JoanMTaylorMD

Anesthesiology • Fletcher, NC

Associate Professor, Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine

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Office
PO Box 610
Anes. Dept
Fletcher, NC 28732
Phone(828) 329-5550
Fax(828) 483-6105
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Education & Training

Emory UniversityResidency, Anesthesiology, 1991 - 1994
Kaiser Foundation HospitalInternship, Transitional Year, 1978 - 1979
Loma Linda University School of MedicineClass of 1978

Certifications & Licensure

NC State Medical License 1979 - 2012
GA State Medical License Active through 2013
American Board of Anesthesiology Anesthesiology

Publications & Presentations

PubMed

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription.
Kyuho Jeong, Jung-Hyun Kim, James M. Murphy, Hyeonsoo Park, Su-Jeong Kim, Yelitza A.R. Rodriguez, Hyunkyung Kong, Chung-Sik Choi, Jun-Lin Guan, Joan M. Taylor, Thomas ...> ;Circulation Research. 2019 Jul 5
Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
Hong Ma, Shuo Yu, Xiaojing Liu, Yingao Zhang, Thomas Fakadej, Ziqing Liu, Chaoying Yin, Weining Shen, Jason W. Locasale, Joan M. Taylor, Li Qian, Jiandong Liu> ;Circulation. 2019 Apr 2
RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF.
Rozenberg, J. M.,Taylor, J. M.,Mack, C. P.> ;Nucleic Acids Res.. 2018 Jul 10
RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF.
Rozenberg, J. M.,Taylor, J. M.,Mack, C. P.> ;Nucleic Acids Res.. 2018 Jun 23
Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype
Laura Weise-Cross, Joan M. Taylor, Christopher P. Mack> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2015 Nov 1
DNA Methylation of a GC Repressor Element in the Smooth Muscle Myosin Heavy Chain Promoter Facilitates Binding of the Notch-Associated Transcription Factor, Recombinat...
Rozenberg, J. M.,Tesfu, D. B.,Musunuri, S.,Taylor, J. M.,Mack, C. P.> ;Arterioscler. Thromb. Vasc. Biol.. 2014 Oct 18
GRAF1 promotes ferlin-dependent myoblast fusion
Kaitlin C. Lenhart, Abby L. Becherer, Jianbin Li, Xiao Xiao, Elizabeth M. McNally, Christopher P. Mack, Joan M. Taylor> ;Developmental Biology. 2014 Sep 15
Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.
Dean P. Staus, Laura Weise-Cross, Kevin D. Mangum, Matt D. Medlin, Lee E. Mangiante, Joan M. Taylor, Christopher P. Mack> ;American Journal of Physiology-heart and Circulatory Physiology. 2014 Aug 1
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1
Zhaokang Cheng, Laura A. DiMichele, Mauricio Rojas, Cyrus Vaziri, Christopher P. Mack, Joan M. Taylor> ;Journal of Molecular and Cellular Cardiology. 2014 Feb 1
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.
Xue Bai, Kaitlin C. Lenhart, Kim E. Bird, Alisa A. Suen, Mauricio Rojas, Masao Kakoki, Feng Li, Oliver Smithies, Christopher P. Mack, Joan M. Taylor> ;Nature Communications. 2013 Dec 13
The CASZ1/Egfl7 transcriptional pathway is required for RhoA expression in vascular endothelial cells
Marta S. Charpentier, Joan M. Taylor, Frank L. Conlon> ;Small GTPases. 2013 Oct 22
Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels.
Hawes, E. M.,Deal, A. M.,Funk-Adcock, D.,Gosselin, R.,Jeanneret, C.,Cook, A. M.,Taylor, J. M.,Whinna, H. C.,Winkler, A. M.,Moll, S.> ;J. Thromb. Haemost.. 2013 Aug
CASZ1 Promotes Vascular Assembly and Morphogenesis through the Direct Regulation of an EGFL7/RhoA-Mediated Pathway
Marta S. Charpentier, Kathleen S. Christine, Nirav M. Amin, Kerry M. Dorr, Erich J. Kushner, Victoria L. Bautch, Joan M. Taylor, Frank L. Conlon> ;Developmental Cell. 2013 Apr 29
Cardiac damage induced by immunization with heat-killed Trypanosoma cruzi is not antibody mediated.
Bonney, K. M.,Gifford, K. M.,Taylor, J. M.,Chen, C. I.,Engman, D. M.> ;Parasite Immunol. 2013 Jan
ROCKs cause SHP-wrecks and broken hearts.
Panna Tandon, Frank L. Conlon, Joan M. Taylor> ;Small GTPases. 2012 Aug 3
Germline deletion of FAK-related non-kinase delays post-natal cardiomyocyte mitotic arrest.
Thomas J. O’Neill, Christopher P. Mack, Joan M. Taylor> ;Journal of Molecular and Cellular Cardiology. 2012 Aug 1
Targeted Focal Adhesion Kinase Activation in Cardiomyocytes Protects the Heart From Ischemia/Reperfusion Injury
Zhaokang Cheng, Laura A. DiMichele, Zeenat S. Hakim, Mauricio Rojas, Christopher P. Mack, Joan M. Taylor> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Apr 1
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton
Yvette Langdon, Panna Tandon, Erika Paden, Jennifer Duddy, Joan M. Taylor, Frank L. Conlon> ;Development. 2012 Mar 1
Quantifying Sphingosine-1-Phosphate-Dependent Activation of the RhoGTPases
Matt D. Medlin, Joan M. Taylor, Christopher P. Mack> ;Methods of Molecular Biology. 2012 Jan 1
Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility.
Britni Zajac, Zeenat S. Hakim, Morgan V. Cameron, Oliver Smithies, Joan M. Taylor> ;Methods of Molecular Biology. 2012 Jan 1
Focal Adhesion Kinase Regulates Smooth Muscle Cell Recruitment to the Developing Vasculature
Zhaokang Cheng, Liisa J. Sundberg-Smith, Lee E. Mangiante, Rebecca L. Sayers, Zeenat S. Hakim, Srilaxmi Musunuri, Colin T. Maguire, Mark W. Majesky, Zhigang Zhou, Chri...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2011 Oct 1
Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain.
Dean P. Staus, Joan M. Taylor, Christopher P. Mack> ;Biochemical Journal. 2011 Oct 1
Skeletal Muscle Differentiation and Fusion Are Regulated by the BAR-containing Rho-GTPase-activating Protein (Rho-GAP), GRAF1
Jason T. Doherty, Kaitlin C. Lenhart, Morgan V. Cameron, Christopher P. Mack, Frank L. Conlon, Joan M. Taylor> ;Journal of Biological Chemistry. 2011 Jul 22
Formin Homology Domain–Containing Protein 1 Regulates Smooth Muscle Cell Phenotype
Dean P. Staus, Alicia L. Blaker, Matt D. Medlin, Joan M. Taylor, Christopher P. Mack> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2011 Feb 1
Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation
Matt D. Medlin, Dean P. Staus, Adi D. Dubash, Joan M. Taylor, Christopher P. Mack> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Sep 1
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Grant Support

Control Of Adhesion-Dependent SMC Plasticity During Coronary And Outflow Tract DENational Heart, Lung, And Blood Institute2010–2012
FAK Signaling In Cardiac Growth And HypertrophyNational Heart, Lung, And Blood Institute2005–2012
Adhesion Signaling In Vascular Growth And DevelopmentNational Heart, Lung, And Blood Institute2003–2006
Convergence Of Integrin And RHO Signaling PathwaysNational Institute Of General Medical Sciences1996–1997