JonChristopherAsterMD

PubMed

• Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain.
  Lena Tveriakhina, Gustavo Scanavachi, Emily D Egan, Ricardo Bango Da Cunha Correia, Alexandre P Martin, Julia M Rogers, Jeremy S Yodh, Tom Kirchhausen, Stephen C Black...> ;Developmental Cell. 2024 Mar 29
• Structural Requirements for Activity of Mind bomb1 in Notch Signaling.
  Ruili Cao, Oren Gozlan, Lena Tveriakhina, Haixia Zhou, Hanjie Jiang, Philip A Cole, David Sprinzak, Stephen C Blacklow, Jon C Aster> ;Biorxiv. 2024 Mar 3
• Optimization of Advanced Molecular Genetic Testing Utilization in Hematopathology: A Goldilocks Approach to Bone Marrow Testing.
  Ali AlJabban, Henry Paik, Jon C Aster, Nancy Berliner, Jennifer Brouillard, Jennifer R Brown, Kathleen H Burns, Jorge J Castillo, James Card, Paola Dal Cin, Daniel J D...> ;JCO Oncology Practice. 2024 Feb 1
• Molecular Mechanism of PP2A/B55α Inhibition by IER5.
  Ruili Cao, Daniel Td Jones, Li Pan, Shumei Wang, Shaun Rawson, Jon C Aster, Stephen C Blacklow> ;Biorxiv. 2023 Aug 29
• Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining.
  Karan Patel, Massimiliano Manzo, Brindley Hapuarachi, Samuel Rack, Philip Jermann, Laura Feeney, Emily Heathcote, Guy Betts, Jon C Aster, Maximilien Murone, Maria Boba...> ;Oral Oncology. 2023 Nov 1
• 2 citations
  A spatiotemporal Notch interaction map from plasma membrane to nucleus.
  Alexandre P Martin, Gary A Bradshaw, Robyn J Eisert, Emily D Egan, Lena Tveriakhina, Julia M Rogers, Andrew N Dates, Gustavo Scanavachi, Jon C Aster, Tom Kirchhausen, ...> ;Science Signaling. 2023 Aug 1
• 14 citations
  Recruited macrophages elicit atrial fibrillation.
  Maarten Hulsmans, Maximilian J Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, N...> ;Science. 2023 Jul 14
• 2 citations
  Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma.
  Cristina Mastini, Marco Campisi, Enrico Patrucco, Giulia Mura, Antonio Ferreira, Carlotta Costa, Chiara Ambrogio, Giulia Germena, Cinzia Martinengo, Silvia Peola, Ines...> ;Science Translational Medicine. 2023 Jun 28
• 3 citations
  What is in a Name? Consequences of the Classification Schism in Hematopathology.
  Jon C Aster> ;Journal of Clinical Oncology. 2023 Mar 10
• 7 citations
  Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma.
  Anuraag S Parikh, Avishai Wizel, Daniel Davis, Armida Lefranc-Torres, Alejandro I Rodarte-Rascon, Lauren E Miller, Kevin S Emerick, Mark A Varvares, Daniel G Deschler,...> ;Cell Reports. 2022 Nov 29
• 7 citations
  Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.
  Jonathan S Duke-Cohan, Aoi Akitsu, Robert J Mallis, Cameron M Messier, Patrick H Lizotte, Jon C Aster, Wonmuk Hwang, Matthew J Lang, Ellis L Reinherz> ;Nature. 2023 Jan 1
• p53 Pathway Inactivation Drives SMARCB1-deficient p53-wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition.
  Felix Oppel, Senyao Shao, Sarah Gendreizig, Mark W Zimmerman, Matthias Schürmann, Viyof Ful Flavian, Peter Goon, Susan N Chi, Jon C Aster, Holger Sudhoff, A Thomas Look> ;Molecular Cancer Therapeutics. 2022 Nov 3
• 12 citations
  AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling.
  Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christophe...> ;Cell Death & Disease. 2022 Aug 5
• 2 citations
  Gamma Secretase Inhibition for a Child With Metastatic Glomus Tumor and Activated NOTCH1.
  Ellen Zhang, Amber Miller, Catherine Clinton, Kylene DeSmith, Stephan D Voss, Jon C Aster, Alanna J Church, Reza Rahbar, Nadezhda Eberhart, Katherine A Janeway, Steven...> ;JCO Precision Oncology. 2022 Jun 1
• 6 citations
  A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.
  Kohta Miyawaki, Koji Kato, Takeshi Sugio, Kensuke Sasaki, Hiroaki Miyoshi, Yuichiro Semba, Yoshikane Kikushige, Yasuo Mori, Yuya Kunisaki, Hiromi Iwasaki, Toshihiro Mi...> ;Blood Advances. 2021 Oct 12
• 12 citations
  Primary Cytotoxic T Cell Lymphomas Harbor Recurrent Targetable Alterations in the JAK-STAT Pathway.
  , , , , , , , , , , , , , , , , , , , , , > ;Blood. 2021 Aug 25
• 47 citations
  FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
  Vijayashree Mysore, Xavier Cullere, Joseph R. Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris K. Madera-Salcedo, Frank Rosenbauer, Richard Stone, J...> ;Nature Communications. 2021 Aug 9
• 18 citations
  Notch signaling in cancer: Complexity and challenges on the path to clinical translation
  Antonio P A Ferreira, Jon C. Aster> ;Seminars in Cancer Biology. 2021 Apr 20
• 13 citations
  Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors.
  Vignesh Shanmugam, Jeffrey W. Craig, Laura K. Hilton, Matthew Nguyen, Christopher Rushton, Kian Fahimdanesh, Scott B. Lovitch, Ben Ferland, David Scott, Jon C. Aster> ;Blood Advances. 2021 Jan 12
• 11 citations
  Activation of Notch and Myc signaling via B cell-restricted depletion of Dnmt3a generates a consistent murine model of chronic lymphocytic leukemia.
  Anat Biran, Shanye Yin, Helene Kretzmer, Elisa Ten Hacken, Salma Parvin, Fabienne Lucas, Mohamed Uduman, Catherine Gutierrez, Nathan J Dangle, Leah Billington, Fara Fa...> ;Cancer Research. 2021 Jan 1
• 10 citations
  Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.
  Peter Miller, Adam S. Sperling, Christopher J. Gibson, Kaushik Viswanathan, Cecilia A. Castellano, Marie McConkey, John J Ceremsak, Martin S. Taylor, Sebastian Birndt,...> ;Blood. 2020 Dec 24
• 28 citations
  Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL
  Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Jollyette Rogers, Madhu M. Ouseph, Monica S. Nair, Sayalee Pot...> ;Blood. 2021 May 6
• 46 citations
  Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
  Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack...> ;Clinical Cancer Research. 2021 Feb 1
• 20 citations
  Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.
  Yanyu Zhao, Anahita Pilvar, Anup Tank, Hannah M. Peterson, John Jiang, Jon C. Aster, John P. Dumas, Mark C. Pierce, Darren Roblyer> ;Nature Communications. 2020 Oct 23
• 6 citations
  IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation
  Li Pan, Madeleine E. Lemieux, Tom Thomas, Julia M. Rogers, Colin H. Lipper, Winston Y. Lee, Carl Johnson, Lynette M. Sholl, Andrew P. South, Jarrod A. Marto, Guillaume...> ;Elife. 2020 Sep 16
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Abstracts/Posters

• Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL
  Jon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALL
  Jon C. Aster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Other

• Epidemiology, clinical manifestations, pathologic features, and diagnosis of Burkitt lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/epidemiology-clinical-manifestations-pathologic-features-and-diagno
  UpToDate, Wolters Kluwer Health - 2013-01-18
• Clinical manifestations, pathologic features, and diagnosis of anaplastic large cell lymphoma, ALK positive 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-anapla
  UpToDate, Wolters Kluwer Health - 2012-11-29
• Clinical manifestations, pathologic features, and diagnosis of peripheral T cell lymphoma, not otherwise specified 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-periph
  UpToDate, Wolters Kluwer Health - 2012-11-28
• Clinical features and diagnosis of hairy cell leukemia 
  Aster JC, Tallman MS
  http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-hairy-cell-leukemia
  UpToDate, Wolters Kluwer Health - 2013-04-02
• Clinical presentation and diagnosis of non-Hodgkin lymphoma 
  Aster JC, Freedman AS, Friedberg JW
  http://www.uptodate.com/contents/clinical-presentation-and-diagnosis-of-non-hodgkin-lymphoma
  UpToDate, Wolters Kluwer Health - 2012-10-24
• Classification of the hematopoietic neoplasms 
  Aster JC, Freedman AS, Friedberg JW
  http://www.uptodate.com/contents/classification-of-the-hematopoietic-neoplasms
  UpToDate, Wolters Kluwer Health - 2012-06-25
• Castleman's disease 
  Aster JC, Freedman AS, Brown JR
  http://www.uptodate.com/contents/castlemans-disease
  UpToDate, Wolters Kluwer Health - 2013-02-27
• Clinical manifestations, pathologic features, and diagnosis of B cell prolymphocytic leukemia 
  Aster JC, Freedman AS, Dearden C
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-b-cell
  UpToDate, Wolters Kluwer Health - 2012-11-06
• Clinical manifestations, pathologic features, and diagnosis of T cell prolymphocytic leukemia 
  Aster JC, Freedman AS, Dearden C
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-t-cell
  UpToDate, Wolters Kluwer Health - 2012-08-13
• Clinical manifestations, pathologic features, and diagnosis of adult T cell leukemia-lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-adult-
  UpToDate, Wolters Kluwer Health - 2013-01-04
• Clinical manifestations, pathologic features, and diagnosis of angioimmunoblastic T cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-angioi
  UpToDate, Wolters Kluwer Health - 2013-02-05
• Epidemiology, clinical manifestations, and diagnosis of post-transplant lymphoproliferative disorders 
  Aster JC, Friedberg JW
  http://www.uptodate.com/contents/epidemiology-clinical-manifestations-and-diagnosis-of-post-transpla
  UpToDate, Wolters Kluwer Health - 2013-03-05
• Clinical manifestations, pathologic features, and diagnosis of enteropathy-associated T cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-entero
  UpToDate, Wolters Kluwer Health - 2013-01-15
• Clinical manifestations, pathologic features, and diagnosis of extranodal (MALT) and nodal marginal zone lymphomas 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-extran
  UpToDate, Wolters Kluwer Health - 2013-02-27
• Clinical manifestations, pathologic features, and diagnosis of extranodal NK/T cell lymphoma, nasal type 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-extran
  UpToDate, Wolters Kluwer Health - 2013-01-04
• Clinical manifestations, pathologic features, and diagnosis of hepatosplenic T cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-hepato
  UpToDate, Wolters Kluwer Health - 2012-07-27
• Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lympho
  UpToDate, Wolters Kluwer Health - 2013-04-16
• Clinical manifestations, pathologic features, and diagnosis of mantle cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-mantle
  UpToDate, Wolters Kluwer Health - 2013-03-05
• Clinical manifestations, pathologic features, and diagnosis of precursor B cell acute lymphoblastic leukemia/lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-precur
  UpToDate, Wolters Kluwer Health - 2013-01-10
• Clinical manifestations, pathologic features, and diagnosis of precursor T cell acute lymphoblastic leukemia/lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-precur
  UpToDate, Wolters Kluwer Health - 2012-04-27
• Clinical manifestations, pathologic features, and diagnosis of primary mediastinal large B-cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-primar
  UpToDate, Wolters Kluwer Health - 2012-05-09
• Clinical manifestations, pathologic features, and diagnosis of small lymphocytic lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-small-
  UpToDate, Wolters Kluwer Health - 2012-07-12
• Clinical manifestations, pathologic features, and diagnosis of splenic marginal zone lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-spleni
  UpToDate, Wolters Kluwer Health - 2013-02-27
• Clinical manifestations, pathologic features, and diagnosis of subcutaneous panniculitis-like T-cell lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-subcut
  UpToDate, Wolters Kluwer Health - 2012-07-20
• Clinical manifestations, pathologic features, diagnosis, and prognosis of follicular lymphoma 
  Aster JC, Freedman AS
  http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-diagnosis-and-prognosis
  UpToDate, Wolters Kluwer Health - 2013-02-05
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