treated with talc poudrage.
Kaine, J. L.> ;Ann Rheum Dis. 1985 Jan 01
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Press Mentions

The Negative Consequences of a Missed DiagnosisAugust 26th, 2019

Professional Memberships

American College of Rheumatology - ACR
Fellow

Hospital Affiliations

Sarasota Memorial Hospital - SarasotaSarasota, Florida