JessicaMorganFeldmanMDScM

Resident Physician • Cambridge, MA

Resident Physician, Postdoctoral Fellow

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Office
330 Mount Auburn Street
Cambridge, MA 02138
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Summary

Dr. Jessica Feldman is a resident physician in Cambridge, MA and is affiliated with multiple hospitals in the area, including Mount Auburn Hospital. She received her medical degree from Brown University and has been in practice 1 year. She also speaks multiple languages, including Spanish. As an MD/PhD, Dr. Feldman works at the forefront of novel technology development to both study the brain to increase our knowledge of basic neurophysiology in primary motor cortex neurons and ensembles and to identify neural correlates of cognition in M1 neurons and ensembles. She has worked on BrainGate, a pilot human clinical trial enabled by the engineering of a tiny introcortical 96+ electrode array inserted in M1 of its participants, ability to record high and low level signal data (neuronal and LFPs, and beyond). Participants who are individuals with locked-in syndrome from with a range of underlying pathology including brainstem stroke and ALS, among others. We record LFPs, higher bandwidth signal from a local neural network, and filtered collected signal to extract single spikes of multiple single neurons thru the implantable in M1 96-channel neural implant (intra-cortical arrays that can record activity of local single neurons. then extract single neurons and signals based on bandwidth filtering to reveal signal neurons and their activity. This has implications in both the applied realm and in the neurophysiological, unable to, prior to this, yield such granular information including even preferred directors of MI neurons. This work also occurs in the context of the BrainGate2 pilot human clinical trials, with multiple participants - locked in via a brain stem stroke, ALS, or upper SCI, among others.

Education & Training

Cambridge Health AllianceInternship, Transitional Year, 2017 - 2018
The Warren Alpert Medical School of Brown UniversityClass of 2015
Brown UniversityM.S., Neuroscience, 2015
The Warren Alpert Medical School of Brown UniversityMD/PhD program in Neuroscience, 2010 - 2014
Stanford UniversityBA, Human Biology, 2002 - 2006
Stanford UniversityB.A., Human Biology, concentration in Biotechnology, Philosophy, and Ethics, with Honors, 2006

Certifications & Licensure

MA State Medical License 2017 - 2018

Awards, Honors, & Recognition

Sigma Xi Honor Society
BCI Award, Finalist 2012
Brown Medical Research Fellow Alpert Medical School, Brown University, 2009-2010
Summer Research Fellow American Generics Foundation, 2004-2005
Stanford STARS Alumni Leadership Award 2017
Sigma Xi 2017
Award for Completion of Canopy Medical Spanish Program NIH, 2016
Brown Academic Scholarship Alpert Medical School, 2015
Research Award Nominee BCI, 2012
Full Merit Tuition Scholarship, MD/PhD Program Alpert Medical School, 2010
Brown Medical Research Fellow Alpert Medical School, 2009
Honors Program in Human Biology Stanford University, 2004
Book Award Williams College, 2002
American Classical League Award (for highest score on all levels of the National Latin Exam; one of 3 recipients) 2002
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Clinical Trials

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Start of enrollment: 2009 May 01
Recruiting
Not Applicable

Publications & Presentations

PubMed

18 citations
Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia.
Carlos E. Vargas-Irwin, Jessica M. Feldman, Brandon King, John D. Simeral, Brittany L Sorice, Erin M. Oakley, Sydney S. Cash, Emad N. Eskandar, Gerhard Friehs, Leigh R...> ;Frontiers in Human Neuroscience. 2018 Nov 15

Journal Articles

Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans with Tetraplegia
Feldman J.M., Vargas-Irwin C.E., King B., Simeral JD, Sorice BL, Oakley EM, Cash SS, Eskandar EN, Friehs GM, Hochberg LR and Donoghue JP, Front Hum Neurosci, 1/1/2018

Abstracts/Posters

State space modeling of local field potential in motor cortex during observed, imagined and attempted arm movement in humans with tetraplegia.
Menzer, D.L., Feldman J.M., Oakley, E., Hochberg L.R., & Donoghue J.P., Society for Neuroscience, Chicago, IL, 1/1/2014
Action representations with neural networks: an updated perspective on the simulation hypothesis of motor cognition.
Feldman J.M., Truccolo W., Hochberg L.R., & Donoghue J.P., Society for Neuroscience, New Orleans, LA, 1/1/2012
Modulation of local field potentials in primary motor cortex during observed, imagined, and attempted arm movement in humans with tetraplegia.
Menzer, D.L., Feldman J.M., Hochberg L.R., & Donoghue J.P., Society for Neuroscience, New Orleans, LA, 1/1/2012
BrainGate pilot clinical trials: progress in translating neural engineering principles to clinical testing.
L.R. Hochberg, D. Bacher, L. Barefoot, E. Berhanu, M.J. Black, S.S. Cash, J.M. Feldman, E.M. Gallivan, M. Homer, B. Jarosiewicz, B. King, J. Liu, W.Q. Malik, N. Masse,..., Proc IEEE Eng Med. Biol Conf, Boston, MA, 1/1/2011
Action observation in human primary motor cortex.
Feldman J.M., Truccollo, W.T., Hochberg, L.R. & Donoghue J.P., Annual Neuroscience Graduate Program Retreat, Bristol, RI, 1/1/2011
Neural representations of action in human primary motor cortex.
Feldman J.M., King B., Truccolo, W.T., Hochberg L.R., & Donoghue J.P., Conference on Single Neuron Studies of the Human Brain, New York, NY, 1/1/2011
Use of the BrainGate Neural Interface System for more than five years by a woman with tetraplegia.
Hochberg L.R., Bacher, D., Barefoot L., Berhanu E., Black M.J., Cash, S.S., Feldman J.M., Gallivan E.M., Homer M., Jarosiewicz B., King B., , Liu J., Malik, W.Q., Mas..., Society for Neuroscience, Washington, DC, 1/1/2011
Decoding neural representations of action from motor cortex ensembles during action observation in humans with tetraplegia.
Feldman J.M., King, B, Truccolo, W.T, Hochberg, L.R., & Donoghue, J.P., Inaugural Norman Prince Neuroscience Institute Symposium; Society for Neuroscience, Washington, DC, 2011; Providence, RI, 2011, 1/1/2011
Effect of verbal instructions on human primary motor cortex.
Feldman J.M., King B. Hochberg, L.R., & Donoghue J.P., Annual Neuroscience Graduate Program Retreat, Bristol, RI, 1/1/2010
Verbal instructions to watch, imagine, or attempt movement differentially engage neurons in the motor cortex of humans with tetraplegia.
King B., Feldman J.M., Hochberg L.R., & Donoghue J.P., Society for Neuroscience, San Diego, CA, 1/1/2010
Developing a methodology for tracking single neuron stability over time: applications to the BrainGate pilot human clinical trial.
Feldman, J.M. & Donoghue, J.P., Summer Research Symposium, Alpert Medical School, Providence, RI, 1/1/2008
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Lectures

Overview of the 2016 WHO Classification of CNS Tumors: a paradigm shift for neuropathology.
Rhode Island Hospital, Providence, RI - 1/10/2017
Neuroradiology two mystery cases.
Rhode Island Hospital, Providence, RI - 1/8/2017
Weight loss, cough, and leukocytosis.
Mount Auburn Hospital, Cambridge, MA - 1/1/2017
Case Presentation: GI bleed complicated by Roux-en-Y gastric bypass anatomy.
Miriam Hospital, Providence, RI - 1/12/2016
Erythema: more than meets the eye.
Mount Auburn Hospital, Cambridge, MA - 1/1/2016
Learning in human primary motor cortex: outstanding issues.
Hyannis, MA - 1/1/2012
Action observation and motor imagery neurons in human primary motor cortex.
Brown University, Providence, RI - 1/1/2011
Motor learning in human MI: outstanding issues.
Hyannis, MA - 1/1/2011
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Other

Perception, action and cognition in human motor cortex neurons: implications for neural interface system design.
Feldman, J.M., Master�s Thesis, Dept of Neuroscience
Brown University, Providence, RI - 1/1/2014
Characterization and detection of two novel point mutations in the uroporphyriogen III synthase gene causing congenital erythropoietic porphyria.
Feldman, J.M., Honors Thesis, Program in Human Biology
Stanford University - 1/1/2006

Press Mentions

The Gateway to Advanced Neuroprosthetics: Jessica Feldman Talks BrainGate and BCIMarch 4th, 2014

Research History

Graduate Researcher, Brown Medical Research Fellow2009 - 2014
Medical Student ResearcherDonoghue lab, Department of Neuroscience, Brown University2008 - 2009
Research AssistantStanford Center for Biomedical Ethics2005 - 2006
Undergraduate Researcher/American Genetics Foundation FellowDesnick lab, Department of Human Genetics, Mount Sinai School of Medicine (NY)2003 - 2006