JimmyRuizMD

Thoracic Cancer

Professor of Medicine, Hematology and Oncology Assistant Director for Clinical Research Wake Forest Comprehensive Cancer Center Section Chief, Hematology and Oncology Salisbury VAMC Deputy ACOS Medicine, VAMC Salisbury

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Office
Medical Center Blvd
Winston-Salem, NC 27157
Phone+1 336-716-2255
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Education & Training

Wake Forest University Baptist Medical CenterFellowship, Hematology and Medical Oncology, 2008 - 2011
Wake Forest University School of MedicineResidency, Internal Medicine, 2004 - 2007
Southern Illinois University School of MedicineClass of 2004

Certifications & Licensure

NC State Medical License 2004 - 2024
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology
National Board of Physicians and Surgeons Internal Medicine

Clinical Trials

Molecular and Diagnostic Classification of Non-Small Cell Lung Cancer From Fine Needle Aspirates Start of enrollment: 2012 Jun 01
Completed
Immunotherapy Study in Progressive or Relapsed Non-Small Cell Lung Cancer Start of enrollment: 2013 Feb 01
Terminated
Phase 2, Phase 3
CPI-613 in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer Start of enrollment: 2013 Oct 01
Completed
Phase 1
Bioelectrical Impedance Phase Angle in Predicting Treatment Outcome in Patients With Extensive Stage Small Cell Lung Cancer Receiving First-Line Chemotherapy Start of enrollment: 2014 Feb 01
Terminated
Not Applicable
Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) Start of enrollment: 2015 Feb 11
Active, not recruiting
Phase 3
Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual Treatments (Carboplatin and Gemcitabine) and to Pembrolizumab for Patients With Advanced Squamous Cell Non-small Cell Lung Cancer Start of enrollment: 2021 Apr 14
Active, not recruiting
Phase 1, Phase 2
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Publications & Presentations

PubMed

Delayed Imaging Changes 18 Months or Longer After Stereotactic Radiosurgery for Brain Metastases: Necrosis or Progression.
Michelle M Williams, Arian K Sohrabi, Carol A Kittel, Jaclyn J White, Christina K Cramer, Claire M Lanier, Jimmy Ruiz, Fei Xing, Wencheng Li, Christopher T Whitlow, St...> ;World Neurosurgery. 2024 Jan 1
2 citations
Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment.
Qianqian Song, Jimmy Ruiz, Fei Xing, Hui-Wen Lo, Lou Craddock, Ashok K Pullikuth, Lance D Miller, Michael H Soike, Stacey S O'Neill, Kounosuke Watabe, Michael D Chan, ...> ;Communications Biology. 2023 Jul 21
2 citations
c-Met Mediated Cytokine Network Promotes Brain Metastasis of Breast Cancer by Remodeling Neutrophil Activities.
Yin Liu, Margaret R Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L Kucera, Lance D Miller, Wencheng Li, Michael D Chan, Michael Farris, J...> ;Cancers. 2023 May 5
Five-year survivors from brain metastases treated with stereotactic radiosurgery: Biology, improving treatments, or just plain luck?
Jane B Pearce, Fang-Chi Hsu, Claire M Lanier, Christina K Cramer, Jimmy Ruiz, Hui-Wen Lo, Fei Xing, Margaret Smith, Wencheng Li, Christopher Whitlow, Jaclyn J White, S...> ;Neuro-Oncology Practice. 2023 Apr 1
3 citations
Prognostic Mutational Signatures of NSCLC Patients treated with chemotherapy, immunotherapy and chemoimmunotherapy.
Margaret R Smith, Yuezhu Wang, Ralph D'Agostino Jr, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N Abdulha...> ;NPJ Precision Oncology. 2023 Mar 27
Modulation of oxidative phosphorylation and mitochondrial biogenesis by cigarette smoke influence the response to immune therapy in NSCLC patients.
Yuezhu Wang, Margaret Smith, Jimmy Ruiz, Yin Liu, Gregory L Kucera, Umit Topaloglu, Michael D Chan, Wencheng Li, Jing Su, Fei Xing> ;Lung Cancer. 2023 Apr 1
1 citations
Collagen deposition within brain metastases is associated with leptomeningeal failure after cavity-directed radiosurgery.
Mohammed Abdulhaleem, Jimmy Ruiz, Stacey O'Neill, Ryan T Hughes, Shadi Qasem, Roy E Strowd, Cristina Furdui, Konousuke Watabe, Lance D Miller, Waldemar Debinski, Steph...> ;Neuro-Oncology Advances. 2023 Jan 6
Use of comprehensive genomic profiling for biomarker discovery for the management of non-small cell lung cancer brain metastases.
Abdulhaleem, M., Hunting, J., Wang, Y., Smith, M., Agostino, R., Lycan, T., Farris, M., Ververs, J., Lo, H., Watabe, K., Topaloglu, U., Li, W., Whitlow, C., Su, J., Wa...> ;Frontiers in Oncology. 2023 Jan 1
1 citations
Long term survivors of stereotactic radiosurgery for brain metastases: do distant brain failures reach a plateau and what factors are associated with a brain metastasi...
Claire M Lanier, Jane Pearce, Scott Isom, Fei Xing, Hui-Wen Lo, Christopher T Whitlow, Jimmy Ruiz, Jaclyn J White, Adrian W Laxton, Stephen B Tatter, Christina K Crame...> ;Journal of Neuro-Oncology. 2022 Dec 1
3 citations
Military exposures and lung cancer in United States veterans.
William Grier, Hatoon Abbas, Rediet Regassa Gebeyehu, Ankur Kumar Singh, Jimmy Ruiz, Stella Hines, Fahid Alghanim, Janaki Deepak> ;Seminars in Oncology. 2022 Jul 19
Team-Based Hospice Referrals: A Potential Quality Metric for Lung Cancer in the Immunotherapy Era.
Thomas W Lycan Jr, Alyssa Buckenheimer, Jimmy Ruiz, Gregory Russell, Andy Shipe Dothard, Tamjeed Ahmed, Stefan Grant, Carl Grey, William J Petty> ;The American Journal of Hospice & Palliative Care. 2023 Jan 1
28 citations
Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis.
Abhishek Tyagi, Shih-Ying Wu, Sambad Sharma, Kerui Wu, Dan Zhao, Ravindra Deshpande, Ravi Singh, Wencheng Li, Umit Topaloglu, Jimmy Ruiz, Kounosuke Watabe> ;Oncogene. 2022 May 1
6 citations
NEDD4 degrades TUSC2 to promote glioblastoma progression.
Tadas K Rimkus, Austin B Arrigo, Dongqin Zhu, Richard L Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T Regua, Grace L Wong, Sara Manore, Calvin Wagner, Hui-Ku...> ;Cancer Letters. 2022 Apr 10
13 citations
Local control outcomes for combination of stereotactic radiosurgery and immunotherapy for non-small cell lung cancer brain metastases.
Mohammed Abdulhaleem, Hannah Johnston, Ralph D'Agostino Jr, Claire Lanier, Michael LeCompte, Christina K Cramer, Jimmy Ruiz, Thomas Lycan, Hui-Wen Lo, Kuonosuke Watabe...> ;Journal of Neuro-Oncology. 2022 Mar 1
3 citations
Upfront immunotherapy leads to lower brain metastasis velocity in patients undergoing stereotactic radiosurgery for brain metastases.
Mohammed Abdulhaleem, Emmanuel Scott, Hannah Johnston, Scott Isom, Claire Lanier, Michael LeCompte, Christina K Cramer, Jimmy Ruiz, Hui-Wen Lo, Kuonosuke Watabe, Stace...> ;Journal of Radiosurgery and SBRT. 2022 Jan 1
Upfront Immunotherapy at the Time of Metastatic Cancer Diagnosis Leads to Lower Brain Metastasis Velocity in Patient Undergoing Stereotactic Radiosurgery for Brain Met...
E. Scott, Michael D. Chan, H. Johnston, C.M. Lanier, M.C. LeCompte, Christina K. Cramer, Jimmy Ruiz, Hui-Wen Lo, Kounosuke Watabe, Stacey S O'Neill, Christopher T. Whi...> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
5 citations
Correction: Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis.
Fei Xing, Yin Liu, Shih-Ying Wu, Kerui Wu, Sambad Sharma, Yin-Yuan Mo, Jiamei Feng, Stephanie Sanders, Guangxu Jin, Ravi Singh, Pierre-Alexandre Vidi, Abhishek Tyagi, ...> ;Cancer Research. 2021 Nov 1
1 citations
Review of brain metastasis prognostic nomograms and brain metastasis velocity: narrative review.
Mohammed Abdulhaleem, Jimmy Ruiz, Christina K. Cramer, Fei Xing, Hui-Wen Lo, Jing Su, Michael D. Chan> ;Chinese Clinical Oncology. 2021 Oct 28
1 citations
Treatment of Leptomeningeal Metastases: New Hammer, the Same Nail
Jimmy Ruiz, Michael D. Chan, Roy E. Strowd> ;Journal of Thoracic Oncology. 2021 Aug 1
5 citations
TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers.
Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel Doheny, Sara G. Manore, Dongqin Zhu, Grace L. Wong, Austin Arrigo, Calvin J. Wagner, Yang Yu, Alexandra Th...> ;Cancers. 2021 May 12
1 citations
Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer Fr...
Jing Su, Lynn S. Huang, Ryan T. Barnard, Graham E. Parks, James O. Cappellari, Christina Bellinger, Travis Dotson, Lou Craddock, Bharat Prakash, Jonathan T. Hovda, Hol...> ;Frontiers in Oncology. 2021 Apr 16
29 citations
Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy.
Jing Su, Qianqian Song, Shadi Qasem, Stacey S O'Neill, Jingyun Lee, Cristina M. Furdui, Boris Pasche, Linda J. Metheny-Barlow, Adrianna H. Masters, Hui-Wen Lo, Fei Xin...> ;Frontiers in Oncology. 2021 Apr 6
Correction: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor micro...
Sherona R Sirkisoon, Richard L Carpenter, Tadas Rimkus, Daniel Doheny, Dongqin Zhu, Noah R Aguayo, Fei Xing, Michael Chan, Jimmy Ruiz, Linda J Metheny-Barlow, Roy Stro...> ;Oncogene. 2021 Mar 1
12 citations
Unmet Care Needs and Financial Hardship in Patients With Metastatic Non–Small-Cell Lung Cancer on Immunotherapy or Chemoimmunotherapy in Clinical Practice
Laurie E. McLouth, Chandylen L Nightingale, Beverly J. Levine, Jessica L. Burris, Jean A. McDougall, Thomas Lycan, Jennifer Gabbard, Jimmy Ruiz, Michael Farris, Arthur...> ;JCO Oncology Practice. 2021 Feb 4
25 citations
SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis
Liang Liu, Tamjeed Ahmed, William J. Petty, Stefan C. Grant, Jimmy Ruiz, Thomas Lycan, Umit Topaloglu, Ping Chieh Chou, Lance D. Miller, Gregory A. Hawkins, Martha A. ...> ;Molecular Oncology. 2021 Feb 1
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