JonathanS.SilverMD

Cardiology • Burlington, MA

Adult Congenital Heart Disease, Cardiac Electrophysiology, Interventional Cardiology

Assistant Professor, Medicine, Tufts Medical Center

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Office
Lahey Clinic
41 Mall Road
Burlington, MA 01805
Phone+1 781-744-8863

Fax+1 781-744-5577
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Education & Training

Lahey ClinicFellowship, Clinical Cardiac Electrophysiology, 2008 - 2009
Lahey ClinicFellowship, Cardiovascular Disease, 2005 - 2008
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 2002 - 2005
Lewis Katz School of Medicine at Temple UniversityClass of 2002

Certifications & Licensure

NH State Medical License 2013 - 2025
MA State Medical License 2004 - 2025
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Clinical Cardiac Electrophysiology

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

Ranolazine Implantable Cardioverter-Defibrillator Trial Start of enrollment: 2011 Sep 01
Completed
Phase 3

Publications & Presentations

PubMed

1 citations
Assessing the impact of atrial fibrillation on symptoms and quality of life in hypertrophic cardiomyopathy.
Ethan J Rowin, Mark Wadid, Martin S Maron, Maggie White, Bruce G Hook, Paul Harnish, Jonathan S Silver, Matthew R Reynolds, Barry J Maron> ;Journal of Cardiovascular Electrophysiology. 2024 Apr 1
Junctional AV ablation in patients with atrial fibrillation undergoing cardiac resynchronization therapy (JAVA-CRT): results of a multicenter randomized clinical trial...
Jonathan S Steinberg, John Gorcsan, Alexander Mazur, Sandeep K Jain, Mayer Rashtian, G Stephen Greer, Ignatius Zarraga, Margot Vloka, Michele Murphy Cook, Tariq Salam,...> ;Journal of Interventional Cardiac Electrophysiology. 2022 Aug 1
21 citations
IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii.
Joseph T. Clark, David A. Christian, Jodi A. Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet, James C. Tarrant, Enrico Radaelli, Jonathan S. Silver, Christop...> ;Elife. 2021 Apr 30
93 citations
Hybrid Convergent Procedure for the Treatment of Persistent and Long Standing Persistent Atrial Fibrillation: Results of CONVERGE Clinical Trial.
David B. DeLurgio, Karl J. Crossen, Jaswinder Gill, Christopher Blauth, Saumil Oza, Anthony R. Magnano, Mark A. Mostovych, Michael E. Halkos, David Tschopp, Faraz Kere...> ;Circulation. Arrhythmia and Electrophysiology. 2020 Nov 13
Appropriate Implantable Cardioverter-Defibrillator Therapies Delivered 5 Years After End of Service.
Matthew F Yuyun, Fareed N. Ali, Jonathan S. Silver, Mary Ellen Gray, G. Muqtada Chaudhry> ;JACC. Case Reports. 2020 May 1
Bradycardia: What is the mechanism?
Ajay K. Sharma, Matthew F Yuyun, Jonathan S. Silver> ;Journal of Electrocardiology. 2018 Jan 1
8 citations
Without Further Delay: Lyme Carditis.
Ajay K. Sharma, Nureddin Almaddah, Kashif Chaudhry, Sarju Ganatra, Ghulam M. Chaudhry, Jonathan S. Silver> ;The American Journal of Medicine. 2017 Nov 20
7 citations
NK cells join the plasticity party.
Jonathan S. Silver, Alison A. Humbles> ;Nature Immunology. 2017 Aug 22
78 citations
T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow
Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B. Wing, Radhika Goenka, Daniela Gómez Atria, Jonathan S. Silver, Sunglim Cho, Amaya I. Wolf, William ...> ;Cell Reports. 2017 Feb 21
Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.
Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA> ;Nat. Immunol.. 2016-07-19
Erratum: IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.
Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu Y> ;Nat. Immunol.. 2016-07-19
IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.
Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu Y> ;Nat. Immunol.. 2016-06-01
153 citations
Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.
Jonathan S Silver, Jennifer Kearley, Alan M Copenhaver, Caroline Sanden, Michiko Mori, Li Yu, Gretchen Harms Pritchard, Aaron A Berlin, Christopher A Hunter, Russell B...> ;Nature Immunology. 2016 Jun 1
236 citations
Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.
Jennifer Kearley, Jonathan S. Silver, Caroline Sanden, Zheng Liu, Aaron A Berlin, Natalie White, Michiko Mori, Tuyet-Hang Pham, Christine K. Ward, Gerard J. Criner, Na...> ;Immunity. 2015 Mar 17
9 citations
Adverse Structural Remodeling of the Left Ventricle and Ventricular Arrhythmias in Patients With Depressed Ejection Fraction
Timothy S. Draper, Jonathan S. Silver, William H. Gaasch> ;Journal of Cardiac Failure. 2015 Feb 1
52 citations
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
Alba Llop-Guevara, Derek K. Chu, Tina D. Walker, Susanna Goncharova, Ramzi Fattouh, Jonathan S. Silver, Cheryl Lynn Moore, Juliana L. Xie, Paul M. O'Byrne, Anthony J. ...> ;Plos One. 2014 Feb 14
6 citations
Coronary Sinus to Left Atrium Communication
Almamoon I. Justaniah, Brady McKee, Jonathan S. Silver, Christoph Wald, Sebastian Flacke> ;Journal of Radiology Case Reports. 2013 Dec 1
22 citations
IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection.
Jason S. Stumhofer, Jonathan S. Silver, Christopher A. Hunter> ;Plos One. 2013 May 7
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.
Brinkworth JF, Pechenkina EA, Silver J, Goyert SM> ;J. Med. Primatol.. 2012-12-01
32 citations
Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture.
Arielle Glatman Zaretsky, Jonathan S. Silver, Marie Siwicki, Amy C. Durham, Carl F. Ware, Christopher A. Hunter> ;Infection and Immunity. 2012 Oct 1
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno EDT, Wagage S, Roos DS, ...> ;Immunity. 2012-09-21
19 citations
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Daniel Traum, Patricia Timothee, Jonathan S. Silver, Stefan Rose-John, Matthias Ernst, David F. LaRosa> ;Journal of Leukocyte Biology. 2012 Mar 1
93 citations
The immunobiology of IL-27.
Aisling O’Hara Hall, Jonathan S. Silver, Christopher A. Hunter> ;Advances in Immunology. 2012 Jan 1
183 citations
Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation
Radhika Goenka, Lisa G. Barnett, Jonathan S. Silver, Patrick J. O'Neill, Christopher A. Hunter, Michael P. Cancro, Terri M. Laufer> ;Journal of Immunology. 2011 Aug 1
33 citations
IL-6 Mediates the Susceptibility of Glycoprotein 130 Hypermorphs to Toxoplasma gondii
Jonathan S. Silver, Jason S. Stumhofer, Sara T. Passos, Matthias Ernst, Christopher A. Hunter> ;Journal of Immunology. 2011 Jul 1
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Professional Memberships

American College of Cardiology - ACC
Member

Hospital Affiliations

Beverly HospitalBeverly, Massachusetts
Lahey Hospital & Medical CenterBurlington, Massachusetts