JonathanDanielSchoenfeldMDMPH

Attending Radiation Oncologist, Director of Head and Neck Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center; Associate Professor in Radiation Oncology Harvard Medical School

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Office
75 Francis St
Department Of Radiation Oncology
Boston, MA 02115
Phone+1 617-632-3591
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Radiation Oncology, 2009 - 2013
Harvard Medical SchoolClass of 2008, cum laude
University of CambridgeMPhil, 2002 - 2003
Harvard School of Public HealthMPH
Yale UniversityBS, summa cum laude

Certifications & Licensure

MA State Medical License 2010 - 2025
FL State Medical License 2020 - 2022
ME State Medical License 2020 - 2021
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

Gates Cambridge Scholar Gates Cambridge Trust

Clinical Trials

Study Evaluating a Stereotactic Boost/Treatment for Recurrent or Metastatic Cancer of the Head and Neck Start of enrollment: 2015 Nov 01
Active, not recruiting
Phase 1
Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity Start of enrollment: 2016 Nov 01
Active, not recruiting
Phase 2
Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN Start of enrollment: 2017 Jun 30
Active, not recruiting
Phase 2
Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial Start of enrollment: 2021 Dec 27
Recruiting
Not Applicable
Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study Start of enrollment: 2021 Jul 02
Recruiting
Phase 2
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Publications & Presentations

PubMed

1 citations
The Next Chapter in Immunotherapy and Radiation Combination Therapy: Cancer-Specific Perspectives.
Amy J Wisdom, Christopher A Barker, Joe Y Chang, Sandra Demaria, Silvia Formenti, Clemens Grassberger, Fabiana Gregucci, Bradford S Hoppe, David G Kirsch, Ariel E Marc...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
Outcomes of palliative radiation therapy for cutaneous squamous cell carcinoma: A retrospective cohort study.
Kim, E., Granger, E., Silk, A., Schoenfeld, J., Margalit, D., Tishler, R., Ruiz, E.> ;JAAD International. 2024 Mar 1
Patterns of metastasis from a multicenter cohort of metastatic basal cell carcinoma.
Groover, M., Gupta, N., Granger, E., Anstadt, E., Heusinkveld, L., Forrester, V., Su, W., Lukens, J., Silk, A., Schoenfeld, J., Koyfman, S., Vidimos, A., Ruiz, E.> ;Journal of the American Academy of Dermatology. 2024 Feb 7
Xevinapant plus radiotherapy in resected, high-risk, cisplatin-ineligible LA SCCHN: the phase III XRay Vision study design.
Robert L Ferris, Hisham Mehanna, Jonathan D Schoenfeld, Makoto Tahara, Sue S Yom, Robert Haddad, André König, Pauline Witzler, Marcis Bajars, Christophe Le Tourneau> ;Future Oncology. 2024 Apr 1
3 citations
Multicenter Evaluation of Radiation and Immune Checkpoint Inhibitor Therapy in Mucosal Melanoma and Review of Recent Literature.
Smart, A., Giobbie-Hurder, A., Desai, V., Lukens, J., Taunk, N., Sullivan, R., Mooradian, M., Hsu, C., Buchbinder, E., Schoenfeld, J., Xing, J.> ;Advances in Radiation Oncology. 2024 Jan 1
In Reply to Fabi.
Smart, A., Schoenfeld, J.> ;Advances in Radiation Oncology. 2024 Jan 1
AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors.
Carmès, L., Bort, G., Lux, F., Seban, L., Rocchi, P., Muradova, Z., Hagège, A., Heinrich-Balard, L., Delolme, F., Gueguen-Chaignon, V., Truillet, C., Crowley, S., Bell...> ;Nanoscale. 2024 Feb 1
A multicenter real-world analysis of first-line systemic monotherapy for locally advanced basal cell carcinoma.
Groover, M., Gupta, N., Granger, E., Murad, F., Anstadt, E., Heusinkveld, L., Forrester, V., Su, W., Lukens, J., Silk, A., Vidimos, A., Schoenfeld, J., Koyfman, S., Ru...> ;JAAD Case Reports. 2023 Dec 1
A multicenter real-world analysis of risk factors, therapeutics, and outcomes of patients with metastatic basal cell carcinoma.
Morgan Groover, Neha Gupta, Emily Granger, Vernon J Forrester, Emily J Anstadt, William Su, Lauren Heusinkveld, Anna Chen, John N Lukens, Ann W Silk, Allison T Vidimos...> ;Journal of the American Academy of Dermatology. 2024 Mar 1
Proceed With Caution: Eliminating Elective Nodal Irradiation With Immunotherapy for Head and Neck Cancer.
Jonathan D Schoenfeld> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Oct 1
Definitive radiation therapy for inoperable stage III/IV cutaneous squamous cell carcinoma: A single-institution retrospective cohort study.
Emily E Granger, Emily Y Kim, Emily E Karn, Morgan K Groover, Ann W Silk, Danielle N Margalit, Roy B Tishler, Jonathan D Schoenfeld, Emily S Ruiz> ;Journal of the American Academy of Dermatology. 2024 Jan 1
5 citations
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.
Oliveira, G., Egloff, A., Afeyan, A., Wolff, J., Zeng, Z., Chernock, R., Zhou, L., Messier, C., Lizotte, P., Pfaff, K., Stromhaug, K., Penter, L., Haddad, R., Hanna, G...> ;Science Immunology. 2023 Sep 8
Lost in the shadow of giants: The neglected treatment modalities in oncologic trials.
Homan Mohammadi, Jonathan D Schoenfeld> ;Cancer. 2023 Nov 1
A multicenter retrospective cohort analysis of advanced basal cell carcinoma outcomes by sex.
Morgan Groover, Neha Gupta, Emily Granger, Fadi Murad, Vernon J Forrester, Emily J Anstadt, William Su, Lauren Heusinkveld, John N Lukens, Ann W Silk, Jonathan D Schoe...> ;Journal of the American Academy of Dermatology. 2024 Jan 1
7 citations
Development and Validation of an Automated Image-Based Deep Learning Platform for Sarcopenia Assessment in Head and Neck Cancer.
Zezhong Ye, Anurag Saraf, Yashwanth Ravipati, Frank Hoebers, Paul J Catalano, Yining Zha, Anna Zapaishchykova, Jirapat Likitlersuang, Christian Guthier, Roy B Tishler,...> ;JAMA Network Open. 2023 Aug 1
Radiotherapy Dose in Patients Receiving Immunotherapy.
Kelly J Fitzgerald, Jonathan D Schoenfeld> ;Seminars in Radiation Oncology. 2023 Jul 1
10 citations
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, rand...
Benjamin H Kann, Jirapat Likitlersuang, Dennis Bontempi, Zezhong Ye, Sanjay Aneja, Richard Bakst, Hillary R Kelly, Amy F Juliano, Sam Payabvash, Jeffrey P Guenette, Ra...> ;The Lancet. Digital Health. 2023 Jun 1
Fully-automated sarcopenia assessment in head and neck cancer: development and external validation of a deep learning pipeline.
Zezhong Ye, Anurag Saraf, Yashwanth Ravipati, Frank Hoebers, Yining Zha, Anna Zapaishchykova, Jirapat Likitlersuang, Roy B Tishler, Jonathan D Schoenfeld, Danielle N M...> ;Medrxiv. 2023 Mar 6
4 citations
Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck.
Robert L Ferris, Kevin Harrington, Jonathan D Schoenfeld, Makoto Tahara, Christina Esdar, Satu Salmio, Andreas Schroeder, Jean Bourhis> ;Cancer Treatment Reviews. 2023 Feb 1
4 citations
Diagnostic performance of computed tomography features in detecting oropharyngeal squamous cell carcinoma extranodal extension.
Ngoc-Anh Tran, Miklos Palotai, Glenn J Hanna, Jonathan D Schoenfeld, Camden P Bay, Eleni M Rettig, Paul M Bunch, Amy F Juliano, Hillary R Kelly, Chong Hyun Suh, David ...> ;European Radiology. 2023 May 1
20 citations
Association of Pretreatment Circulating Tumor Tissue-Modified Viral HPV DNA With Clinicopathologic Factors in HPV-Positive Oropharyngeal Cancer.
Eleni M Rettig, Annette A Wang, Ngoc-Anh Tran, Evan Carey, Tanujit Dey, Jonathan D Schoenfeld, Kartik Sehgal, Jeffrey P Guenette, Danielle N Margalit, Rosh Sethi, Ravi...> ;JAMA Otolaryngology-- Head & Neck Surgery. 2022 Dec 1
3 citations
Image quality comparisons of coil setups in 3T MRI for brain and head and neck radiotherapy simulations.
Evangelia Kaza, Jeffrey P Guenette, Christian V Guthier, Steven Hatch, Alexander Marques, Lisa Singer, Jonathan D Schoenfeld> ;Journal of Applied Clinical Medical Physics. 2022 Dec 1
91 citations
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.
Adrienne M Luoma, Shengbao Suo, Yifan Wang, Lauren Gunasti, Caroline B M Porter, Nancy Nabilsi, Jenny Tadros, Andrew P Ferretti, Sida Liao, Cagan Gurer, Yu-Hui Chen, S...> ;Cell. 2022 Aug 4
13 citations
Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-cent...
Emily S Ruiz, Kylee J B Kus, Timothy D Smile, Fadi Murad, Guohai Zhou, Evelyn O Ilori, Jonathan D Schoenfeld, Danielle N Margalit, Roy B Tishler, Allison T Vidimos, Sh...> ;Journal of the American Academy of Dermatology. 2022 Jul 1
2 citations
Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers.
Mona Arbab, Yu-Hui Chen, Roy B Tishler, Lauren Gunasti, Jason Glass, Jo Ann Fugazzotto, Joseph H Killoran, Rosh Sethi, Eleni Rettig, Donald Annino, Laura Goguen, Ravin...> ;Head & Neck. 2022 Jun 1
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Lectures

A randomized phase II study of pembrolizumab with or without radiation in patients with recurrent or metastatic adenoid cystic carcinoma.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Study Identifies T-cell Populations That Predict Response to ImmunotherapyJuly 12th, 2022
Study Identifies T-cell Populations That Predict Response to ImmunotherapyJuly 11th, 2022
ECOG-ACRIN Research Highlights at ASCO 2022May 27th, 2022
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