
Jill P Smith MD
Hepatology & Liver Transplantation, Pancreas Disease
Professor, Medicine, Georgetown University College of Medicine
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3800 Reservoir Rd NWPasquerilla Healthcare Center, 6th FloorWashington, DC 20007
Phone+1 202-444-8168
Fax+1 877-303-1460
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Summary
- Dr. Jill Smith is a gastroenterologist based in Washington, DC, with subspecialty in hepatology, as well as pancreas diseases. She completed her medical education at the University of Florida College of Medicine in 1980, with further training in internal medicine and gastroenterology at the University of Missouri-Columbia. Her expertise includes hepatology, pancreatic cancer, and hereditary pancreatitis. Dr. Smith has a robust publication record, contributing studies on topics like hepatocellular cancer and pancreatic cancer. She has also been the principal investigator in clinical trials investigating treatments for chronic pancreatitis, hepatic impairment, MASH, pancreatic cancer, and Crohn's disease. Her accolades include the Innovator of the Year award from Georgetown University and the Harrington Discovery Scholar Innovator Award. Her research laboratory is funded by the National Cancer Institutes, NIH with a focus on pancreatic cancer biology and nanotechnology.
Education & Training
University of Missouri-ColumbiaFellowship, Gastroenterology, 1985 - 1987
University of Missouri-ColumbiaResidency, Internal Medicine, 1981 - 1983
University of Florida College of MedicineClass of 1980
Certifications & Licensure
DC State Medical License 2014 - 2026
PA State Medical License 1987 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology
Awards, Honors, & Recognition
- Innovator of the Year award Georgetown University, 2024
- Harrington Discovery Scholar Innovator Award Cleveland Clinics- Harrington, 2021
- Biochemistry Graduate School Mentoring Award Georgetown University, 2019
Clinical Trials
- Opioid Growth Factor in Treating Patients With Advanced Pancreatic Cancer That Cannot Be Removed By Surgery Start of enrollment: 2003 Oct 01
- The Effects of Naltrexone on Active Crohn's Disease Start of enrollment: 2006 Sep 01
- Treatment of Unresectable Hepatocellular Cancer With Opioid Growth Factor Start of enrollment: 2008 Jun 01
Publications & Presentations
PubMed
- Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth.Jill P Smith, Mahdis Mohit, Joi Kenner, Ajay Nathan, Jack Drda
Cell Communication and Signaling. 2026-01-16 - Probiotics Mitigate Cholesterol-induced Gut Dysbiosis and Promotion of Pancreatic Cancer Progression.Jack C Drda, Jill P Smith
Cellular and Molecular Gastroenterology and Hepatology. 2026-01-01 - Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer.Jill P Smith, Narayan Shivapurkar, Wenqiang Chen, Godhanjali Chekuri, Amani Dabney
Molecular Cancer Therapeutics. 2025-08-01
Journal Articles
- Cholecystokinin and pancreatic cancer: the chicken or the egg?Smith JP, Solomon TE, Gastrointest Liver Physiol 2014;306:G91-G101
- Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in miceSmith JP, Cooper TK, McGovern CO, et al, Pancreas 2014;43:1050-9
Press Mentions
Title: Professor Makes Strides in Pancreatic Cancer Detection and TreatmentDecember 19th, 2025
Cancer Advances, Inc. Announces Publication, "Gastrin Vaccine Alone and in Combination with an Immune Checkpoint Antibody Inhibits Growth and Metastases of Gastric Cancer" in Frontiers in OncologyDecember 6th, 2021
Cancer Advances, Inc. Announces Publication, “Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model" in Cancer Prevention ResearchAugust 24th, 2021
Grant Support
- The CCK-B receptor signaling pathway as a driver of pancreatic cellular plasticity and carcinogenesisNIH /NCI2023–2028
- Activation of Cholecystokinin-B Receptor-Positive Stem Cells Induces Hepatic CarcinogenesisDOD2021–2024
- Targeted nanoparticle for early diagnosis & treatment of pancreatic cancerAACR2021–2023
- Proglumide and the Pancreatic Tumor MicroenvironmentPancreatic Action Network2020–2023
- Phase 1 study to test safety and dose of proglumide as an anti-fibrotic agentNCI2019–2021
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