JonasO'garaHannestadMD

PubMed

• 2 citations
  CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
  Sanket V Rege, Arnaud Teichert, Juliet Masumi, Onkar S Dhande, Reema Harish, Brett W Higgins, Yesenia Lopez, Lily Akrapongpisak, Hannah Hackbart, Sofia Caryotakis, Din...> ;Communications Biology. 2023 Mar 18
• 3 citations
  Drug characteristics derived from kinetic modeling: combinedC-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.
  Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun H...> ;EJNMMI Research. 2022 Nov 8
• 8 citations
  Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer's Disease: A Phase II Double-Blind Placebo-Controlled Trial.
  Jonas Hannestad, Tiffanie Duclos, Whitney Chao, Katie Koborsi, Vicki Klutzaritz, Brian Beck, Ashok K. Patel, James Scott, Stephen G. Thein, Jeffrey L. Cummings, Gary K...> ;Journal of Alzheimer's Disease. 2021 Jan 1
• 9 citations
  Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach.
  Pierandrea Muglia, Jonas Hannestad, Christian Brandt, Steven DeBruyn, Massimiliano Germani, Brigitte Lacroix, Marian Majoie, Christian Otoul, David Sciberras, Bernhard...> ;Brain Communications. 2020 Nov 2
• 5 citations
  Inverse changes in raphe and cortical 5-HT 1B receptor availability after acute tryptophan depletion in healthy human subjects.
  Stephen R. Baldassarri, Eunkyung Park, Sjoerd J. Finnema, Beata Planeta, Nabeel Nabulsi, Soheila Najafzadeh, Jim Ropchan, Yiyun Huang, Jonas Hannestad, Kathleen Malone...> ;Synapse. 2020 Apr 23
• 5 citations
  Safety and tolerability of GRF6019 in mild-to-moderate Alzheimer's disease dementia
  Jonas Hannestad, Katie Koborsi, Vicki Klutzaritz, Whitney Chao, Rebecca Ray, Antonio Páez, Samuel J. Jackson, Scott Lohr, Jeffrey L. Cummings, Gary Kay, Karoly Nikolic...> ;Alzheimer's & Dementia. 2020 Jan 1
• 37 citations
  A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.
  Sjoerd J. Finnema, Samantha Rossano, Mika Naganawa, Shannan Henry, Hong Gao, Richard Pracitto, Ralph Paul Maguire, Joël Mercier, Sophie Kervyn, Jean-Marie Nicolas, Hen...> ;Epilepsia. 2019 Mar 29
• 103 citations
  The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.
  Celine Vermeiren, Philippe Motte, Delphine Viot, Georges Mairet-Coello, Jean-Philippe Courade, Martin Citron, Joël Mercier, Jonas Hannestad, Michel Gillard> ;Movement Disorders. 2018 Feb 1
• 1 citations
  PET Imaging in Psychoneuroimmunology Research.
  Jonas Hannestad> ;Methods in Molecular Biology. 2018 Jan 1
• 120 citations
  Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in h...
  Sjoerd J. Finnema, Nabeel Nabulsi, Joël Mercier, Shu-fei Lin, Ming-Kai Chen, David Matuskey, Jean-Dominique Gallezot, Shannan Henry, Jonas Hannestad, Yiyun Huang, Rich...> ;Journal of Cerebral Blood Flow and Metabolism. 2017 Aug 9
• 54 citations
  Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.
  Chadi G. Abdallah, Jonas Hannestad, Graeme F. Mason, Sophie E. Holmes, Nicole DellaGioia, Gerard Sanacora, Lihong Jiang, David Matuskey, Ritvij Satodiya, Fabrizio Gasp...> ;Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2017 Jul 1
• 38 citations
  Systemic inflammation enhances stimulant-induced striatal dopamine elevation
  Joseph Petrulli, B Kalish, Nabeel Nabulsi, Y. Huang, Jonas Hannestad, Evan D. Morris> ;Translational Psychiatry. 2017 Mar 28
• 57 citations
  In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence
  Ansel T. Hillmer, Christine M. Sandiego, Jonas Hannestad, Gustavo A. Angarita, Aditya Kumar, Erin McGovern, Y. Huang, Kevin C. O’Connor, Richard E. Carson, Stephanie S...> ;Molecular Psychiatry. 2017 Feb 28
• 293 citations
  Imaging synaptic density in the living human brain
  Sjoerd J. Finnema, Nabeel Nabulsi, Tore Eid, Kamil Detyniecki, Shu-fei Lin, Ming-Kai Chen, Roni Dhaher, David Matuskey, Evan Baum, Daniel Holden, Dennis D. Spencer, Jo...> ;Science Translational Medicine. 2016 Jul 20
• 25 citations
  OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.
  Christopher Pittenger, Thomas G. Adams, Jean-Dominique Gallezot, Michael J. Crowley, Nabeel Nabulsi, James Ropchan, Hong Gao, Stephen A. Kichuk, Ryan Simpson, Eileen B...> ;Journal of Affective Disorders. 2016 May 15
• 170 citations
  Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
  Nabeel Nabulsi, Joël Mercier, Daniel Holden, Stephane Carre, Soheila Najafzadeh, Marie-Christine Vandergeten, Shu-fei Lin, Anand K. Deo, Nathalie Price, Martyn Wood, T...> ;Journal of Nuclear Medicine. 2016 May 1
• 107 citations
  Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment
  Henrik Klitgaard, Alain Matagne, Jean-Marie Nicolas, Michel Gillard, Yves Lamberty, Marc Roger De Ryck, Rafal M. Kaminski, Karine Leclercq, Isabelle Niespodziany, Chri...> ;Epilepsia. 2016 Apr 1
• 100 citations
  Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
  Jean-Marie Nicolas, Jonas Hannestad, Daniel Holden, Sophie Kervyn, Nabeel Nabulsi, Dominique Tytgat, Yiyun Huang, Hugues Chanteux, Ludovicus Staelens, Alain Matagne, F...> ;Epilepsia. 2016 Feb 1
• 35 citations
  In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl
  Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M. Catafau, Jonas Hannestad, ...> ;Journal of Nuclear Medicine. 2016 Feb 1
• 228 citations
  Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
  Christine M. Sandiego, Jean-Dominique Gallezot, Brian Pittman, Nabeel Nabulsi, Keunpoong Lim, Shu-fei Lin, David Matuskey, Jae-Yun Lee, Kevin C. O’Connor, Yiyun Huang,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct 6
• 38 citations
  Characterization in Humans of 18F-MNI-444, a PET Radiotracer for Brain Adenosine 2A Receptors
  Olivier Barret, Jonas Hannestad, Christine Vala, David Alagille, Adriana Tavares, Marc Laruelle, Danna Jennings, Ken Marek, David S. Russell, John Seibyl, Gilles Tamagnan> ;Journal of Nuclear Medicine. 2015 Apr 1
• 16 citations
  Comparison of Standardized Uptake Values with Volume of Distribution for Quantitation of [11C]PBR28 Brain Uptake
  Karmen K. Yoder, Paul R. Territo, Gary D. Hutchins, Jonas Hannestad, Evan D. Morris, Jean-Dominique Gallezot, Marc D. Normandin, Kelly P. Cosgrove> ;Nuclear Medicine and Biology. 2015 Mar 1
• 24 citations
  Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys
  Olivier Barret, Jonas Hannestad, David Alagille, Christine Vala, Adriana Tavares, Caroline Papin, Thomas J. Morley, Krista Fowles, Hsiaoju Lee, John Seibyl, Dominique ...> ;Journal of Nuclear Medicine. 2014 Oct 1
• 52 citations
  Dopamine D3 Receptor Alterations in Cocaine-Dependent Humans Imaged with [11C](+)PHNO
  David Matuskey, Jean-Dominique Gallezot, Brian Pittman, Wendol Williams, Jane Wanyiri, Edward C. Gaiser, Dianne Lee, Jonas Hannestad, Keunpoong Lim, Minq-Qiang Zheng, ...> ;Drug and Alcohol Dependence. 2014 Jun 1
• 46 citations
  Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography
  Jonas Hannestad, Kelly P. Cosgrove, Nicole DellaGioia, Evgenia Perkins, Frederic Bois, Zubin Bhagwagar, John Seibyl, Tristan D. McClure-Begley, Marina R. Picciotto, Ir...> ;Biological Psychiatry. 2013 Nov 15
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