JeffreyJamesRadeMD

Cardiology • Worcester, MA

Adult Congenital Heart Disease, Interventional Cardiology

Physician

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Office
55 Lake Ave N
Worcester, MA 01655
Phone+1 774-441-6310

Fax+1 774-441-6303
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Education & Training

Johns Hopkins UniversityFellowship, Cardiovascular Disease, 1992 - 1997
Johns Hopkins UniversityResidency, Internal Medicine, 1989 - 1992
Case Western Reserve University School of MedicineClass of 1989

Certifications & Licensure

MA State Medical License 2011 - 2025
MD State Medical License 1992 - 2017
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Interventional Cardiology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Fellow (FACC) American College of Cardiology

Clinical Trials

Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Start of enrollment: 2012 Nov 13
Terminated
Phase 1, Phase 2
Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention Start of enrollment: 2016 May 27
Completed
Phase 2
Thromboxane Receptor Antagonist to Improve Endothelial Cell Function Start of enrollment: 2019 Sep 20
Active, not recruiting
Phase 2

Publications & Presentations

PubMed

2 citations
Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure.
Essa Hariri, Nikolaos Kakouros, David A Bunsick, Stuart D Russell, James O Mudd, Katherine Laws, Mikhailia W Lake, Jeffrey J Rade> ;American Journal of Physiology. Heart and Circulatory Physiology. 2022 Jul 1
11 citations
Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers.
Jeffrey J Rade, Bruce A Barton, Ramachandran S Vasan, Shari S Kronsberg, Vanessa Xanthakis, John F Keaney Jr, Naomi M Hamburg, Nikolaos Kakouros, Thomas A Kickler> ;Journal of the American College of Cardiology. 2022 Jul 19
103 citations
SARS-CoV-2 Initiates Programmed Cell Death in Platelets.
Milka Koupenova, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Rohan Bhandari, Matthew Godwin, Krishna Mohan Pars...> ;Circulation Research. 2021 Sep 3
1 citations
Evaluation of a Real-World In-Hospital Antiplatelet-Switching Strategy Following Coronary Interventions: The SWITCH Study.
Antoine Soueid, Ibrahim Kassas, Jeffrey J. Rade, Nikolaos Kakouros> ;The Journal of Invasive Cardiology. 2021 Apr 1
4 citations
Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Dis...
Elizabeth K. Fletcher, Yanling Wang, Laura K. Flynn, Susan E. Turner, Jeffrey J. Rade, Carey Kimmelstiel, Paul A. Gurbel, Kevin P. Bliden, Lidija Covic, Athan Kuliopulos> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 May 5
5 citations
Comparison of Prevalence, Presentation, and Prognosis of Acute Coronary Syndromes in ≤35 years, 36 - 54 years, and ≥ 55 years Patients.
Waqas Qureshi, Nikolaos Kakouros, Joe Fahed, Jeffrey J. Rade> ;The American Journal of Cardiology. 2021 Feb 1
13 citations
PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac ...
Athan Kuliopulos, Paul A. Gurbel, Jeffrey J. Rade, Carey Kimmelstiel, Susan E. Turner, Kevin P. Bliden, Elizabeth K. Fletcher, Daniel H. Cox, Lidija Covic> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Oct 8
5 citations
Post myocardial infarction complications during the COVID-19 pandemic - A case series.
Waqas Qureshi, Summer Aldrugh, Adedotun Ogunsua, Colleen Harrington, Wahaj Aman, Leora B. Balsam, Biswajit Kar, Gerard P. Aurigemma, Amartya Kundu, Nirmal Kaur, Craig ...> ;Cardiovascular Revascularization Medicine. 2021 Jul 1
57 citations
Impact of COVID-19 pandemic on STEMI care: An expanded analysis from the United States.
Santiago Garcia, Larissa Stanberry, Christian W. Schmidt, Scott Sharkey, Michael Megaly, Mazen Albaghdadi, Perwaiz Meraj, Ross Garberich, Farouc A. Jaffer, Ada C. Stef...> ;Catheterization and Cardiovascular Interventions. 2021 Aug 1
852 citations
Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States During COVID-19 Pandemic.
Santiago Garcia, Mazen Albaghdadi, Perwaiz Meraj, Christian W. Schmidt, Ross Garberich, Farouc A. Jaffer, Simon R. Dixon, Jeffrey J. Rade, Mark Tannenbaum, Jenny Chamb...> ;Journal of the American College of Cardiology. 2020 Jun 9
Are We Optimizing the Use of Dual Antiplatelet Therapy in Patients Hospitalized with Acute Myocardial Infarction
Essa Hariri, Darleen M. Lessard, Joel M. Gore, Jeffrey J. Rade, Robert J. Goldberg> ;Cardiovascular Revascularization Medicine. 2020 Feb 1
4 citations
ST-Segment Elevation Myocardial Infarction and Out-of-Hospital Cardiac Arrest: Contemporary Management From the Multicenter START Registry.
Meena Zareh, Jeffrey J. Rade, Joseph L. Thomas, Atman P. Shah, Ankush Chhabra, Jordan Prutkin, Zach Shinar, Michael K. Abraham, Nathan Deal, Dick C. Kuo, David Pearson...> ;The Journal of Invasive Cardiology. 2020 Jan 15
177 citations
The role of platelets in mediating a response to human influenza infection.
Milka Koupenova, Heather A. Corkrey, Olga Vitseva, Giorgia Manni, Catherine J. Pang, Lauren Clancy, Chen Yao, Jeffrey J. Rade, Daniel Levy, Jennifer P. Wang, Robert W....> ;Nature Communications. 2019 Apr 16
32 citations
Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis
Rajashree Rana, Tianfang Huang, Georgios Koukos, Elizabeth K. Fletcher, Susan E. Turner, Andrew Shearer, Paul A. Gurbel, Jeffrey J. Rade, Carey Kimmelstiel, Kevin P. B...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 Jan 1
3 citations
Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long-Term Outcome After Cardiac Surgery.
Nikolaos Kakouros, Tyler J Gluckman, John V. Conte, Thomas S. Kickler, Katherine Laws, Bruce A. Barton, Jeffrey J. Rade> ;Journal of the American Heart Association. 2017 Nov 2
11 citations
Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery
Nikolaos Kakouros, Susanna M. Nazarian, Patrizia B. Stadler, Thomas S. Kickler, Jeffrey J. Rade> ;Journal of the American Heart Association. 2016 Mar 1
3 citations
Role of Fractional-Flow Reserve in Guiding Percutaneous Revascularization in Stable Coronary Artery Disease
Nikolaos Kakouros, Jeffrey J. Rade> ;Current Atherosclerosis Reports. 2015 Jul 24
4 citations
FFR-guided PCI - FAME may not be so fleeting after all
Jeffrey J. Rade> ;The New England Journal of Medicine. 2014 Sep 24
6 citations
Operator and institutional experience reduces room-to-balloon times for transradial primary percutaneous coronary intervention.
Kurt G. Barringhaus, Mohammed W. Akhter, Jeffrey J. Rade, Craig S. Smith, Daniel Z. Fisher> ;The Journal of Invasive Cardiology. 2014 Feb 1
4 citations
Routine thienopyridine pretreatment for acute coronary syndrome without ST elevation
Jeffrey J. Rade> ;BMJ. 2014 Oct 24
13 citations
Thromboxane A2 Generation, in the Absence of Platelet COX-1 Activity, in Patients With and Without Atherothrombotic Myocardial Infarction
Andrew P. DeFilippis, Oluwasegun S. Oloyede, Efstathia Andrikopoulou, Amy K. Saenger, Joel M Palachuvattil, Yetunde A. Fasoro, Eliseo Guallar, Roger S. Blumenthal, Tho...> ;Circulation Journal. 2013 Oct 25
42 citations
Hematocrit alters VerifyNow P2Y12 assay results independently of intrinsic platelet reactivity and clopidogrel responsiveness.
Nikolaos Kakouros, Thomas S. Kickler, Katherine Laws, Jeffrey J. Rade> ;Journal of Thrombosis and Haemostasis. 2013 Oct 1
5 citations
Human Thromboxane A2 Receptor Genetic Variants: In Silico, In Vitro and “In Platelet” Analysis
Scott Gleim, Jeremiah Stitham, Wai Ho Tang, Hong Li, Karen Douville, Prashen Chelikani, Jeffrey J. Rade, Kathleen A. Martin, John Hwa> ;Plos One. 2013 Jun 28
18 citations
Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk.
M. T. Olson, Thomas S. Kickler, John A. Lawson, Rhondalyn C. McLean, Jayesh Jani, Garret A. FitzGerald, Jeffrey J. Rade> ;Journal of Thrombosis and Haemostasis. 2012 Dec 1
8 citations
Platelet Function Testing in Patients With Coronary Artery Disease Is the Who and the When Any Clearer Than the What and the What Then
Jeffrey J. Rade> ;Circulation. 2012 Jun 26
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Grant Support

Hemodynamic Regulation Of ThromboresistanceNational Heart, Lung, And Blood Institute2010
Hemodynamic Regulation Of ThromboresistanceNational Heart, Lung, And Blood Institute2006–2010
Reduction In Graft Occlusion Rates (RIGOR) StudyNational Center For Research Resources2005–2007