Dr. Whitsett is on Doximity
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Office3333 Burnet Ave # 7029
Cincinnati, OH 45229
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- Dr. Whitsett's laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. They identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. They identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. They produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. They have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. They utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models.
Dr. Whitsett has a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and has contributed to the direct training of more than 80 graduate or post-graduate students in his laboratory. The scope of his work is represented in several recent reviews. Initial discoveries from his laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD.
Education & Training
- Cincinnati Children's Hospital Medical CenterFellowship, Neonatal-Perinatal Medicine, 1976 - 1978
- Icahn School of Medicine at Mount Sinai/Kravis Children'sResidency, Pediatrics, 1973 - 1976
- Columbia University Vagelos College of Physicians and SurgeonsClass of 1973
Certifications & Licensure
- OH State Medical License 1978 - 2025
- American Board of Pediatrics Pediatrics
- American Board of Pediatrics Neonatal-Perinatal Medicine
Awards, Honors, & Recognition
- 2018 Edward Livingston Trudeau Medalist American Thoracic Society, 2018
- P&S Alumni Gold Medal Award Columbia University, 2018
- Virginia Apgar Award American Academy of Pediatrics, 2015
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Publications & Presentations
- A novel non-recurrent CNV deletion involving TBX4 and leaving TBX2 intact causes congenital alveolar dysplasia.Katarzyna Bzdęga, Mateusz Biela, Gail H Deutsch, Joseph A Kitzmiller, Małgorzata Rydzanicz, Rafał Płoski, Jeffrey A Whitsett, Robert Śmigiel, Justyna A Karolak> ;Clinical Genetics. 2023 Oct 11
- 4 citationsGuided construction of single cell reference for human and mouse lung.Minzhe Guo, Michael P Morley, Cheng Jiang, Yixin Wu, Guangyuan Li, Yina Du, Shuyang Zhao, Andrew Wagner, Adnan Cihan Cakar, Michal Kouril, Kang Jin, Nathan Gaddis, Jos...> ;Nature Communications. 2023 Jul 29
- Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.Minzhe Guo, Kathryn A Wikenheiser-Brokamp, Joseph A Kitzmiller, Cheng Jiang, Guolun Wang, Allen Wang, Sebastian Preissl, Xiaomeng Hou, Justin Buchanan, Justyna A Karol...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Sep 15
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- Fgf10 Signaling-Based Evidence for the Existence of an Embryonic Stage Distinct from the Pseudoglandular Stage During Mouse Lung DevelopmentOctober 22nd, 2020
- Cincinnati Children's Hospital Medical CenterCincinnati, Ohio
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