
John L Berk MD
Critical Care Medicine, Pleural Disease
Associate Professor of Medicine, Boston University
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- 725 Albany St# ShapiroBoston, MA 02118 
- Phone+1 617-638-7480 
- Fax+1 617-638-7486 
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Education & Training
 Boston University Medical CenterFellowship, Pulmonary Disease and Critical Care Medicine, 1987 - 1991 Boston University Medical CenterFellowship, Pulmonary Disease and Critical Care Medicine, 1987 - 1991
 University of California (San Diego) Medical CenterResidency, Internal Medicine, 1985 - 1985 University of California (San Diego) Medical CenterResidency, Internal Medicine, 1985 - 1985
 Case Western Reserve University/University Hospitals Cleveland Medical CenterInternship, Internal Medicine, 1983 - 1984 Case Western Reserve University/University Hospitals Cleveland Medical CenterInternship, Internal Medicine, 1983 - 1984
 Case Western Reserve University School of MedicineClass of 1983 Case Western Reserve University School of MedicineClass of 1983
Certifications & Licensure
 MA State Medical License 1987 - 2027 MA State Medical License 1987 - 2027
 OH State Medical License 1986 - 1990 OH State Medical License 1986 - 1990
 American Board of Internal Medicine Internal Medicine American Board of Internal Medicine Internal Medicine
 American Board of Internal Medicine Pulmonary Disease American Board of Internal Medicine Pulmonary Disease
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2010-2014
- Boston Magazine Castle Connolly, 2009-2013
- Super Doctor SuperDoctors.com
Clinical Trials
- The Effect of Diflunisal on Familial Amyloidosis Start of enrollment: 2006 Feb 01
- Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis Start of enrollment: 2010 Nov 01
- Safety and Effect of Doxycycline in Patients With Amyloidosis Start of enrollment: 2012 Jul 01
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Publications & Presentations
PubMed
- 3 citationsEffects of eplontersen on symptoms of autonomic neuropathy in hereditary transthyretin-mediated amyloidosis: secondary analysis from the NEURO-TTRansform trial.Jonas Wixner, John L Berk, David Adams, Michael Polydefkis, Isabel Conceição
 Amyloid. 2025-03-01
- 8 citationsFive-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension.David Adams, Jonas Wixner, Michael Polydefkis, John L Berk, Isabel M Conceição
 JAMA Neurology. 2025-03-01
- Correction: Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform.Isabel Conceição, John L Berk, Markus Weiler, Pedro A Kowacs, Noel R Dasgupta
 Journal of Neurology. 2025-02-03
Journal Articles
- Unusual Duplication Mutation in a Surface Loop of Human Transthyretin Leads to an Aggressive Drug-Resistant Amyloid DiseaseJohn L Berk, Paul J Kurtin, Proceedings of the National Academy of Sciences
- Inotersen Treatment for Patients with Hereditary Transthyretin AmyloidosisWilliam J Litchy, Peter D Gorevic, Morie A Gertz, Amil M Shah, John L Berk, Peter J Dyck, The New England Journal of Medicine
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin AmyloidosisPeter J Dyck, John L Berk, The New England Journal of Medicine
Press Mentions
 Faculty Promotions Announced, May 2021August 17th, 2021 Faculty Promotions Announced, May 2021August 17th, 2021
 Intellia, with First Results, Delivers a 'Landmark' for CRISPR Gene EditingJune 26th, 2021 Intellia, with First Results, Delivers a 'Landmark' for CRISPR Gene EditingJune 26th, 2021
 Hear from the Experts on Hereditary AmyloidosisJune 3rd, 2019 Hear from the Experts on Hereditary AmyloidosisJune 3rd, 2019
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Grant Support
- Effect Of Diflunisal (IND68092) On Familial AmyloidosisNational Institute Of Neurological Disorders And Stroke2005–2009
- The Effect Of Diflunisal On Hereditary AmyloidosisNational Center For Research Resources2007
- Effect Of Diflunisal On Familial AmyloidosisFood And Drug Administration2006–2007
- Adrenal Insufficiency In Primary Systemic AmyloidosisNational Center For Research Resources1999–2001
- Retinoids And Collagen Transcription In Lung FibroblastsNational Heart, Lung, And Blood Institute1996–1999
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