JoeWheelerGrishamMD

Pathology • Chapel Hill, NC

Physician

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Office
Unc-Ch Dept Pth Cb 7525
Chapel Hill, NC 27599
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Education & Training

Vanderbilt University School of MedicineClass of 1957

Certifications & Licensure

NC State Medical License 1973 - 2011

Publications & Presentations

PubMed

13 citations
Calcium Signals Induce Liver Stem Cells to Acquire a Cardiac Phenotype
Page A.W. Anderson, Barbara J. Muller-Borer, Gwyn L. Esch, William B. Coleman, Joe W. Grisham, Nadia N. Malouf> ;Cell Cycle. 2007 Jul 2
20 citations
Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells.
Barbara J. Muller-Borer, Wayne E. Cascio, Gwyn L. Esch, Hyung Suk Kim, William B. Coleman, Joe W. Grisham, Page A.W. Anderson, Nadia N. Malouf> ;Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 6
50 citations
Molecular prognostication of liver cancer: End of the beginning
Snorri S. Thorgeirsson, Ju Seog Lee, Joe W. Grisham> ;Journal of Hepatology. 2006 Apr 1
109 citations
Functional genomics of hepatocellular carcinoma.
Snorri S. Thorgeirsson, Ju Seog Lee, Joe W. Grisham> ;Hepatology. 2006 Feb 1
172 citations
Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence
Snorri S. Thorgeirsson, Joe W. Grisham> ;Hepatology. 2006 Jan 1
1 citations
Acquired Cell-to-Cell Coupling and "Cardiac-Like" Calcium Oscillations in Adult Stem Cells in a Cardiomyocyte Microenvironment
Barbara J. Muller-Borer, Wayne E. Cascio, Gwyn L. Esch, Joe W. Grisham, Page A.W. Anderson, Nadia N. Malouf> ;Conference Proceedings. 2006 Jan 1
42 citations
Comparative functional genomics for identifying models of human cancer.
Ju Seog Lee, Joe W. Grisham, Snorri S. Thorgeirsson> ;Carcinogenesis. 2005 Jun 1
21 citations
Adult-derived liver stem cells acquire a cardiomyocyte structural and functional phenotype ex vivo
Barbara J. Muller-Borer, Wayne E. Cascio, Page A.W. Anderson, John N. Snowwaert, James R. Frye, Niyati Desai, Gwyn L. Esch, Joe A. Brackham, C. Robert Bagnell, William...> ;The American Journal of Pathology. 2004 Jul 1
48 citations
Overview of recent experimental studies on liver stem cells.
Snorri S. Thorgeirsson, Joe W. Grisham> ;Seminars in Liver Disease. 2003 Nov 1
5 citations
Molecular regulation of hepatocyte generation in adult animals.
Joe W. Grisham, William B. Coleman> ;The American Journal of Pathology. 2002 Oct 1
1169 citations
Molecular pathogenesis of human hepatocellular carcinoma
Snorri S. Thorgeirsson, Joe W. Grisham> ;Nature Genetics. 2002 Aug 1
12 citations
Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response
Patty A. Lange, Laura W. Schrum, Joe W. Grisham, Richard A. Rippe, Kevin E. Behrns, Mark A. Bird> ;Surgery. 2002 May 1
39 citations
Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats.
Gavin J. Gordon, Genelle M. Butz, Joe W. Grisham, William B. Coleman> ;Transplantation. 2002 Apr 27
4 citations
Suppression of tumorigenicity of rat liver tumor cells by human chromosome 13: Evidence against the involvement of pRb and BRCA2
Michelle A. Rider, Genelle M. Butz, Sharon L. Ricketts, Suzanne T. Newberry, Joe W. Grisham, William B. Coleman> ;International Journal of Oncology. 2002 Feb 1
11 citations
Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells.
William K. Kaufmann, Cynthia I. Behe, Vita Golubovskaya, Laura L. Byrd, Craig D. Albright, Kristen M. Borchet, Sharon C. Presnell, William B. Coleman, Joe W. Grisham, ...> ;Carcinogenesis. 2001 Aug 1
1 citations
Kenneth Merle Brinkhous, M.D. 1908-2000.
Joe W. Grisham, J. Charles Jennette> ;The American Journal of Pathology. 2001 Jul 1
97 citations
Adult-Derived Stem Cells from the Liver Become Myocytes in the Heart in Vivo
Nadia N. Malouf, William B. Coleman, Joe W. Grisham, Ruth A. Lininger, Victoria J. Madden, Matthew Sproul, Page A.W. Anderson> ;The American Journal of Pathology. 2001 Jun 1
32 citations
Autocrine expression of activated transforming growth factor-β1 induces apoptosis in normal rat liver
Laura W. Schrum, Salcher Olga, Elmar-Reinhold Burchardt, Joe W. Grisham, David A. Brenner, Richard A. Rippe, Kevin E. Behrns, Mark A. Bird> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001 Jan 1
100 citations
Temporal Analysis of Hepatocyte Differentiation by Small Hepatocyte-Like Progenitor Cells during Liver Regeneration in Retrorsine-Exposed Rats
Gavin J. Gordon, William B. Coleman, Joe W. Grisham> ;The American Journal of Pathology. 2000 Sep 1
35 citations
Bax-mediated apoptosis in the livers of rats after partial hepatectomy in the retrorsine model of hepatocellular injury.
Gavin J. Gordon, William B. Coleman, Joe W. Grisham> ;Hepatology. 2000 Aug 1
36 citations
Induction of cytochrome P450 enzymes in the livers of rats treated with the pyrrolizidine alkaloid retrorsine.
Gavin J. Gordon, William B. Coleman, Joe W. Grisham> ;Experimental and Molecular Pathology. 2000 Aug 1
136 citations
Liver Regeneration in Rats with Retrorsine-Induced Hepatocellular Injury Proceeds through a Novel Cellular Response
Gavin J. Gordon, William B. Coleman, Douglas C. Hixson, Joe W. Grisham> ;The American Journal of Pathology. 2000 Feb 1
4 citations
Induction of rat WT1 gene expression correlates with human chromosome 11p11.2-p12-mediated suppression of tumorigenicity in rat liver epithelial tumor cell lines.
William B. Coleman, Sharon L. Ricketts, Kristen M. Borchert, Sharon C. Presnell, Gwyn L. Esch, Karen D. McCullough, Bernard E. Weissman, Gary J. Smith, Joe W. Grisham> ;International Journal of Oncology. 1999 May 1
58 citations
Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors
Karen D. McCullough, William B. Coleman, Sharon L. Ricketts, Julie W. Wilson, Gary J. Smith, Joe W. Grisham> ;Proceedings of the National Academy of Sciences of the United States of America. 1998 Dec 22
21 citations
Spontaneous Neoplastic Transformation of WB-F344 Rat Liver Epithelial Cells
Michelle J. Hooth, William B. Coleman, Sharon C. Presnell, Kristen M. Borchert, Joe W. Grisham, Gary J. Smith> ;The American Journal of Pathology. 1998 Dec 1
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Grant Support

Clonal Analysis Of Carcinogenesis In VitroNational Cancer Institute1987–2002
Clonal Analysis Of Carcinogenesis In VitroNational Cancer Institute1990–1997
Environmental PathologyNational Institute Of Environmental Health Sciences1985–1994
Mechanisms Of DNA Dependent Cytotoxicity By ChemicalsNational Cancer Institute1986–1992
Mechanism Of DNA Dependent Cytotoxicity By ChemicalsNational Cancer Institute1988–1990
DNA Adducts, Replication, Mutation And TransformationNational Cancer Institute1986–1988
Mechamisms Of DNA Dependent Cytotoxicity By ChemicalsNational Cancer Institute1986–1987
DNA Methyl Adducts: Toxicity, Mutation, &TransformationNational Cancer Institute1986
Analysis Of Tumor Progression In Liver Cells In VitroNational Cancer Institute1985–1986
Mechanisms Of DNA Dependent Cytoxicity By ChemicalsNational Cancer Institute1985

JoeWheelerGrishamMD

Dr. Grisham is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Grant Support

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