JohnGiddensJr.MD

PubMed

• 69 citations
  Glycoengineering of Antibodies for Modulating Functions.
  Lai-Xi Wang, Xin Tong, Chao Li, John P. Giddens, Tiezheng Li> ;Annual Review of Biochemistry. 2019 Jun 20
• 64 citations
  Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody
  John P. Giddens, Joseph V. Lomino, David J. DiLillo, Jeffrey V. Ravetch, Lai-Xi Wang> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 20
• 9 citations
  Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.
  Lindsay Bennett, Qiang Yang, Brian R. Berquist, John P. Giddens, Zhongjie Ren, Vally Kommineni, Ryan P Murray, Earl L White, Barry R. Holtz, Lai-Xi Wang, Sylvain Marcel> ;International Journal of Molecular Sciences. 2018 Jan 31
• 35 citations
  Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses
  Hui Cai, Jared Orwenyo, John P. Giddens, Qiang Yang, Roushu Zhang, Celia C. LaBranche, David C. Montefiori, Lai-Xi Wang> ;Cell Chemical Biology. 2017 Dec 21
• 231 citations
  Modulating IgG effector function by Fc glycan engineering.
  Tiezheng Li, David J. DiLillo, Stylianos Bournazos, John P. Giddens, Jeffrey V. Ravetch, Lai-Xi Wang> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Mar 28
• 76 citations
  Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling.
  Tiezheng Li, Xin Tong, Qiang Yang, John P. Giddens, Lai-Xi Wang> ;The Journal of Biological Chemistry. 2016 Aug 5
• 62 citations
  Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins
  John P. Giddens, Joseph V. Lomino, Mohammed N. Amin, Lai-Xi Wang> ;The Journal of Biological Chemistry. 2016 Apr 22
• 15 citations
  Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion
  Renpeng Liu, John P. Giddens, Colleen McClung, Paula Magnelli, Lai-Xi Wang, Ellen Guthrie> ;Mabs. 2016 Jan 1
• 111 citations
  Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins
  Alysia A. Ahmed, John P. Giddens, Andrew Pincetic, Joseph V. Lomino, Jeffrey V. Ravetch, Lai-Xi Wang, Pamela J. Bjorkman> ;Journal of Molecular Biology. 2014 Sep 9
• 36 citations
  Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
  Beatriz Trastoy, Joseph V. Lomino, Brian G. Pierce, Lester G. Carter, Sebastian Günther, John P. Giddens, Greg A. Snyder, Thomas M. Weiss, Zhiping Weng, Lai-Xi Wang, E...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 May 6
• 51 citations
  Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags
  Elizabeth L. Smith, John P. Giddens, Anthony T. Iavarone, Kamil Godula, Lai-Xi Wang, Carolyn R. Bertozzi> ;Bioconjugate Chemistry. 2014 Apr 7
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Journal Articles

• Site-Selective Chemoenzymatic Glycoengineering of Fab and Fc Glycans of a Therapeutic Antibody  
  John Giddens Jr., MD, Proceedings of the National Academy of Sciences