JohnA.SaundersMD

PubMed

• 79 citations
  Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.
  Valerie M. Tatard-Leitman, Catherine R. Jutzeler, Jimmy Suh, John A. Saunders, Eddie N. Billingslea, Susumu Morita, Rachel E. White, Robert E. Featherstone, Rabindrana...> ;Biological Psychiatry. 2015 Mar 15
• 89 citations
  Parvalbumin Cell Ablation of NMDA-R1 Causes Increased Resting Network Excitability with Associated Social and Self-Care Deficits
  Eddie N. Billingslea, Valerie M. Tatard-Leitman, Jaynie Anguiano, Catherine R. Jutzeler, Jimmy Suh, John A. Saunders, Susumu Morita, Robert E. Featherstone, Pavel I. O...> ;Neuropsychopharmacology. 2014 Feb 14
• Automated generation of turn mimetics: proof of concept study for the MC4 receptor.
  Baber, J. C., Lowe, R., Saunders, J., Feher, M.> ;Bioorg Med Chem. 2012 Jun 1
• 66 citations
  NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia
  John A. Saunders, Michael J. Gandal, Steve J. Siegel> ;Neurobiology of Disease. 2012 Apr 1
• Reduced parenteral nutrition requirements following anastomosis of a short residual colonic segment to a short jejunum.
  Smith, K.H., Saunders, J.A., Nugent, K.P., Jackson, A.A., Stroud, M.A.> ;JPEN J Parenter Enteral Nutr. 2011 Nov
• Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamin...
  Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu Y, Wade W, Saunders J, Bozigian H, St...> ;J. Med. Chem.. 2008-12-11
• Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.
  Dyck B, Tamiya J, Jovic F, Pick RR, Bradbury MJ, O'Brien J, Wen J, Johns M, Madan A, Fleck BA, Foster AC, Li B, Zhang M, Tran JA, Vickers T, Grey J, Saunders J, Chen C> ;J. Med. Chem.. 2008-11-27
• Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
  Regan CF, Guo Z, Chen Y, Huang CQ, Chen M, Jiang W, Rueter JK, Coon T, Chen C, Saunders J, Brown MS, Betz SF, Struthers RS, Yang C, Wen J, Madan A, Zhu Y> ;Bioorg. Med. Chem. Lett.. 2008-08-15
• Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
  Chen C, Chen Y, Pontillo J, Guo Z, Huang CQ, Wu D, Madan A, Chen T, Wen J, Xie Q, Tucci FC, Rowbottom M, Zhu Y, Wade W, Saunders J, Bozigian H, Struthers RS> ;Bioorg. Med. Chem. Lett.. 2008-06-01
• Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
  Chen C, Tucci FC, Jiang W, Tran JA, Fleck BA, Hoare SR, Wen J, Chen T, Johns M, Markison S, Foster AC, Marinkovic D, Chen CW, Arellano M, Harman J, Saunders J, Bozigia...> ;Bioorg. Med. Chem.. 2008-05-15
• Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists.
  Tran JA, Arellano M, Fleck BA, Pontillo J, Marinkovic D, Tucci FC, Wen J, Saunders J, Chen C> ;Med Chem. 2008-01-01
• Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
  Chen C, Jiang W, Tran JA, Tucci FC, Fleck BA, Markison S, Wen J, Madan A, Hoare SR, Foster AC, Marinkovic D, Chen CW, Arellano M, Saunders J> ;Bioorg. Med. Chem. Lett.. 2008-01-01
• Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 recep...
  Tran JA, Jiang W, Tucci FC, Fleck BA, Wen J, Sai Y, Madan A, Chen TK, Markison S, Foster AC, Hoare SR, Marks D, Harman J, Chen CW, Arellano M, Marinkovic D, Bozigian H...> ;J. Med. Chem.. 2007-12-13
• Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active anta...
  Chen C, Jiang W, Tucci F, Tran JA, Fleck BA, Hoare SR, Joppa M, Markison S, Wen J, Sai Y, Johns M, Madan A, Chen T, Chen CW, Marinkovic D, Arellano M, Saunders J, Fost...> ;J. Med. Chem.. 2007-11-01
• Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
  Jiang W, Tucci FC, Tran JA, Fleck BA, Wen J, Markison S, Marinkovic D, Chen CW, Arellano M, Hoare SR, Johns M, Foster AC, Saunders J, Chen C> ;Bioorg. Med. Chem. Lett.. 2007-10-15
• Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.
  Tran JA, Tucci FC, Jiang W, Marinkovic D, Chen CW, Arellano M, Markison S, Fleck BA, Wen J, White NS, Pontillo J, Saunders J, Marks D, Hoare SR, Madan A, Foster AC, Ch...> ;Bioorg. Med. Chem.. 2007-08-01
• Propionylpiperazines as human melanocortin-4 receptor ligands.
  Chen CW, Tran JA, Jiang W, Tucci FC, Arellano M, Wen J, Fleck BA, Marinkovic D, White NS, Pontillo J, Saunders J, Madan A, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2006-09-15
• Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.
  Jiang W, Tucci FC, Chen CW, Arellano M, Tran JA, White NS, Marinkovic D, Pontillo J, Fleck BA, Wen J, Saunders J, Madan A, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2006-09-01
• Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.
  Tran JA, Pontillo J, Fleck BA, Marinkovic D, Arellano M, Tucci FC, Lanier M, Saunders J, Jiang W, Chen CW, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2006-07-15
• Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.
  Pontillo J, Tran JA, White NS, Arellano M, Fleck BA, Marinkovic D, Tucci FC, Saunders J, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2005-12-01
• Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.
  Tucci FC, White NS, Markison S, Joppa M, Tran JA, Fleck BA, Madan A, Dyck BP, Parker J, Pontillo J, Arellano LM, Marinkovic D, Jiang W, Chen CW, Gogas KR, Goodfellow V...> ;Bioorg. Med. Chem. Lett.. 2005-10-01
• Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor.
  Tran JA, Pontillo J, Arellano M, Fleck BA, Tucci FC, Marinkovic D, Chen CW, Saunders J, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2005-07-15
• A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.
  Pontillo J, Tran JA, Markison S, Joppa M, Fleck BA, Marinkovic D, Arellano M, Tucci FC, Lanier M, Nelson J, Saunders J, Hoare SRJ, Foster AC, Chen C> ;Bioorg. Med. Chem. Lett.. 2005-05-16
• Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
  Guo Z, Chen Y, Huang CQ, Gross TD, Pontillo J, Rowbottom MW, Saunders J, Struthers S, Tucci FC, Xie Q, Wade W, Zhu Y, Wu D, Chen C> ;Bioorg. Med. Chem. Lett.. 2005-05-16
• Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
  Lowe RF, Nelson J, Dang TN, Crowe PD, Pahuja A, McCarthy JR, Grigoriadis DE, Conlon P, Saunders J, Chen C, Szabo T, Chen TK, Bozigian H> ;J. Med. Chem.. 2005-03-10
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