JonathanSevranskyMD

Critical Care Medicine

Professor of Medicine, Emory University Director EUH MICU Assistant Director for EUH and Medicine, Emory Center for Critical Care

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Office
1365 Clifton Rd NE
Atlanta, GA 30322
Phone+1 404-686-6162

Fax+1 404-778-7466
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Education & Training

Johns Hopkins UniversityFellowship, Pulmonary Disease and Critical Care Medicine, 1997 - 1999
National Institutes of Health Clinical CenterFellowship, Critical Care Medicine (Internal Medicine), 1994 - 1996
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1991 - 1994
George Washington University School of Medicine and Health SciencesClass of 1991

Certifications & Licensure

DC State Medical License 1996 - Present
GA State Medical License 2011 - 2024
MD State Medical License 1996 - 2013
NY State Medical License 1993 - 1999
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

Protocol-driven Hemodynamic Support for Patients With Septic Shock Start of enrollment: 2006 Sep 01
Unknown status
Not Applicable
Critical Illness Outcomes Study Start of enrollment: 2010 Jul 01
Unknown status
Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury Start of enrollment: 2014 Apr 01
Completed
Phase 2
Vitamin C, Thiamine, and Steroids in Sepsis Start of enrollment: 2018 Aug 22
Completed
Phase 3
Trial of Therapeutic Hypothermia in Patients With ARDS Start of enrollment: 2021 Jun 29
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Is It Time to Reconsider the Concept of "Salvage Therapy" in Refractory Shock?
Patrick M Wieruszewski, Jonathan E Sevransky, Russel J Roberts> ;Critical Care Medicine. 2023 Dec 1
2 citations
Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial.
Laurence W Busse, Christopher L Schaich, Mark C Chappell, Erin M Staples, Caitlin C Ten Lohuis, Jeremiah S Hinson, Jonathan E Sevransky, Richard E Rothman, David W Wri...> ;Critical Care Medicine. 2024 Mar 1
How Electronic Medical Record Integration Can Support More Efficient Critical Care Clinical Trials.
Ankita Agarwal, Joseph Marion, Paul Nagy, Matthew Robinson, Allan Walkey, Jonathan Sevransky> ;Critical Care Clinics. 2023 Oct 1
2 citations
Thiamine for Septic Shock: Take Your Vitamins?
Tomoko Fujii, Jonathan Sevransky> ;American Journal of Respiratory and Critical Care Medicine. 2023 Sep 1
Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.
Li Gao, Nicholas Rafaels, Tanda M Dudenkov, Mahendra Damarla, Rachel Damico, James P Maloney, Marc Moss, Greg S Martin, Jonathan Sevransky, Carl Shanholtz, Dan L Herr,...> ;Respiratory Research. 2023 Jul 6
4 citations
Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic.
George L Anesi, Adair Andrews, He Julia Bai, Pavan K Bhatraju, David M Brett-Major, M Jana Broadhurst, Elizabeth Salvagio Campbell, J Perren Cobb, Martin Gonzalez, Son...> ;Critical Care Medicine. 2023 Apr 1
Under Pressure: Do We "Dare Change Our Way of Caring" for Patients With Shock?
Russel J Roberts, Jonathan E Sevransky, Allan J Walkey, Jen-Ting Chen> ;Critical Care Medicine. 2023 Feb 1
Resuscitation in the First 3 Hours of Sepsis-Induced Hypotension Varies by Patient and Hospital Factors.
Jen-Ting Chen, Russel J Roberts, Jonathan Eliot Sevransky, Michelle Ng Gong> ;Critical Care Explorations. 2023 Feb 1
7 citations
Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analy...
Shawniqua Williams Roberson, Samuel Nwosu, Erin M Collar, Amy L Kiehl, Fiona E Harrison, Julie Bastarache, Jo Ellen Wilson, Matthew F Mart, Jonathan E Sevransky, E Wes...> ;JAMA Network Open. 2023 Feb 1
5 citations
Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity.
Pavan K Bhatraju, Eric D Morrell, Ian B Stanaway, Neha A Sathe, Avantika Srivastava, Radu Postelnicu, Richard Green, Adair Andrews, Martin Gonzalez, Christopher J Krat...> ;Critical Care Explorations. 2023 Jan 1
12 citations
Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS.
Xian Qiao, Markos G Kashiouris, Michael L'Heureux, Bernard J Fisher, Stefan W Leichtle, Jonathon D Truwit, Rahul Nanchal, Robert Duncan Hite, Peter E Morris, Greg S Ma...> ;Nutrients. 2022 Oct 21
2 citations
Severe Acute Respiratory Infection-Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections.
Radu Postelnicu, Avantika Srivastava, Pavan K Bhatraju, Mark M Wurfelc, George L Anesi, Martin Gonzalez, Adair Andrews, Karen Lutrick, Vishakha K Kumar, Timothy M Uyek...> ;Critical Care Explorations. 2022 Oct 1
3 citations
SWEAT ICU-An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs.
Ankita Agarwal, Jen-Ting Chen, Craig M Coopersmith, Joshua L Denson, Neal W Dickert, Lauren E Ferrante, Hayley B Gershengorn, Adhiraj D Gosine, Bradley J Hayward, Navn...> ;Critical Care Explorations. 2022 Oct 1
Is "Set It and Forget It" Bad Medicine for Sedation and Analgesia for Intubated Emergency Department Patients?
Jonathan Sevransky, Winkle, J.> ;Critical Care Medicine. 2022 Aug 1
4 citations
Implementation of an EMS protocol to improve prehospital sepsis recognition.
Carmen C Polito, Ingrid Bloom, Charity Dunn, Renee' Moore, Jiandong Chen, Arthur H Yancey 2nd, Jonathan E Sevransky> ;The American Journal of Emergency Medicine. 2022 Jul 1
117 citations
Redefining critical illness.
David M Maslove, Benjamin Tang, Manu Shankar-Hari, Patrick R Lawler, Derek C Angus, J Kenneth Baillie, Rebecca M Baron, Michael Bauer, Timothy G Buchman, Carolyn S Cal...> ;Nature Medicine. 2022 Jun 1
1 citations
The authors reply.
Thomas P Bleck, Timothy G Buchman, Cherylee W J Chang, R Phillip Dellinger, Clifford S Deutschman, Sameer S Kadri, John C Marshall, David M Maslove, Henry Masur, Tiffa...> ;Critical Care Medicine. 2022 Jun 1
Phase 2 Vitamin C Sepsis Trials: Another Brick in the (Evidence) Wall?
Ankita Agarwal, Simon Oczkowski, Jonathan Sevransky> ;Critical Care Medicine. 2022 May 1
Effects of Timing of Invasive Mechanical Ventilation in Patients with Shock. An Analysis of the Multicenter Prospective Observational VOLUME-CHASERS Cohort.
Neha N Goel, Jen-Ting Chen, Russel Roberts, Jonathan Sevransky, Michelle N Gong, Kusum S Mathews> ;Journal of Intensive Care Medicine. 2022 Nov 1
8 citations
The Future of Critical Care: Optimizing Technologies and a Learning Healthcare System to Potentiate a More Humanistic Approach to Critical Care.
Heather Meissen, Michelle Ng Gong, An-Kwok Ian Wong, Jerry J Zimmerman, Nalini Nadkarni, Sandra L Kane-Gil, Javier Amador-Castaneda, Heatherlee Bailey, Samuel M Brown,...> ;Critical Care Explorations. 2022 Mar 1
140 citations
Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.
Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M. Coopersmith, Craig French, Flávia Ribeiro Machado, Lauralyn McIntyre, Marlies Ostermann, Hall...> ;Critical Care Medicine. 2021 Nov 1
365 citations
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M. Coopersmith, Craig French, Flávia Ribeiro Machado, Lauralyn McIntyre, Marlies Ostermann, Hall...> ;Critical Care Medicine. 2021 Nov 1
1519 citations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M. Coopersmith, Craig French, Flávia Ribeiro Machado, Lauralyn McIntyre, Marlies Ostermann, Hall...> ;Intensive Care Medicine. 2021 Oct 2
1 citations
21st Century Evidence: Randomized Controlled Trials Versus Systematic Reviews and Meta-Analyses.
Ankita Agarwal, Bram Rochwerg, Jonathan E. Sevransky> ;Critical Care Medicine. 2021 Sep 24
6 citations
Any Role of High-Dose Vitamin C for Septic Shock in 2021?
Ankita Agarwal, David N. Hager, Jonathan E. Sevransky> ;Seminars in Respiratory and Critical Care Medicine. 2021 Sep 20
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Journal Articles

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients with Sepsis
Jonathan E Sevransky, Richard E Rothman, David N Hager, Laurence W Busse, David F Gaieski, Michelle N Gong, Jeremiah S Hinson, Michael H Hooper, Gabor D Kelen, Katheri..., JAMA

Press Mentions

Vitamin C Treatment Ineffective Against Sepsis, Another Study ShowsMarch 2nd, 2021
Can Vitamin C Improve Sepsis Outcomes? A New Study Offers Reason for SkepticismMarch 2nd, 2021
Vitamin C Study Fails to Improve Sepsis OutcomesFebruary 25th, 2021
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