JeffreyDavidRoizenMDPhD, FAAP

PubMed

• 5 citations
  A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity.
  Shana E McCormack, Zi Wang, Kristin L Wade, Anna Dedio, Nicolette Cilenti, Julia Crowley, Franziska Plessow, Vaneeta Bamba, Jeffrey D Roizen, Yaoguang Jiang, Jack Styl...> ;Journal of the Endocrine Society. 2023 Mar 6
• 8 citations
  Improved genetic risk scoring algorithm for type 1 diabetes prediction.
  Hui-Qi Qu, Jingchun Qu, Joseph Glessner, Yichuan Liu, Frank Mentch, Xiao Chang, Michael March, Jin Li, Jeffrey D Roizen, John J Connolly, Patrick Sleiman, Hakon Hakona...> ;Pediatric Diabetes. 2022 May 1
• 7 citations
  Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients
  Jingchun Qu, Hui-Qi Qu, Jonathan P. Bradfield, Joseph T. Glessner, Xiao Chang, Lifeng Tian, Michael E. March, John J. Connolly, Jeffrey D. Roizen, Patrick M. A. Sleima...> ;Scientific Reports. 2021 Aug 6
• 8 citations
  Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.
  Hui-Qi Qu, Jingchun Qu, Jonathan P. Bradfield, Luc Marchand, Joseph T. Glessner, Xiao Chang, Michael E. March, Jin Li, John J. Connolly, Jeffrey D. Roizen, Patrick M. ...> ;Communications Biology. 2021 Jul 23
• Combined application of genetic and polygenic risk scores for type 1 diabetes risk prediction
  Hui-Qi Qu, Jingchun Qu, Jonathan P. Bradfield, Joseph T. Glessner, Xiao Chang, Michael E. March, Frank D. Mentch, Jeffrey D. Roizen, John J. Connolly, Patrick M. A. Sl...> ;Diabetes, Obesity & Metabolism. 2021 Aug 1
• 5 citations
  Growth in Children with a Fontan Circulation
  Edna E. Mancilla, Benjamin Zielonka, Jeffrey D. Roizen, Kathryn Dodds, Elizabeth B. Rand, Jennifer Heimall, Feiyan Chen, Chao Wu, David J. Goldberg, Jack Rychik> ;The Journal of Pediatrics. 2021 Apr 19
• 4 citations
  Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score.
  Jingchun Qu, Hui-Qi Qu, Jonathan P. Bradfield, Joseph T. Glessner, Xiao Chang, Lifeng Tian, Michael E. March, Jeffrey D. Roizen, Patrick M. A. Sleiman, Hakon Hakonarson> ;Metabolism. 2021 Jan 1
• 3 citations
  Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis.
  Alex Casella, Caela Long, Jingman Zhou, Meizan Lai, Lauren O'Lear, Ilana Caplan, Michael A. Levine, Jeffrey D. Roizen> ;The Journal of Clinical Endocrinology and Metabolism. 2020 May 1
• 1 citations
  Vitamin D Therapy and the Era of Precision Medicine
  Jeffrey D. Roizen, Michael A. Levine> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Mar 1
• 2 citations
  Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD-/-) mice due to requirement for embryo 15-HPGD activity.
  Jeffrey D. Roizen, Minoru Asada, Min Tong, Hsin-Hsiung Tai, Louis J. Muglia> ;Scientific Reports. 2019 Nov 26
• Response to: Obesity and Vitamin D Metabolism Modifications.
  Jeffrey D. Roizen, Michael A. Levine> ;Journal of Bone and Mineral Research. 2019 Jul 1
• 77 citations
  Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D.
  Jeffrey D. Roizen, Caela Long, Alex Casella, Lauren O'Lear, Ilana Caplan, Meizan Lai, Issac Sasson, Ravinder J. Singh, Andrew J Makowski, Rebecca A. Simmons, Michael A...> ;Journal of Bone and Mineral Research. 2019 Feb 21
• 15 citations
  CLEC16A regulates splenocyte and NK cell function in part through MEK signaling
  Rahul Pandey, Marina Bakay, Heather S. Hain, Bryan Strenkowski, Barakat Z Elsaqa, Jeffrey D. Roizen, Jake A. Kushner, Jordan S. Orange, Hakon Hakonarson> ;Plos One. 2018 Sep 18
• 13 citations
  Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance.
  Jeffrey D. Roizen, Alex Casella, Meizan Lai, Caela Long, Zahra Tara, Ilana Caplan, Lauren O'Lear, Michael A. Levine> ;Endocrinology. 2018 Aug 1
• 55 citations
  CYP3A4 mutation causes Vitamin D-dependent rickets type 3
  Jeffrey D. Roizen, Dong Li, Lauren O'Lear, Muhammad Javaid, Nicholas Shaw, Peter R. Ebeling, Hanh H. Nguyen, Christine Rodda, Kenneth E. Thummel, Tom D. Thacher, Hakon...> ;The Journal of Clinical Investigation. 2018 May 1
• 27 citations
  Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response.
  Dong Xi, Caela Long, Meizan Lai, Alex Casella, Lauren O'Lear, Bassil Kublaoui, Jeffrey D. Roizen> ;Journal of the Endocrine Society. 2017 Aug 1
• 19 citations
  Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma
  Erik B. Hysinger, Jeffrey D. Roizen, Frank D. Mentch, Lyam Vazquez, John J. Connolly, Jonathan P. Bradfield, Berta Almoguera, Patrick M. A. Sleiman, Julian L. Allen, M...> ;The Journal of Allergy and Clinical Immunology. 2016 Dec 1
• 28 citations
  Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A
  Jeffrey D. Roizen, Jennifer Danzig, Veronique Groleau, Shana E. McCormack, Alex Casella, Jennifer Harrington, Etienne Sochett, Andrew M. Tershakovec, Babette S. Zemel,...> ;The Journal of Clinical Endocrinology and Metabolism. 2016 Mar 1
• 16 citations
  Progress in Understanding Type 1 Diabetes Through Its Genetic Overlap with Other Autoimmune Diseases
  Jeffrey D. Roizen, Jonathan P. Bradfield, Hakon Hakonarson> ;Current Diabetes Reports. 2015 Oct 10
• 61 citations
  CYP2R1 mutations impair generation of 25-hydroxyvitamin D and cause an atypical form of vitamin D deficiency
  Tom D. Thacher, Philip R. Fischer, Ravinder J. Singh, Jeffrey D. Roizen, Michael A. Levine> ;The Journal of Clinical Endocrinology and Metabolism. 2015 May 5
• 26 citations
  A meta-analysis comparing the biochemistry of primary hyperparathyroidism in youths to the biochemistry of primary hyperparathyroidism in adults.
  Jeffrey D. Roizen, Michael A. Levine> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Sep 2
• 3 citations
  Vitamin D and your patients: don't accept wimpy.
  Michael F. Roizen, Jeffrey D. Roizen> ;Anesthesia and Analgesia. 2014 Sep 1
• 1 citations
  Correction: Paraventricular Nucleus Sim1 Neuron Ablation Mediated Obesity Is Resistant to High Fat Diet
  Dong Xi, Jeffrey D. Roizen, Meizan Lai, Nilay Gandhi, Bassil Kublaoui> ;Plos One. 2014 Jan 6
• 12 citations
  Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.
  Dong Xi, Jeffrey D. Roizen, Meizan Lai, Nilay Gandhi, Bassil Kublaoui> ;Plos One. 2013 Nov 19
• 8 citations
  Determination of Reference Intervals for Serum Total Calcium in the Vitamin D-replete Pediatric Population
  Michael A Levine, Jeffrey D Roizen, Dean C Carlow> ;Endocrine Society. 2013 Nov 11
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Journal Articles

• Obesity Decreases Hepatic 25‐Hydroxylase Activity Causing Low Serum 25‐Hydroxyvitamin D  
  Michael A Levine, Jeffrey D Roizen, Journal of Bone and Mineral Research
• Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated with Reduced Hepatic Cyp2r1 Abundance  
  Jeffrey D Roizen, Michael A Levine, Endocrinology
• Progress in understanding type 1 diabetes through its genetic overlap with other autoimmune diseases  
  Roizen JD, Bradfield JB, Hakonarson H, Current Diabetes Reports, 1/1/2015
• A meta-analysis comparing the Biochemistry of Primary Hyperparathyroidism in Youths to the Biochemistry of Primary Hyperparathyroidism in Adults  
  Roizen, J. and Levine, MA, J Clin Endocrinol Metab, 1/1/2014
• Vitamin D and your patients: don't accept wimpy  
  Roizen, MF and Roizen JD, Anesth Analg, 1/1/2014
• Determination of reference intervals for serum total calcium in the vitamin D-replete pediatric population  
  Roizen JD, Shah V, Levine MA, Carlow DC, J Clin Endocrinol Metab, 1/1/2013
• Primary hyperparathyroidism in children and adolescents  
  Roizen J, Levine MA, Journal of the Chinese Medical Association, 1/1/2012
• Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice  
  Roizen JD, Asada M, Tong M, Tai HH, Muglia LJ, Mol Endo, 1/1/2007
• Understanding the Timing of Birth: The Continuing Challenge to Prevent Prematurity  
  Roizen JD, Muglia LJ, NeoReviews, 1/1/2006
• Modulation of Recombinant Small Conductance Ca2+-Activated K+ Channels by the Muscle Relaxant Chlorzoxazone and Structurally Related Compounds  
  Cao YJ, Dreixler JC, Roizen JD, Roberts MT, Houamed KM, Journal of Pharmacology and Experimental Therapeutics, 1/1/2001
• Patch-Clamp Analysis of Anesthetic Interactions with Recombinant, SK2 Subtype, Neuronal Calcium-Activated Potassium Channels  
  Dreixler JC, Cao YJ, Roberts MT, Roizen JD, Houamed KM, Anaesthesia and Analgesia, 1/1/2000
• Block of Recombinant Rat Brain SK Potassium Channels by Tricyclic Antidepressants and Structurally Related Compounds  
  Dreixler JC, Bian JT, Cao YJ, Roizen JD, Houamed KM, European Journal of Pharmacology, 1/1/2000
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Books/Book Chapters

• The Parathyroids 
  Chapter: Chapter 25, Primary Hyperparathyroidism in Children and Adolescents. 
  Page 389 - 399Roizen J, Levine MAElsevierEdition 3rd,2014
• 5-Minute Pediatric Consult. 
  Chapter: Growth Hormone Deficiency 
  Page 378 - 379Roizen JD, Alter CEditors: Schwartz MW.Lippincott Williams and WilkinsEdition 6th,2012
• 5-Minute Pediatric Consult. 
  Chapter: Panhypopitutarism 
  Page 620 - 621Roizen JD, Alter CEditors: Schwartz MW.Lippincott Williams and WilkinsEdition 6th,2012
• 5-Minute Pediatric Consult. 
  Chapter: Short Stature 
  Page 796 - 797Roizen JD, Bamba VEditors: Schwartz MW.Lippincott Williams and WilkinsEdition 6th,2012
• You(R) Teen: Losing Weight – The Owner’s Manual to Simple and Healthy Weight Management at Any Age. 
  Roizen MF, Rome E, Oz MC, with Ted Spiker, Craig Wynett, Zoe Oz, Linda G Kahn and Jeffrey D. RoizenFree Press, New York, NY2012
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Abstracts/Posters

• Common polymorphism in Vitamin D 25-hydroxylase gene (CYP2R1) abrogates promoter activity.
  Roizen JD, Casella A, Levine M, J Bone Miner Res; ASBMR, 1/1/2015
• Resting Energy Expenditure (REE) is Decreased in Pseudohypoparathyroidism Type 1A
  Roizen JD, Danzig J, Groleau V, Bhoj E, Mulchandani S, Casella A, Harrington J, Sochett E, Tershekovec A, Zemel B, Stallings V, Levine, M, University of Pennsylvania IDOM Annual Meeting, 1/1/2015
• Decreasing CYP2R1 activity with aging is responsible for decreased calcidiol response to calciferol supplementation with age.
  Roizen JD, Casella A, Levine M, Endocrine Reviews; ENDO Society, 1/1/2014
• Serum Total Calcium Concentrations in the Vitamin D replete Pediatric Population Clin Chem 2013.
  Roizen, JD, Levine, MA, Shah, V. and Carlow, D, Clin Chem; AACC, 1/1/2013
• Modulation of CYP2R1 Expression: A Potential Mechanism for Determining Vitamin D Requirements in Aging and Obesity.
  Roizen JD, Sasson, I, Levine M, Endocrine Reviews; ENDO Society, 1/1/2012
• Polymorphisms in the CYP2R1 Gene Present in the General Population Affect 25-hydroxylase Activity.
  Roizen, JD, Zhou, J and Levine, MA, J Bone Miner Res; ASBMR, 1/1/2012
• Nature and Nurture: Multifactoral rickets in two pre-school aged children.
  Roizen JD, Levine M, E-PAS; PAS, 1/1/2011
• 15-Hydroxyprostaglandin Dehydrogenase in Mouse Pregnancy.
  Roizen, JD, Asada M, Vogt S, Tong M, Tai HH, Muglia LJ, ENDO Society, 1/1/2005
• A molecular mechanism of action for neuroprotectants and paralytic drugs.
  Cao YJ, Dreixler J. C., Roizen JD., Roberts M.T., Houamed K. M., Anesthesiology, 1/1/2000
• Are SK channels the molecular target for action of antidepressants, anticonvulsants, and antipsychotics on neurons?
  Dreixler J. C., Bian JT, Cao YJ, Roizen JD., Houamed K. M., Anesthesiology, 1/1/2000
• Riluzole: Chlorzoxazone and analogs activate recombinant small conductance calcium activated potassium channels in a calcium independent manner.
  Dreixler J. C., Cao YJ, Roizen JD., Roberts M.T., Richardson J.L., Houamed K. M., Neuroscience Abs, 1/1/2000
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Lectures

• Vitamin D in Children and Hyper and Hypocalcemia in Children 
  Lancaster, PA - 1/8/2015
• Hypoparathyroidism, Pseudohypoparathyroidism and APS1 
  Sacramento, CA - 1/6/2014
• Exenetide (Byetta) Prevents Obesity in Mouse Model of Hypothalamic Obesity. 
  1/1/2014
• The Electronic Lab notebook: A case report. 
  Philadelphia, PA - 1/1/2012
• 15-Hydroxyprostaglandin Dehydrogenase in Mouse Pregnancy. 
  1/1/2006
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Other

• Metformin alters cardiometabolic fitness and may alter propensity to exercise. 
  Roizen JD, Pediatrics Online
  http://pediatrics.aappublications.org/content/131/3/e850.full/reply#pediatrics_el_55451
  1/25/2013
• Letter in Response to The Numbers Behind the Transit Strike 
  Roizen JD, The Wall Street Journal Online
  http://www.wsj.com/articles/SB113631113499836645
  New York, NY - 1/6/2006