JohnKorethMD

Oncology • Boston, MA

Hematologic Oncology

Assistant Professor, Medicine, Brigham & Women's Hospital, Harvard Medical School

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Office
450 Brookline Ave
D1B05
Boston, MA 02215
Phone+1 617-632-3470
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2000 - 2004
Brigham and Women's HospitalResidency, Internal Medicine, 1998 - 2000
Maulana Azad Medical CollegeClass of 1993

Certifications & Licensure

CA State Medical License 2008 - Present
ME State Medical License 2022 - 2025
MA State Medical License 2001 - 2024
American Board of Internal Medicine Hematology

Clinical Trials

Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Ultra-Low Dose Interleukin-2 for Refractory Chronic Graft Versus Host Disease Start of enrollment: 2007 Aug 01
Completed
Phase 1
Infusion of Donor Lymphocytes Depleted of CD25+ Regulatory T-cells in Patients With Relapsed Hematologic Malignancies Start of enrollment: 2007 Dec 01
Completed
Phase 1
Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft Versus Host Disease Start of enrollment: 2008 Dec 01
Completed
Phase 2
Bortezomib-based GVHD Prophylaxis After Allogeneic Transplant for Patients Without Matched Related Donors Start of enrollment: 2011 May 01
Completed
Phase 2
Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease Start of enrollment: 2011 Jul 01
Active, not recruiting
Phase 2
A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease Start of enrollment: 2013 Jul 01
Completed
Phase 2
Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell Transplant Start of enrollment: 2013 Jan 01
Completed
Phase 2
Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease Start of enrollment: 2013 Nov 01
Active, not recruiting
Phase 1
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203) Start of enrollment: 2014 Aug 01
Completed
Phase 2
A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT Start of enrollment: 2019 Jul 10
Recruiting
Phase 1
IS-free Treg HaploHCT Start of enrollment: 2021 Jan 12
Recruiting
Phase 1
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Publications & Presentations

PubMed

Nonpathogenicengineered to surface display cytokines as a new platform for immunotherapy.
Shaobo Yang, Michal Sheffer, Isabel E Kaplan, Zongqi Wang, Mubin Tarannum, Khanhlinh Dinh, Yasmin Abdulhamid, Roman Shapiro, Rebecca Porter, Robert Soiffer, Jerome Rit...> ;Research Square. 2024 Mar 22
Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplan...
Anna Sureda, Paul A Carpenter, Andrea Bacigalupo, Vijaya Raj Bhatt, Josu de la Fuente, Aloysius Ho, Leslie Kean, Jong Wook Lee, Isabel Sánchez-Ortega, Bipin N Savani, ...> ;Bone Marrow Transplantation. 2024 Mar 5
1 citations
Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML.
Garcia, J., Kim, H., Murdock, H., Ansuinelli, M., Brock, J., Cutler, C., Gooptu, M., Ho, V., Koreth, J., Nikiforow, S., Romee, R., Shapiro, R., DeAngelo, D., Stone, R....> ;Blood Advances. 2024 Feb 27
1 citations
Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML.
Joshua A Fein, Roni Shouval, Elizabeth Krieger, Stephen R Spellman, Tao Wang, Henning Baldauf, Katharina Fleischhauer, Nicolaus Kröger, Mary Horowitz, Martin Maiers, J...> ;Blood Advances. 2024 Feb 13
Persistent Sweet syndrome post-hematopoietic stem cell transplantation heralding molecular relapse of myelofibrosis.
Xiang, D., Pakyari, M., Koreth, J., Shi, C.> ;American Journal of Hematology. 2023 Dec 28
1 citations
Opportunistic Infections in Patients Receiving Post-Transplantation Cyclophosphamide: Impact of Haploidentical versus Unrelated Donor Allograft.
Jessica S Little, Rémy Duléry, Roman M Shapiro, Muneerah M Aleissa, Susan E Prockop, John Koreth, Jerome Ritz, Joseph H Antin, Corey Cutler, Sarah Nikiforow, Rizwan Ro...> ;Transplantation and Cellular Therapy. 2024 Feb 1
1 citations
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease.
Holly Wobma, Malika Kapadia, Haesook T Kim, Francesca Alvarez-Calderon, Susanne H C Baumeister, Christine Duncan, Suzanne Forrest, Lev Gorfinkel, Jennifer Huang, Lesli...> ;Blood Advances. 2023 Aug 22
Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse.
Roman M Shapiro, Haesook T Kim, Michela Ansuinelli, Indira Guleria, Corey S Cutler, John Koreth, Mahasweta Gooptu, Joseph H Antin, Amar Kelkar, Jerome Ritz, Catherine ...> ;Blood Advances. 2023 Aug 8
5 citations
Posttransplant cyclophosphamide vs tacrolimus-based GVHD prophylaxis: lower incidence of relapse and chronic GVHD.
Katie Maurer, Vincent T Ho, Eno Inyang, Corey Cutler, John Koreth, Roman M Shapiro, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, Joseph H Antin, Catherine J Wu, Je...> ;Blood Advances. 2023 Aug 8
Clinical Features of Acute Kidney Injury in the Early Post-Transplantation Period Following Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplan...
Juliana Vergara-Cadavid, P Connor Johnson, Haesook T Kim, Alisha Yi, Meghan E Sise, David E Leaf, Paul E Hanna, Vincent T Ho, Corey S Cutler, Joseph H Antin, Mahasweta...> ;Transplantation and Cellular Therapy. 2023 Jul 1
Expanding post-transplant cyclophosphamide to matched unrelated donor transplants and beyond.
Mahasweta Gooptu, Javier Bolaños-Meade, John Koreth> ;Blood Reviews. 2023 Nov 1
3 citations
Lower incidence of chronic GVHD observed after transplantation with cryopreserved unrelated allogeneic stem cells.
Katie Maurer, Haesook T Kim, Heather M Garrity, Deborah Liney, Corey Cutler, Joseph H Antin, John Koreth, Jerome Ritz, Roman M Shapiro, Rizwan Romee, Vincent T Ho, Mah...> ;Blood Advances. 2023 Jun 13
2 citations
A Multicenter Phase II, Double-Blind, Placebo-Controlled Trial of Maintenance Ixazomib After Allogeneic Transplantation for High-Risk Multiple Myeloma: Results of the ...
Qaiser Bashir, Taiga Nishihori, Marcelo C Pasquini, Michael J Martens, Juan Wu, Melissa Alsina, Claudio Anasetti, Claudio Brunstein, Peter Dawson, Yvonne Efebera, Cris...> ;Transplantation and Cellular Therapy. 2023 Jun 1
26 citations
Impact of diagnostic genetics on remission MRD and transplantation outcomes in older patients with AML.
H Moses Murdock, Haesook T Kim, Nathan Denlinger, Pankit Vachhani, Bryan Hambley, Bryan S Manning, Shannon Gier, Christina Cho, Harrison K Tsai, Shannon McCurdy, Vince...> ;Blood. 2022 Jun 16
45 citations
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse.
Roman M Shapiro, Grace C Birch, Guangan Hu, Juliana Vergara Cadavid, Sarah Nikiforow, Joanna Baginska, Alaa K Ali, Mubin Tarannum, Michal Sheffer, Yasmin Z Abdulhamid,...> ;The Journal of Clinical Investigation. 2022 Jun 1
8 citations
Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease.
Haesook T Kim, John Koreth, Jennifer Whangbo, Sarah Nikiforow, Carol G Reynolds, Peter Stowe, Vincent T Ho, Corey Cutler, Joseph H Antin, Robert J Soiffer, Jerome Ritz> ;Blood Advances. 2022 Aug 9
11 citations
Trajectories of quality of life recovery and symptom burden after autologous hematopoietic cell transplantation in multiple myeloma.
Anita D'Souza, Ruta Brazauskas, Edward A Stadtmauer, Marcelo C Pasquini, Parameswaran Hari, Asad Bashey, Natalie Callander, Steven Devine, Yvonne Efebera, Siddhartha G...> ;American Journal of Hematology. 2023 Jan 1
5 citations
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.
Michael C Zaiken, Ryan Flynn, Katelyn G Paz, Stephanie Y Rhee, Sujeong Jin, Fathima A Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M C Park, Matthew L Hemming, Pe...> ;Blood. 2022 May 12
8 citations
Invasive Yeast Infection after Haploidentical Donor Hematopoietic Cell Transplantation Associated with Cytokine Release Syndrome.
Jessica S Little, Roman M Shapiro, Muneerah M Aleissa, Austin Kim, Jun Bai Park Chang, David W Kubiak, Guohai Zhou, Joseph H Antin, John Koreth, Sarah Nikiforow, Corey...> ;Transplantation and Cellular Therapy. 2022 Aug 1
2 citations
Phenotypic and functional characterization of the CD6-ALCAM T-cell co-stimulatory pathway after allogeneic cell transplantation.
Benedetta Rambaldi, Haesook T Kim, Yohei Arihara, Takeru Asano, Carol Reynolds, Mariah Manter, Max Halpern, Augustine Weber, John Koreth, Corey Cutler, Mahasweta Goopt...> ;Haematologica. 2022 Nov 1
11 citations
A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease.
Jennifer S Whangbo, Sarah Nikiforow, Haesook T Kim, Jonathan Wahl, Carol G Reynolds, Sharmila C Rai, Soomin Kim, Andrew Burden, Ana C Alho, João F Lacerda, Edwin P Aly...> ;Blood Advances. 2022 Nov 8
Molecular assessment and the current limits of post-transplant prognostication for chronic myelomonocytic leukemia.
Christopher J Gibson, John Koreth> ;Haematologica. 2023 Jan 1
6 citations
Favorable outcomes following allogeneic transplantation in adults with hemophagocytic lymphohistiocytosis.
Mahasweta Gooptu, Haesook T Kim, Eric Jacobsen, David C Fisher, Ann LaCasce, Vincent T Ho, Corey S Cutler, John Koreth, Robert J Soiffer, Joseph H Antin, Nancy Berline...> ;Blood Advances. 2023 Jun 13
2 citations
Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease.
Veronica Donato, Haesook T Kim, Peter Stowe, Carol G Reynolds, Jerome Ritz, John Koreth, Jennifer S Whangbo> ;Frontiers in Immunology. 2022 Jan 1
10 citations
GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized double blinded phase 2 trial.
Vincent T. Ho, Haesook T. Kim, Jennifer Brock, Ilene Galinsky, Heather Daley, Carol Reynolds, Augustine Weber, Olga Pozdnyakova, Mariano Severgnini, Sarah Nikiforow, C...> ;Blood Advances. 2021 Nov 22
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Journal Articles

Small-Molecule BCL6 Inhibitor Effectively Treats Mice with Non-Sclerodermatous Chronic Graft-Versus-Host Disease
Joseph H Antin, Bruce Blazar, Leo Luznik, John Koreth, Ivan Maillard, Robert J Soiffer, James E Bradner, Jonathan S Serody, Jerome Ritz, Blood

Press Mentions

Equillium Announces Positive Topline Results from the EQUATE Study in First-Line Treatment of Acute Graft-Versus-Host DiseaseJune 11th, 2021
Equillium Announces Oral Presentation Highlighting Positive Data from the EQUATE Study in Acute Graft-Versus-Host Disease at the EHA2021 Virtual Congress of the European Hematology AssociationMay 13th, 2021
Equillium Presents Positive Interim Clinical Data of Itolizumab in First-Line Treatment of Acute Graft-Versus-Host Disease at the 2021 Transplantation and Cellular Therapy Meetings Digital ExperienceFebruary 12th, 2021
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Hospital Affiliations

Dana-Farber Cancer InstituteBoston, Massachusetts
Brigham and Women's HospitalBoston, Massachusetts
Salem HospitalSalem, Massachusetts