JessicaLBoklanMD

Pediatric Hematology & Oncology • Phoenix, AZ

Pediatric Hematologic Oncology

Phoenix Children's Hospital

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Office
1919 E Thomas Rd
Phoenix, AZ 85016
Phone+1 602-933-0920
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Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 1997 - 2000
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1994 - 1997
New York University School of MedicineClass of 1994

Certifications & Licensure

AZ State Medical License 2001 - 2025
PA State Medical License 1995 - 2002
NY State Medical License 1997 - 2002
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Start of enrollment: 2001 Feb 01
Unknown status
Phase 3
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma Start of enrollment: 2004 Sep 04
Completed
Phase 3
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma Start of enrollment: 2004 Apr 01
Active, not recruiting
Phase 3
Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Start of enrollment: 2005 Nov 14
Completed
Phase 3
Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Start of enrollment: 2006 Jun 01
Completed
Phase 2
Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma Start of enrollment: 2007 Aug 06
Active, not recruiting
Phase 3
Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor Start of enrollment: 2006 Oct 30
Active, not recruiting
Phase 3
Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Start of enrollment: 2006 Dec 26
Completed
Phase 3
Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Start of enrollment: 2007 Mar 01
Completed
Phase 3
Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor Start of enrollment: 2007 Feb 26
Active, not recruiting
Phase 3
Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Start of enrollment: 2007 Mar 01
Completed
Phase 3
Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Start of enrollment: 2007 Mar 01
Completed
Phase 3
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Start of enrollment: 2007 Jan 22
Active, not recruiting
Phase 3
Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia Start of enrollment: 2008 Jan 01
Completed
Phase 2
Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2008 Jan 15
Active, not recruiting
Phase 3
Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Start of enrollment: 2008 Apr 01
Completed
Phase 2
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia Start of enrollment: 2009 Mar 09
Completed
Phase 3
Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Start of enrollment: 2009 Mar 01
Completed
Phase 2
Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2006 Sep 25
Completed
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma Start of enrollment: 2006 Oct 23
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Study of Blood Samples From Newborns With Down Syndrome Start of enrollment: 2009 Feb 23
Completed
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma Start of enrollment: 2005 May 30
Completed
External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas Start of enrollment: 2009 Oct 30
Completed
Phase 2
Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma Start of enrollment: 2010 Jan 01
Completed
Phase 2
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Start of enrollment: 2010 Oct 04
Active, not recruiting
Phase 1
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Clinical Study of Vorinostat in Combination With Etoposide in Pediatric Patients < 21 Years at Diagnosis With Refractory Solid Tumors Start of enrollment: 2011 Feb 09
Completed
Phase 1, Phase 2
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 1
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma Start of enrollment: 2011 Dec 01
Completed
Phase 2
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia Start of enrollment: 2013 Jun 24
Completed
Phase 2
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients. Start of enrollment: 2013 Aug 20
Completed
Phase 2
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Start of enrollment: 2014 Jul 11
Active, not recruiting
Phase 2, Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children Start of enrollment: 2016 Feb 16
Completed
Phase 1
Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia Start of enrollment: 2016 Jan 14
Terminated
Phase 2
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor Start of enrollment: 2020 Jan 22
Active, not recruiting
Phase 1, Phase 2
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma Start of enrollment: 2020 Mar 04
Terminated
Phase 1, Phase 2
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06
Active, not recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Start of enrollment: 2021 Feb 24
Active, not recruiting
Phase 1, Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

13 citations
Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium
Kristin A. Shimano, Anupama Narla, Melissa J. Rose, Nicholas J. Gloude, Steven W. Allen, Katie Bergstrom, Larisa Broglie, Beth A Carella, Paul Castillo, Jill L. O. de ...> ;American Journal of Hematology. 2021 Aug 20
4 citations
Cytotoxicity and Target Modulation in Pediatric Solid Tumors by the Proteasome Inhibitor Carfilzomib.
Satbir Thakur, Yibing Ruan, Aarthi Jayanthan, Jessica Boklan, Aru Narendran> ;Current Cancer Drug Targets. 2021 May 3
15 citations
A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma
Karen Wright, Xiaopan Yao, Wendy B. London, Pei Chi Kao, Lia Gore, Stephen P. Hunger, Russ Geyer, Kenneth J. Cohen, Jeffrey C. Allen, Howard M. Katzenstein, Amy Smith,...> ;Pediatric Blood & Cancer. 2021 Feb 1
2 citations
Dual functionality of the antimicrobial agent taurolidine which demonstrates effective anti-tumor properties in pediatric neuroblastoma
Lucy Swift, Chunfen Zhang, Olga Kovalchuk, Jessica Boklan, Tanya M. Trippett, Aru Narendran> ;Investigational New Drugs. 2020 Jun 1
13 citations
Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia.
Nirali N. Shah, Deepa Bhojwani, Keith J. August, André Baruchel, Yves Bertrand, Jessica Boklan, Luciano Dalla-Pozza, Robyn M. Dennis, Nobuko Hijiya, Franco Locatelli, ...> ;Pediatric Blood & Cancer. 2020 May 1
28 citations
Outcomes of Hematopoietic Cell Transplantation in Patients with Germline SAMD9/SAMD9L Mutations
Ibrahim Ahmed, Midhat S. Farooqi, Mark Vander Lugt, Jessica Boklan, Melissa J. Rose, Erika Friehling, Brandon M. Triplett, Kenneth Lieuw, Blachy J. Dávila Saldaña, Chr...> ;Biology of Blood and Marrow Transplantation. 2019 Nov 1
37 citations
Immunosuppressive therapy for pediatric aplastic anemia: A North American Pediatric Aplastic Anemia Consortium study
, , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Haematologica. 2019 Oct 1
Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells.
Aarthi Jayanthan, Bradley Hofmann, Vanessa Meier-Stephenson, Maneka Perinpanayagam, Sandra E. Dunn, Jessica Boklan, Tanya M. Trippett, Tony H. Truong, Aru Narendran> ;Journal of Pediatric Hematology/oncology. 2019 Aug 1
7 citations
Targeting the Proteasome in Refractory Pediatric Leukemia Cells: Characterization of Effective Cytotoxicity of Carfilzomib
Lucy Swift, Aarthi Jayanthan, Yibing Ruan, Ronald Anderson, Jessica Boklan, Tanya M. Trippett, Aru Narendran> ;Targeted Oncology. 2018 Nov 16
6 citations
A phase 1/2 dose-finding, safety, and activity study of cabazitaxel in pediatric patients with refractory solid tumors including tumors of the central nervous system.
Peter E. Manley, Tanya M. Trippett, Amy Smith, Margaret E. Macy, Sarah Leary, Jessica Boklan, Kenneth J. Cohen, Stewart Goldman, Lindsay Kilburn, Girish Dhall, Jeanne ...> ;Pediatric Blood & Cancer. 2018 Sep 1
3 citations
Pediatric Chronic Myeloid Leukemia Presenting With Extreme Thrombocytosis Simulating Essential Thrombocythemia.
Jessica Boklan, Alexandra Walsh, Michelina C. de la Maza, Leon Su, Francisco A. Nizzi, Kristian T. Schafernak> ;Journal of Pediatric Hematology/oncology. 2018 Aug 1
74 citations
Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.
Victor B Pastor, Sushree Sangita Sahoo, Jessica Boklan, Georg C. Schwabe, Ebru Tugrul Saribeyoglu, Brigitte Strahm, Dirk Lebrecht, Matthias Voss, Yenan T. Bryceson, Mi...> ;Haematologica. 2017 Dec 7
12 citations
Combination of clofarabine, cyclophosphamide, and etoposide for relapsed or refractory childhood and adolescent acute myeloid leukemia.
Yoav H. Messinger, Jessica Boklan, John M. Goldberg, Steven G. DuBois, Javier Oesterheld, Oussama Abla, Alissa Martin, Joanna Weinstein, Nobuko Hijiya> ;Pediatric Hematology and Oncology. 2017 Oct 17
22 citations
A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML
Lia Gore, Timothy J. Triche, Jason E. Farrar, Daniel H. Wai, Christophe Legendre, Gerald C. Gooden, Winnie S. Liang, John D. Carpten, David W. Lee, Frank Alvaro, Marga...> ;Clinical Epigenetics. 2017 Oct 5
55 citations
A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or my...
Todd Cooper, Edward Allan R. Sison, Sharyn D. Baker, Lie Li, Amina Ahmed, Tanya M. Trippett, Lia Gore, Margaret E. Macy, Aru Narendran, Keith J. August, Michael J. Abs...> ;Pediatric Blood & Cancer. 2017 Aug 1
19 citations
A Multicenter, First-in-Pediatrics, Phase 1, Pharmacokinetic and Pharmacodynamic Study of Ridaforolimus in Patients with Refractory Solid Tumors
Lia Gore, Tanya M. Trippett, Howard M. Katzenstein, Jessica Boklan, Aru Narendran, Amy Smith, Margaret E. Macy, Katherine Rolla, Narayana Narashimhan, Rachel M. Squill...> ;Clinical Cancer Research. 2013 Jul 1
9 citations
A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors
Margaret E. Macy, Tracey Duncan, James A. Whitlock, Stephen P. Hunger, Jessica Boklan, Aru Narendren, Cynthia E. Herzog, Robert J. Arceci, Rochelle Bagatell, Tanya M. ...> ;Pediatric Blood & Cancer. 2013 Feb 1
6 citations
Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for M...
Kimberley A. Hoeksema, Aarthi Jayanthan, Todd Cooper, Lia Gore, Tanya M. Trippett, Jessica Boklan, Robert J. Arceci, Aru Narendran> ;Oncotargets and Therapy. 2011 Sep 5
39 citations
Phase I and Pharmacokinetic Study of Cetuximab and Irinotecan in Children With Refractory Solid Tumors: A Study of the Pediatric Oncology Experimental Therapeutic Inve...
Tanya M. Trippett, Cynthia E. Herzog, James A. Whitlock, Johannes E. A. Wolff, John F. Kuttesch, Rochelle Bagatell, Stephen P. Hunger, Jessica Boklan, Amy Smith, Rober...> ;Journal of Clinical Oncology. 2009 Oct 20
52 citations
Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells.
Shan Gao, Aaron K. Mobley, Claudia P. Miller, Jessica Boklan, Joya Chandra> ;Leukemia Research. 2008 May 1
75 citations
Phase I Pharmacokinetic and Pharmacodynamic Study of 17-N-Allylamino-17-Demethoxygeldanamycin in Pediatric Patients with Recurrent or Refractory Solid Tumors: A Pediat...
Rochelle Bagatell, Lia Gore, Merrill J. Egorin, Richard H. Ho, Glenn Heller, Nichole Boucher, Eleanor G. Zuhowski, James A. Whitlock, Stephen P. Hunger, Aru Narendran,...> ;Clinical Cancer Research. 2007 Mar 15
29 citations
Little patients, losing patience: pediatric cancer drug development.
Jessica Boklan> ;Molecular Cancer Therapeutics. 2006 Aug 1
35 citations
Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts.
Jessica Boklan, Gouri Nanjangud, Karen L. MacKenzie, Chad May, Michel Sadelain, Malcolm A.S. Moore> ;Cancer Research. 2002 Apr 1
28 citations
Lung transplantation after allogeneic marrow transplantation in pediatric patients: the Memorial Sloan-Kettering experience.
John A. Heath, Geoffrey Kurland, Thomas L. Spray, Nancy A. Kernan, Trudy N. Small, Joel A. Brochstein, Alfred P. Gillio, Jessica Boklan, Richard J. O'Reilly, Farid Boulad> ;Transplantation. 2001 Dec 27
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Abstracts/Posters

Establishing a Novel in Vitro Informed Precision Clinical Trial Pathway for Refractory Pediatric Leukemia
Jessica Boklan, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019