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Office
243 Charles St
Boston, MA 02114Phone+1 617-573-3915Fax+1 617-573-3698- Is this information wrong?
Summary
- As an ophthalmologist with subspecialty expertise in retina, I am dedicated to understanding the molecular mechanisms of ocular disease and improving therapeutic interventions. I pursue these objectives using a combination of laboratory and clinical research, clinical care, teaching, and administrative leadership. These activities take place primarily at Massachusetts Eye and Ear—the flagship academic center for the Harvard Medical School Department of Ophthalmology—and extend worldwide through global collaborations and partnerships.
My research interests focus on neovascular diseases of the retina and choroid, particularly age-related macular degeneration (AMD) and diabetic retinopathy. My work has led to two significant advances: the first pharmacologic therapy for AMD, and the identification of a prominent therapeutic target in neovascular retinal disease. The first endeavor comprised the development of photodynamic therapy (PDT) with verteporfin (Visudyne), from preclinical studies to clinical trials to FDA approval, for the treatment of choroidal neovascularization. A parallel line of investigation identified the key role of vascular endothelial growth factor (VEGF) in pathological retinal and choroidal neovascularization. Several drugs targeting VEGF were subsequently developed, and many are now approved by health authorities worldwide. Ongoing studies are pursuing other mechanisms of vision loss in retinal disease, and identifying novel therapeutic targets through genetic studies.
Education & Training
- Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolFellowship, Surgical Retina and Vitreous, 1989 - 1991
- Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolResidency, Ophthalmology, 1986 - 1989
- Newton-Wellesley HospitalInternship, Internal Medicine, 1985 - 1986
- Harvard Medical SchoolClass of 1985
- Massachusetts Institute of TechnologySB, 1976 - 1980
Certifications & Licensure
- MA State Medical License 1989 - 2024
- American Board of Ophthalmology Ophthalmology
Awards, Honors, & Recognition
- Super Doctor SuperDoctors.com
- Fellow (FAAO) American Academy of Ophthalmology
Publications & Presentations
PubMed
- A Comprehensive Surgical Curriculum Reduced Intra-operative Complication Rates of Resident-performed Cataract Surgeries.Borboli-Gerogiannis, S., Jeng-Miller, K. W., Koulisis, N., Moustafa, G. A., Chang, K. K., Chen, S. H., Gardiner, M. F., Greenstein, S. H., Luo, Z., Chen, T. C., Loewen...> ;Journal of surgical education. 2018 Aug 23
- Age-Related Macular Degeneration Revisited - Piecing the Puzzle: The LXIX Edward Jackson Memorial LectureJoan W. Miller, MD> ;Elsevier.
- Vascular Endothelial Growth Factor A in Intraocular Vascular DiseaseJoan W Miller, Erich C Strauss> ;Ophthalmology.
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Authored Content
- Ophthalmology in the Time of COVID-19November 2020
Press Mentions
- The Blind Can SeeJune 13th, 2017
- Patients with Macular Degeneration Show Improvement with High-Dose Statin TreatmentFebruary 4th, 2016
- Mass. Eye and Ear Endows Lecture to Honor Joan W. MillerAugust 2nd, 2017
Grant Support
- Unrestricted GrantResearch to Prevent Blindness2004–Present
- Retinal and choroidal disease: Translational researchRetinal Neovascularization Fund (Philanthropy)1995–Present
- A natural history observation and registry study of macular telangiectasia type 2: The Mactel StudyLowy Medical Research Institute Limited (Lowy Medical Research)2011–2015
Research History
- Co-director, Angiogenesis Laboratory, Massachusetts Eye and Ear2003 - Present
- Co-director, Retina Research Institute, Massachusetts Eye and Ear2003 - Present
- Director, Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear2003 - 2009
Professional Memberships
- Fellow
- Association for Research in Vision and Ophthalmology - ARVOGold Fellow
- Macula SocietyMember
- Retina SocietyMember
- New England Ophthalmological SocietyMember
- Association of University Professors of OphthalmologyMember
- Women in RetinaFounding Member
- Women in OphthalmologyMember
- National Academy of Medicine (formerly Institute of Medicine)Member
- Academia Ophthalmologica InternationalisMember
Hospital Affiliations
- Massachusetts Eye and EarBoston, Massachusetts
- Massachusetts General HospitalBoston, Massachusetts
- Massachusetts General HospitalBoston, Massachusetts
- Brigham and Women's HospitalBoston, Massachusetts
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