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John McDonnell, MD, Allergy & Immunology, Cleveland, OH

John McDonnell MD MS

Allergy & Immunology•Cleveland, OH

Pediatric Asthma & Allergic Conditions, Clinical & Laboratory Immunology, Clinical Informatics

Staff Physician - Cleveland Clinic Children’s Hospital

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  • 9500 Euclid Ave / R3Cleveland, OH 44195

  • Phone+1 440-258-6938

  • Fax+1 216-442-5975

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Summary

  • John McDonnell, MD, MS is a Staff Physician in the Departments of Pediatric Allergy and Immunology and Pediatric Hematology and Oncology at Cleveland Clinic. His clinical expertise centers on inborn errors of immunity, encompassing both immunodeficiency and immune dysregulation. Dr. McDonnell completed his pediatric residency at the National Capital Consortium and served for seven years as an active-duty pediatrician in the United States Navy, including overseas assignments. Following his military service, he pursued fellowship training in Allergy and Clinical Immunology at Cleveland Clinic, followed by an advanced fellowship in Primary Immunodeficiency at Cincinnati Children’s Hospital. During fellowship, he also earned a Master of Science in Biostatistics from Case Western Reserve University. His clinical and research interests include the care of children with complex immunodeficiencies, especially those managed with hematopoietic cell transplantation.

    In addition to his clinical and research responsibilities, he is the co-host of "Immune Matters: a PIDTC Podcast".

Education & Training

  • Case Western Reserve University
    Case Western Reserve UniversityMS, Biostatistics, 2017 - 2021
  • The University of Toledo College of Medicine
    The University of Toledo College of MedicineClass of 2010
  • Baldwin-Wallace College
    Baldwin-Wallace CollegeB.Mus., Piano Performance, Summa Cum Laude, 2001 - 2006

Certifications & Licensure

  • OH State Medical License
    OH State Medical License 2012 - 2026
  • MD State Medical License
    MD State Medical License 2016 - 2017
  • Allergy & Immunology
    American Board of Allergy and Immunology Allergy & Immunology
  • Pediatrics
    American Board of Pediatrics Pediatrics
  • Allergy and Immunology
    National Board of Physicians and Surgeons Allergy and Immunology
  • Pediatrics
    National Board of Physicians and Surgeons Pediatrics

Awards, Honors, & Recognition

  • Continuing Medical Education Award AAP, 2015
  • Excellence in Patient Safety Award 2015
  • National Resident Research Award Academic Pediatric Association, 2013
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Publications & Presentations

PubMed

Journal Articles

  • Association of Parental Use of Patient Portals with Breastfeeding Rates in Infants  
    Ossai C, McDonnell J, Behairy M, Schelzig C, Larkin L, Jones J, et al., Journal of Consumer Health on the Internet, 7/3/2021

Books/Book Chapters

  • Primary and Secondary Immunodeficiency: A Case-Based Guide to Evaluation and Management. 
    Chapter: Chapter 13: Autoinflammatory Syndromes 
    Fernandez J, McDonnell J, Royer C.Editors: Jonathan Bernstein.Springer2021

Abstracts/Posters

  • CTLA-4 and CVID: Analysis of USIDNET Patients.
    S Ghannam, J McDonnell, S Rotz, J Fernandez., Clinical Immunology Society Virtual Annual Meeting, 4/2021
  • The Association Between Risk Stratification Models and the Likelihood of Positive Penicillin Skin Tests
    M Kuder, J McDonnell, K Weller, M Li, X Wang, D Lang, The American Academy of Allergy, Asthma & Immunology Virtual Annual Meeting, 3/2021
  • Undetectable Serum IgE is Associated with Malignancy Risk
    J McDonnell, K Weller, R Burton, J Albert, F Hsieh, The American Academy of Allergy, Asthma & Immunology Virtual Annual Meeting, 3/2021
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Committees

  • Chair, Primary Immune Deficiency Treatment Consortium (PIDTC) Digital Media Committee 2025 - Present

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