JohnAWidnessMD

Neonat/Perinatology • Iowa City, IA

Professor, Pediatrics, University of Iowa College of Medicine

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Office
200 Hawkins Dr
Iowa City, IA 52242
Phone+1 319-356-8102

Fax+1 319-356-4685
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Education & Training

Case Western Reserve Univ/Univ Hosps Cleveland Med Ctr/Rainbow Babies and Childrens HospitalResidency, Pediatrics, 1973 - 1975
UPMC Medical EducationInternship, Internal Medicine, 1972 - 1973
Duke University School of MedicineClass of 1972

Certifications & Licensure

IA State Medical License 1988 - 2018
American Board of Pediatrics Pediatrics
American Board of Pediatrics Neonatal-Perinatal Medicine

Clinical Trials

Red Blood Cell (RBC) Survival Following Transfusion in Infants Start of enrollment: 2008 Jun 01
Completed
Phase 2
Optimized Erythropoietin (EPO) Treatment Start of enrollment: 2014 Jun 01
Completed
Phase 2
BioRBC Survival in Adults With Prior Antibody Response to BioRBCs Start of enrollment: 2013 May 01
Completed
Phase 1
Mathematical Modeling to Predict the Duration of Thrombocytopenia in Neonates Start of enrollment: 2013 Apr 01
Active, not recruiting
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Publications & Presentations

PubMed

1 citations
A Full Target-Mediated Drug Disposition (TMDD) Model to Explain the Changes in Recombinant Human Erythropoietin (rhEpo) Pharmacokinetics in Patients with Different Bon...
Nan Wu, John A Widness, Xiaoyu Yan, Peter Veng-Pedersen, Guohua An> ;Journal of Pharmaceutical Sciences. 2022 Sep 1
10 citations
Early brain and abdominal oxygenation in extremely low birth weight infants.
Valerie Y Chock, Emily Smith, Sylvia Tan, M Bethany Ball, Abhik Das, Susan R Hintz, Haresh Kirpalani, Edward F Bell, Lina F Chalak, Waldemar A Carlo, C Michael Cotten,...> ;Pediatric Research. 2022 Oct 1
8 citations
Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.
Donald M Mock, Sean R Stowell, Robert S Franco, Svetlana V Kyosseva, Demet Nalbant, Robert L Schmidt, Gretchen A Cress, Ronald G Strauss, José A Cancelas, Melissa von ...> ;Transfusion. 2022 Apr 1
5 citations
Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuropr...
Dennis E. Mayock, Semsa Gogcu, Mihai Puia-Dumitrescu, Dennis W. W. Shaw, Jason N. Wright, Bryan A. Comstock, Patrick J. Heagerty, Sandra E. Juul, Rajan Wadhawan, Sherr...> ;The Journal of Pediatrics. 2021 Aug 26
2 citations
Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.
Ariel A. Salas, Waldemar A. Carlo, Barbara Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, Seetha Shankaran, Noelle Younge, Kristi L. Watterbe...> ;The Journal of Pediatrics. 2021 Jun 19
96 citations
Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants
Haresh Kirpalani, Edward F. Bell, Susan R. Hintz, Sylvia Tan, Barbara Schmidt, Aasma S. Chaudhary, Karen J. Johnson, Margaret M. Crawford, Jamie E. Newman, Betty R. Vo...> ;The New England Journal of Medicine. 2020 Dec 30
3 citations
Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.
Patrick D. Carroll, M. Bridget Zimmerman, Demet Nalbant, Earl L Gingerich, Guohua An, Gretchen A. Cress, Peter Veng-Pedersen, John A. Widness> ;Neonatology. 2020 Jun 19
4 citations
Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision
Elisabeth C. McGowan, Abbot R. Laptook, Jean Lowe, Myriam Peralta-Carcelen, Dhuly Chowdhury, Rosemary D. Higgins, Susan R. Hintz, Betty R. Vohr, Richard A. Polin, A. R...> ;The Journal of Pediatrics. 2019 Sep 6
7 citations
Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens
Ronilda D'Cunha, Robert L. Schmidt, John A. Widness, Donald M. Mock, Xiaoyu Yan, Gretchen A. Cress, Denison Kuruvilla, Peter Veng-Pedersen, Guohua An> ;European Journal of Pharmaceutical Sciences. 2019 Oct 1
4 citations
A Mechanism‐Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses
Ronilda D'Cunha, John A. Widness, Xiaoyu Yan, Robert L. Schmidt, Peter Veng-Pedersen, Guohua An> ;Journal of Clinical Pharmacology. 2019 Jun 1
13 citations
Association between Policy Changes for Oxygen Saturation Alarm Settings and Neonatal Morbidity and Mortality in Infants Born Very Preterm.
Elizabeth E. Foglia, Benjamin Carper, Marie G. Gantz, Sara B. DeMauro, Satyan Lakshminrusimha, Michele C. Walsh, Barbara Schmidt, Michael S. Caplan, A. R. Laptook, Mar...> ;The Journal of Pediatrics. 2019 Apr 5
32 citations
Anemia induces gut inflammation and injury in an animal model of preterm infants
Connie M. Arthur, Demet Nalbant, Henry A. Feldman, Bejan Saeedi, Jason D. Matthews, Brian S. Robinson, Nourine A. Kamili, Ashley Bennett, Gretchen A. Cress, Martha Sol...> ;Transfusion. 2019 Apr 1
1 citations
Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin
Guohua An, Robert L. Schmidt, Donald M. Mock, Peter Veng-Pedersen, John A. Widness> ;The AAPS Journal. 2019 Jan 1
10 citations
A Brief History of Milk Hygiene and Its Impact on Infant Mortality from 1875 to 1925 and Implications for Today: A Review
Russell W Currier, John A. Widness> ;Journal of Food Protection. 2018 Oct 1
19 citations
Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs.
Kari Teramo, Miira M. Klemetti, John A. Widness> ;Pediatric Research. 2018 Jun 12
15 citations
Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analy...
Donald M. Mock, Demet Nalbant, Svetlana V. Kyosseva, Robert L. Schmidt, Guohua An, Nell I. Matthews, Alexander P.J. Vlaar, Robin van Bruggen, Dirk de Korte, Ronald G. ...> ;Transfusion. 2018 May 16
8 citations
In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.
Demet Nalbant, Jose A. Cancelas, Donald M. Mock, Svetlana V. Kyosseva, Robert L. Schmidt, Gretchen A. Cress, M. Bridget Zimmerman, Ronald G. Strauss, John A. Widness> ;Transfusion. 2018 Feb 1
34 citations
Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage
Athina Pappas, Ira Adams-Chapman, Seetha Shankaran, Scott A. McDonald, Barbara J. Stoll, Abbot R. Laptook, Waldemar A. Carlo, Krisa P. Van Meurs, Susan R. Hintz, Marth...> ;JAMA Pediatrics. 2018 Jan 1
31 citations
Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants
Erik A. Jensen, Kevin Dysart, Marie G. Gantz, Benjamin Carper, Rosemary D. Higgins, Martin Keszler, Matthew M. Laughon, Brenda B. Poindexter, Barbara J. Stoll, Michele...> ;The Journal of Pediatrics. 2017 Jul 1
43 citations
Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.
Juliann M. Di Fiore, Richard J. Martin, Hong Li, Nathan Morris, Waldemar A. Carlo, Neil N. Finer, Michele C. Walsh, Alan H. Jobe, Michael S. Caplan, Richard A. Polin, ...> ;The Journal of Pediatrics. 2017 Jul 1
42 citations
Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants
Katherine A. Sparger, Susan F. Assmann, Suzanne Granger, Abigail B. Winston, Robert D. Christensen, John A. Widness, Cassandra D. Josephson, Sean R. Stowell, Matthew A...> ;JAMA Pediatrics. 2016 Jul 1
4 citations
Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing
Guohua An, Robin K. Ohls, Robert D. Christensen, John A. Widness, Donald M. Mock, Peter Veng-Pedersen> ;Journal of Pharmaceutical Sciences. 2017 Jun 1
16 citations
Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.
Robert L. Schmidt, Donald M. Mock, Robert S. Franco, Robert M. Cohen, Anne North, Jose A. Cancelas, Christof Geisen, Ronald G. Strauss, Alexander P.J. Vlaar, Demet Nal...> ;Transfusion. 2017 Jun 1
16 citations
Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities
Denison Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt, Donald M. Mock, Guohua An, Peter Veng-Pedersen> ;Pediatric Research. 2017 Jan 18
22 citations
Research Opportunities to Improve Neonatal Red Blood Cell Transfusion
Ravi Mangal Patel, Erin K. Meyer, John A. Widness> ;Transfusion Medicine Reviews. 2016 Oct 1
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Journal Articles

Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants
Haresh Kirpalani, Susan R Hintz, Betty R Vohr, Waldemar A Carlo, Kathleen A Kennedy, Robin K Ohls, Kurt Schibler, John A Widness, John AF Zupancic, Myra H Wyckoff, Wil..., The New England Journal of Medicine

Grant Support

Red Cell Survival Following Transfusion In InfantsNational Heart, Lung, And Blood Institute2006–2010
Neonatal Anemia:Pathophysiology And TreatmentNational Heart, Lung, And Blood Institute2006–2010
Administrative, Statistical, Research, And LaboratoryNational Heart, Lung, And Blood Institute2006–2010
Physician Training Program In Neonatal BiologyEunice Kennedy Shriver National Institute Of Child Health &Human Development2003–2007
Erythropoietin Physiology And Pharmacology In InfantsNational Center For Research Resources2004–2005
Erythropoeitin Physiology And Pharmacology In InfantsNational Heart, Lung, And Blood Institute1999–2002
VIA 1 01 Lvm Blood GAS &Chemistry Monitor Testing VS StandardNational Center For Research Resources1999–2002
Erythropoietin Physiology &Pharmacology In InfantsNational Center For Research Resources1999–2002
Effect Of Enteral Iron Supplementation On Iron Status In Premature InfantsNational Center For Research Resources1999–2000
Effect Of Enteral Iron Supplementation On Iron Status Of Premature InfantsNational Center For Research Resources1996–1998
Response To Anemia During The Neonatal PeriodNational Heart, Lung, And Blood Institute1996
Response Of Anemic Infants To ErythropoietinNational Center For Research Resources1992–1996
Hematopoiesis In The Developing Embryo And FetusFogarty International Center1993
|National Heart, Lung, And Blood Institute1991
Erythropoietic And Hemodynamic Response To HypoxemiaNational Heart, Lung, And Blood Institute1989–1990
Erythropoietic And Hemodynamic Response To HypoxemiaNational Heart, Lung, And Blood Institute1987