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Jeffrey Rubens, MD, Oncology, Baltimore, MD, Johns Hopkins Hospital

JeffreyRubensMD

Oncology • Baltimore, MD

Neuro-Oncology

Physician

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Summary

  • I am a physician-scientist in the Department of Oncology at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. My research focuses on developing new, targeted therapies to improve survival in deadly pediatric brain tumors. Our group works to identify molecular pathways that aggressive pediatric brain tumors uniquely rely on to drive their tumorigenicity and drug resistance and describe the translatable efficacy of targeting these pathways to improve pediatric brain tumor survival. Our research groups has developed an important and unique niche in pediatric brain tumor research emphasizing epigenetics, metabolomics, tumor biology, and drug discovery. Our work has identified a reliance in MYC-drive AT/RT on glutamine metabolism for tumor growth and survival. We have demonstrated that the glutamine analogue, DON precisely targets MYC-driven AT/RT to improve survival in orthotopic models. We have also demonstrated a reliance on the mTOR pathway in AT/RT and the survival benefit treating mouse models with dual mTORC1/2 inhibitors. As our group works to translate these findings into new clinical trials, we continue to work in the lab to identify novel targets and develop new therapies to help better treat patients suffering from these deadly diseases.

    Complete list of publications: https://www.ncbi.nlm.nih.gov/myncbi/jeffrey.rubens.1/bibliography/public/

Education & Training

  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Neuro-Oncology, 2015 - 2017
  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Pediatric Hematology/Oncology, 2013 - 2016
  • McGaw Medical Center of Northwestern University
    McGaw Medical Center of Northwestern UniversityResidency, Pediatrics, 2009 - 2012
  • Georgetown University School of Medicine
    Georgetown University School of MedicineClass of 2009

Certifications & Licensure

  • MD State Medical License
    MD State Medical License 2017 - 2025
  • MA State Medical License
    MA State Medical License 2012 - 2017
  • IL State Medical License
    IL State Medical License 2009 - 2012
  • American Board of Pediatrics Pediatrics
  • American Board of Pediatrics Pediatric Hematology-Oncology

Publications & Presentations

PubMed

Press Mentions

  • Positive Data for Paxalisib in Two Childhood Brain Cancers Presented at 20th Ispno Annual Meeting
    Positive Data for Paxalisib in Two Childhood Brain Cancers Presented at 20th Ispno Annual MeetingJune 13th, 2022
  • 'Metabolic Inhibitor' Compound Extends Survival in Mice with MYC-Expressing Pediatric Brain Tumors
    'Metabolic Inhibitor' Compound Extends Survival in Mice with MYC-Expressing Pediatric Brain TumorsSeptember 23rd, 2019
  • PRESS RELEASE: Alex’s Lemonade Stand Foundation Announces Pediatric Oncology Student Training (POST) Grant Recipients
    PRESS RELEASE: Alex’s Lemonade Stand Foundation Announces Pediatric Oncology Student Training (POST) Grant RecipientsAugust 10th, 2018

Hospital Affiliations

Dr. Jeffrey Rubens, Dr. Jeffrey Rubens, MD, Dr. J Rubens