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Jeffrey Whitsett, MD, Neonat/Perinatology, Cincinnati, OH, Cincinnati Children's Hospital Medical Center


Neonat/Perinatology Cincinnati, OH

Professor of Pediatrics, University Cincinnati

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  • Dr. Whitsett's laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. They identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. They identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. They produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. They have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. They utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models.

    Dr. Whitsett has a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and has contributed to the direct training of more than 80 graduate or post-graduate students in his laboratory. The scope of his work is represented in several recent reviews. Initial discoveries from his laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD.
  • Whitsett Lab

    Jeffrey Whitsett's laboratory makes extensive use of conditional gene targeting in transgenic mice, bioinformatics, physiology and biochemistry in the study of

    Jeffrey A. Whitsett, MD

    Co-Director, Perinatal Institute Section Chief, Division of Neonatology, Perinatal and Pulmonary Biology Professor, UC Department of Pediatrics jeffrey.whitsett

Education & Training

  • Cincinnati Childrens Hospital Medical Center
    Cincinnati Childrens Hospital Medical CenterFellowship, Neonatal-Perinatal Medicine, 1976 - 1978
  • Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount SinaiResidency, Pediatrics, 1973 - 1976
  • Columbia University Vagelos College of Physicians and Surgeons
    Columbia University Vagelos College of Physicians and SurgeonsClass of 1973

Certifications & Licensure

  • OH State Medical License
    OH State Medical License 1978 - 2023
  • American Board of Pediatrics Pediatrics
  • American Board of Pediatrics Neonatal-Perinatal Medicine

Awards, Honors, & Recognition

  • 2018 Edward Livingston Trudeau Medalist American Thoracic Society, 2018
  • P&S Alumni Gold Medal Award Columbia University, 2018
  • Virginia Apgar Award American Academy of Pediatrics, 2015
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Publications & Presentations


Press Mentions

  • Fgf10 Signaling-Based Evidence for the Existence of an Embryonic Stage Distinct from the Pseudoglandular Stage During Mouse Lung Development
    Fgf10 Signaling-Based Evidence for the Existence of an Embryonic Stage Distinct from the Pseudoglandular Stage During Mouse Lung DevelopmentNovember 18th, 2020

Hospital Affiliations