JohnJ.SavareseMD

PubMed

• 1 citations
  Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cyste...
  John J. Savarese, Hiroshi Sunaga, Jeff D. McGilvra, Matthew R. Belmont, Matthew T. Murrell, Erin Jeannotte, Farrell E. Cooke, William B. Wastila, Paul M. Heerdt> ;Anesthesiology. 2018 Nov 1
• Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
  Josh D. Kaullen, Joel S. Owen, Kim L. R. Brouwer, Paul M. Heerdt, Cynthia A. Lien, John J. Savarese, Virginia D. Schmith> ;Anesthesiology. 2018 Jun 1
• 8 citations
  Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man.
  Paul M. Heerdt, Hiroshi Sunaga, Joel S. Owen, Matthew T. Murrell, Jaideep K. Malhotra, Deena Godfrey, Michelle Steinkamp, Peter M. Savard, John J. Savarese, Cynthia A....> ;Anesthesiology. 2016 Dec 1
• 7 citations
  Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of...
  Hiroshi Sunaga, John J. Savarese, Jeff D. McGilvra, Paul M. Heerdt, Matthew R. Belmont, Scott G. Van Ornum, Matthew T. Murrell, Jaideep K. Malhotra, Peter M. Savard, E...> ;Anesthesiology. 2016 Oct 1
• 10 citations
  Novel neuromuscular blocking drugs and antagonists.
  Paul M. Heerdt, Hiroshi Sunaga, John J. Savarese> ;Current Opinion in Anaesthesiology. 2015 Aug 1
• 22 citations
  Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles.
  Paul M. Heerdt, Christa L. Wagner, Marissa DeMais, John J. Savarese> ;Journal of Pharmacological and Toxicological Methods. 2011 Sep 1
• 19 citations
  Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantac...
  John J. Savarese, Jeff D. McGilvra, Hiroshi Sunaga, Matthew R. Belmont, Scott G. Van Ornum, Peter M. Savard, Paul M. Heerdt> ;Anesthesiology. 2010 Jul 1
• 8 citations
  Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs.
  Hiroshi Sunaga, Yi Zhang, John J. Savarese, Charles W. Emala> ;Anesthesiology. 2010 Apr 1
• 13 citations
  Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.
  Hiroshi Sunaga, Jaideep K. Malhotra, Edward Yoon, John J. Savarese, Paul M. Heerdt> ;Anesthesiology. 2010 Apr 1
• 12 citations
  Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
  Paul M. Heerdt, Jaideep K. Malhotra, Brian Y. Pan, Hiroshi Sunaga, John J. Savarese> ;Anesthesiology. 2010 Apr 1
• 17 citations
  Fumarates: unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine.
  Cynthia A. Lien, Peter M. Savard, Matthew R. Belmont, Hiorshi Sunaga, John J. Savarese> ;Journal of Critical Care. 2009 Mar 1
• 30 citations
  Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.
  John J. Savarese, Matthew R. Belmont, Mir Hashim, Robert A. Mook, Eric E. Boros, Vicente Samano, Patel Sanjay Shashikant, Paul L. Feldman, Jan-Ake I. Schultz, Michael ...> ;Anesthesiology. 2004 Apr 1
• 40 citations
  Clinical pharmacology of GW280430A in humans.
  Matthew R. Belmont, Cynthia A. Lien, Joseph Tjan, Eleanor Bradley, Brenna Stein, Patel Sanjay Shashikant, John J. Savarese> ;Anesthesiology. 2004 Apr 1
• 18 citations
  Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs.
  Paul M. Heerdt, Richard Kang, Mir Hashim, Robert J. Mook, John J. Savarese> ;Anesthesiology. 2004 Apr 1
• 5 citations
  Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.
  Takahiro Suzuki, Cynthia A. Lien, Matthew R. Belmont, Joseph Tjan, John J. Savarese> ;Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. 2003 Nov 1
• 14 citations
  Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.
  Eric E. Boros, Vicente Samano, John A. Ray, James B. Thompson, David Kendall Jung, Istvan Kaldor, Cecilia S. Koble, Michael Tolar Martin, Virgil L. Styles, Robert A. M...> ;Journal of Medicinal Chemistry. 2003 May 8
• 6 citations
  Pharmacodynamics and the plasma concentration of mivacurium during spontaneous recovery and neostigmine-facilitated recovery.
  Cynthia A. Lien, Matthew R. Belmont, Doreen L. Wray Roth, Michiko Okamoto, Amy Abalos, John J. Savarese> ;Anesthesiology. 1999 Jul 1
• 1 citations
  Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers
  Boros, Bigham, Boswell, Mook Jr, Patel, Savarese, Ray, Thompson, Hashim, Wisowaty, Feldman, Samano V> ;Journal of Medicinal Chemistry. 1999 Mar 25
• 8 citations
  The nature of spontaneous recovery from mivacurium-induced neuromuscular block.
  Cynthia A. Lien, Matthew R. Belmont, Amy Abalos, David Hass, John J. Savarese> ;Anesthesia and Analgesia. 1999 Mar 1
• Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers.
  Boros EE, Bigham EC, Boswell GE, Mook RA, Patel SS, Savarese JJ, Ray JA, Thompson JB, Hashim MA, Wisowaty JC, Feldman PL, Samano V> ;J. Med. Chem.. 1999-01-28
• [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].
  Savarese JJ, Lien CA, Belmont MR, Wastila WB> ;Anaesthesist. 1997-10-01
• 7 citations
  Pseudocholinesterase hyperactivity with succinylcholine resistance: An unusual cause of difficult intubation
  Fun-Sun F. Yao, John J. Savarese> ;Journal of Clinical Anesthesia. 1997 Jun 1
• 1 citations
  Reversal of nondepolarizing block: only when necessary
  John J. Savarese> ;Acta Anaesthesiologica Scandinavica. Supplementum. 1997 Jun 1
• 54 citations
  Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats.
  William B. Wastila, R. B. Maehr, Turner Geoffrey Lloyd, Hill Derek Anthony, M. Phil., John J. Savarese> ;Anesthesiology. 1996 Jul 1
• 2 citations
  Antagonism of Residual Mivacurium BlockadeSetting the Record Straight
  John J. Savarese, Cynthia A. Lien, Matthew R. Belmont> ;Anesthesiology. 1996 Jun 1
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Lectures

• The Ultra-Short Acting Neuromuscular Blocker CW 1759-50 Has Very High Autonomic Safety in the Isoflurane-Anesthetized Cat 
  Anesthesiology, Weill Cornell Medical College, New York, NY, USA - 10/14/2014
• The Ultra-Short Acting Neuromuscular Blocker CW 1759-50 Has Approximately 5 Times the Safety of Rapacurium at M2 and M3 Receptors in the Guinea Pig Airway 
  Anesthesiology, Weill Cornell Medical College, New York, NY, USA - 10/14/2014