JohnPSheehanMD

PubMed

• A novel factor IXa-specific enzyme-linked immunosorbent assay detects factor IXa in human plasma.
  Tina M Misenheimer, Michael R Lasarev, Kraig T Kumfer, John P Sheehan, Bradford S Schwartz> ;Research and Practice in Thrombosis and Haemostasis. 2024 Jan 1
• 1 citations
  Mapping the zymogen to protease transition in FIXa.
  John P. Sheehan> ;Journal of Thrombosis and Haemostasis. 2021 Jun 1
• 12 citations
  Phenotype of ribonuclease 1 deficiency in mice.
  Emily Garnett, Jo E. Lomax, Bassem M. Mohammed, David Gailani, John P. Sheehan, Ronald T. Raines> ;RNA. 2019 May 3
• 20 citations
  Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.
  William E. Plautz, Vijaya S. Pilli, Brian C. Cooley, Rima Chattopadhyay, Pamela R. Westmark, Todd M. Getz, David L. Paul, Wolfgang Bergmeier, John P. Sheehan, Rinku Ma...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 Jan 1
• 7 citations
  Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception.
  Pansakorn Tanratana, Paul E. R. Ellery, Pamela R. Westmark, Alan E. Mast, John P. Sheehan> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 Jan 1
• Zebrafish factor 10 and the life aquatic.
  John P. Sheehan> ;Blood. 2017 Aug 3
• 27 citations
  Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer
  Alice Chanakira, Pamela R. Westmark, Irene M. Ong, John P. Sheehan> ;Gynecologic Oncology. 2017 Apr 1
• 21 citations
  New developments in the management of moderate-to-severe hemophilia B.
  Moniba Nazeef, John P. Sheehan> ;Journal of Blood Medicine. 2016 Apr 1
• 16 citations
  Increased Red Blood Cell Stiffness Increases Pulmonary Vascular Resistance and Pulmonary Arterial Pressure
  David A. Schreier, Omid Forouzan, Timothy A. Hacker, John P. Sheehan, Naomi C. Chesler> ;Journal of Biomechanical Engineering. 2016 Feb 1
• 13 citations
  Selective disruption of heparin and antithrombin‐mediated regulation of human factor IX
  Pamela R. Westmark, Pansakorn Tanratana, John P. Sheehan> ;Journal of Thrombosis and Haemostasis. 2015 Jun 1
• 31 citations
  Factor XI anion-binding sites are required for productive interactions with polyphosphate
  Yipeng Geng, Ingrid M. Verhamme, Stephanie A. Smith, Qiufang Cheng, Mao-fu Sun, John P. Sheehan, James H. Morrissey, David Gailani> ;Journal of Thrombosis and Haemostasis. 2013 Nov 1
• 1 citations
  Low‐molecular‐weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: a reply to rebuttal
  Yang Buyue, Tina M. Misenheimer, John P. Sheehan> ;Journal of Thrombosis and Haemostasis. 2013 Mar 1
• 25 citations
  Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: contribution of the serpin-independent mechanism.
  Yang Buyue, Tina M. Misenheimer, John P. Sheehan> ;Journal of Thrombosis and Haemostasis. 2012 Oct 1
• 57 citations
  Activation of factor XI by products of prothrombin activation
  Anton Matafonov, Suryakala Sarilla, Mao-fu Sun, John P. Sheehan, Vladimir Serebrov, Ingrid M. Verhamme, David Gailani> ;Blood. 2011 Jul 14
• 5 citations
  The regulation of factor IXa by supersulfated low molecular weight heparin.
  Tina M. Misenheimer, John P. Sheehan> ;Biochemistry. 2010 Nov 23
• 54 citations
  Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite
  Yang Buyue, John P. Sheehan> ;Blood. 2009 Oct 1
• 51 citations
  The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis
  Yang Buyue, Herbert C. Whinna, John P. Sheehan> ;Blood. 2008 Oct 15
• 16 citations
  The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: the role of arginine 165 and factor X.
  Tina M. Misenheimer, Yang Buyue, John P. Sheehan> ;Biochemistry. 2007 Jun 12
• 68 citations
  Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism.
  John P. Sheehan, Erik N. Walke> ;Blood. 2005 Nov 16
• 29 citations
  The factor IXa heparin-binding exosite is a cofactor interactive site: mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin.
  Qiu-Ping Yuan, Erik N. Walke, John P. Sheehan> ;Biochemistry. 2005 Feb 10
• 34 citations
  Heparin inhibits the intrinsic tenase complex by interacting with an exosite on factor IXa.
  John P. Sheehan, Catherine E. Kobbervig, Heidi M. Kirkpatrick> ;Biochemistry. 2003 Sep 6
• 54 citations
  Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII
  John P. Sheehan, Michael Templer, Michael Gregory, Ravikumar Hanumanthaiah, Dean A. Troyer, Thao M. Phan, Bharath Thankavel, Pudur Jagadeeswaran> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Jul 17
• 41 citations
  Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism.
  John P. Sheehan, Thao M. Phan> ;Biochemistry. 2001 Apr 24
• 151 citations
  Identification and characterization of zebrafish thrombocytes
  P. Jagadeeswaran, John P. Sheehan, F. E. Craig, Dean A. Troyer> ;British Journal of Haematology. 1999 Dec 1
• 73 citations
  Analysis of blood coagulation in the zebrafish.
  Pudur Jagadeeswaran, John P. Sheehan> ;Blood Cells, Molecules & Diseases. 1999 Aug 1
• Join now to see all

Books/Book Chapters

• Conn’s Current Therapy 2020 
  Chapter: Venous Thromboembolism 
  Page 881 - 892Nazeef, M. and Sheehan, J.P.Editors: R. Kellerman & D. Rakel.Elsevier, Philadelphia2020

Abstracts/Posters

• Antithrombin- and Heparin-Binding Exosites Regulate Extravascular Binding and Clearance of Factor IXa
  John P. Sheehan, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• Role of Protease Exosites for In Vivo Hemostatic Activity and Clearance of FIX 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018