
Jeremie Heath Estepp MD
Medical Director; Genetically Defined Diseases; Agios Pharmaceuticals
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St. Jude Children's Research Hospital262 Danny Thomas PlaceMemphis, TN 38105
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Summary
- Dr. Jeremie Estepp is a pediatric hematologist/oncologist and serves as a Medical Director of Genetically Defined Diseases at Agios Pharmaceuticals in Cambridge, MA. He was previously affiliated with multiple hospitals in Memphis, TN, including St. Jude Children's Research Hospital and Methodist Healthcare Memphis Hospitals. He received his medical degree from Marshall University School of Medicine and has been in practice 10+ years. He is experienced in sickle cell disease, pediatric hematology / oncology, genetic modifiers of sickle cell disease, fetal hemoglobin and clinical severity of homozygous sickle cell, and clinical and hematologic effects of hydroxyurea in children with SCD. He is recognized as an international expert in SCD.
Education & Training
- University of TennesseeFellowship, Pediatric Hematology/Oncology, 2009 - 2012
- University of TennesseeResidency, Pediatrics, 2006 - 2009
- Marshall University Joan C. Edwards School of MedicineClass of 2006
- Carson-Newman CollegeB.A., 2001
Certifications & Licensure
- TN State Medical License 2012 - 2023
Awards, Honors, & Recognition
- Resident Teaching Award University of Tennessee Health Science Center; Le Bonheur Children's Hospital, 2017
- Awarded "Outstanding Poster Presentation" University of Tennessee Health Science Center (4th Annual Pediatric Research Day), 2011
- Outstanding Biology Senior 2001
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Clinical Trials
- Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease Start of enrollment: 2006 Mar 03
- A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) Start of enrollment: 2013 Apr 01
- Investigation of the Genetics of Hematologic Diseases Start of enrollment: 2016 Jun 17
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Publications & Presentations
PubMed
- A Novel One-Sample Mendelian Randomization Approach for Count-Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects.Janaka S S Liyanage, Jane S Hankins, Jeremie H Estepp, Deokumar Srivastava, Sara R Rashkin
Genetic Epidemiology. 2025-01-01 - 1 citationsSocial determinants of health affect disease severity among preschool children with sickle cell disease.Hamda Khan, Guolian Kang, Jerlym S Porter, Juan Ding, Winfred C Wang
Blood Advances. 2024-12-10 - Changes in indicators of cerebral metabolic stress following treatment with voxelotor in children and adolescents with sickle cell anemia.Andrew M Heitzer, Ping Zou, Jason Hodges, Clark Brown, Mark Davis
Ejhaem. 2024-10-01
Journal Articles
- A Clinically Meaningful Fetal Hemoglobin Threshold for Children with Sickle Cell Anemia During Hydroxyurea TherapyEstepp JH, Smeltzer MP, Kang G, Aygun B, Abrams C, Wang W, Ware RE, Nottage K, Hankins J, American Journal of Hematology, 1/1/2017
Books/Book Chapters
Abstracts/Posters
- Disease Modeling and Phenotype Rescue Using Inducible Pluripotent Stem Cells from Patients with Diamond-Blackfan AnemiaJeremie H. Estepp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
- Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric A...Jeremy H. Estepp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Progression of Central Nervous System Vasculopathy in Young Adults with Sickle Cell AnemiaJeremie H. Estepp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures
- Transcranial Doppler Velocities Conversion Rate Based on Increasing Hemoglobin Concentration: Analysis from the SCCRIP Cohort Study61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
- Fetal Hemoglobin Level during Hydroxyurea Therapy Varies By Neighborhood2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
- Effects of Hydroxyurea on Neurocognitive Performance in Children with Sickle Cell Disease: A Prospective Trial.Atlanta, GA - 1/1/2018
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Authored Content
- Hydroxyurea: When more is better.December 2018
Press Mentions
- GBT and SCDAA to Host 8th Annual Sickle Cell Disease (SCD) Therapeutics ConferenceSeptember 5th, 2019
- GBT Announces Upcoming Data Presentations at 24th European Hematology Association (EHA) Congress Supporting Voxelotor Sickle Cell Disease ProgramMay 16th, 2019
- Whole Genome Sequencing of Pediatric Sickle Cell Disease PatientsFebruary 5th, 2019
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