JeffreyERubnitzMD

Pediatric Hematology & Oncology • Memphis, TN

Director, Leukemia/Lymphoma Division, St. Jude Children's Research Hospital

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Office
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Pediatric Hematology/Oncology, 1991 - 1994
Stanford Health Care-Sponsored Stanford UniversityResidency, Pediatrics, 1988 - 1991
University of California San Diego School of MedicineClass of 1988

Certifications & Licensure

CA State Medical License 1989 - Present
TN State Medical License 1995 - 2026
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia Start of enrollment: 2002 Aug 01
Completed
Phase 3
Treatment of Children and Adolescents With Refractory or Relapsed Acute Myeloid Leukemia Start of enrollment: 2002 Mar 01
Completed
Phase 3
Natural Killer (NK) Cell Transplantation for AML Start of enrollment: 2005 Sep 01
Completed
Not Applicable
Clofarabine Plus Cytarabine Versus Conventional Induction Therapy And A Study Of NK Cell Transplantation In Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2008 Aug 04
Completed
Phase 3
Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome Start of enrollment: 2014 Aug 01
Completed
Phase 1
Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome Start of enrollment: 2016 May 03
Terminated
Phase 1
Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia Start of enrollment: 2016 Jan 14
Terminated
Phase 2
Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage Start of enrollment: 2017 Jul 11
Completed
Phase 1
PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Start of enrollment: 2019 Feb 12
Active, not recruiting
Phase 1, Phase 2
A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2017 Jun 15
Active, not recruiting
Phase 2
Roles: Contact, Principal Investigator
Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy Start of enrollment: 2023 Feb 23
Recruiting
Phase 1
Roles: Contact, Principal Investigator
Expanded Access Program for SNDX-5613
Available
Roles: Contact
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Publications & Presentations

PubMed

Household income and health-related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity res...
Haley Newman, Yimei Li, Yuan-Shung V Huang, Caitlin W Elgarten, Regina M Myers, Jenny Ruiz, Daniel J Zheng, Alison Barz Leahy, Catherine Aftandilian, Staci D Arnold, K...> ;Cancer Medicine. 2024 Apr 1
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors.
Kathryn P Goggin, Lu Lu, Carrie R Howell, Deokumar Srivastava, Tara M Brinkman, Gregory T Armstrong, Leslie L Robison, Mathew J Ehrhardt, Melissa M Hudson, Kevin R Kru...> ;JAMA Network Open. 2024 Mar 4
Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion.
Jingqun Ma, Yen-Chun Liu, Rebecca K Voss, Jing Ma, Ajay Palagani, Elizabeth Caldwell, Wojciech Rosikiewicz, Maria Cardenas, Scott Foy, Masayuki Umeda, Mark R Wilkinson...> ;Leukemia. 2024 Mar 1
7 citations
Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Juan M Barajas, Milad Rasouli, Masayuki Umeda, Ryan Hiltenbrand, Sherif Abdelhamed, Rebecca Mohnani, Bright Arthur, Tamara Westover, Melvin E Thomas 3rd, Minoo Ashtian...> ;Blood. 2024 Feb 15
1 citations
COVID-19 in Pediatric Patients With Acute Lymphoblastic Leukemia or Lymphoma.
Bodea, J., Patni, T., Angel, S., Wolf, J., Li, Y., Hashmi, S., Bhakta, N., Jeha, S., Karol, S., Ribeiro, R., Rubnitz, J., Pui, C., Hijano, D., Inaba, H.> ;JAMA Network Open. 2024 Feb 5
Neurocognitive and psychosocial outcomes in survivors of childhood leukemia with Down syndrome.
Gandy, K., Hall, L., Krull, K., Esbensen, A., Jacola, L., Rubnitz, J.> ;Cancer Medicine. 2024 Feb 1
1 citations
A new genomic framework to categorize pediatric acute myeloid leukemia.
Masayuki Umeda, Jing Ma, Tamara Westover, Yonghui Ni, Guangchun Song, Jamie L Maciaszek, Michael Rusch, Delaram Rahbarinia, Scott Foy, Benjamin J Huang, Michael P Wals...> ;Nature Genetics. 2024 Feb 1
Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical::fusion events.
Mahsa Khanlari, Wei Wang, Yen-Chun Liu, Lu Wang, Jeffrey E Rubnitz, Stephanie Dixon, Brent A Orr, Zhongshan Cheng, Vidya Balagopal, Jeffery M Klco, Anelo, O.> ;Haematologica. 2024 Mar 1
2 citations
Rituximab administration in pediatric patients with newly diagnosed acute lymphoblastic leukemia.
Keito Hoshitsuki, Yinmei Zhou, April M Miller, John K Choi, Hope D Swanson, Nickhill H Bhakta, Sima Jeha, Seth E Karol, Raul C Ribeiro, Jeffrey E Rubnitz, Charles G Mu...> ;Leukemia. 2023 Sep 1
1 citations
Clinical impact of minimal residual disease in blood and bone marrow of children with acute myeloid leukemia.
Seth E Karol, Elaine Coustan-Smith, Stanley Pounds, Lei Wang, Hiroto Inaba, Raul C Ribeiro, Ching-Hon Pui, Jeffery M Klco, Jeffrey E Rubnitz> ;Blood Advances. 2023 Jul 25
Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis.
Masayuki Umeda, Jing Ma, Tamara Westover, Yonghui Ni, Guangchun Song, Jamie L Maciaszek, Michael Rusch, Delaram Rahbarinia, Scott Foy, Benjamin J Huang, Michael P Wals...> ;Research Square. 2023 May 29
7 citations
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood-Rearranged Acute Myeloid Leukemia: A Study by the Internati...
Romy E van Weelderen, Kim Klein, Christine J Harrison, Yilin Jiang, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloos...> ;Journal of Clinical Oncology. 2023 Jun 1
Clinical characteristics and outcomes of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis managed with different cytoreductive methods.
Georgios E Christakopoulos, Kendra N Walker, Jesse Smith, Clifford M Takemoto, Yan Zheng, Ching-Hon Pui, Raul C Ribeiro, Lei Wang, Stanley B Pounds, Jeffrey E Rubnitz,...> ;Cancer. 2023 Jun 15
Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
Jennifer L Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W Lam, Elizabeth A R Garfinkle, Pratima Nallagatla, Amelia M R Smith, Sharnise Mitchel...> ;Nature Communications. 2023 Mar 9
6 citations
Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
Jennifer L Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W Lam, Elizabeth A R Garfinkle, Pratima Nallagatla, Amelia M R Smith, Sharnise Mitchel...> ;Nature Communications. 2023 Feb 13
3 citations
SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
Richard J Marrero, Xueyuan Cao, Huiyun Wu, Abdelrahman H Elsayed, Jeffery M Klco, Raul C Ribeiro, Jeffrey E Rubnitz, Xiaotu Ma, Soheil Meshinchi, Richard Aplenc, E And...> ;Blood Advances. 2023 Jun 13
Characterisation of children and adolescents with acute lymphoblastic leukaemia who presented without peripheral blood blasts at diagnosis.
David Spencer Mangum, Johnathon D Bishop, Yinmei Zhou, Cheng Cheng, Seth E Karol, Jeffrey E Rubnitz, Raul C Ribeiro, Jun J Yang, Charles G Mullighan, Sima Jeha, Ching-...> ;British Journal of Haematology. 2023 Feb 1
3 citations
Clofarabine treatment of KMT2Ar infantile patients with acute lymphoblastic leukemia in St. Jude Total Therapy Study 16.
Tanja A Gruber, Deqing Pei, John Choi, Cheng Cheng, Elaine Coustan-Smith, Dario Campana, Hope D Swanson, Jennifer L Pauley, Hiroto Inaba, Monika L Metzger, Jeffrey E R...> ;Blood Advances. 2022 Dec 27
1 citations
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.
Georgina L Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E Rubnitz, Rhonda E Ries, Hansen J Kosasih, Pa...> ;Blood. 2023 Feb 16
15 citations
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia.
Benjamin J Huang, Jenny L Smith, Jason E Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E Ries, Amanda R Leonti, Erin Crowgey, Scott N Furlan, Katherine Tarlock, Marcos...> ;Nature Communications. 2022 Sep 19
3 citations
Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML.
Nam H K Nguyen, Roya Rafiee, Abderrahmane Tagmount, Amin Sobh, Alex Loguinov, Angelica K de Jesus Sosa, Abdelrahman H Elsayed, Mohammed Gbadamosi, Nathan Seligson, Chr...> ;Blood Advances. 2023 May 9
5 citations
Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature.
Sakshi Bami, Jennifer Hidinger, Arshia Madni, Virginia Hargest, Stacey Schultz-Cherry, Valerie Cortez, Shane J Cross, Deborah A Ward, Randall T Hayden, Jeffrey Rubnitz...> ;Journal of the Pediatric Infectious Diseases Society. 2022 Sep 29
3 citations
Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication.
Hiroto Inaba, Jolieke G van Oosterwijk, John C Panetta, Lie Li, Daelynn R Buelow, James S Blachly, Sheila Shurtleff, Ching-Hon Pui, Raul C Ribeiro, Jeffrey E Rubnitz, ...> ;Clinical Cancer Research. 2022 Jun 13
10 citations
Relapsed acute myeloid leukemia in children and adolescents: current treatment options and future strategies.
Sara Zarnegar-Lumley, Kenneth J Caldwell, Jeffrey E Rubnitz> ;Leukemia. 2022 Aug 1
3 citations
Changes in body mass index, weight, and height in children with acute myeloid leukemia and the associations with outcome.
Mayuko Iijima, Melanie Stall, Lei Wang, John C Panetta, Brandon M Triplett, Ching-Hon Pui, Raul C Ribeiro, Jeffrey E Rubnitz, Stanley B Pounds, Hiroto Inaba> ;Blood Advances. 2022 May 10
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Abstracts/Posters

Safety and Efficacy of Venetoclax in Combination with Navitoclax in Adult and Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma
Jeffrey Rubnitz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Home or Away from Home: A Multi-Institution Study Comparing Medical Outcomes, Patient Perspectives, and Health-Related Quality of Life for Outpatient Versus Inpatient ...
Jeffrey Rubnitz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A 5-Gene Ara-C, Daunorubicin and Etoposide (ADE) Drug Response Score As a Prognostic Tool to Predict AML Treatment Outcome
Jeffrey Rubnitz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid LeukemiaClinically Relevant Ab...
Jeffrey Rubnitz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses
Jeffrey Rubnitz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

Metabolomics Profiling Reveals Markers for Chemosensitivity and Clinical Outcomes in Pediatric AML Patients
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Health News - Drug Offers Promising Approach to Improve Outcome for Children with High-Risk LeukemiaFebruary 10th, 2016
Drug Offers Promising Approach to Improve Outcome for Children with High-Risk LeukemiaFebruary 10th, 2016
Polygenic Score May Help Personalize Induction Chemo, Improve Black Pediatric AML Patients' OutcomesDecember 12th, 2023
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