John Sampson, MD

John Sampson, MD

Neurosurgery Durham, NC

Associate Professor of Surgery, Duke University

Office Address

  • 2100 Erwin Rd
    Duke University Medical Center - Dumc 3050
    Durham, NC 27710
    Phone: (919) 684-9041
    Fax: (919) 684-9045

John Sampson, MD

Neurosurgery Durham, NC

Associate Professor of Surgery, Duke University


  • Large research focus on immunotherapy for high grade glioma.

Clinical Specialties & Interests

  • Brain & Spinal Tumor
  • Clinical Interests: Antineoplastic Combined Chemotherapy Protocols; Glioma; Treatment Outcome; Local Neoplasm Recurrence; Glioblastoma

Education & Training

  • Fuqua School of Business, Duke University
  • Duke UniversityDuke University
  • Duke University HospitalDuke University Hospital
  • Duke University HospitalDuke University Hospital
  • University of ManitobaUniversity of Manitoba
  • St. John's College, University of Manitoba

Certifications & Licensure

  • WV State Medical LicenseWV State Medical License1997 - 2017
  • NC State Medical LicenseNC State Medical License1996 - 2015
  • American Board of Neurological SurgeryNeurological Surgery

    Awards, Honors, & Recognition

    • CMS Meaningful Use Stage 1 CertificationEpicCare Ambulatory EMR, Epic Systems Corporation, 2013
    • America's Top SurgeonsSLD Industries, Inc., 2012
    • Fuqua Scholar AwardDuke University, Fuqua School of Business, 2012

    Publications & Presentations


    Journal Articles

    • Complete response to steroids in dural inflammatory pseudotumor associated with Still's disease  Batich, K.B., St. Clair, E.W., McLendon, R.E., Sampson, J.H., J Clin Neurosci, 10/1/2013
    • Isocitrate dehydrogenase 1 (IDH1): What it means to the neurosurgeon  Hodges, T.R., Choi, B.D., Bigner, D.D., Yan, H., Sampson, J.H., J Neurosurg, 6/1/2013
    • Clinicopathological Characteristics and Treatment of Rhabdoid Glioblastoma  Babu, R., Hatef, J., McLendon, R., Cummings, T., Sampson, J.H., Friedman, A.H., Adamson, C., J Neurosurg, 5/3/2013

    Books/Book Chapters

    • Glioma: Symptoms, Diagnosis and Treatment Options. Chapter: Current immunotherapeutic targets in gliomas. 
      Chandramohan, V., Mitchell, D.A., Gromeier, M., Sampson, J.H., and Bigner, D.D.
      Editors: Vrionis, F.D., Wiranowska, M.Nova Science Publishers, Inc.
    • Drug Delivery to the Central Nervous System. Chapter: Convection-enhanced drug delivery to the brain. Page 893 - 2336
      Ding, D., Kanaly, C.W., Brady, M.L., Mittermeyer, S., Raghavan, R., Sampson, J.H.
      Editors: Jain K.Springer, New York, NY
    • Neurosurgical Operative Atlas, Functional Neurosurgery. Chapter: Microvascular decompression of the facial nerve for hemifacial spasm. 
      Sampson, J.H., Ellis, M.J., Grossi, P.M., Fukushima, T.
      Editors: Starr, P., Barbaro N., and Larson, L..Thieme, New York, NY
      Edition 2nd,2009


    • Safety results from a prospective study of concurrent radiosurgery and bevacizumab for recurrent malignant glioma. Cuneo, K.C., Cabrera, A.R., Sampson, J.H., Allen, K.J., Vredenburgh, J.J., Peters, K., Chang, Z., Herndon, J.E., Desjardins, A., Reardon, D.A., Kirkpatrick, J., J Clin Oncol, 1/1/2011
    • Concurrent Bevacizumab and Radiosurgery for Recurrent Malignant Glioma: Toxicity Results from a Prospective Pilot Study. Cuneo, K.C., Cabrera, A.R., Sampson, J.H., Allen, K., Duffy, E., Vredenburgh, J.J., Peters, K.B., Chang, Zheng, Desjardins, A., Kirkpatrick, J.P., ASTRO, Int J Radiat Oncol Biol Phys, 1/1/2011
    • Dendritic cell vaccines targeting cytomegalovirus in glioblastoma. Mitchell, D.A., Archer, G.E., Friedman, H.S., Herndon, J.E., Bigner, D.D., Sampson, J.H., 16th Annual Society for Neuro-oncology meeting, Neuro-oncol, 1/1/2011


    • Novel role for enhancing immunotherapy against pediatric brain tumors using hematopoietic stem cells. San Francisco, CA - 11/21/2013
    • Developmentally regulated antigens for immunologic targeting of medulloblastoma subtypes. San Francisco, CA - 11/21/2013
    • RNA nanoparticle vaccines re-direct host-immunity against intracranial malignancies. San Francisco, CA - 11/21/2013


    • Novel Therapies in the Management of Malignant Brain Tumors: Bevacizumab and Surgery. Chang, S., Sampson, J.H., Aghi, M., Theodosopoulos, P.V., CNS Neurosurger Webinars, Controversies in Neuro-Oncology: An Academic- Community Forum
    • Cell-mediated immunotherapy of brain tumors. Sampson, J.H., Doctoral Thesis Defense, Duke University

    Professional Memberships

    Hospital Affiliations

    Insurance Accepted

    • Aetna Choice POS II
    • Aetna HMO
    • BCBS Blue Card PPO
    • BCBS North Carolina BlueOptions PPO
    • CIGNA Open Access
    • First Health PPO
    • Humana ChoiceCare Network PPO
    • Multiplan PHCS PPO
    • Multiplan PPO
    • United Healthcare - Direct Choice Plus POS
    • United Healthcare - Direct Options PPO
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