JohnCHedreenMD

Pathology • Belmont, MA

Neuropathology, Anatomic Pathology, Clinical Pathology

Neuropathologist at McLean Hospital Brain Bank (Harvard Brain Tissue resource Center)

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Office
115 Mill St
Belmont, MA 02478
Phone+1 800-272-4622
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Education & Training

Johns Hopkins UniversityResidency, Pathology-Anatomic and Clinical, 1983 - 1985
Johns Hopkins UniversityFellowship, Neuropathology, 1981 - 1983
Case Western Reserve University School of MedicineClass of 1965

Certifications & Licensure

MA State Medical License 1994 - 2019
MD State Medical License 1985 - 1994
American Board of Pathology Anatomic Pathology
American Board of Pathology Neuropathology

Publications & Presentations

PubMed

Postmortem neuropathology in early Huntington disease.
Sabina Berretta, Charles L White Iii, John C Hedreen> ;Journal of Neuropathology and Experimental Neurology. 2024 Apr 19
296 citations
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease
Hendrik Wesseling, Waltraud Mair, Mukesh Kumar, Christoph N. Schlaffner, Shaojun Tang, Pieter Beerepoot, Benoit Fatou, Amanda J. Guise, Long Cheng, Shuko Takeda, Jan M...> ;Cell. 2020 Dec 10
12 citations
Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates
Helen Ling, Ellen Gelpi, Karen Davey, Zane Jaunmuktane, Kin Y. Mok, Edwin Jabbari, Roberto Simone, Lea R'Bibo, Sebastian Brandner, Matthew Ellis, Johannes Attems, Davi...> ;Acta Neuropathologica. 2020 Jan 16
1 citations
Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Xianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J. Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang, Charles H. ...> ;Nature Neuroscience. 2019 Jan 1
55 citations
Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Xianjun Dong, Zhixiang Liao, David Gritsch, Yavor Hadzhiev, Yunfei Bai, Joseph J. Locascio, Boris Guennewig, Ganqiang Liu, Cornelis Blauwendraat, Tao Wang, Charles H. ...> ;Nature Neuroscience. 2018 Sep 17
5 citations
What can we learn about brain donors? Use of clinical information in human postmortem brain research.
Kathleen Sullivan, Harry Pantazopoulos, Elizabeth Liebson, Tsung-Ung W. Woo, Ross J. Baldessarini, John C. Hedreen, Sabina Berretta> ;Handbook of Clinical Neurology. 2018 Jan 1
8 citations
Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) p...
Richard A. Armstrong, Ronald L. Hamilton, Ian R. A. Mackenzie, John C. Hedreen, Nigel J. Cairns> ;Neuropathology and Applied Neurobiology. 2013 Jun 1
39 citations
Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease
Kavita Prasad, Thomas G. Beach, John C. Hedreen, Eric K. Richfield> ;Brain Pathology. 2012 Nov 1
637 citations
PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease
Bin Zheng, Zhixiang Liao, Joseph J. Locascio, Kristen A. Lesniak, Sarah S. Roderick, Marla L. Watt, Aron Charles Eklund, Yanli Zhang-James, Peter D. Kim, Michael A. Ha...> ;Science Translational Medicine. 2010 Oct 6
45 citations
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis
Richard A. Armstrong, William G. Ellis, Ronald L. Hamilton, Ian R. A. Mackenzie, John C. Hedreen, Marla Gearing, Thomas J. Montine, Jean Paul G. Vonsattel, Elizabeth H...> ;Journal of Neural Transmission. 2010 Feb 1
9 citations
TorsinB expression in the developing human brain.
E. Bahn, S. Siegert, T. Pfander, Michael L. Kramer, Walter J. Schulz-Schaeffer, Jeffrey W. Hewett, Xandra O. Breakefield, John C. Hedreen, Kevin Rostasy> ;Brain Research. 2006 Oct 20
23 citations
TorsinA expression is detectable in human infants as young as 4 weeks old
S. Siegert, E. Bahn, Michael L. Kramer, Walter J. Schulz-Schaeffer, Jeffrey W. Hewett, Xandra O. Breakefield, John C. Hedreen, Kevin Rostasy> ;Brain Research. Developmental Brain Research. 2005 Jun 9
66 citations
SDF-1α Is Expressed in Astrocytes and Neurons in the AIDS Dementia Complex: An In Vivo and In Vitro Study
Kevin Rostasy, Christophe Egles, Ashok Chauhan, Michelle Kneissl, Padmanabhan Bahrani, Constantin T. Yiannoutsos, Dale D. Hunter, Avindra Nath, John C. Hedreen, Bradfo...> ;Journal of Neuropathology and Experimental Neurology. 2003 Jun 1
114 citations
TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion.
Kevin Rostasy, Sarah J. Augood, Jeffrey W. Hewett, Joanne Chung On Leung, Hikaru Sasaki, Laurie J. Ozelius, Vijaya Ramesh, David G. Standaert, Xandra O. Breakefield, J...> ;Neurobiology of Disease. 2003 Feb 1
60 citations
RNA Editing of the Glutamate Receptor Subunits GluR2 and GluR6 in Human Brain Tissue
Wulf Paschen, John C. Hedreen, Christopher A. Ross> ;Journal of Neurochemistry. 2002 Nov 23
15 citations
Tau protein expression in frontotemporal dementias
Emil Adamec, Howard Chang, Edward G. Stopa, John C. Hedreen, Jean Paul G. Vonsattel> ;Neuroscience Letters. 2001 Nov 23
34 citations
NFkappaB activation, TNF-alpha expression, and apoptosis in the AIDS-Dementia-Complex.
Kevin Rostasy, Laura Monti, Constantin T. Yiannoutsos, Joyce Wu, Jeanne E. Bell, John C. Hedreen, Bradford A. Navia> ;Journal of Neurovirology. 2000 Jan 1
68 citations
Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation : Pathogenetic relationship to the acquired immunodeficie...
Kevin Rostasy, Laura Monti, Constantin T. Yiannoutsos, Michelle L Kneissl, Jeanne E. Bell, Thomas L. Kemper, John C. Hedreen, Bradford A. Navia> ;Annals of Neurology. 1999 Aug 1
64 citations
Tyrosine hydroxylase-immunoreactive elements in the human globus pallidus and subthalamic nucleus.
John C. Hedreen> ;The Journal of Comparative Neurology. 1999 Jul 5
65 citations
What was wrong with the Abercrombie and empirical cell counting methods? A review
John C. Hedreen> ;The Anatomical Record. 1998 Mar 1
87 citations
Lost caps in histological counting methods
John C. Hedreen> ;The Anatomical Record. 1998 Mar 1
3 citations
Centenary of Gaule and Lewin, pioneers in cell counting methodology.
John C. Hedreen, J P Vonsattel> ;Journal of Microscopy. 1997 Sep 1
355 citations
Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly in...
David C. Rubinsztein, Jayne Leggo, Rhian Coles, E. Almqvist, Biancalana, Jean Jaques Cassiman, Chotai K, Connarty M, Crauford D, Curtis A, Curtis D, Mark Davidson, Dif...> ;American Journal of Human Genetics. 1996 Jul 1
22 citations
Lack of association of the apoE4 allele with hippocampal sclerosis dementia
Juan C. Troncoso, Claudia H. Kawas, Craig K. Chang, Marshal F. Folstein, John C. Hedreen> ;Neuroscience Letters. 1996 Feb 2
72 citations
Accuracy of clinical diagnosis of Alzheimer disease and clinical features of patients with non-Alzheimer disease neuropathology.
D X Rasmusson, Jason Brandt, C. Steele, John C. Hedreen, Juan C. Troncoso, Marshal F. Folstein> ;Alzheimer Disease and Associated Disorders. 1996 Jan 1
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Grant Support

Striosomal Neuronal Loss In Huntington'S DiseaseNational Institute Of Neurological Disorders And Stroke1994–1996