JoelMNeutelMD

Internal Medicine • Tustin, CA

Preventative Cardiology

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Office
14351 Myford Rd
Suite B
Tustin, CA 92780
Phone+1 714-550-9990

Fax+1 714-550-1226
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Education & Training

University of California (Irvine)Residency, Internal Medicine, 1991 - 1993
University of the WitwatersrandClass of 1983

Certifications & Licensure

CA State Medical License 1992 - 2026

Clinical Trials

Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus Start of enrollment: 2010 Jun 18
Completed
Phase 3
Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure Start of enrollment: 2012 Jan 01
Completed
Phase 2
Evaluation of Cross-Linked Polyelectrolyte (CLP) With Placebo in Heart Failure Subjects Start of enrollment: 2013 Jan 01
Unknown status
Phase 2
Phase III Study to Evaluate Efficacy and Safety of DSC127 in Diabetic Foot Ulcers Start of enrollment: 2013 Feb 01
Terminated
Phase 3
Open-Label Study in Diabetic Foot Ulcers (DFU), to Evaluate Safety of 0.03% DSC127 Topical Gel in Chronic Use Start of enrollment: 2015 Dec 01
Terminated
Phase 3
A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure Start of enrollment: 2013 Sep 01
Completed
Phase 1
A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics Start of enrollment: 2014 Mar 01
Completed
Phase 2
Phase II Safety and Efficacy Study of Oral ORMD-0801 in Patients With Type 2 Diabetes Mellitus Start of enrollment: 2015 Jul 27
Completed
Phase 2
Finasteride Treatment of Severe Nodulocystic Acne Start of enrollment: 2015 Jul 01
Completed
Phase 2
A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (25) Start of enrollment: 2016 Jan 21
Completed
Phase 3
Glycemic Response to Three Oral Nutrition Supplements in Persons With Type 2 Diabetes Mellitus Start of enrollment: 2016 Jul 01
Completed
Not Applicable
Glycemic Response to Two Enteral Formulas in Persons With Type 2 Diabetes Mellitus Start of enrollment: 2016 Aug 01
Completed
Not Applicable
A Study of Single and Multiple Doses of Oral Insulin or Placebo in Subjects With Type 2 Diabetes Mellitus Start of enrollment: 2016 Oct 01
Completed
Phase 2
Glycemic Response to Six Meal Replacements in Persons With Type 2 Diabetes Mellitus Start of enrollment: 2017 Apr 05
Completed
Not Applicable
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis Start of enrollment: 2017 Sep 19
Completed
Phase 1, Phase 2
A Study to Evaluate the Efficacy and Safety of ORMD-0801 (Oral Insulin) in Patients With Type 2 Diabetes Mellitus Start of enrollment: 2018 May 29
Completed
Phase 2
A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function Start of enrollment: 2018 Mar 30
Completed
Phase 1
A Safety Study of Tucatinib in Healthy and Hepatically-Impaired Subjects Start of enrollment: 2018 Oct 10
Completed
Phase 1
A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy Start of enrollment: 2018 Oct 10
Recruiting
Phase 1
Glycemic Response in Persons With Type 2 Diabetes Mellitus Start of enrollment: 2018 Feb 05
Completed
Not Applicable
A Study to Evaluate the Effect of ORMD-0801 in Patients With Type 2 Diabetes Mellitus Start of enrollment: 2020 Nov 23
Completed
Phase 2
Pharmacokinetic and Safety Study of Naltrexone Release From Subcutaneous BICX104 Pellets Compared to Vivitrol Injections Start of enrollment: 2022 Jun 17
Completed
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

3 citations
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Véniant, M., Lu, S., Atangan, L., Komorowski, R., Stanislaus, S., Cheng, Y., Wu, B., Falsey, J., Hager, T., Thomas, V., Ambhaikar, M., Sharpsten, L., Zhu, Y., Kurra, V...> ;Nature Metabolism. 2024 Feb 1
1 citations
Effect of Hepatic Impairment on the Pharmacokinetics of Nirmatrelvir/Ritonavir, the First Oral Protease Inhibitor for the Treatment of COVID-19.
Ravi Shankar P Singh, Robert R LaBadie, Sima S Toussi, Haihong Shi, Jolene Kay Berg, Joel M Neutel, Sudeepta Aggarwal> ;Journal of Clinical Pharmacology. 2024 Feb 1
4 citations
Oral insulin (ORMD-0801) in type 2 diabetes mellitus: A dose-finding 12-week randomized placebo-controlled study.
Roy Eldor, Bruce H Francis, Alexander Fleming, Joel Neutel, Kenneth Homer, Miriam Kidron, Julio Rosenstock> ;Diabetes, Obesity & Metabolism. 2023 Apr 1
A Randomized, Placebo-Controlled Crossover Study to Evaluate Postprandial Glucometabolic Effects of Mulberry Leaf Extract, Vitamin D, Chromium, and Fiber in People wit...
Mafauzy Mohamed, Roberto Luis Zagury, Kalpana Bhaskaran, Joel Neutel, Barakatun Nisak Mohd Yusof, Linda Mooney, Lihe Yeo, Bridget-Anne Kirwan, Olivier Aprikian, Maximi...> ;Diabetes Therapy. 2023 Apr 1
25 citations
Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID-19, in Subjects With Renal Impairment.
Sima S Toussi, Joel Michael Neutel, Jesus Navarro, Richard Alfred Preston, Haihong Shi, Olga Kavetska, Robert R LaBadie, Michael Binks, Phylinda L S Chan, Neil Demers,...> ;Clinical Pharmacology and Therapeutics. 2022 Oct 1
12 citations
Pharmacokinetics, Pharmacodynamics, and Tolerability of Olpasiran in Healthy Japanese and Non-Japanese Participants: Results from a Phase I, Single-dose, Open-label St...
Winnie Sohn, Peter Winkle, Joel Neutel, You Wu, Freeman Jabari, Caitlin Terrio, Tracy Varrieur, Jingying Wang, Jennifer Hellawell> ;Clinical Therapeutics. 2022 Sep 1
7 citations
A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients.
Peter Winkle, Steven Goldsmith, Michael J Koren, Serge Lepage, Jennifer Hellawell, Ashit Trivedi, Kate Tsirtsonis, Siddique A Abbasi, Allegra Kaufman, Richard Troughto...> ;Cardiovascular Drugs and Therapy. 2023 Aug 1
105 citations
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).
Michael J Koren, Patrick Maurice Moriarty, Seth J Baum, Joel Neutel, Martha Hernandez-Illas, Howard S Weintraub, Monica Florio, Helina Kassahun, Stacey Melquist, Tracy...> ;Nature Medicine. 2022 Jan 1
14 citations
Efficacy and safety of 28-day treatment with oral insulin (ORMD-0801) in patients with type 2 diabetes: A randomized, placebo-controlled trial.
Roy Eldor, Joel Neutel, Kenneth E. Homer, Miriam Kidron> ;Diabetes, Obesity & Metabolism. 2021 Nov 1
11 citations
Safety, Tolerability, and Physiological Effects of AXA1665, a Novel Composition of Amino Acids, in Subjects With Child-Pugh A and B Cirrhosis.
Manu V. Chakravarthy, Joel Neutel, Scharmen Confer, Peng Zhao, Noriaki Tatsuta, Sam Rebello, William Comb, Michael Hamill, Tony Tramontin, Sean M. Carroll, Raffi Afeya...> ;Clinical and Translational Gastroenterology. 2020 Aug 1
6 citations
Risk of Hospitalization for Cardiovascular Events with β-Blockers in Hypertensive Patients: A Retrospective Cohort Study
Jan Basile, Brent M. Egan, Henry Punzi, Sanjida Ali, Qian Li, Mehul D. Patel, Joel M. Neutel> ;Cardiology and Therapy. 2018 Sep 6
8 citations
Very high-protein and low-carbohydrate enteral nutrition formula and plasma glucose control in adults with type 2 diabetes mellitus: a randomized crossover trial
Maureen B. Huhmann, Shinobu Yamamoto, Joel M. Neutel, Sarah S. Cohen, Juan B. Ochoa Gautier> ;Nutrition & Diabetes. 2018 Aug 30
4 citations
Human placental membrane as a wound cover for chronic diabetic foot ulcers: a prospective, postmarket, CLOSURE study.
Douglas J Pacaccio, Shawn Cazzell, Gabriel J Halperin, Maria A Kasper, Joel M Neutel, Brian D O'Carroll, Alexander M. Reyzelman> ;Journal of Wound Care. 2018 Jul 14
4 citations
Additivity of nebivolol/valsartan single-pill combinations versus other single-pill combinations for hypertension.
Jack Ishak, Michael Rael, Henry Punzi, Alan H. Gradman, Lynn M. Anderson, Mehul Patel, Sanjida Ali, William S. Ferguson, Joel M. Neutel> ;Journal of Clinical Hypertension. 2018 Jan 1
5 citations
Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide.
Joel M. Neutel, William C. Cushman, Eric E. Lloyd, Bruce Barger, Alison Handley> ;Journal of Clinical Hypertension. 2017 Sep 1
14 citations
A First-in-Patient, Multicenter, Double-Blind, 2-Arm, Placebo-Controlled, Randomized Safety and Tolerability Study of a Novel Oral Drug Candidate, CTP-499, in Chronic ...
LuAnn Sabounjian, Philip B. Graham, Lijun Wu, Virginia Braman, Changfu Cheng, Julie Liu, James Shipley, Joel Neutel, Michael Dao> ;Clinical Pharmacology in Drug Development. 2016 Jul 1
Additivity of Nebivolol/Valsartan Single-Pill Combination Versus Other Single-Pill Combinations for Hypertension.
J. Ishak, M. Rael, Henry Punzi, Alan H. Gradman, Mehul Patel, S. Ali, William S. Ferguson, Joel M. Neutel> ;Journal of the American Society of Hypertension. 2016 Jul 1
144 citations
Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in stati...
Christie M. Ballantyne, Joel M. Neutel, Anne B. Cropp, William T. Duggan, Ellen Q. Wang, David R. Plowchalk, Kevin Sweeney, Nitin Kaila, John Vincent, Harold E. Bays> ;The American Journal of Cardiology. 2015 May 1
7 citations
Long-term safety of nebivolol and valsartan combination therapy in patients with hypertension: an open-label, single-arm, multicenter study
Joel M. Neutel, Thomas D. Giles, Henry Punzi, Robert J. Weiss, Huiling Li, Amy Finck> ;Journal of the American Society of Hypertension. 2014 Dec 1
308 citations
Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab.
Michael J. Koren, Pernille Lundqvist, Michael A. Bolognese, Joel M. Neutel, Maria Laura Monsalvo, Jingyuan Yang, Jae B. Kim, Rob Scott, Scott M. Wasserman, Harold E. B...> ;Journal of the American College of Cardiology. 2014 Jun 17
Telmisartan in combination with hydrochlorothiazide 12.5 mg for the management of patients with hypertension
Steen Neldam, Helmut Schumacher, Sverre E. Kjeldsen, Joel M. Neutel> ;Current Medical Research and Opinion. 2014 May 19
380 citations
Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized...
Jennifer G. Robinson, Bettina S. Nedergaard, William J. Rogers, Jonathan Fialkow, Joel M. Neutel, David Ramstad, Ransi Somaratne, Jason C. Legg, Patric Nelson, Rob Sco...> ;JAMA. 2014 May 14
11 citations
Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects
Jeffrey Thompson, Joel Neutel, Ken Homer, Ken Tempero, Ajit K. Shah, Raj Khankari> ;Journal of Clinical Pharmacology. 2014 May 1
12 citations
Rationale and Design of LAPLACE‐2: A Phase 3, Randomized, Double‐Blind, Placebo‐ and Ezetimibe‐Controlled Trial Evaluating the Efficacy and Safety of Evolocumab in Sub...
Jennifer G. Robinson, William J. Rogers, Bettina S. Nedergaard, Jonathan Fialkow, Joel M. Neutel, David Ramstad, Ransi Somaratne, Jason C. Legg, Patric Nelson, Rob Sco...> ;Clinical Cardiology. 2014 Apr 1
10 citations
Adding Saxagliptin to Metformin Extended Release (XR) or Uptitration of Metformin XR: Efficacy on Daily Glucose Measures
Joel M. Neutel, Cathy Zhao, C.S. Karyekar> ;Diabetes Therapy. 2013 Jul 24
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Journal Articles

Very High-Protein and Low-Carbohydrate Enteral Nutrition Formula and Plasma Glucose Control in Adults with Type 2 Diabetes Mellitus: A Randomized Crossover Trial
Joel Neutel, MD, Nature

Press Mentions

BioCorRx Completes Enrollment in Trial of Naltrexone Implant for Treating Opioid Use DisorderOctober 13th, 2022
OC Firm Fighting Addiction Seeks Volunteers for Clinical TrialJuly 7th, 2022
BioCorRx Begins Recruitment for Clinical Trial of BICX104, an Implantable Naltrexone Pellet for the Treatment of Opioid Use DisorderApril 27th, 2022
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Hospital Affiliations

Providence St. Joseph Hospital OrangeOrange, California

JoelMNeutelMD

Dr. Neutel is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Hospital Affiliations

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