John W. Winkelman MD

Sleep Medicine

Associate Professor in Psychiatry at Harvard Medical School and chief of the Sleep Disorders Clinical Research Program in the Department of Psychiatry at Massachusetts General Hospital

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55 Fruit StBoston, MA 02114
Phone+1 617-724-7426

Education & Training

Mass General Brigham/Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1988 - 1991
University of California (San Francisco)/Mount ZionInternship, Internal Medicine, 1987 - 1988
Harvard Medical SchoolClass of 1987

Certifications & Licensure

CA State Medical License 1993 - 2027
MA State Medical License 1991 - 2026
ME State Medical License 2021 - 2026
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Sleep Medicine

Clinical Trials

A Double Blind Crossover Trial of Levetiracetam (Keppra®) and Placebo in the Treatment of Restless Legs Syndrome (RLS) Start of enrollment: 2003 Nov 01
Completed
Phase 2
Sleep Loss and Mechanisms of Impaired Glucose Metabolism Start of enrollment: 2006 Mar 01
Completed
Not Applicable
Efficacy and Safety of Topiramate in the Treatment of Sleep-Related Eating Disorder Start of enrollment: 2008 Jan 01
Completed
Early Phase 1
Altered Brain GABA and Glutamate in Restless Legs Syndrome Start of enrollment: 2010 Apr 01
Completed
Switching From Oral Dopamine Agonists to Rotigotine Start of enrollment: 2014 Aug 01
Completed
Phase 4
Butrans for Treatment of Restless Legs Syndrome Start of enrollment: 2014 Apr 01
Withdrawn
Phase 4
Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Start of enrollment: 2019 Mar 15
COMPLETED
PHASE4
Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Start of enrollment: 2021 Aug 12
Completed
Phase 4
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Publications & Presentations

PubMed

1 citations
Assessing Early Efficacy After Initiation of Once-Nightly Sodium Oxybate (ON-SXB; FT218) in Participants with Narcolepsy Type 1 or 2: A Post Hoc Analysis from the Phas...
Lois Krahn, Asim Roy, John W Winkelman, Anne Marie Morse, Jennifer Gudeman
CNS Drugs. 2025-03-01
9 citations
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.
John W Winkelman, J Andrew Berkowski, Lourdes M DelRosso, Brian B Koo, Matthew T Scharf
Journal of Clinical Sleep Medicine. 2025-01-01
1 citations
Relationship of Suboptimal and Disordered Sleep with Cardiovascular Disease and Its Risk Factors - A Narrative Review.
Benjamin Wipper, Lukas Mayer-Suess, Matteo Cesari, Abubaker Ibrahim, John Winkelman
Neuroepidemiology. 2025-01-01

Other

Nocturnal leg cramps
Winkelman JW
http://www.uptodate.com/contents/nocturnal-leg-cramps
UpToDate, Wolters Kluwer Health - 2013-01-22

Press Mentions

Updated Guidelines for the Treatment of Restless Leg Syndrome: New Research Prompts a Significant Shift in RecommendationsDecember 3rd, 2024
Guidelines Developed for Treatment of Restless Legs SyndromeDecember 3rd, 2024
An RLS Prescription Revolution May Have BegunNovember 20th, 2024
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Grant Support

Eszopiclone To Counteract Adverse Metabolic Consequences Of Primary InsomniaNational Center For Research Resources2007–2008