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Jill Smith, MD, Gastroenterology, Washington, DC

Jill P Smith MD

Hepatology & Liver Transplantation, Pancreas Disease


Professor, Medicine, Georgetown University College of Medicine

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  • 3800 Reservoir Rd NWPasquerilla Healthcare Center, 6th FloorWashington, DC 20007

  • Phone+1 202-444-8168

  • Fax+1 877-303-1460

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Summary

  • Dr. Jill Smith is a gastroenterologist based in Washington, DC, with subspecialty in hepatology, as well as pancreas diseases. She completed her medical education at the University of Florida College of Medicine in 1980, with further training in internal medicine and gastroenterology at the University of Missouri-Columbia. Her expertise includes hepatology, pancreatic cancer, and hereditary pancreatitis. Dr. Smith has a robust publication record, contributing studies on topics like hepatocellular cancer and pancreatic cancer. She has also been the principal investigator in clinical trials investigating treatments for chronic pancreatitis, hepatic impairment, MASH, pancreatic cancer, and Crohn's disease. Her accolades include the Innovator of the Year award from Georgetown University and the Harrington Discovery Scholar Innovator Award. Her research laboratory is funded by the National Cancer Institutes, NIH with a focus on pancreatic cancer biology and nanotechnology.

Education & Training

  • University of Missouri-Columbia
    University of Missouri-ColumbiaFellowship, Gastroenterology, 1985 - 1987
  • University of Missouri-Columbia
    University of Missouri-ColumbiaResidency, Internal Medicine, 1981 - 1983
  • University of Florida College of Medicine
    University of Florida College of MedicineClass of 1980

Certifications & Licensure

  • DC State Medical License
    DC State Medical License 2014 - 2026
  • PA State Medical License
    PA State Medical License 1987 - 2026
  • Internal Medicine
    American Board of Internal Medicine Internal Medicine
  • Gastroenterology
    American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

  • Innovator of the Year award Georgetown University, 2024
  • Harrington Discovery Scholar Innovator Award Cleveland Clinics- Harrington, 2021
  • Biochemistry Graduate School Mentoring Award Georgetown University, 2019

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Cholecystokinin and pancreatic cancer: the chicken or the egg?  
    Smith JP, Solomon TE, Gastrointest Liver Physiol 2014;306:G91-G101
  • Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice  
    Smith JP, Cooper TK, McGovern CO, et al, Pancreas 2014;43:1050-9

Press Mentions

  • Title: Professor Makes Strides in Pancreatic Cancer Detection and Treatment
    Title: Professor Makes Strides in Pancreatic Cancer Detection and TreatmentDecember 19th, 2025
  • Cancer Advances, Inc. Announces Publication, "Gastrin Vaccine Alone and in Combination with an Immune Checkpoint Antibody Inhibits Growth and Metastases of Gastric Cancer" in Frontiers in Oncology
    Cancer Advances, Inc. Announces Publication, "Gastrin Vaccine Alone and in Combination with an Immune Checkpoint Antibody Inhibits Growth and Metastases of Gastric Cancer" in Frontiers in OncologyDecember 6th, 2021
  • Cancer Advances, Inc. Announces Publication, “Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model" in Cancer Prevention Research
    Cancer Advances, Inc. Announces Publication, “Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model" in Cancer Prevention ResearchAugust 24th, 2021

Grant Support

  • The CCK-B receptor signaling pathway as a driver of pancreatic cellular plasticity and carcinogenesisNIH /NCI2023–2028
  • Activation of Cholecystokinin-B Receptor-Positive Stem Cells Induces Hepatic CarcinogenesisDOD2021–2024
  • Targeted nanoparticle for early diagnosis & treatment of pancreatic cancerAACR2021–2023
  • Proglumide and the Pancreatic Tumor MicroenvironmentPancreatic Action Network2020–2023
  • Phase 1 study to test safety and dose of proglumide as an anti-fibrotic agentNCI2019–2021

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