JohnR.SpurzemMD

Pulmonology • Jackson, MS

Critical Care Medicine, Interventional Pulmonology, Pleural Disease

Professor, Medicine, University of Mississippi School of Medicine

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Office
2500 North State Street
Department Of Medicine/Division Of Pulmonary
Jackson, MS 39216
Phone+1 601-984-5650
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Education & Training

University of Utah HealthFellowship, Pulmonary Disease and Critical Care Medicine, 1982 - 1985
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1979 - 1982
University of California, Irvine, School of MedicineClass of 1979

Certifications & Licensure

MS State Medical License 2005 - 2024
CA State Medical License 2012 - 2024
UT State Medical License 1981 - 1988
MN State Medical License 1980 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Publications & Presentations

PubMed

About severe sepsis and septic shock
Dominique J. Pepper, Rajesh Bhagat, Feriyl Bhaijee, John R. Spurzem> ;Journal of the Mississippi State Medical Association. 2013 Jun 1
Outpatient management of patients following pulmonary embolism.
John R. Spurzem, Stephen A. Geraci> ;The American Journal of Medicine. 2010 Nov 1
15 citations
Adenosine promotion of cellular migration in bronchial epithelial cells is mediated by the activation of cyclic adenosine monophosphate-dependent protein kinase A.
Diane Allen-Gipson, Karl Spurzem, Nicole Kolm, John R. Spurzem, Todd A. Wyatt> ;Journal of Investigative Medicine. 2007 Nov 1
39 citations
Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells
Diane Allen-Gipson, J. Wong, John R. Spurzem, J.H. Sisson, Todd A. Wyatt> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2006 May 1
26 citations
TGF-β1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels
Tetsu Kobayashi, Xiangde Liu, Hui Jung Kim, Tadashi Kohyama, Fu Qiang Wen, Shinji Abe, Qiuhong Fang, Yu Kui Zhu, John R. Spurzem, Peter B. Bitterman, Stephen I. Rennard> ;Respiratory Research. 2005 Dec 2
179 citations
Pathogenesis of COPD.
John R. Spurzem, Stephen I. Rennard> ;Seminars in Respiratory and Critical Care Medicine. 2005 Apr 1
3 citations
Tumor necrosis factor-α hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers
G. Patrick Lambert, John R. Spurzem, Debra J. Romberger, Todd A. Wyatt, Elizabeth Lyden, Ann M. Stromquist, James A. Merchant, Susanna G. Von Essen> ;Journal of Agromedicine. 2005 May 23
35 citations
Alcohol intake is associated with altered pulmonary function
Joseph H. Sisson, Julie A. Stoner, Debra J. Romberger, John R. Spurzem, Todd A. Wyatt, Joseph Owens-Ream, David M. Mannino> ;Alcohol. 2005 May 1
23 citations
Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair.
Todd A. Wyatt, Kusum K. Kharbanda, Dean J. Tuma, Joseph H. Sisson, John R. Spurzem> ;Alcohol. 2005 May 1
10 citations
Ethanol treatment reduces bovine bronchial epithelial cell migration.
John R. Spurzem, Tom Veys, Jane M. DeVasure, Joseph H. Sisson, Todd A. Wyatt> ;Alcoholism, Clinical and Experimental Research. 2005 Apr 1
4 citations
Gamma radiation inhibits fibroblast-mediated collagen gel retraction.
S Carnevali, Tadashi Mio, Yuichi Adachi, John R. Spurzem, Ilja Striz, D. J. Romberger, M. Illig, S. I. Rennard> ;Tissue & Cell. 2003 Dec 1
20 citations
Ethanol increases phosphodiesterase 4 activity in bovine bronchial epithelial cells.
Mary A. Forgèt, Joseph H. Sisson, John R. Spurzem, Todd A. Wyatt> ;Alcohol. 2003 Aug 1
26 citations
Agricultural lung disease.
John R. Spurzem, Debra J. Romberger, Susanna G. Von Essen> ;Clinics in Chest Medicine. 2002 Dec 1
23 citations
Relaxin stimulates bronchial epithelial cell PKA activation, migration, and ciliary beating
Todd A. Wyatt, Joseph H. Sisson, Mary A. Forgèt, R. G. Bennett, F. G. Hamel, John R. Spurzem> ;Experimental Biology and Medicine. 2002 Dec 1
27 citations
Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density.
Hangjun Wang, Xiangde Liu, Takeshi Umino, Tadashi Kohyama, Yun Kui Zhu, Fu Qiang Wen, John R. Spurzem, Debra J. Romberger, Hui Jung Kim, Stephen I. Rennard> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2003 Jan 1
41 citations
Activation of protein kinase A accelerates bovine bronchial epithelial cell migration
John R. Spurzem, Jitendrakumar Gupta, Thomas J. Veys, Kristen R Kneifl, Stephen I. Rennard, Todd A. Wyatt> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2002 May 1
80 citations
Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma
Fu-Qiang Wen, Tadashi Kohyama, Xiangde Liu, Yun Kui Zhu, Hangjun Wang, Hui Jun Kim, Tetsu Kobayashi, Shinji Abe, John R. Spurzem, Stephen I. Rennard> ;American Journal of Respiratory Cell and Molecular Biology. 2002 Apr 1
117 citations
Cigarette smoke inhibits human bronchial epithelial cell repair processes.
Hangjun Wang, Xiangde Liu, Takeshi Umino, C. Magnus Sköld, Yunkui Zhu, Tadashi Kohyama, John R. Spurzem, Debra J. Romberger, Stephen I. Rennard> ;American Journal of Respiratory Cell and Molecular Biology. 2001 Dec 1
23 citations
Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture.
Yun Kui Zhu, Xiangde Liu, Ronald F. Ertl, Tadashi Kohyama, Fu Qiang Wen, Hangjun Wang, John R. Spurzem, Debra J. Romberger, Stephen I. Rennard> ;American Journal of Respiratory Cell and Molecular Biology. 2001 Nov 1
140 citations
Prostaglandin E2 inhibits fibroblast chemotaxis
Tadashi Kohyama, Ronald F. Ertl, Vincenzo Valenti, John R. Spurzem, Masashi Kawamoto, Yoichi Nakamura, Tom Veys, Luigi Allegra, Debra J. Romberger, Stephen I. Rennard> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2001 Nov 1
50 citations
Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture.
Yunkui Zhu, X. D. Liu, C. M. Skold, Takeshi Umino, Hangjun Wang, John R. Spurzem, Tadashi Kohyama, Ronald F. Ertl, S. I. Rennard> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2001 Oct 1
55 citations
Cytokine Inhibition of Fibroblast-Induced Gel Contraction Is Mediated by PGE2 and NO Acting Through Separate Parallel Pathways
Yun Kui Zhu, Xiang-der Liu, Magnus C. Sköld, Takeshi Umino, Hangjun Wang, Debra J. Romberger, John R. Spurzem, Tadashi Kohyama, Fu-Qiang Wen, Stephen I. Rennard> ;American Journal of Respiratory Cell and Molecular Biology. 2001 Aug 1
18 citations
Bradykinin augments fibroblast-mediated contraction of released collagen gels.
Tadashi Mio, Xiangde Liu, Myron L. Toews, Yuichi Adachi, Debra J. Romberger, John R. Spurzem, Stephen I. Rennard> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2001 Jul 1
24 citations
PERSISTENCE OF TGF-β1 INDUCTION OF INCREASED FIBROBLAST CONTRACTILITY
X. D. Liu, Takeshi Umino, Ronald F. Ertl, Tom Veys, C. M. Skold, Keiichi Takigawa, Debra J. Romberger, John R. Spurzem, Yunkui Zhu, Tadashi Kohyama, Hangjun Wang, S. I...> ;In Vitro Cellular & Developmental Biology. Animal. 2001 Mar 1
29 citations
Cigarette smoke inhibits osteogenic differentiation and proliferation of human osteoprogenitor cells in monolayer and three-dimensional collagen gel culture.
X. D. Liu, Yunkui Zhu, Takeshi Umino, John R. Spurzem, Debra J. Romberger, Hangjun Wang, Elizabeth C. Reed, S. I. Rennard> ;The Journal of Laboratory and Clinical Medicine. 2001 Mar 1
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Hospital Affiliations

University of Mississippi Medical CenterJackson, Mississippi
G.V. (Sonny) Montgomery Department of Veterans Affairs Medical CenterJackson, Mississippi