Joann E Manson MD

Endocrinology•Boston, MA

Diabetes, Lipid Metabolism

Michael and Lee Bell Professor of Women's Health, Brigham and Women's Hospital, Preventative Cardiology

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Brigham & Women's Hosp900 Commonwealth Ave E.Boston, MA 02215
Phone+1 617-278-0871

Summary

JoAnn Manson, MD, DrPH, is an endocrinologist based in Boston, MA, with subspecialties in diabetes, lipid metabolism, vitamin D, and estrogen therapy decision making. She completed her residency in Internal Medicine at Beth Israel Deaconess Medical Center and a fellowship in Endocrinology, Diabetes, and Metabolism at Boston Medical Center/University Hospital. Dr. Manson graduated from Harvard College in 1975, Case Western Reserve University School of Medicine in 1979, and Harvard School of Public Health in 1984 (MPH) and 1987 (DrPH). Her recent publications include research on benefits and risks of estrogen therapy, adipose tissue and postmenopausal breast cancer, frailty and mortality, blood pressure and white matter hyperintensities, and noise exposure and hypertension. She has been involved in notable clinical trials such as the Women's Health Initiative, the VITamin D and OmegA-3 TriaL (VITAL), the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), and others. Dr. Manson has received recognition as an Elected Member of the Institute of Medicine (National Academy of Medicine) and the Association of American Physicians, a Distinguished Scientist of the American Heart Association, has been listed in Marquis Who's Who in Medicine and Healthcare, and is a Master of the American College of Physicians.

Education & Training

Harvard School of Public HealthMPH and DrPH, Epidemiology, 1983 - 1987
Boston University Medical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1982 - 1984
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1979 - 1982
Case Western Reserve University School of MedicineClass of 1979

Certifications & Licensure

MA State Medical License 1981 - 2027
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Elected Member Institute of Medicine, 2011
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACE) American Association of Clinical Endocrinology

Clinical Trials

Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) Start of enrollment: 1993 May 01
Completed
Phase 2
Nurses' Health Study (Cardiovascular Component)
ACTIVE_NOT_RECRUITING
KEEPS Cognitive and Affective Study Start of enrollment: 2007 May 01
Vitamin D and Omega-3 Trial (VITAL)
ACTIVE_NOT_RECRUITING
PHASE3
COcoa Supplement and Multivitamin Outcomes Study for the Mind Start of enrollment: 2016 Sep 01
Completed
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Publications & Presentations

PubMed

Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension.
Rikuta Hamaya, Sidong Li, Jessica Lau, Matthew Allison, Bernhard Haring
Hypertension. 2025-10-01
Ultra-processed Foods and Diet Quality in Association With Long-term Weight Change and Progression to Type 2 Diabetes Among Individuals With a History of Gestational D...
Jiaxi Yang, Xin Yin, Deirdre K Tobias, Zhangling Chen, Qi Sun
Diabetes Care. 2025-10-01
The Growing Promise of Elinzanetant for Treatment of Menopausal Symptoms-Sustained Relief Without Hormones.
Jaya M Mehta, Denise M Millstine, JoAnn E Manson
JAMA Internal Medicine. 2025-09-08

Journal Articles

Associations of Menstrual Cycle Characteristics Across the Reproductive Life Span and Lifestyle Factors with Risk of Type 2 Diabetes
Joann Manson, MD, JAMA Network Open
Association of Adverse Pregnancy Outcomes with Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women
Mark A Hlatky, Joann E Manson, JAMA Cardiology
Marine N−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
Joann E Manson, Samia Mora, Christine M Albert, The New England Journal of Medicine
Habitual Sleep Quality, Plasma Metabolites and Risk of Coronary Heart Disease in Post-Menopausal Women
Susan Redline, Elizabeth M Poole, JoAnn E Manson, Kathryn M Rexrode, International Journal of Epidemiology
Predicting Fracture Risk in Younger Postmenopausal Women: Comparison of the Garvan and FRAX Risk Calculators in the Women’s Health Initiative Study
Erin S LeBlanc, Beatrice J Edwards, Kristine Ensrud, Meryl S LeBoff, Carolyn J Crandall, JoAnn E Manson, Journal of General Internal Medicine
Clinical Research Physical Activity and Incidence of Heart Failure in Postmenopausal Women
Liviu Klein, Karen C Johnson, JoAnn E Manson, Cora E Lewis, ScienceDirect
Using High-Dimensional Machine Learning Methods to Estimate an Anatomical Risk Factor for Alzheimer's Disease Across Imaging Databases
Stephen R Rapp, JoAnn E Manson, ScienceDirect
Menstrual Cycle Characteristics in Adolescence and Early Adulthood Are Associated with Risk of Early Natural Menopause
Brian W Whitcomb, JoAnn E Manson, The Journal of Clinical Endocrinology and Metabolism
Evaluation of the Pooled Cohort Risk Equations for Cardiovascular Risk Prediction in a Multiethnic Cohort from the Women’s Health Initiative
Marian C Limacher, Lisa W Martin, Paul M Ridker, Nancy R Cook, Jennifer G Robinson, Monika M Safford, Nanette K Wenger, Samia Mora, JoAnn E Manson, JAMA
A Transcriptome-Wide Association Study of 229,000 Women Identifies New Candidate Susceptibility Genes for Breast Cancer
JoAnn E Manson, Olufunmilayo I Olopade, Wei Zheng, Nature
Biomarker-Calibrated Total Sugars Intake and Risk of Type 2 Diabetes and Cardiovascular Disease in the Women's Health Initiative Observational Study
JoAnn E Manson, Cynthia A Thomson, American Journal of Epidemiology
Anti-Müllerian Hormone Levels and Incidence of Early Natural Menopause in a Prospective Study
Brian W Whitcomb, Anne Z Steiner, JoAnn E Manson, Human Reproduction
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Lectures

Reproductive Health as a Marker of Subsequent Cardiovascular Disease
93rd Annual Meeting & Expo, Boston, Massachusetts, USA
Reproductive Health as a Marker of Subsequent Cardiovascular Disease
American College of Cardiology, 60th Annual Scientific Session & Expo, New Orleans, Louisiana, USA
Reproductive Health as a Marker of Subsequent Cardiovascular Disease
Endocrine Society, 93rd Annual Meeting & Expo, Boston, Massachusetts, USA
Reproductive Health as a Marker of Subsequent Cardiovascular Disease
60th Annual Scientific Session & Expo, New Orleans, Louisiana, USA
Reproductive Health as a Marker of Subsequent Cardiovascular Disease
American Institute for Cancer Research, Washington, Dist Of Col - 11/3/2011
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Press Mentions

Changes to ‘Black Box’ Warning on Hormone Therapy for Menopause Symptoms Expected Soon, FDA Chief SaysOctober 2nd, 2025
Could Chocolate Compounds Help Slow Aging? Scientists Suggest They MightSeptember 17th, 2025
Brigham and Women's Study Finds Vitamin D May Slow Biological AgingAugust 12th, 2025
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Grant Support

RISK FACTORS FOR CVD IN WOMENTULANE UNIVERSITY OF LOUISIANA1984–2028
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchHARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH2019–2026
The VITamin D and OmegA-3 TriaL (VITAL): Post-Intervention Follow-UpBRIGHAM AND WOMEN'S HOSPITAL2009–2026
Vitamin D And Omega-3 Trial (VITAL)National Cancer Institute2009–2011
The Kronos Early Estrogen Prevention Study (KEEPS)National Center For Research Resources2007–2008
Trial Of Antioxidant Therapy Of CVD In WomenNational Heart, Lung, And Blood Institute1993–2005
Biochemical And Genetic Markers Of Type 2 Diabetes RiskNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2004
Vanguard Center For Women'S Health InitiativeWomen'S Health Initiative - Office Of The Director Nih1993–2000
Biochemical Predictors Of NIDDM In WomenNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1998
Modifiable Determinants Of NIDDMNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1997