JohnSChorbaMD

Cardiology • San Francisco, CA

Adult Congenital Heart Disease, Cardiac Electrophysiology, Echocardiography, Non-Invasive Cardiology

Assistant Adjunct Professor, San Francisco General Hospital, University of California San Francisco

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Office
San Francisco General Hospital, Division of Cardiology
1001 Potrero Ave, Room 5G1
San Francisco, CA 94110
Phone+1 415-206-8315
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Education & Training

University of California (San Francisco)Fellowship, Cardiovascular Disease, 2010 - 2014
Massachusetts General HospitalResidency, Internal Medicine, 2007 - 2010
Harvard Medical SchoolClass of 2007

Certifications & Licensure

CA State Medical License 2010 - 2026
MA State Medical License 2009 - 2012
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Clinical Trials

Phono- and Electrocardiogram Assisted Detection of Valvular Disease Start of enrollment: 2018 Feb 22
Completed

Publications & Presentations

PubMed

Deep Learning Algorithms to Detect Murmurs Associated With Structural Heart Disease.
John Prince, John Maidens, Spencer Kieu, Caroline Currie, Daniel Barbosa, Cody Hitchcock, Adam Saltman, Kambiz Norozi, Philipp Wiesner, Nicholas Slamon, Erica Del Grip...> ;Journal of the American Heart Association. 2023 Oct 17
Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture.
John S Chorba, Vivian Q Xia, Geoffrey A Smith, Arun Padmanabhan> ;Bio-Protocol. 2023 Jan 20
1 citations
Heparin Does Not Regulate Circulating Human PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) in a General Population-Brief Report.
Vivian Q Xia, Chui Mei Ong, Lucas S Zier, John S MacGregor, Alan H B Wu, John S Chorba> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Feb 1
5 citations
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
Geoffrey A Smith, Arun Padmanabhan, Bryan H Lau, Akhil Pampana, Li Li, Clara Y Lee, Angelo Pelonero, Tomohiro Nishino, Nandhini Sadagopan, Vivian Q Xia, Rajan Jain, Pr...> ;Science Translational Medicine. 2022 Sep 14
1 citations
Physical Maneuvers and Recent Tools to Break the Silence of Clinically Undetectable Heart Sounds.
John Maidens, John S Chorba, James D Thomas> ;JAMA Internal Medicine. 2022 May 1
37 citations
Deep Learning Algorithm for Automated Cardiac Murmur Detection via a Digital Stethoscope Platform.
John S. Chorba, Avi M. Shapiro, Le Le, John Maidens, John Prince, Steve Pham, Mia M. Kanzawa, Daniel N. Barbosa, Caroline Currie, Catherine Brooks, Brent E. White, Ann...> ;Journal of the American Heart Association. 2021 May 4
2771 citations
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Sw...> ;Nature. 2020 Apr 30
219 citations
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, ...> ;Biorxiv. 2020 Mar 22
13 citations
Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake
Adri M. Galvan, John S. Chorba> ;Journal of Lipid Research. 2019 Jan 1
1 citations
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9.
John S. Chorba, Adri M. Galvan, Kevan M. Shokat> ;Journal of Visualized Experiments. 2018 Aug 28
1 citations
Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
John S Chorba, Adri M Galvan, Kevan M Shokat> ;The Journal of Biological Chemistry. 2018 May 4
1 citations
Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
John S Chorba, Adri M Galvan, Kevan M Shokat> ;The Journal of Biological Chemistry. 2018 Feb 9
24 citations
An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service.
Bradley M. Wertheim, Andrew J. Aguirre, Roby P. Bhattacharyya, John S. Chorba, Ashutosh P Jadhav, Vanessa B. Kerry, Eric A. Macklin, Gabriela Motyckova, Shveta Raju, K...> ;The American Journal of Medicine. 2017 Jan 1
24 citations
The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis.
John S. Chorba, Kevan M. Shokat> ;The Journal of Biological Chemistry. 2014 Oct 17
67 citations
Brain Natriuretic Peptide Predicts Functional Outcome in Ischemic Stroke
Natalia S. Rost, Alessandro Biffi, Lisa Cloonan, John S. Chorba, Peter J. Kelly, David M. Greer, Patrick T. Ellinor, Karen L. Furie> ;Stroke. 2012 Feb 1
3 citations
Sustained ventricular fibrillation in a conscious patient.
Thomas A. Dewland, John S. Chorba, Nora Goldschlager, Gregory M. Marcus> ;Archives of Internal Medicine. 2011 Jun 13
26 citations
Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation.
Jianrong Li, John S. Chorba, Sean P. J. Whelan> ;Journal of Virology. 2007 Apr 15
7 citations
Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
T. G. Murali Dhar, Scott H. Watterson, Ping Chen, Zhongqi Shen, Henry H. Gu, Derek J. Norris, Marianne Carlsen, Kristin D. Haslow, William J. Pitts, Junqing Guo, John ...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Feb 10
16 citations
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Scott H. Watterson, Marianne Carlsen, T. G. Murali Dhar, Zhongqi Shen, William J. Pitts, Junqing Guo, Henry H. Gu, Derek J. Norris, John S. Chorba, Ping Chen, Daniel L...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Feb 10
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Press Mentions

Eko Launches SENSORA™ Cardiac Disease Detection PlatformFebruary 23rd, 2023
Eko's AI Analysis Algorithm Validated as a Clinical Tool for Detecting Heart MurmursMay 12th, 2021
ECG, Smart Stethoscope Company Eko Gets $5M, Plans New TrialFebruary 28th, 2018
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